Amino acid dipepetide frequency for Cycloclasticus sp. symbiont of Bathymodiolus heckerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.292AlaAla: 7.292 ± 0.151
1.062AlaCys: 1.062 ± 0.037
4.845AlaAsp: 4.845 ± 0.079
5.369AlaGlu: 5.369 ± 0.101
3.291AlaPhe: 3.291 ± 0.077
6.169AlaGly: 6.169 ± 0.11
1.676AlaHis: 1.676 ± 0.053
6.055AlaIle: 6.055 ± 0.119
4.942AlaLys: 4.942 ± 0.097
9.41AlaLeu: 9.41 ± 0.13
2.369AlaMet: 2.369 ± 0.064
3.35AlaAsn: 3.35 ± 0.063
2.627AlaPro: 2.627 ± 0.076
3.124AlaGln: 3.124 ± 0.077
3.465AlaArg: 3.465 ± 0.076
5.377AlaSer: 5.377 ± 0.092
4.28AlaThr: 4.28 ± 0.083
5.956AlaVal: 5.956 ± 0.107
0.939AlaTrp: 0.939 ± 0.041
2.335AlaTyr: 2.335 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.877CysAla: 0.877 ± 0.042
0.161CysCys: 0.161 ± 0.015
0.662CysAsp: 0.662 ± 0.033
0.657CysGlu: 0.657 ± 0.033
0.482CysPhe: 0.482 ± 0.027
0.911CysGly: 0.911 ± 0.04
0.355CysHis: 0.355 ± 0.024
0.688CysIle: 0.688 ± 0.04
0.503CysLys: 0.503 ± 0.027
1.061CysLeu: 1.061 ± 0.042
0.223CysMet: 0.223 ± 0.019
0.386CysAsn: 0.386 ± 0.024
0.54CysPro: 0.54 ± 0.032
0.394CysGln: 0.394 ± 0.029
0.498CysArg: 0.498 ± 0.028
0.724CysSer: 0.724 ± 0.036
0.495CysThr: 0.495 ± 0.032
0.737CysVal: 0.737 ± 0.038
0.116CysTrp: 0.116 ± 0.016
0.338CysTyr: 0.338 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.729AspAla: 4.729 ± 0.09
0.589AspCys: 0.589 ± 0.031
3.581AspAsp: 3.581 ± 0.085
4.261AspGlu: 4.261 ± 0.102
2.649AspPhe: 2.649 ± 0.063
3.869AspGly: 3.869 ± 0.098
1.074AspHis: 1.074 ± 0.04
4.555AspIle: 4.555 ± 0.086
3.348AspLys: 3.348 ± 0.079
5.403AspLeu: 5.403 ± 0.091
1.549AspMet: 1.549 ± 0.053
2.315AspAsn: 2.315 ± 0.068
1.936AspPro: 1.936 ± 0.062
1.788AspGln: 1.788 ± 0.048
2.24AspArg: 2.24 ± 0.063
3.389AspSer: 3.389 ± 0.069
2.71AspThr: 2.71 ± 0.069
4.454AspVal: 4.454 ± 0.082
0.804AspTrp: 0.804 ± 0.04
1.825AspTyr: 1.825 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.302GluAla: 5.302 ± 0.104
0.56GluCys: 0.56 ± 0.032
2.972GluAsp: 2.972 ± 0.078
4.087GluGlu: 4.087 ± 0.105
2.383GluPhe: 2.383 ± 0.067
3.922GluGly: 3.922 ± 0.086
1.604GluHis: 1.604 ± 0.056
3.981GluIle: 3.981 ± 0.076
4.687GluLys: 4.687 ± 0.106
6.994GluLeu: 6.994 ± 0.124
1.744GluMet: 1.744 ± 0.056
2.756GluAsn: 2.756 ± 0.066
2.141GluPro: 2.141 ± 0.082
3.527GluGln: 3.527 ± 0.089
3.254GluArg: 3.254 ± 0.079
3.869GluSer: 3.869 ± 0.092
3.381GluThr: 3.381 ± 0.077
4.088GluVal: 4.088 ± 0.108
