Amino acid dipepetide frequency for Rhinocladiella mackenziei CBS 650.93

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.156AlaAla: 8.156 ± 0.056	1.086AlaCys: 1.086 ± 0.015	4.161AlaAsp: 4.161 ± 0.026	5.052AlaGlu: 5.052 ± 0.036	3.153AlaPhe: 3.153 ± 0.026	5.584AlaGly: 5.584 ± 0.038	1.759AlaHis: 1.759 ± 0.017	4.368AlaIle: 4.368 ± 0.031	3.95AlaLys: 3.95 ± 0.036	7.561AlaLeu: 7.561 ± 0.04	1.985AlaMet: 1.985 ± 0.02	2.93AlaAsn: 2.93 ± 0.022	4.289AlaPro: 4.289 ± 0.034	3.328AlaGln: 3.328 ± 0.025	4.896AlaArg: 4.896 ± 0.036	6.788AlaSer: 6.788 ± 0.044	5.039AlaThr: 5.039 ± 0.031	5.205AlaVal: 5.205 ± 0.036	1.142AlaTrp: 1.142 ± 0.014	2.139AlaTyr: 2.139 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.947CysAla: 0.947 ± 0.013	0.227CysCys: 0.227 ± 0.007	0.65CysAsp: 0.65 ± 0.011	0.607CysGlu: 0.607 ± 0.011	0.55CysPhe: 0.55 ± 0.01	0.882CysGly: 0.882 ± 0.014	0.347CysHis: 0.347 ± 0.008	0.698CysIle: 0.698 ± 0.013	0.49CysLys: 0.49 ± 0.009	1.325CysLeu: 1.325 ± 0.015	0.282CysMet: 0.282 ± 0.008	0.398CysAsn: 0.398 ± 0.008	0.649CysPro: 0.649 ± 0.012	0.482CysGln: 0.482 ± 0.009	0.78CysArg: 0.78 ± 0.013	0.903CysSer: 0.903 ± 0.013	0.677CysThr: 0.677 ± 0.012	0.81CysVal: 0.81 ± 0.013	0.211CysTrp: 0.211 ± 0.006	0.364CysTyr: 0.364 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.475AspAla: 4.475 ± 0.031	0.607AspCys: 0.607 ± 0.01	4.191AspAsp: 4.191 ± 0.043	4.486AspGlu: 4.486 ± 0.038	2.301AspPhe: 2.301 ± 0.024	3.944AspGly: 3.944 ± 0.03	1.361AspHis: 1.361 ± 0.018	3.108AspIle: 3.108 ± 0.026	2.385AspLys: 2.385 ± 0.021	5.227AspLeu: 5.227 ± 0.036	1.27AspMet: 1.27 ± 0.016	1.834AspAsn: 1.834 ± 0.018	3.488AspPro: 3.488 ± 0.024	2.053AspGln: 2.053 ± 0.019	3.225AspArg: 3.225 ± 0.028	4.023AspSer: 4.023 ± 0.034	2.922AspThr: 2.922 ± 0.024	3.784AspVal: 3.784 ± 0.026	0.914AspTrp: 0.914 ± 0.015	1.543AspTyr: 1.543 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.161GluAla: 5.161 ± 0.038	0.638GluCys: 0.638 ± 0.01	4.153GluAsp: 4.153 ± 0.036	5.265GluGlu: 5.265 ± 0.045	2.002GluPhe: 2.002 ± 0.019	3.606GluGly: 3.606 ± 0.026	1.401GluHis: 1.401 ± 0.017	3.282GluIle: 3.282 ± 0.028	3.756GluLys: 3.756 ± 0.033	5.131GluLeu: 5.131 ± 0.028	1.575GluMet: 1.575 ± 0.018	2.427GluAsn: 2.427 ± 0.021	2.753GluPro: 2.753 ± 0.027	2.437GluGln: 2.437 ± 0.024	4.037GluArg: 4.037 ± 0.036	4.356GluSer: 4.356 ± 0.03	3.498GluThr: 3.498 ± 0.026	3.563GluVal: 3.563 ± 0.03	0.9GluTrp: 0.9 ± 0.012	1.699GluTyr: 1.699 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.032PheAla: 3.032 ± 0.023	0.58PheCys: 0.58 ± 0.01	2.384PheAsp: 2.384 ± 0.023	2.215PheGlu: 2.215 ± 0.02	1.662PhePhe: 1.662 ± 0.021	2.908PheGly: 2.908 ± 0.035	0.94PheHis: 0.94 ± 0.014	1.85PheIle: 1.85 ± 0.02	1.523PheLys: 1.523 ± 0.018	3.621PheLeu: 3.621 ± 0.028	0.806PheMet: 0.806 ± 0.012	1.417PheAsn: 1.417 ± 0.016	2.018PhePro: 2.018 ± 0.018	1.463PheGln: 1.463 ± 0.016	2.046PheArg: 2.046 ± 0.02	3.011PheSer: 3.011 ± 0.027	2.129PheThr: 2.129 ± 0.023	2.452PheVal: 2.452 ± 0.02	0.695PheTrp: 0.695 ± 0.012	1.141PheTyr: 1.141 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	5.035GlyAla: 5.035 ± 0.035	0.839GlyCys: 0.839 ± 0.013	3.491GlyAsp: 3.491 ± 0.026	3.558GlyGlu: 3.558 ± 0.027	2.85GlyPhe: 2.85 ± 0.026	5.344GlyGly: 5.344 ± 0.045	1.705GlyHis: 1.705 ± 0.02	3.678GlyIle: 3.678 ± 0.03	3.445GlyLys: 3.445 ± 0.03	6.111GlyLeu: 6.111 ± 0.038	1.644GlyMet: 1.644 ± 0.019	2.441GlyAsn: 2.441 ± 0.022	3.443GlyPro: 3.443 ± 0.026	2.641GlyGln: 2.641 ± 0.022	4.192GlyArg: 4.192 ± 0.03	5.408GlySer: 5.408 ± 0.035	4.005GlyThr: 4.005 ± 0.027	4.288GlyVal: 4.288 ± 0.034	1.143GlyTrp: 1.143 ± 0.014	2.117GlyTyr: 2.117 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.829HisAla: 1.829 ± 0.018	0.33HisCys: 0.33 ± 0.007	1.413HisAsp: 1.413 ± 0.016	1.425HisGlu: 1.425 ± 0.016	0.972HisPhe: 0.972 ± 0.014	1.769HisGly: 1.769 ± 0.017	0.853HisHis: 0.853 ± 0.013	1.249HisIle: 1.249 ± 0.015	0.942HisLys: 0.942 ± 0.013	2.291HisLeu: 2.291 ± 0.022	0.49HisMet: 0.49 ± 0.009	0.83HisAsn: 0.83 ± 0.014	1.709HisPro: 1.709 ± 0.019	1.036HisGln: 1.036 ± 0.014	1.603HisArg: 1.603 ± 0.017	1.857HisSer: 1.857 ± 0.02	1.284HisThr: 1.284 ± 0.014	1.518HisVal: 1.518 ± 0.019	0.362HisTrp: 0.362 ± 0.01	0.701HisTyr: 0.701 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.177IleAla: 4.177 ± 0.034	0.812IleCys: 0.812 ± 0.012	2.975IleAsp: 2.975 ± 0.025	2.957IleGlu: 2.957 ± 0.023	2.099IlePhe: 2.099 ± 0.02	3.342IleGly: 3.342 ± 0.03	1.287IleHis: 1.287 ± 0.015	2.55IleIle: 2.55 ± 0.026	2.194IleLys: 2.194 ± 0.022	4.931IleLeu: 4.931 ± 0.036	1.028IleMet: 1.028 ± 0.014	1.814IleAsn: 1.814 ± 0.018	3.257IlePro: 3.257 ± 0.022	2.021IleGln: 2.021 ± 0.02	2.979IleArg: 2.979 ± 0.023	4.098IleSer: 4.098 ± 0.028	2.81IleThr: 2.81 ± 0.023	3.299IleVal: 3.299 ± 0.028	0.769IleTrp: 0.769 ± 0.011	1.462IleTyr: 1.462 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.14LysAla: 4.14 ± 0.033	0.514LysCys: 0.514 ± 0.011	2.848LysAsp: 2.848 ± 0.027	3.365LysGlu: 3.365 ± 0.029	1.553LysPhe: 1.553 ± 0.017	2.906LysGly: 2.906 ± 0.026	1.136LysHis: 1.136 ± 0.016	2.438LysIle: 2.438 ± 0.025	3.141LysLys: 3.141 ± 0.041	4.054LysLeu: 4.054 ± 0.03	1.107LysMet: 1.107 ± 0.015	1.752LysAsn: 1.752 ± 0.017	2.661LysPro: 2.661 ± 0.022	1.826LysGln: 1.826 ± 0.02	3.439LysArg: 3.439 ± 0.03	3.68LysSer: 3.68 ± 0.034	2.813LysThr: 2.813 ± 0.023	2.761LysVal: 2.761 ± 0.028	0.712LysTrp: 0.712 ± 0.012	1.452LysTyr: 1.452 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.692LeuAla: 7.692 ± 0.042	1.262LeuCys: 1.262 ± 0.015	5.24LeuAsp: 5.24 ± 0.031	5.545LeuGlu: 5.545 ± 0.043	3.379LeuPhe: 3.379 ± 0.029	5.95LeuGly: 5.95 ± 0.035	2.268LeuHis: 2.268 ± 0.021	4.115LeuIle: 4.115 ± 0.032	4.279LeuLys: 4.279 ± 0.035	8.367LeuLeu: 8.367 ± 0.056	1.859LeuMet: 1.859 ± 0.021	3.276LeuAsn: 3.276 ± 0.024	5.422LeuPro: 5.422 ± 0.034	3.893LeuGln: 3.893 ± 0.032	5.815LeuArg: 5.815 ± 0.041	7.327LeuSer: 7.327 ± 0.041	4.976LeuThr: 4.976 ± 0.032	5.373LeuVal: 5.373 ± 0.034	1.248LeuTrp: 1.248 ± 0.017	2.394LeuTyr: 2.394 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.302MetAla: 2.302 ± 0.024	0.247MetCys: 0.247 ± 0.006	1.273MetAsp: 1.273 ± 0.014	1.284MetGlu: 1.284 ± 0.016	0.77MetPhe: 0.77 ± 0.013	1.491MetGly: 1.491 ± 0.019	0.482MetHis: 0.482 ± 0.01	1.085MetIle: 1.085 ± 0.016	1.063MetLys: 1.063 ± 0.014	1.893MetLeu: 1.893 ± 0.019	0.565MetMet: 0.565 ± 0.01	0.866MetAsn: 0.866 ± 0.014	1.286MetPro: 1.286 ± 0.016	0.836MetGln: 0.836 ± 0.014	1.259MetArg: 1.259 ± 0.016	1.921MetSer: 1.921 ± 0.019	1.451MetThr: 1.451 ± 0.014	1.349MetVal: 1.349 ± 0.017	0.256MetTrp: 0.256 ± 0.008	0.538MetTyr: 0.538 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.112AsnAla: 3.112 ± 0.025	0.441AsnCys: 0.441 ± 0.009	2.044AsnAsp: 2.044 ± 0.021	2.097AsnGlu: 2.097 ± 0.021	1.403AsnPhe: 1.403 ± 0.019	2.957AsnGly: 2.957 ± 0.024	0.907AsnHis: 0.907 ± 0.013	2.068AsnIle: 2.068 ± 0.02	1.496AsnLys: 1.496 ± 0.019	3.386AsnLeu: 3.386 ± 0.025	0.828AsnMet: 0.828 ± 0.013	1.393AsnAsn: 1.393 ± 0.017	2.515AsnPro: 2.515 ± 0.023	1.424AsnGln: 1.424 ± 0.018	1.988AsnArg: 1.988 ± 0.02	2.716AsnSer: 2.716 ± 0.024	2.172AsnThr: 2.172 ± 0.023	2.424AsnVal: 2.424 ± 0.023	0.559AsnTrp: 0.559 ± 0.011	1.043AsnTyr: 1.043 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	4.808ProAla: 4.808 ± 0.038	0.513ProCys: 0.513 ± 0.011	3.349ProAsp: 3.349 ± 0.022	3.843ProGlu: 3.843 ± 0.027	2.101ProPhe: 2.101 ± 0.02	3.973ProGly: 3.973 ± 0.03	1.378ProHis: 1.378 ± 0.018	2.629ProIle: 2.629 ± 0.022	2.715ProLys: 2.715 ± 0.024	4.719ProLeu: 4.719 ± 0.028	1.104ProMet: 1.104 ± 0.015	2.333ProAsn: 2.333 ± 0.026	5.251ProPro: 5.251 ± 0.063	2.48ProGln: 2.48 ± 0.03	3.482ProArg: 3.482 ± 0.027	5.96ProSer: 5.96 ± 0.046	3.978ProThr: 3.978 ± 0.033	3.545ProVal: 3.545 ± 0.029	0.766ProTrp: 0.766 ± 0.014	1.518ProTyr: 1.518 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.396GlnAla: 3.396 ± 0.027	0.447GlnCys: 0.447 ± 0.009	2.143GlnAsp: 2.143 ± 0.019	2.479GlnGlu: 2.479 ± 0.024	1.307GlnPhe: 1.307 ± 0.017	2.405GlnGly: 2.405 ± 0.021	1.089GlnHis: 1.089 ± 0.016	2.122GlnIle: 2.122 ± 0.019	2.053GlnLys: 2.053 ± 0.02	3.404GlnLeu: 3.404 ± 0.026	0.934GlnMet: 0.934 ± 0.015	1.685GlnAsn: 1.685 ± 0.021	2.498GlnPro: 2.498 ± 0.028	2.169GlnGln: 2.169 ± 0.035	2.718GlnArg: 2.718 ± 0.025	3.265GlnSer: 3.265 ± 0.028	2.417GlnThr: 2.417 ± 0.021	2.18GlnVal: 2.18 ± 0.019	0.581GlnTrp: 0.581 ± 0.01	1.207GlnTyr: 1.207 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.586ArgAla: 4.586 ± 0.032	0.727ArgCys: 0.727 ± 0.013	3.509ArgAsp: 3.509 ± 0.033	3.907ArgGlu: 3.907 ± 0.033	2.168ArgPhe: 2.168 ± 0.021	3.748ArgGly: 3.748 ± 0.031	1.685ArgHis: 1.685 ± 0.021	3.083ArgIle: 3.083 ± 0.024	3.661ArgLys: 3.661 ± 0.029	5.54ArgLeu: 5.54 ± 0.034	1.356ArgMet: 1.356 ± 0.017	2.35ArgAsn: 2.35 ± 0.023	3.69ArgPro: 3.69 ± 0.031	2.766ArgGln: 2.766 ± 0.024	5.255ArgArg: 5.255 ± 0.046	4.882ArgSer: 4.882 ± 0.043	3.425ArgThr: 3.425 ± 0.024	3.307ArgVal: 3.307 ± 0.025	0.976ArgTrp: 0.976 ± 0.014	1.749ArgTyr: 1.749 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.344SerAla: 6.344 ± 0.04	0.841SerCys: 0.841 ± 0.014	4.183SerAsp: 4.183 ± 0.029	4.196SerGlu: 4.196 ± 0.03	3.037SerPhe: 3.037 ± 0.027	5.411SerGly: 5.411 ± 0.035	1.984SerHis: 1.984 ± 0.022	4.102SerIle: 4.102 ± 0.03	3.756SerLys: 3.756 ± 0.03	7.167SerLeu: 7.167 ± 0.044	1.762SerMet: 1.762 ± 0.022	3.022SerAsn: 3.022 ± 0.026	5.592SerPro: 5.592 ± 0.051	3.371SerGln: 3.371 ± 0.029	5.177SerArg: 5.177 ± 0.037	8.624SerSer: 8.624 ± 0.064	5.745SerThr: 5.745 ± 0.041	4.514SerVal: 4.514 ± 0.027	1.136SerTrp: 1.136 ± 0.018	2.038SerTyr: 2.038 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.024ThrAla: 5.024 ± 0.032	0.729ThrCys: 0.729 ± 0.012	2.865ThrAsp: 2.865 ± 0.023	3.126ThrGlu: 3.126 ± 0.028	2.327ThrPhe: 2.327 ± 0.021	4.153ThrGly: 4.153 ± 0.029	1.253ThrHis: 1.253 ± 0.017	3.151ThrIle: 3.151 ± 0.024	2.64ThrLys: 2.64 ± 0.02	5.257ThrLeu: 5.257 ± 0.032	1.264ThrMet: 1.264 ± 0.015	2.221ThrAsn: 2.221 ± 0.02	4.244ThrPro: 4.244 ± 0.037	2.101ThrGln: 2.101 ± 0.022	3.266ThrArg: 3.266 ± 0.029	5.54ThrSer: 5.54 ± 0.039	4.408ThrThr: 4.408 ± 0.045	3.71ThrVal: 3.71 ± 0.028	0.879ThrTrp: 0.879 ± 0.015	1.629ThrTyr: 1.629 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.039ValAla: 5.039 ± 0.031	0.814ValCys: 0.814 ± 0.012	3.739ValAsp: 3.739 ± 0.027	3.845ValGlu: 3.845 ± 0.029	2.46ValPhe: 2.46 ± 0.023	3.985ValGly: 3.985 ± 0.032	1.459ValHis: 1.459 ± 0.017	3.031ValIle: 3.031 ± 0.029	2.909ValLys: 2.909 ± 0.025	5.577ValLeu: 5.577 ± 0.036	1.353ValMet: 1.353 ± 0.016	2.276ValAsn: 2.276 ± 0.026	3.536ValPro: 3.536 ± 0.03	2.456ValGln: 2.456 ± 0.021	3.538ValArg: 3.538 ± 0.028	4.583ValSer: 4.583 ± 0.03	3.481ValThr: 3.481 ± 0.031	4.252ValVal: 4.252 ± 0.032	0.873ValTrp: 0.873 ± 0.013	1.686ValTyr: 1.686 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.12TrpAla: 1.12 ± 0.015	0.201TrpCys: 0.201 ± 0.006	0.859TrpAsp: 0.859 ± 0.012	0.84TrpGlu: 0.84 ± 0.012	0.556TrpPhe: 0.556 ± 0.01	0.882TrpGly: 0.882 ± 0.014	0.367TrpHis: 0.367 ± 0.009	0.853TrpIle: 0.853 ± 0.014	0.832TrpLys: 0.832 ± 0.013	1.393TrpLeu: 1.393 ± 0.019	0.383TrpMet: 0.383 ± 0.008	0.644TrpAsn: 0.644 ± 0.012	0.645TrpPro: 0.645 ± 0.012	0.571TrpGln: 0.571 ± 0.01	1.007TrpArg: 1.007 ± 0.014	1.09TrpSer: 1.09 ± 0.015	0.99TrpThr: 0.99 ± 0.014	0.867TrpVal: 0.867 ± 0.014	0.286TrpTrp: 0.286 ± 0.008	0.457TrpTyr: 0.457 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.196TyrAla: 2.196 ± 0.021	0.425TyrCys: 0.425 ± 0.01	1.672TyrAsp: 1.672 ± 0.019	1.545TyrGlu: 1.545 ± 0.017	1.243TyrPhe: 1.243 ± 0.016	2.138TyrGly: 2.138 ± 0.026	0.804TyrHis: 0.804 ± 0.013	1.406TyrIle: 1.406 ± 0.015	1.069TyrLys: 1.069 ± 0.017	2.725TyrLeu: 2.725 ± 0.021	0.618TyrMet: 0.618 ± 0.011	1.064TyrAsn: 1.064 ± 0.013	1.502TyrPro: 1.502 ± 0.019	1.145TyrGln: 1.145 ± 0.017	1.669TyrArg: 1.669 ± 0.018	1.969TyrSer: 1.969 ± 0.019	1.566TyrThr: 1.566 ± 0.018	1.69TyrVal: 1.69 ± 0.018	0.433TyrTrp: 0.433 ± 0.008	0.891TyrTyr: 0.891 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11378 proteins (5555827 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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