Amino acid dipepetide frequency for Streptomyces sp. A0642

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.018AlaAla: 22.018 ± 0.166
1.062AlaCys: 1.062 ± 0.023
8.335AlaAsp: 8.335 ± 0.066
8.596AlaGlu: 8.596 ± 0.098
3.591AlaPhe: 3.591 ± 0.048
13.908AlaGly: 13.908 ± 0.096
2.894AlaHis: 2.894 ± 0.037
3.344AlaIle: 3.344 ± 0.042
2.847AlaLys: 2.847 ± 0.056
14.591AlaLeu: 14.591 ± 0.102
2.581AlaMet: 2.581 ± 0.035
1.877AlaAsn: 1.877 ± 0.036
7.514AlaPro: 7.514 ± 0.091
3.855AlaGln: 3.855 ± 0.044
10.06AlaArg: 10.06 ± 0.097
6.187AlaSer: 6.187 ± 0.054
7.042AlaThr: 7.042 ± 0.061
12.338AlaVal: 12.338 ± 0.084
1.892AlaTrp: 1.892 ± 0.03
2.86AlaTyr: 2.86 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.053CysAla: 1.053 ± 0.026
0.09CysCys: 0.09 ± 0.006
0.481CysAsp: 0.481 ± 0.015
0.394CysGlu: 0.394 ± 0.013
0.214CysPhe: 0.214 ± 0.01
0.96CysGly: 0.96 ± 0.021
0.18CysHis: 0.18 ± 0.009
0.176CysIle: 0.176 ± 0.009
0.129CysLys: 0.129 ± 0.008
0.701CysLeu: 0.701 ± 0.019
0.123CysMet: 0.123 ± 0.006
0.134CysAsn: 0.134 ± 0.008
0.459CysPro: 0.459 ± 0.016
0.155CysGln: 0.155 ± 0.009
0.575CysArg: 0.575 ± 0.015
0.442CysSer: 0.442 ± 0.015
0.52CysThr: 0.52 ± 0.015
0.657CysVal: 0.657 ± 0.017
0.134CysTrp: 0.134 ± 0.008
0.139CysTyr: 0.139 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.91AspAla: 7.91 ± 0.07
0.419AspCys: 0.419 ± 0.014
3.483AspAsp: 3.483 ± 0.049
3.908AspGlu: 3.908 ± 0.051
1.648AspPhe: 1.648 ± 0.028
6.526AspGly: 6.526 ± 0.065
1.382AspHis: 1.382 ± 0.022
1.872AspIle: 1.872 ± 0.027
1.195AspLys: 1.195 ± 0.033
5.948AspLeu: 5.948 ± 0.054
0.821AspMet: 0.821 ± 0.018
0.968AspAsn: 0.968 ± 0.021
4.48AspPro: 4.48 ± 0.042
1.479AspGln: 1.479 ± 0.026
4.87AspArg: 4.87 ± 0.05
2.6AspSer: 2.6 ± 0.037
3.167AspThr: 3.167 ± 0.042
4.564AspVal: 4.564 ± 0.045
1.041AspTrp: 1.041 ± 0.022
1.141AspTyr: 1.141 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
7.455GluAla: 7.455 ± 0.085
0.378GluCys: 0.378 ± 0.014
2.852GluAsp: 2.852 ± 0.04
3.517GluGlu: 3.517 ± 0.049
1.419GluPhe: 1.419 ± 0.027
4.501GluGly: 4.501 ± 0.044
1.431GluHis: 1.431 ± 0.023
2.221GluIle: 2.221 ± 0.034
1.453GluLys: 1.453 ± 0.031
6.599GluLeu: 6.599 ± 0.071
0.889GluMet: 0.889 ± 0.021
1.052GluAsn: 1.052 ± 0.02
3.296GluPro: 3.296 ± 0.048
2.258GluGln: 2.258 ± 0.036
5.277GluArg: 5.277 ± 0.055
2.652GluSer: 2.652 ± 0.036
2.892GluThr: 2.892 ± 0.039
4.248GluVal: 4.248 ± 0.048
0.764GluTrp: 0.764 ± 0.019
1.084GluTyr: 1.084 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.704PheAla: 3.704 ± 0.042
0.276PheCys: 0.276 ± 0.012
1.944PheAsp: 1.944 ± 0.03
1.435PheGlu: 1.435 ± 0.023
0.864PhePhe: 0.864 ± 0.021
3.084PheGly: 3.084 ± 0.044
0.617PheHis: 0.617 ± 0.019
0.744PheIle: 0.744 ± 0.02
0.537PheLys: 0.537 ± 0.016
2.568PheLeu: 2.568 ± 0.041
0.411PheMet: 0.411 ± 0.015
0.572PheAsn: 0.572 ± 0.016
1.383PhePro: 1.383 ± 0.028
0.667PheGln: 0.667 ± 0.014
1.803PheArg: 1.803 ± 0.026
1.503PheSer: 1.503 ± 0.023
2.025PheThr: 2.025 ± 0.034
2.162PheVal: 2.162 ± 0.038
0.431PheTrp: 0.431 ± 0.016
0.586PheTyr: 0.586 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
11.671GlyAla: 11.671 ± 0.087
0.835GlyCys: 0.835 ± 0.02
5.321GlyAsp: 5.321 ± 0.049
5.18GlyGlu: 5.18 ± 0.045
2.995GlyPhe: 2.995 ± 0.038
9.203GlyGly: 9.203 ± 0.095
2.373GlyHis: 2.373 ± 0.034
3.582GlyIle: 3.582 ± 0.038
2.506GlyLys: 2.506 ± 0.047
9.712GlyLeu: 9.712 ± 0.072
2.062GlyMet: 2.062 ± 0.031
1.827GlyAsn: 1.827 ± 0.035
5.509GlyPro: 5.509 ± 0.06
2.714GlyGln: 2.714 ± 0.039
7.909GlyArg: 7.909 ± 0.073
5.724GlySer: 5.724 ± 0.06
6.384GlyThr: 6.384 ± 0.064
7.485GlyVal: 7.485 ± 0.057
1.704GlyTrp: 1.704 ± 0.031
2.314GlyTyr: 2.314 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
2.719HisAla: 2.719 ± 0.037
0.201HisCys: 0.201 ± 0.01
1.319HisAsp: 1.319 ± 0.023
1.205HisGlu: 1.205 ± 0.023
0.64HisPhe: 0.64 ± 0.019
2.409HisGly: 2.409 ± 0.036
0.703HisHis: 0.703 ± 0.022
0.691HisIle: 0.691 ± 0.018
0.338HisLys: 0.338 ± 0.012
2.342HisLeu: 2.342 ± 0.039
0.331HisMet: 0.331 ± 0.012
0.367HisAsn: 0.367 ± 0.012
1.843HisPro: 1.843 ± 0.031
0.635HisGln: 0.635 ± 0.018
2.079HisArg: 2.079 ± 0.032
1.018HisSer: 1.018 ± 0.024
1.377HisThr: 1.377 ± 0.029
1.651HisVal: 1.651 ± 0.028
0.377HisTrp: 0.377 ± 0.015
0.468HisTyr: 0.468 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.806IleAla: 4.806 ± 0.05
0.293IleCys: 0.293 ± 0.011
2.32IleAsp: 2.32 ± 0.035
2.02IleGlu: 2.02 ± 0.031
0.699IlePhe: 0.699 ± 0.021
3.736IleGly: 3.736 ± 0.047
0.596IleHis: 0.596 ± 0.016
0.932IleIle: 0.932 ± 0.026
0.77IleLys: 0.77 ± 0.019
2.396IleLeu: 2.396 ± 0.035
0.458IleMet: 0.458 ± 0.013
0.718IleAsn: 0.718 ± 0.02
1.773IlePro: 1.773 ± 0.03
0.77IleGln: 0.77 ± 0.018
2.183IleArg: 2.183 ± 0.031
1.708IleSer: 1.708 ± 0.03
2.237IleThr: 2.237 ± 0.03
2.709IleVal: 2.709 ± 0.037
0.377IleTrp: 0.377 ± 0.016
0.53IleTyr: 0.53 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
3.006LysAla: 3.006 ± 0.05
0.113LysCys: 0.113 ± 0.006
1.388LysAsp: 1.388 ± 0.026
1.233LysGlu: 1.233 ± 0.03
0.46LysPhe: 0.46 ± 0.015
1.915LysGly: 1.915 ± 0.041
0.45LysHis: 0.45 ± 0.016
0.886LysIle: 0.886 ± 0.023
0.949LysLys: 0.949 ± 0.037
2.027LysLeu: 2.027 ± 0.032
0.408LysMet: 0.408 ± 0.013
0.554LysAsn: 0.554 ± 0.019
1.373LysPro: 1.373 ± 0.031
0.716LysGln: 0.716 ± 0.022
1.44LysArg: 1.44 ± 0.027
1.188LysSer: 1.188 ± 0.025
1.289LysThr: 1.289 ± 0.026
1.89LysVal: 1.89 ± 0.039
0.28LysTrp: 0.28 ± 0.014
0.435LysTyr: 0.435 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
14.738LeuAla: 14.738 ± 0.105
0.831LeuCys: 0.831 ± 0.017
6.619LeuAsp: 6.619 ± 0.072
4.514LeuGlu: 4.514 ± 0.051
2.638LeuPhe: 2.638 ± 0.038
9.235LeuGly: 9.235 ± 0.08
2.329LeuHis: 2.329 ± 0.034
3.441LeuIle: 3.441 ± 0.049
2.029LeuLys: 2.029 ± 0.034
11.167LeuLeu: 11.167 ± 0.096
1.726LeuMet: 1.726 ± 0.03
1.747LeuAsn: 1.747 ± 0.033
6.382LeuPro: 6.382 ± 0.06
2.167LeuGln: 2.167 ± 0.033
8.35LeuArg: 8.35 ± 0.076
5.4LeuSer: 5.4 ± 0.048
6.926LeuThr: 6.926 ± 0.066
8.662LeuVal: 8.662 ± 0.076
1.291LeuTrp: 1.291 ± 0.024
1.881LeuTyr: 1.881 ± 0.031
0.0LeuXaa: 0.0 ± 0.0
Met
2.293MetAla: 2.293 ± 0.034
0.135MetCys: 0.135 ± 0.007
0.938MetAsp: 0.938 ± 0.021
0.8MetGlu: 0.8 ± 0.019
0.468MetPhe: 0.468 ± 0.016
1.343MetGly: 1.343 ± 0.025
0.348MetHis: 0.348 ± 0.011
0.67MetIle: 0.67 ± 0.02
0.442MetLys: 0.442 ± 0.016
1.69MetLeu: 1.69 ± 0.03
0.323MetMet: 0.323 ± 0.011
0.464MetAsn: 0.464 ± 0.014
1.149MetPro: 1.149 ± 0.026
0.457MetGln: 0.457 ± 0.015
1.416MetArg: 1.416 ± 0.023
1.36MetSer: 1.36 ± 0.024
1.582MetThr: 1.582 ± 0.024
1.303MetVal: 1.303 ± 0.025
0.215MetTrp: 0.215 ± 0.009
0.334MetTyr: 0.334 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.24AsnAla: 2.24 ± 0.032
0.152AsnCys: 0.152 ± 0.008
0.989AsnAsp: 0.989 ± 0.023
0.846AsnGlu: 0.846 ± 0.019
0.497AsnPhe: 0.497 ± 0.016
2.039AsnGly: 2.039 ± 0.04
0.408AsnHis: 0.408 ± 0.015
0.648AsnIle: 0.648 ± 0.017
0.439AsnLys: 0.439 ± 0.015
1.605AsnLeu: 1.605 ± 0.031
0.329AsnMet: 0.329 ± 0.011
0.428AsnAsn: 0.428 ± 0.014
1.304AsnPro: 1.304 ± 0.025
0.513AsnGln: 0.513 ± 0.015
1.301AsnArg: 1.301 ± 0.023
0.977AsnSer: 0.977 ± 0.024
1.12AsnThr: 1.12 ± 0.025
1.36AsnVal: 1.36 ± 0.03
0.304AsnTrp: 0.304 ± 0.011
0.449AsnTyr: 0.449 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
9.129ProAla: 9.129 ± 0.091
0.343ProCys: 0.343 ± 0.014
4.391ProAsp: 4.391 ± 0.048
4.221ProGlu: 4.221 ± 0.045
1.518ProPhe: 1.518 ± 0.029
6.806ProGly: 6.806 ± 0.069
1.408ProHis: 1.408 ± 0.027
1.148ProIle: 1.148 ± 0.023
1.173ProLys: 1.173 ± 0.026
5.364ProLeu: 5.364 ± 0.054
0.982ProMet: 0.982 ± 0.021
0.858ProAsn: 0.858 ± 0.022
3.527ProPro: 3.527 ± 0.061
1.867ProGln: 1.867 ± 0.032
3.807ProArg: 3.807 ± 0.039
3.245ProSer: 3.245 ± 0.045
3.021ProThr: 3.021 ± 0.05
5.745ProVal: 5.745 ± 0.059
0.908ProTrp: 0.908 ± 0.023
1.415ProTyr: 1.415 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.699GlnAla: 3.699 ± 0.046
0.161GlnCys: 0.161 ± 0.009
1.452GlnAsp: 1.452 ± 0.028
1.521GlnGlu: 1.521 ± 0.028
0.663GlnPhe: 0.663 ± 0.016
2.382GlnGly: 2.382 ± 0.032
0.637GlnHis: 0.637 ± 0.015
1.098GlnIle: 1.098 ± 0.021
0.664GlnLys: 0.664 ± 0.017
3.045GlnLeu: 3.045 ± 0.04
0.519GlnMet: 0.519 ± 0.015
0.54GlnAsn: 0.54 ± 0.017
1.704GlnPro: 1.704 ± 0.035
1.334GlnGln: 1.334 ± 0.043
2.313GlnArg: 2.313 ± 0.036
1.304GlnSer: 1.304 ± 0.024
1.341GlnThr: 1.341 ± 0.029
2.26GlnVal: 2.26 ± 0.031
0.504GlnTrp: 0.504 ± 0.016
0.599GlnTyr: 0.599 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
9.657ArgAla: 9.657 ± 0.092
0.556ArgCys: 0.556 ± 0.016
4.085ArgAsp: 4.085 ± 0.044
4.558ArgGlu: 4.558 ± 0.055
2.239ArgPhe: 2.239 ± 0.032
5.821ArgGly: 5.821 ± 0.059
1.97ArgHis: 1.97 ± 0.035
3.389ArgIle: 3.389 ± 0.035
1.696ArgLys: 1.696 ± 0.033
8.415ArgLeu: 8.415 ± 0.074
1.729ArgMet: 1.729 ± 0.026
1.424ArgAsn: 1.424 ± 0.024
4.836ArgPro: 4.836 ± 0.051
2.198ArgGln: 2.198 ± 0.036
7.282ArgArg: 7.282 ± 0.078
4.152ArgSer: 4.152 ± 0.046
5.675ArgThr: 5.675 ± 0.048
5.57ArgVal: 5.57 ± 0.057
1.283ArgTrp: 1.283 ± 0.026
1.748ArgTyr: 1.748 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
7.03SerAla: 7.03 ± 0.065
0.418SerCys: 0.418 ± 0.012
2.802SerAsp: 2.802 ± 0.036
2.444SerGlu: 2.444 ± 0.038
1.577SerPhe: 1.577 ± 0.029
6.29SerGly: 6.29 ± 0.06
1.058SerHis: 1.058 ± 0.022
1.43SerIle: 1.43 ± 0.028
1.064SerLys: 1.064 ± 0.025
4.944SerLeu: 4.944 ± 0.06
1.109SerMet: 1.109 ± 0.019
0.916SerAsn: 0.916 ± 0.02
3.177SerPro: 3.177 ± 0.041
1.281SerGln: 1.281 ± 0.023
3.673SerArg: 3.673 ± 0.041
2.965SerSer: 2.965 ± 0.043
3.133SerThr: 3.133 ± 0.044
4.461SerVal: 4.461 ± 0.05
0.953SerTrp: 0.953 ± 0.022
1.251SerTyr: 1.251 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
9.166ThrAla: 9.166 ± 0.066
0.408ThrCys: 0.408 ± 0.014
3.636ThrAsp: 3.636 ± 0.047
3.286ThrGlu: 3.286 ± 0.042
1.642ThrPhe: 1.642 ± 0.032
7.088ThrGly: 7.088 ± 0.076
1.226ThrHis: 1.226 ± 0.025
1.645ThrIle: 1.645 ± 0.029
1.192ThrLys: 1.192 ± 0.031
5.737ThrLeu: 5.737 ± 0.05
0.923ThrMet: 0.923 ± 0.021
0.991ThrAsn: 0.991 ± 0.023
4.148ThrPro: 4.148 ± 0.061
1.338ThrGln: 1.338 ± 0.027
3.79ThrArg: 3.79 ± 0.045
3.129ThrSer: 3.129 ± 0.046
3.858ThrThr: 3.858 ± 0.06
6.161ThrVal: 6.161 ± 0.058
0.884ThrTrp: 0.884 ± 0.022
1.426ThrTyr: 1.426 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
10.536ValAla: 10.536 ± 0.075
0.739ValCys: 0.739 ± 0.019
4.752ValAsp: 4.752 ± 0.044
4.54ValGlu: 4.54 ± 0.053
2.397ValPhe: 2.397 ± 0.032
6.293ValGly: 6.293 ± 0.063
1.953ValHis: 1.953 ± 0.027
3.054ValIle: 3.054 ± 0.043
1.777ValLys: 1.777 ± 0.036
9.509ValLeu: 9.509 ± 0.079
1.456ValMet: 1.456 ± 0.025
1.655ValAsn: 1.655 ± 0.029
5.136ValPro: 5.136 ± 0.047
2.097ValGln: 2.097 ± 0.036
7.092ValArg: 7.092 ± 0.064
4.454ValSer: 4.454 ± 0.049
5.706ValThr: 5.706 ± 0.061
7.689ValVal: 7.689 ± 0.081
1.136ValTrp: 1.136 ± 0.022
1.612ValTyr: 1.612 ± 0.024
0.0ValXaa: 0.0 ± 0.0
Trp
1.651TrpAla: 1.651 ± 0.029
0.149TrpCys: 0.149 ± 0.008
0.839TrpAsp: 0.839 ± 0.019
0.757TrpGlu: 0.757 ± 0.017
0.505TrpPhe: 0.505 ± 0.016
1.117TrpGly: 1.117 ± 0.023
0.355TrpHis: 0.355 ± 0.012
0.557TrpIle: 0.557 ± 0.016
0.384TrpLys: 0.384 ± 0.014
1.697TrpLeu: 1.697 ± 0.03
0.302TrpMet: 0.302 ± 0.01
0.421TrpAsn: 0.421 ± 0.014
0.793TrpPro: 0.793 ± 0.019
0.632TrpGln: 0.632 ± 0.016
1.236TrpArg: 1.236 ± 0.025
0.986TrpSer: 0.986 ± 0.024
1.115TrpThr: 1.115 ± 0.023
0.991TrpVal: 0.991 ± 0.022
0.344TrpTrp: 0.344 ± 0.013
0.359TrpTyr: 0.359 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.911TyrAla: 2.911 ± 0.037
0.164TyrCys: 0.164 ± 0.008
1.48TyrAsp: 1.48 ± 0.036
1.263TyrGlu: 1.263 ± 0.023
0.641TyrPhe: 0.641 ± 0.017
2.353TyrGly: 2.353 ± 0.033
0.391TyrHis: 0.391 ± 0.013
0.501TyrIle: 0.501 ± 0.016
0.417TyrLys: 0.417 ± 0.015
2.016TyrLeu: 2.016 ± 0.031
0.248TyrMet: 0.248 ± 0.011
0.436TyrAsn: 0.436 ± 0.016
1.091TyrPro: 1.091 ± 0.024
0.606TyrGln: 0.606 ± 0.016
1.827TyrArg: 1.827 ± 0.033
0.98TyrSer: 0.98 ± 0.024
1.264TyrThr: 1.264 ± 0.032
1.676TyrVal: 1.676 ± 0.028
0.367TyrTrp: 0.367 ± 0.012
0.46TyrTyr: 0.46 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6934 proteins (2322785 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski