Amino acid dipepetide frequency for Mucinivorans hirudinis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.897AlaAla: 6.897 ± 0.126	0.692AlaCys: 0.692 ± 0.029	4.386AlaAsp: 4.386 ± 0.071	5.014AlaGlu: 5.014 ± 0.088	2.82AlaPhe: 2.82 ± 0.059	5.122AlaGly: 5.122 ± 0.079	1.2AlaHis: 1.2 ± 0.04	5.545AlaIle: 5.545 ± 0.08	4.868AlaLys: 4.868 ± 0.089	6.977AlaLeu: 6.977 ± 0.1	2.249AlaMet: 2.249 ± 0.046	3.453AlaAsn: 3.453 ± 0.071	2.269AlaPro: 2.269 ± 0.053	3.081AlaGln: 3.081 ± 0.062	3.691AlaArg: 3.691 ± 0.074	4.136AlaSer: 4.136 ± 0.078	4.585AlaThr: 4.585 ± 0.079	5.339AlaVal: 5.339 ± 0.097	0.722AlaTrp: 0.722 ± 0.029	2.481AlaTyr: 2.481 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.764CysAla: 0.764 ± 0.033	0.205CysCys: 0.205 ± 0.017	0.705CysAsp: 0.705 ± 0.032	0.732CysGlu: 0.732 ± 0.032	0.554CysPhe: 0.554 ± 0.024	1.073CysGly: 1.073 ± 0.039	0.231CysHis: 0.231 ± 0.019	0.639CysIle: 0.639 ± 0.027	0.629CysLys: 0.629 ± 0.026	0.8CysLeu: 0.8 ± 0.029	0.216CysMet: 0.216 ± 0.016	0.551CysAsn: 0.551 ± 0.023	0.466CysPro: 0.466 ± 0.027	0.248CysGln: 0.248 ± 0.017	0.728CysArg: 0.728 ± 0.029	0.809CysSer: 0.809 ± 0.035	0.61CysThr: 0.61 ± 0.028	0.671CysVal: 0.671 ± 0.03	0.109CysTrp: 0.109 ± 0.012	0.445CysTyr: 0.445 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.716AspAla: 3.716 ± 0.063	0.713AspCys: 0.713 ± 0.027	2.61AspAsp: 2.61 ± 0.06	3.577AspGlu: 3.577 ± 0.072	3.185AspPhe: 3.185 ± 0.068	3.975AspGly: 3.975 ± 0.068	0.736AspHis: 0.736 ± 0.027	4.366AspIle: 4.366 ± 0.077	4.023AspLys: 4.023 ± 0.069	4.105AspLeu: 4.105 ± 0.065	1.424AspMet: 1.424 ± 0.042	2.996AspAsn: 2.996 ± 0.067	1.715AspPro: 1.715 ± 0.041	1.035AspGln: 1.035 ± 0.028	2.349AspArg: 2.349 ± 0.06	3.318AspSer: 3.318 ± 0.063	2.551AspThr: 2.551 ± 0.051	3.654AspVal: 3.654 ± 0.071	0.768AspTrp: 0.768 ± 0.033	2.763AspTyr: 2.763 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	4.428GluAla: 4.428 ± 0.085	0.688GluCys: 0.688 ± 0.03	2.958GluAsp: 2.958 ± 0.06	3.948GluGlu: 3.948 ± 0.09	2.894GluPhe: 2.894 ± 0.068	3.84GluGly: 3.84 ± 0.07	1.185GluHis: 1.185 ± 0.038	5.115GluIle: 5.115 ± 0.08	4.864GluLys: 4.864 ± 0.082	6.958GluLeu: 6.958 ± 0.098	1.81GluMet: 1.81 ± 0.052	3.6GluAsn: 3.6 ± 0.076	1.838GluPro: 1.838 ± 0.047	3.387GluGln: 3.387 ± 0.074	4.054GluArg: 4.054 ± 0.079	3.433GluSer: 3.433 ± 0.065	2.689GluThr: 2.689 ± 0.061	4.396GluVal: 4.396 ± 0.078	0.891GluTrp: 0.891 ± 0.03	2.699GluTyr: 2.699 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.811PheAla: 3.811 ± 0.06	0.555PheCys: 0.555 ± 0.028	3.132PheAsp: 3.132 ± 0.063	2.964PheGlu: 2.964 ± 0.054	2.177PhePhe: 2.177 ± 0.057	3.41PheGly: 3.41 ± 0.07	0.729PheHis: 0.729 ± 0.031	3.187PheIle: 3.187 ± 0.065	2.099PheLys: 2.099 ± 0.054	3.716PheLeu: 3.716 ± 0.07	1.147PheMet: 1.147 ± 0.036	2.308PheAsn: 2.308 ± 0.061	1.568PhePro: 1.568 ± 0.039	1.131PheGln: 1.131 ± 0.039	2.367PheArg: 2.367 ± 0.049	3.409PheSer: 3.409 ± 0.064	2.642PheThr: 2.642 ± 0.056	3.233PheVal: 3.233 ± 0.066	0.549PheTrp: 0.549 ± 0.023	1.835PheTyr: 1.835 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	5.139GlyAla: 5.139 ± 0.092	0.854GlyCys: 0.854 ± 0.038	3.6GlyAsp: 3.6 ± 0.069	4.73GlyGlu: 4.73 ± 0.084	3.278GlyPhe: 3.278 ± 0.066	5.296GlyGly: 5.296 ± 0.112	1.023GlyHis: 1.023 ± 0.034	4.872GlyIle: 4.872 ± 0.08	4.911GlyLys: 4.911 ± 0.081	5.533GlyLeu: 5.533 ± 0.081	1.761GlyMet: 1.761 ± 0.051	3.146GlyAsn: 3.146 ± 0.074	0.701GlyPro: 0.701 ± 0.027	1.903GlyGln: 1.903 ± 0.047	3.368GlyArg: 3.368 ± 0.067	4.196GlySer: 4.196 ± 0.081	3.633GlyThr: 3.633 ± 0.085	5.844GlyVal: 5.844 ± 0.097	0.891GlyTrp: 0.891 ± 0.036	3.308GlyTyr: 3.308 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	0.709HisAla: 0.709 ± 0.032	0.281HisCys: 0.281 ± 0.019	0.673HisAsp: 0.673 ± 0.029	0.688HisGlu: 0.688 ± 0.03	0.895HisPhe: 0.895 ± 0.033	0.932HisGly: 0.932 ± 0.037	0.412HisHis: 0.412 ± 0.027	1.457HisIle: 1.457 ± 0.04	1.145HisLys: 1.145 ± 0.035	1.65HisLeu: 1.65 ± 0.049	0.216HisMet: 0.216 ± 0.015	1.059HisAsn: 1.059 ± 0.036	0.909HisPro: 0.909 ± 0.035	0.604HisGln: 0.604 ± 0.026	1.083HisArg: 1.083 ± 0.035	1.349HisSer: 1.349 ± 0.044	1.061HisThr: 1.061 ± 0.035	0.596HisVal: 0.596 ± 0.027	0.194HisTrp: 0.194 ± 0.016	0.85HisTyr: 0.85 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.191IleAla: 6.191 ± 0.098	0.903IleCys: 0.903 ± 0.036	4.843IleAsp: 4.843 ± 0.08	5.745IleGlu: 5.745 ± 0.082	3.433IlePhe: 3.433 ± 0.066	4.608IleGly: 4.608 ± 0.082	1.098IleHis: 1.098 ± 0.04	5.309IleIle: 5.309 ± 0.084	4.616IleLys: 4.616 ± 0.076	5.888IleLeu: 5.888 ± 0.093	1.484IleMet: 1.484 ± 0.046	3.865IleAsn: 3.865 ± 0.079	3.095IlePro: 3.095 ± 0.059	1.881IleGln: 1.881 ± 0.043	3.284IleArg: 3.284 ± 0.06	4.978IleSer: 4.978 ± 0.077	4.611IleThr: 4.611 ± 0.078	5.069IleVal: 5.069 ± 0.094	0.637IleTrp: 0.637 ± 0.028	2.876IleTyr: 2.876 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	4.327LysAla: 4.327 ± 0.08	0.533LysCys: 0.533 ± 0.029	3.085LysAsp: 3.085 ± 0.064	4.555LysGlu: 4.555 ± 0.088	2.651LysPhe: 2.651 ± 0.051	4.165LysGly: 4.165 ± 0.066	1.032LysHis: 1.032 ± 0.036	5.363LysIle: 5.363 ± 0.088	4.294LysLys: 4.294 ± 0.082	5.574LysLeu: 5.574 ± 0.094	2.143LysMet: 2.143 ± 0.049	3.32LysAsn: 3.32 ± 0.059	2.209LysPro: 2.209 ± 0.059	2.232LysGln: 2.232 ± 0.056	3.494LysArg: 3.494 ± 0.069	3.945LysSer: 3.945 ± 0.067	3.254LysThr: 3.254 ± 0.061	4.291LysVal: 4.291 ± 0.065	0.747LysTrp: 0.747 ± 0.032	2.789LysTyr: 2.789 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	6.644LeuAla: 6.644 ± 0.112	1.139LeuCys: 1.139 ± 0.04	4.454LeuAsp: 4.454 ± 0.072	5.304LeuGlu: 5.304 ± 0.084	4.348LeuPhe: 4.348 ± 0.089	5.685LeuGly: 5.685 ± 0.089	1.5LeuHis: 1.5 ± 0.038	6.058LeuIle: 6.058 ± 0.095	5.768LeuLys: 5.768 ± 0.076	8.544LeuLeu: 8.544 ± 0.131	2.318LeuMet: 2.318 ± 0.057	4.277LeuAsn: 4.277 ± 0.074	3.664LeuPro: 3.664 ± 0.072	2.953LeuGln: 2.953 ± 0.062	4.85LeuArg: 4.85 ± 0.074	6.666LeuSer: 6.666 ± 0.1	5.3LeuThr: 5.3 ± 0.085	5.057LeuVal: 5.057 ± 0.096	1.084LeuTrp: 1.084 ± 0.037	3.414LeuTyr: 3.414 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.086MetAla: 2.086 ± 0.054	0.241MetCys: 0.241 ± 0.018	1.159MetAsp: 1.159 ± 0.037	1.714MetGlu: 1.714 ± 0.048	1.009MetPhe: 1.009 ± 0.04	1.942MetGly: 1.942 ± 0.043	0.378MetHis: 0.378 ± 0.02	1.615MetIle: 1.615 ± 0.045	1.898MetLys: 1.898 ± 0.054	2.423MetLeu: 2.423 ± 0.055	0.736MetMet: 0.736 ± 0.031	1.267MetAsn: 1.267 ± 0.039	1.121MetPro: 1.121 ± 0.037	0.979MetGln: 0.979 ± 0.032	1.416MetArg: 1.416 ± 0.041	1.642MetSer: 1.642 ± 0.038	1.256MetThr: 1.256 ± 0.044	1.938MetVal: 1.938 ± 0.049	0.283MetTrp: 0.283 ± 0.019	0.738MetTyr: 0.738 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.312AsnAla: 3.312 ± 0.066	0.513AsnCys: 0.513 ± 0.028	2.328AsnAsp: 2.328 ± 0.058	2.939AsnGlu: 2.939 ± 0.061	2.549AsnPhe: 2.549 ± 0.058	3.498AsnGly: 3.498 ± 0.066	0.955AsnHis: 0.955 ± 0.035	4.237AsnIle: 4.237 ± 0.073	2.937AsnLys: 2.937 ± 0.058	4.418AsnLeu: 4.418 ± 0.069	1.098AsnMet: 1.098 ± 0.038	2.841AsnAsn: 2.841 ± 0.068	2.596AsnPro: 2.596 ± 0.06	1.648AsnGln: 1.648 ± 0.049	2.701AsnArg: 2.701 ± 0.062	3.309AsnSer: 3.309 ± 0.079	2.565AsnThr: 2.565 ± 0.054	3.073AsnVal: 3.073 ± 0.066	0.588AsnTrp: 0.588 ± 0.025	2.274AsnTyr: 2.274 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	2.654ProAla: 2.654 ± 0.05	0.305ProCys: 0.305 ± 0.021	1.901ProAsp: 1.901 ± 0.047	2.658ProGlu: 2.658 ± 0.048	1.694ProPhe: 1.694 ± 0.041	1.563ProGly: 1.563 ± 0.045	0.702ProHis: 0.702 ± 0.031	2.552ProIle: 2.552 ± 0.048	2.162ProLys: 2.162 ± 0.052	3.269ProLeu: 3.269 ± 0.065	0.941ProMet: 0.941 ± 0.037	1.647ProAsn: 1.647 ± 0.042	1.086ProPro: 1.086 ± 0.039	1.533ProGln: 1.533 ± 0.046	1.598ProArg: 1.598 ± 0.056	2.21ProSer: 2.21 ± 0.056	2.319ProThr: 2.319 ± 0.06	2.408ProVal: 2.408 ± 0.06	0.373ProTrp: 0.373 ± 0.021	1.505ProTyr: 1.505 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.416GlnAla: 2.416 ± 0.05	0.331GlnCys: 0.331 ± 0.019	1.317GlnAsp: 1.317 ± 0.039	2.011GlnGlu: 2.011 ± 0.054	1.448GlnPhe: 1.448 ± 0.04	2.255GlnGly: 2.255 ± 0.046	0.533GlnHis: 0.533 ± 0.023	2.888GlnIle: 2.888 ± 0.061	2.42GlnLys: 2.42 ± 0.059	2.938GlnLeu: 2.938 ± 0.06	1.086GlnMet: 1.086 ± 0.031	1.82GlnAsn: 1.82 ± 0.048	1.242GlnPro: 1.242 ± 0.041	1.662GlnGln: 1.662 ± 0.054	1.98GlnArg: 1.98 ± 0.052	2.188GlnSer: 2.188 ± 0.047	1.992GlnThr: 1.992 ± 0.047	2.009GlnVal: 2.009 ± 0.049	0.465GlnTrp: 0.465 ± 0.025	1.389GlnTyr: 1.389 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	3.777ArgAla: 3.777 ± 0.077	0.537ArgCys: 0.537 ± 0.025	2.669ArgAsp: 2.669 ± 0.053	3.931ArgGlu: 3.931 ± 0.078	2.306ArgPhe: 2.306 ± 0.053	3.422ArgGly: 3.422 ± 0.068	0.999ArgHis: 0.999 ± 0.035	3.637ArgIle: 3.637 ± 0.062	3.193ArgLys: 3.193 ± 0.068	4.643ArgLeu: 4.643 ± 0.081	1.495ArgMet: 1.495 ± 0.042	2.557ArgAsn: 2.557 ± 0.055	1.5ArgPro: 1.5 ± 0.045	1.878ArgGln: 1.878 ± 0.049	2.861ArgArg: 2.861 ± 0.067	2.815ArgSer: 2.815 ± 0.055	2.563ArgThr: 2.563 ± 0.063	3.437ArgVal: 3.437 ± 0.064	0.688ArgTrp: 0.688 ± 0.034	2.378ArgTyr: 2.378 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.832SerAla: 4.832 ± 0.071	0.74SerCys: 0.74 ± 0.035	3.534SerAsp: 3.534 ± 0.066	3.999SerGlu: 3.999 ± 0.075	2.974SerPhe: 2.974 ± 0.053	4.777SerGly: 4.777 ± 0.072	1.086SerHis: 1.086 ± 0.038	4.355SerIle: 4.355 ± 0.086	3.81SerLys: 3.81 ± 0.069	6.004SerLeu: 6.004 ± 0.094	1.455SerMet: 1.455 ± 0.036	2.883SerAsn: 2.883 ± 0.057	2.408SerPro: 2.408 ± 0.048	2.285SerGln: 2.285 ± 0.054	3.116SerArg: 3.116 ± 0.064	3.976SerSer: 3.976 ± 0.066	3.442SerThr: 3.442 ± 0.061	4.304SerVal: 4.304 ± 0.073	0.717SerTrp: 0.717 ± 0.03	2.745SerTyr: 2.745 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	4.255ThrAla: 4.255 ± 0.078	0.414ThrCys: 0.414 ± 0.021	3.06ThrAsp: 3.06 ± 0.062	3.255ThrGlu: 3.255 ± 0.064	2.538ThrPhe: 2.538 ± 0.054	3.908ThrGly: 3.908 ± 0.076	0.996ThrHis: 0.996 ± 0.034	4.642ThrIle: 4.642 ± 0.081	3.275ThrLys: 3.275 ± 0.07	5.298ThrLeu: 5.298 ± 0.077	1.339ThrMet: 1.339 ± 0.041	2.548ThrAsn: 2.548 ± 0.059	2.727ThrPro: 2.727 ± 0.055	1.944ThrGln: 1.944 ± 0.05	2.091ThrArg: 2.091 ± 0.048	2.991ThrSer: 2.991 ± 0.054	3.565ThrThr: 3.565 ± 0.068	3.739ThrVal: 3.739 ± 0.07	0.456ThrTrp: 0.456 ± 0.026	1.934ThrTyr: 1.934 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.871ValAla: 5.871 ± 0.099	0.856ValCys: 0.856 ± 0.035	4.1ValAsp: 4.1 ± 0.075	4.901ValGlu: 4.901 ± 0.074	2.635ValPhe: 2.635 ± 0.059	4.768ValGly: 4.768 ± 0.079	0.937ValHis: 0.937 ± 0.034	4.898ValIle: 4.898 ± 0.088	4.009ValLys: 4.009 ± 0.078	5.479ValLeu: 5.479 ± 0.091	1.71ValMet: 1.71 ± 0.047	3.149ValAsn: 3.149 ± 0.076	2.253ValPro: 2.253 ± 0.055	1.893ValGln: 1.893 ± 0.051	3.403ValArg: 3.403 ± 0.068	4.605ValSer: 4.605 ± 0.074	3.524ValThr: 3.524 ± 0.071	5.767ValVal: 5.767 ± 0.098	0.78ValTrp: 0.78 ± 0.03	2.288ValTyr: 2.288 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.86TrpAla: 0.86 ± 0.032	0.16TrpCys: 0.16 ± 0.013	0.696TrpAsp: 0.696 ± 0.029	0.714TrpGlu: 0.714 ± 0.031	0.498TrpPhe: 0.498 ± 0.028	0.925TrpGly: 0.925 ± 0.036	0.24TrpHis: 0.24 ± 0.017	0.784TrpIle: 0.784 ± 0.03	0.581TrpLys: 0.581 ± 0.03	1.084TrpLeu: 1.084 ± 0.04	0.314TrpMet: 0.314 ± 0.018	0.612TrpAsn: 0.612 ± 0.023	0.116TrpPro: 0.116 ± 0.013	0.66TrpGln: 0.66 ± 0.026	0.685TrpArg: 0.685 ± 0.027	0.829TrpSer: 0.829 ± 0.032	0.479TrpThr: 0.479 ± 0.026	0.767TrpVal: 0.767 ± 0.032	0.176TrpTrp: 0.176 ± 0.014	0.42TrpTyr: 0.42 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.837TyrAla: 2.837 ± 0.056	0.523TyrCys: 0.523 ± 0.03	2.369TyrAsp: 2.369 ± 0.055	2.292TyrGlu: 2.292 ± 0.055	2.084TyrPhe: 2.084 ± 0.048	2.823TyrGly: 2.823 ± 0.063	0.792TyrHis: 0.792 ± 0.034	2.896TyrIle: 2.896 ± 0.063	2.501TyrLys: 2.501 ± 0.053	3.725TyrLeu: 3.725 ± 0.068	0.902TyrMet: 0.902 ± 0.033	2.48TyrAsn: 2.48 ± 0.062	1.595TyrPro: 1.595 ± 0.043	1.455TyrGln: 1.455 ± 0.039	2.168TyrArg: 2.168 ± 0.056	2.639TyrSer: 2.639 ± 0.057	2.334TyrThr: 2.334 ± 0.057	2.236TyrVal: 2.236 ± 0.049	0.48TyrTrp: 0.48 ± 0.028	1.931TyrTyr: 1.931 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2816 proteins (879195 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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