0.669GluTrp: 0.669 ± 0.038
1.684GluTyr: 1.684 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.05PheAla: 3.05 ± 0.067
0.493PheCys: 0.493 ± 0.03
2.753PheAsp: 2.753 ± 0.075
2.497PheGlu: 2.497 ± 0.067
1.886PhePhe: 1.886 ± 0.071
2.834PheGly: 2.834 ± 0.07
0.82PheHis: 0.82 ± 0.035
2.956PheIle: 2.956 ± 0.076
2.393PheLys: 2.393 ± 0.061
3.599PheLeu: 3.599 ± 0.085
1.036PheMet: 1.036 ± 0.048
2.045PheAsn: 2.045 ± 0.064
1.48PhePro: 1.48 ± 0.047
1.214PheGln: 1.214 ± 0.046
1.502PheArg: 1.502 ± 0.053
3.398PheSer: 3.398 ± 0.087
2.061PheThr: 2.061 ± 0.06
2.671PheVal: 2.671 ± 0.06
0.491PheTrp: 0.491 ± 0.034
1.313PheTyr: 1.313 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.339GlyAla: 5.339 ± 0.11
0.948GlyCys: 0.948 ± 0.039
4.009GlyAsp: 4.009 ± 0.089
4.454GlyGlu: 4.454 ± 0.101
3.322GlyPhe: 3.322 ± 0.077
5.025GlyGly: 5.025 ± 0.13
1.733GlyHis: 1.733 ± 0.058
4.799GlyIle: 4.799 ± 0.107
4.301GlyLys: 4.301 ± 0.081
7.368GlyLeu: 7.368 ± 0.132
2.104GlyMet: 2.104 ± 0.067
2.444GlyAsn: 2.444 ± 0.066
1.643GlyPro: 1.643 ± 0.055
2.533GlyGln: 2.533 ± 0.064
3.161GlyArg: 3.161 ± 0.074
4.404GlySer: 4.404 ± 0.096
3.293GlyThr: 3.293 ± 0.083
5.478GlyVal: 5.478 ± 0.098
0.913GlyTrp: 0.913 ± 0.046
2.291GlyTyr: 2.291 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.858HisAla: 1.858 ± 0.051
0.337HisCys: 0.337 ± 0.025
1.134HisAsp: 1.134 ± 0.038
1.217HisGlu: 1.217 ± 0.049
0.988HisPhe: 0.988 ± 0.036
1.659HisGly: 1.659 ± 0.057
0.704HisHis: 0.704 ± 0.039
1.544HisIle: 1.544 ± 0.052
1.166HisLys: 1.166 ± 0.046
2.261HisLeu: 2.261 ± 0.058
0.537HisMet: 0.537 ± 0.031
0.846HisAsn: 0.846 ± 0.038
1.157HisPro: 1.157 ± 0.046
1.121HisGln: 1.121 ± 0.049
1.017HisArg: 1.017 ± 0.042
1.389HisSer: 1.389 ± 0.051
1.147HisThr: 1.147 ± 0.042
1.497HisVal: 1.497 ± 0.049
0.324HisTrp: 0.324 ± 0.022
0.812HisTyr: 0.812 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.117IleAla: 6.117 ± 0.122
0.727IleCys: 0.727 ± 0.038
4.633IleAsp: 4.633 ± 0.089
4.855IleGlu: 4.855 ± 0.084
2.354IlePhe: 2.354 ± 0.07
4.824IleGly: 4.824 ± 0.103
1.45IleHis: 1.45 ± 0.046
4.305IleIle: 4.305 ± 0.098
4.401IleLys: 4.401 ± 0.081
5.621IleLeu: 5.621 ± 0.123
1.328IleMet: 1.328 ± 0.053
3.376IleAsn: 3.376 ± 0.072
2.824IlePro: 2.824 ± 0.067
2.47IleGln: 2.47 ± 0.077
3.078IleArg: 3.078 ± 0.072
4.804IleSer: 4.804 ± 0.09
3.961IleThr: 3.961 ± 0.086
4.332IleVal: 4.332 ± 0.083
0.569IleTrp: 0.569 ± 0.032
1.724IleTyr: 1.724 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.261LysAla: 5.261 ± 0.107
0.382LysCys: 0.382 ± 0.028
2.984LysAsp: 2.984 ± 0.078
4.148LysGlu: 4.148 ± 0.088
1.552LysPhe: 1.552 ± 0.054
4.043LysGly: 4.043 ± 0.098
1.384LysHis: 1.384 ± 0.052
3.817LysIle: 3.817 ± 0.076
4.682LysLys: 4.682 ± 0.116
5.653LysLeu: 5.653 ± 0.087
1.528LysMet: 1.528 ± 0.054
2.948LysAsn: 2.948 ± 0.064
2.535LysPro: 2.535 ± 0.064
3.081LysGln: 3.081 ± 0.077
3.203LysArg: 3.203 ± 0.08
3.708LysSer: 3.708 ± 0.078
3.628LysThr: 3.628 ± 0.083
3.914LysVal: 3.914 ± 0.081
0.516LysTrp: 0.516 ± 0.028
1.448LysTyr: 1.448 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
8.98LeuAla: 8.98 ± 0.122
0.978LeuCys: 0.978 ± 0.04
5.857LeuAsp: 5.857 ± 0.111
6.302LeuGlu: 6.302 ± 0.122
4.134LeuPhe: 4.134 ± 0.089
6.95LeuGly: 6.95 ± 0.119
2.208LeuHis: 2.208 ± 0.067
6.633LeuIle: 6.633 ± 0.102
6.39LeuLys: 6.39 ± 0.114
10.592LeuLeu: 10.592 ± 0.167
2.642LeuMet: 2.642 ± 0.069
4.9LeuAsn: 4.9 ± 0.099
4.48LeuPro: 4.48 ± 0.089
3.626LeuGln: 3.626 ± 0.089
4.453LeuArg: 4.453 ± 0.099
8.168LeuSer: 8.168 ± 0.123
5.795LeuThr: 5.795 ± 0.094
6.569LeuVal: 6.569 ± 0.106
1.022LeuTrp: 1.022 ± 0.046
2.609LeuTyr: 2.609 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.505MetAla: 2.505 ± 0.075
0.228MetCys: 0.228 ± 0.021
1.409MetAsp: 1.409 ± 0.051
1.371MetGlu: 1.371 ± 0.049
0.893MetPhe: 0.893 ± 0.034
1.946MetGly: 1.946 ± 0.06
0.573MetHis: 0.573 ± 0.029
1.376MetIle: 1.376 ± 0.047
1.437MetLys: 1.437 ± 0.047
2.619MetLeu: 2.619 ± 0.063
0.748MetMet: 0.748 ± 0.039
1.165MetAsn: 1.165 ± 0.044
1.251MetPro: 1.251 ± 0.045
1.067MetGln: 1.067 ± 0.042
1.178MetArg: 1.178 ± 0.047
2.099MetSer: 2.099 ± 0.062
1.456MetThr: 1.456 ± 0.05
1.71MetVal: 1.71 ± 0.054
0.174MetTrp: 0.174 ± 0.017
0.503MetTyr: 0.503 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.579AsnAla: 3.579 ± 0.08
0.454AsnCys: 0.454 ± 0.028
2.535AsnAsp: 2.535 ± 0.068
2.824AsnGlu: 2.824 ± 0.077
1.443AsnPhe: 1.443 ± 0.051
2.867AsnGly: 2.867 ± 0.065
0.843AsnHis: 0.843 ± 0.035
3.215AsnIle: 3.215 ± 0.079
2.863AsnLys: 2.863 ± 0.07
3.83AsnLeu: 3.83 ± 0.076
1.057AsnMet: 1.057 ± 0.037
2.156AsnAsn: 2.156 ± 0.062
2.076AsnPro: 2.076 ± 0.056
1.625AsnGln: 1.625 ± 0.057
1.889AsnArg: 1.889 ± 0.056
2.65AsnSer: 2.65 ± 0.069
2.325AsnThr: 2.325 ± 0.065
2.8AsnVal: 2.8 ± 0.067
0.538AsnTrp: 0.538 ± 0.029
1.293AsnTyr: 1.293 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.106ProAla: 3.106 ± 0.078
0.342ProCys: 0.342 ± 0.021
2.483ProAsp: 2.483 ± 0.065
2.945ProGlu: 2.945 ± 0.084
1.646ProPhe: 1.646 ± 0.052
2.307ProGly: 2.307 ± 0.072
0.872ProHis: 0.872 ± 0.041
2.691ProIle: 2.691 ± 0.076
2.117ProLys: 2.117 ± 0.067
3.935ProLeu: 3.935 ± 0.087
1.028ProMet: 1.028 ± 0.048
1.737ProAsn: 1.737 ± 0.049
1.22ProPro: 1.22 ± 0.04
1.297ProGln: 1.297 ± 0.052
1.362ProArg: 1.362 ± 0.044
2.507ProSer: 2.507 ± 0.067
2.076ProThr: 2.076 ± 0.059
3.058ProVal: 3.058 ± 0.072
0.451ProTrp: 0.451 ± 0.028
1.127ProTyr: 1.127 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
3.859GlnAla: 3.859 ± 0.075
0.412GlnCys: 0.412 ± 0.027
1.594GlnAsp: 1.594 ± 0.053
2.173GlnGlu: 2.173 ± 0.059
1.544GlnPhe: 1.544 ± 0.051
2.46GlnGly: 2.46 ± 0.072
1.168GlnHis: 1.168 ± 0.046
2.3GlnIle: 2.3 ± 0.064
2.274GlnLys: 2.274 ± 0.064
4.552GlnLeu: 4.552 ± 0.106
0.922GlnMet: 0.922 ± 0.037
1.464GlnAsn: 1.464 ± 0.047
1.489GlnPro: 1.489 ± 0.047
2.731GlnGln: 2.731 ± 0.082
2.235GlnArg: 2.235 ± 0.066
2.494GlnSer: 2.494 ± 0.068
2.191GlnThr: 2.191 ± 0.064
2.598GlnVal: 2.598 ± 0.066
0.563GlnTrp: 0.563 ± 0.031
1.181GlnTyr: 1.181 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
3.254ArgAla: 3.254 ± 0.067
0.516ArgCys: 0.516 ± 0.031
2.413ArgAsp: 2.413 ± 0.073
2.958ArgGlu: 2.958 ± 0.077
2.219ArgPhe: 2.219 ± 0.064
2.826ArgGly: 2.826 ± 0.068
1.113ArgHis: 1.113 ± 0.043
3.098ArgIle: 3.098 ± 0.064
2.551ArgLys: 2.551 ± 0.073
5.108ArgLeu: 5.108 ± 0.091
1.267ArgMet: 1.267 ± 0.047
1.715ArgAsn: 1.715 ± 0.052
1.601ArgPro: 1.601 ± 0.051
1.977ArgGln: 1.977 ± 0.061
2.261ArgArg: 2.261 ± 0.058
2.748ArgSer: 2.748 ± 0.064
2.107ArgThr: 2.107 ± 0.057
3.169ArgVal: 3.169 ± 0.08
0.591ArgTrp: 0.591 ± 0.031
1.523ArgTyr: 1.523 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
5.474SerAla: 5.474 ± 0.09
0.766SerCys: 0.766 ± 0.038
3.761SerAsp: 3.761 ± 0.084
3.854SerGlu: 3.854 ± 0.08
2.976SerPhe: 2.976 ± 0.07
5.208SerGly: 5.208 ± 0.095
1.518SerHis: 1.518 ± 0.047
4.715SerIle: 4.715 ± 0.095
3.626SerLys: 3.626 ± 0.086
6.987SerLeu: 6.987 ± 0.117
1.746SerMet: 1.746 ± 0.058
2.876SerAsn: 2.876 ± 0.068
2.515SerPro: 2.515 ± 0.072
2.39SerGln: 2.39 ± 0.07
3.005SerArg: 3.005 ± 0.068
4.492SerSer: 4.492 ± 0.092
3.628SerThr: 3.628 ± 0.088
4.611SerVal: 4.611 ± 0.083
0.758SerTrp: 0.758 ± 0.037
1.807SerTyr: 1.807 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.472ThrAla: 4.472 ± 0.088
0.563ThrCys: 0.563 ± 0.029
3.01ThrAsp: 3.01 ± 0.062
2.945ThrGlu: 2.945 ± 0.073
1.986ThrPhe: 1.986 ± 0.052
4.285ThrGly: 4.285 ± 0.085
1.295ThrHis: 1.295 ± 0.045
3.577ThrIle: 3.577 ± 0.086
2.609ThrLys: 2.609 ± 0.06
6.354ThrLeu: 6.354 ± 0.107
1.132ThrMet: 1.132 ± 0.042
1.957ThrAsn: 1.957 ± 0.051
2.657ThrPro: 2.657 ± 0.076
2.113ThrGln: 2.113 ± 0.06
2.252ThrArg: 2.252 ± 0.066
3.221ThrSer: 3.221 ± 0.082
2.886ThrThr: 2.886 ± 0.079
3.778ThrVal: 3.778 ± 0.07
0.548ThrTrp: 0.548 ± 0.032
1.37ThrTyr: 1.37 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.798ValAla: 5.798 ± 0.117
0.792ValCys: 0.792 ± 0.04
4.313ValAsp: 4.313 ± 0.093
4.531ValGlu: 4.531 ± 0.092
2.927ValPhe: 2.927 ± 0.069
4.723ValGly: 4.723 ± 0.106
1.326ValHis: 1.326 ± 0.048
5.084ValIle: 5.084 ± 0.108
3.939ValLys: 3.939 ± 0.088
7.183ValLeu: 7.183 ± 0.126
1.822ValMet: 1.822 ± 0.065
3.06ValAsn: 3.06 ± 0.083
2.461ValPro: 2.461 ± 0.073
2.149ValGln: 2.149 ± 0.065
2.92ValArg: 2.92 ± 0.065
4.763ValSer: 4.763 ± 0.08
3.703ValThr: 3.703 ± 0.075
5.154ValVal: 5.154 ± 0.097
0.727ValTrp: 0.727 ± 0.038
1.79ValTyr: 1.79 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.875TrpAla: 0.875 ± 0.039
0.171TrpCys: 0.171 ± 0.019
0.61TrpAsp: 0.61 ± 0.035
0.586TrpGlu: 0.586 ± 0.032
0.532TrpPhe: 0.532 ± 0.035
0.703TrpGly: 0.703 ± 0.035
0.356TrpHis: 0.356 ± 0.023
0.56TrpIle: 0.56 ± 0.032
0.547TrpLys: 0.547 ± 0.032
1.573TrpLeu: 1.573 ± 0.052
0.299TrpMet: 0.299 ± 0.023
0.379TrpAsn: 0.379 ± 0.024
0.451TrpPro: 0.451 ± 0.029
0.623TrpGln: 0.623 ± 0.029
0.561TrpArg: 0.561 ± 0.033
0.726TrpSer: 0.726 ± 0.039
0.408TrpThr: 0.408 ± 0.026
0.888TrpVal: 0.888 ± 0.034
0.142TrpTrp: 0.142 ± 0.017
0.28TrpTyr: 0.28 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.203TyrAla: 2.203 ± 0.061
0.325TyrCys: 0.325 ± 0.023
1.511TyrAsp: 1.511 ± 0.047
1.57TyrGlu: 1.57 ± 0.051
1.287TyrPhe: 1.287 ± 0.049
2.032TyrGly: 2.032 ± 0.06
0.644TyrHis: 0.644 ± 0.033
1.804TyrIle: 1.804 ± 0.05
1.638TyrLys: 1.638 ± 0.055
3.185TyrLeu: 3.185 ± 0.067
0.625TyrMet: 0.625 ± 0.032
0.988TyrAsn: 0.988 ± 0.038
1.222TyrPro: 1.222 ± 0.053
1.357TyrGln: 1.357 ± 0.045
1.479TyrArg: 1.479 ± 0.051
1.783TyrSer: 1.783 ± 0.056
1.48TyrThr: 1.48 ± 0.053
1.702TyrVal: 1.702 ± 0.062
0.416TyrTrp: 0.416 ± 0.025
0.869TyrTyr: 0.869 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2010 proteins (614684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski