Amino acid dipepetide frequency for Euonymus yellow vein virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.089AlaAla: 7.089 ± 5.619
1.329AlaCys: 1.329 ± 1.636
4.431AlaAsp: 4.431 ± 3.112
3.988AlaGlu: 3.988 ± 2.057
2.658AlaPhe: 2.658 ± 2.263
4.874AlaGly: 4.874 ± 1.695
1.329AlaHis: 1.329 ± 1.918
4.431AlaIle: 4.431 ± 1.261
6.646AlaLys: 6.646 ± 3.185
7.089AlaLeu: 7.089 ± 3.199
1.772AlaMet: 1.772 ± 0.715
4.431AlaAsn: 4.431 ± 2.159
2.658AlaPro: 2.658 ± 1.097
2.215AlaGln: 2.215 ± 1.236
5.317AlaArg: 5.317 ± 4.018
6.646AlaSer: 6.646 ± 1.047
5.317AlaThr: 5.317 ± 1.73
3.988AlaVal: 3.988 ± 2.741
0.443AlaTrp: 0.443 ± 0.888
5.317AlaTyr: 5.317 ± 1.443
0.0AlaXaa: 0.0 ± 0.0
Cys
2.215CysAla: 2.215 ± 2.056
0.443CysCys: 0.443 ± 0.888
0.886CysAsp: 0.886 ± 0.762
1.329CysGlu: 1.329 ± 0.704
0.443CysPhe: 0.443 ± 1.277
1.772CysGly: 1.772 ± 1.003
0.443CysHis: 0.443 ± 0.888
1.329CysIle: 1.329 ± 1.918
0.886CysLys: 0.886 ± 1.131
1.772CysLeu: 1.772 ± 0.787
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.886CysPro: 0.886 ± 1.131
1.772CysGln: 1.772 ± 0.989
0.886CysArg: 0.886 ± 1.131
1.329CysSer: 1.329 ± 0.698
2.215CysThr: 2.215 ± 0.602
0.443CysVal: 0.443 ± 0.888
0.0CysTrp: 0.0 ± 0.0
0.443CysTyr: 0.443 ± 1.228
0.0CysXaa: 0.0 ± 0.0
Asp
3.101AspAla: 3.101 ± 1.414
2.215AspCys: 2.215 ± 1.232
2.658AspAsp: 2.658 ± 1.296
2.658AspGlu: 2.658 ± 0.591
3.988AspPhe: 3.988 ± 1.021
2.215AspGly: 2.215 ± 1.29
0.443AspHis: 0.443 ± 0.888
3.101AspIle: 3.101 ± 1.323
2.215AspLys: 2.215 ± 1.232
4.431AspLeu: 4.431 ± 1.815
0.886AspMet: 0.886 ± 0.494
2.215AspAsn: 2.215 ± 1.29
2.215AspPro: 2.215 ± 1.444
0.443AspGln: 0.443 ± 0.247
3.545AspArg: 3.545 ± 2.057
6.646AspSer: 6.646 ± 2.307
3.101AspThr: 3.101 ± 1.731
3.545AspVal: 3.545 ± 2.143
1.772AspTrp: 1.772 ± 0.787
1.329AspTyr: 1.329 ± 1.132
0.0AspXaa: 0.0 ± 0.0
Glu
5.76GluAla: 5.76 ± 1.694
0.886GluCys: 0.886 ± 0.494
2.658GluAsp: 2.658 ± 0.591
4.431GluGlu: 4.431 ± 1.232
2.215GluPhe: 2.215 ± 0.833
6.646GluGly: 6.646 ± 2.857
0.0GluHis: 0.0 ± 0.0
2.658GluIle: 2.658 ± 1.024
6.203GluLys: 6.203 ± 2.763
7.089GluLeu: 7.089 ± 2.465
0.443GluMet: 0.443 ± 0.247
4.431GluAsn: 4.431 ± 1.165
5.76GluPro: 5.76 ± 1.764
3.101GluGln: 3.101 ± 2.049
2.215GluArg: 2.215 ± 0.935
7.089GluSer: 7.089 ± 2.319
4.874GluThr: 4.874 ± 1.455
5.317GluVal: 5.317 ± 1.715
0.886GluTrp: 0.886 ± 0.691
1.329GluTyr: 1.329 ± 1.636
0.0GluXaa: 0.0 ± 0.0
Phe
3.988PheAla: 3.988 ± 1.711
1.772PheCys: 1.772 ± 0.706
2.658PheAsp: 2.658 ± 0.591
4.431PheGlu: 4.431 ± 1.135
0.443PhePhe: 0.443 ± 0.767
1.772PheGly: 1.772 ± 1.524
0.886PheHis: 0.886 ± 0.494
2.215PheIle: 2.215 ± 1.447
2.658PheLys: 2.658 ± 0.988
4.874PheLeu: 4.874 ± 2.054
1.772PheMet: 1.772 ± 1.042
0.886PheAsn: 0.886 ± 1.535
1.329PhePro: 1.329 ± 1.132
1.772PheGln: 1.772 ± 0.989
0.886PheArg: 0.886 ± 1.066
0.886PheSer: 0.886 ± 1.131
3.101PheThr: 3.101 ± 2.156
3.988PheVal: 3.988 ± 3.465
0.886PheTrp: 0.886 ± 0.494
0.443PheTyr: 0.443 ± 0.247
0.0PheXaa: 0.0 ± 0.0
Gly
7.532GlyAla: 7.532 ± 1.92
2.215GlyCys: 2.215 ± 1.674
3.988GlyAsp: 3.988 ± 1.194
4.431GlyGlu: 4.431 ± 3.112
2.658GlyPhe: 2.658 ± 1.594
3.545GlyGly: 3.545 ± 1.882
1.329GlyHis: 1.329 ± 0.742
2.658GlyIle: 2.658 ± 0.591
4.874GlyLys: 4.874 ± 1.81
3.101GlyLeu: 3.101 ± 2.253
0.443GlyMet: 0.443 ± 0.247
0.886GlyAsn: 0.886 ± 0.494
1.772GlyPro: 1.772 ± 1.381
1.772GlyGln: 1.772 ± 0.706
2.215GlyArg: 2.215 ± 0.935
2.215GlySer: 2.215 ± 0.916
3.545GlyThr: 3.545 ± 2.01
2.658GlyVal: 2.658 ± 1.039
1.772GlyTrp: 1.772 ± 0.73
0.886GlyTyr: 0.886 ± 1.131
0.0GlyXaa: 0.0 ± 0.0
His
1.329HisAla: 1.329 ± 0.704
1.329HisCys: 1.329 ± 1.652
0.0HisAsp: 0.0 ± 0.0
2.658HisGlu: 2.658 ± 1.119
1.329HisPhe: 1.329 ± 0.704
1.772HisGly: 1.772 ± 1.947
1.772HisHis: 1.772 ± 0.989
0.443HisIle: 0.443 ± 0.767
0.886HisLys: 0.886 ± 0.494
1.772HisLeu: 1.772 ± 0.73
0.443HisMet: 0.443 ± 0.247
0.443HisAsn: 0.443 ± 0.247
2.215HisPro: 2.215 ± 0.602
0.886HisGln: 0.886 ± 0.494
1.329HisArg: 1.329 ± 1.082
2.658HisSer: 2.658 ± 1.039
1.772HisThr: 1.772 ± 1.368
2.658HisVal: 2.658 ± 1.603
0.0HisTrp: 0.0 ± 0.0
0.443HisTyr: 0.443 ± 0.767
0.0HisXaa: 0.0 ± 0.0
Ile
3.988IleAla: 3.988 ± 2.094
0.886IleCys: 0.886 ± 1.716
0.886IleAsp: 0.886 ± 1.066
4.874IleGlu: 4.874 ± 1.16
1.772IlePhe: 1.772 ± 0.989
2.215IleGly: 2.215 ± 0.833
2.215IleHis: 2.215 ± 1.29
0.886IleIle: 0.886 ± 0.762
4.431IleLys: 4.431 ± 1.995
4.431IleLeu: 4.431 ± 1.665
0.886IleMet: 0.886 ± 0.494
1.772IleAsn: 1.772 ± 0.787
3.545IlePro: 3.545 ± 1.569
4.431IleGln: 4.431 ± 1.493
4.874IleArg: 4.874 ± 1.455
2.215IleSer: 2.215 ± 2.239
2.658IleThr: 2.658 ± 1.238
3.988IleVal: 3.988 ± 2.458
0.443IleTrp: 0.443 ± 0.247
1.772IleTyr: 1.772 ± 0.787
0.0IleXaa: 0.0 ± 0.0
Lys
4.431LysAla: 4.431 ± 0.756
0.0LysCys: 0.0 ± 0.0
4.431LysAsp: 4.431 ± 1.75
5.317LysGlu: 5.317 ± 2.288
1.772LysPhe: 1.772 ± 0.787
2.658LysGly: 2.658 ± 1.508
2.215LysHis: 2.215 ± 0.935
4.431LysIle: 4.431 ± 2.472
2.215LysLys: 2.215 ± 1.447
6.203LysLeu: 6.203 ± 2.349
1.329LysMet: 1.329 ± 0.742
1.772LysAsn: 1.772 ± 0.73
6.646LysPro: 6.646 ± 2.01
2.215LysGln: 2.215 ± 1.236
3.988LysArg: 3.988 ± 2.225
6.203LysSer: 6.203 ± 1.436
5.317LysThr: 5.317 ± 2.967
3.988LysVal: 3.988 ± 1.172
0.443LysTrp: 0.443 ± 0.247
1.329LysTyr: 1.329 ± 0.698
0.0LysXaa: 0.0 ± 0.0
Leu
6.646LeuAla: 6.646 ± 3.211
0.886LeuCys: 0.886 ± 0.494
5.76LeuAsp: 5.76 ± 2.156
5.76LeuGlu: 5.76 ± 3.172
3.545LeuPhe: 3.545 ± 1.381
4.431LeuGly: 4.431 ± 1.232
1.772LeuHis: 1.772 ± 1.088
4.874LeuIle: 4.874 ± 2.221
6.646LeuLys: 6.646 ± 3.067
7.975LeuLeu: 7.975 ± 3.117
0.886LeuMet: 0.886 ± 0.494
3.988LeuAsn: 3.988 ± 2.113
6.203LeuPro: 6.203 ± 2.215
0.886LeuGln: 0.886 ± 0.762
5.76LeuArg: 5.76 ± 1.246
7.089LeuSer: 7.089 ± 2.319
6.646LeuThr: 6.646 ± 0.722
3.545LeuVal: 3.545 ± 4.546
1.329LeuTrp: 1.329 ± 1.045
2.658LeuTyr: 2.658 ± 1.039
0.0LeuXaa: 0.0 ± 0.0
Met
1.329MetAla: 1.329 ± 0.742
0.443MetCys: 0.443 ± 0.247
1.329MetAsp: 1.329 ± 0.742
0.886MetGlu: 0.886 ± 1.066
1.772MetPhe: 1.772 ± 0.989
1.329MetGly: 1.329 ± 0.742
0.0MetHis: 0.0 ± 0.0
0.886MetIle: 0.886 ± 0.691
1.772MetLys: 1.772 ± 0.787
2.658MetLeu: 2.658 ± 1.483
0.443MetMet: 0.443 ± 0.767
0.886MetAsn: 0.886 ± 0.494
0.443MetPro: 0.443 ± 1.228
0.443MetGln: 0.443 ± 0.247
1.772MetArg: 1.772 ± 1.003
2.658MetSer: 2.658 ± 1.119
0.886MetThr: 0.886 ± 1.535
0.443MetVal: 0.443 ± 1.277
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.988AsnAla: 3.988 ± 2.736
0.886AsnCys: 0.886 ± 1.131
1.329AsnAsp: 1.329 ± 0.742
2.215AsnGlu: 2.215 ± 0.833
0.886AsnPhe: 0.886 ± 0.691
2.215AsnGly: 2.215 ± 0.935
0.443AsnHis: 0.443 ± 0.247
2.215AsnIle: 2.215 ± 0.916
1.329AsnLys: 1.329 ± 1.439
1.772AsnLeu: 1.772 ± 1.385
1.329AsnMet: 1.329 ± 1.439
1.329AsnAsn: 1.329 ± 1.439
2.658AsnPro: 2.658 ± 1.119
2.658AsnGln: 2.658 ± 1.483
2.658AsnArg: 2.658 ± 1.134
1.772AsnSer: 1.772 ± 1.524
3.101AsnThr: 3.101 ± 1.323
1.329AsnVal: 1.329 ± 0.869
0.886AsnTrp: 0.886 ± 0.691
1.772AsnTyr: 1.772 ± 0.989
0.0AsnXaa: 0.0 ± 0.0
Pro
3.545ProAla: 3.545 ± 2.057
0.886ProCys: 0.886 ± 1.131
3.101ProAsp: 3.101 ± 1.731
6.203ProGlu: 6.203 ± 2.375
1.329ProPhe: 1.329 ± 1.082
3.545ProGly: 3.545 ± 1.7
1.772ProHis: 1.772 ± 1.622
3.545ProIle: 3.545 ± 1.381
5.317ProLys: 5.317 ± 2.288
3.545ProLeu: 3.545 ± 2.586
0.886ProMet: 0.886 ± 0.608
3.988ProAsn: 3.988 ± 1.559
3.988ProPro: 3.988 ± 2.979
2.658ProGln: 2.658 ± 1.603
3.988ProArg: 3.988 ± 0.916
2.215ProSer: 2.215 ± 0.602
2.215ProThr: 2.215 ± 1.149
3.545ProVal: 3.545 ± 1.882
0.443ProTrp: 0.443 ± 0.247
0.886ProTyr: 0.886 ± 0.494
0.0ProXaa: 0.0 ± 0.0
Gln
3.101GlnAla: 3.101 ± 1.017
0.886GlnCys: 0.886 ± 0.691
3.101GlnAsp: 3.101 ± 3.309
5.317GlnGlu: 5.317 ± 2.967
1.329GlnPhe: 1.329 ± 0.869
3.545GlnGly: 3.545 ± 2.057
1.329GlnHis: 1.329 ± 0.742
1.329GlnIle: 1.329 ± 0.742
1.772GlnLys: 1.772 ± 0.989
3.545GlnLeu: 3.545 ± 1.374
1.329GlnMet: 1.329 ± 0.86
0.886GlnAsn: 0.886 ± 0.494
1.329GlnPro: 1.329 ± 0.704
1.329GlnGln: 1.329 ± 0.698
0.886GlnArg: 0.886 ± 1.066
2.215GlnSer: 2.215 ± 1.236
2.658GlnThr: 2.658 ± 1.119
2.658GlnVal: 2.658 ± 0.591
0.443GlnTrp: 0.443 ± 0.247
0.886GlnTyr: 0.886 ± 1.131
0.0GlnXaa: 0.0 ± 0.0
Arg
5.317ArgAla: 5.317 ± 2.349
0.886ArgCys: 0.886 ± 1.14
4.874ArgAsp: 4.874 ± 2.142
3.101ArgGlu: 3.101 ± 1.467
3.101ArgPhe: 3.101 ± 2.269
2.215ArgGly: 2.215 ± 1.366
0.443ArgHis: 0.443 ± 0.888
3.101ArgIle: 3.101 ± 0.677
2.658ArgLys: 2.658 ± 0.591
3.545ArgLeu: 3.545 ± 0.83
1.329ArgMet: 1.329 ± 1.045
0.886ArgAsn: 0.886 ± 0.494
2.658ArgPro: 2.658 ± 1.134
4.431ArgGln: 4.431 ± 1.314
3.545ArgArg: 3.545 ± 2.652
3.988ArgSer: 3.988 ± 2.692
5.76ArgThr: 5.76 ± 1.187
1.772ArgVal: 1.772 ± 0.989
0.443ArgTrp: 0.443 ± 0.247
2.215ArgTyr: 2.215 ± 0.935
0.0ArgXaa: 0.0 ± 0.0
Ser
3.545SerAla: 3.545 ± 2.507
0.886SerCys: 0.886 ± 0.494
4.874SerAsp: 4.874 ± 1.81
3.988SerGlu: 3.988 ± 1.085
2.215SerPhe: 2.215 ± 0.833
1.772SerGly: 1.772 ± 1.368
1.329SerHis: 1.329 ± 0.869
6.203SerIle: 6.203 ± 1.602
6.646SerLys: 6.646 ± 1.16
8.861SerLeu: 8.861 ± 4.064
0.443SerMet: 0.443 ± 0.767
2.658SerAsn: 2.658 ± 0.896
3.545SerPro: 3.545 ± 1.354
3.545SerGln: 3.545 ± 1.057
3.988SerArg: 3.988 ± 1.241
3.545SerSer: 3.545 ± 1.381
4.431SerThr: 4.431 ± 1.892
3.101SerVal: 3.101 ± 2.202
0.0SerTrp: 0.0 ± 0.0
2.215SerTyr: 2.215 ± 1.089
0.0SerXaa: 0.0 ± 0.0
Thr
4.874ThrAla: 4.874 ± 1.156
0.886ThrCys: 0.886 ± 1.131
1.329ThrAsp: 1.329 ± 0.698
3.988ThrGlu: 3.988 ± 1.599
4.874ThrPhe: 4.874 ± 1.716
3.988ThrGly: 3.988 ± 2.094
3.988ThrHis: 3.988 ± 2.204
4.431ThrIle: 4.431 ± 1.165
2.658ThrLys: 2.658 ± 0.896
4.431ThrLeu: 4.431 ± 1.493
2.215ThrMet: 2.215 ± 1.236
2.658ThrAsn: 2.658 ± 1.119
4.874ThrPro: 4.874 ± 1.912
2.215ThrGln: 2.215 ± 0.935
3.988ThrArg: 3.988 ± 1.78
3.545ThrSer: 3.545 ± 1.057
3.101ThrThr: 3.101 ± 0.677
5.76ThrVal: 5.76 ± 1.992
0.443ThrTrp: 0.443 ± 1.277
1.772ThrTyr: 1.772 ± 0.989
0.0ThrXaa: 0.0 ± 0.0
Val
5.317ValAla: 5.317 ± 3.931
1.772ValCys: 1.772 ± 0.73
0.886ValAsp: 0.886 ± 0.762
4.431ValGlu: 4.431 ± 0.756
3.988ValPhe: 3.988 ± 1.368
3.545ValGly: 3.545 ± 2.5
1.329ValHis: 1.329 ± 1.132
3.545ValIle: 3.545 ± 3.544
4.874ValLys: 4.874 ± 1.968
6.646ValLeu: 6.646 ± 2.662
0.886ValMet: 0.886 ± 0.494
2.215ValAsn: 2.215 ± 1.366
3.545ValPro: 3.545 ± 0.77
1.329ValGln: 1.329 ± 1.045
3.545ValArg: 3.545 ± 2.007
2.658ValSer: 2.658 ± 3.064
2.215ValThr: 2.215 ± 0.935
3.545ValVal: 3.545 ± 0.77
0.443ValTrp: 0.443 ± 0.767
1.329ValTyr: 1.329 ± 0.742
0.0ValXaa: 0.0 ± 0.0
Trp
0.886TrpAla: 0.886 ± 0.691
0.0TrpCys: 0.0 ± 0.0
0.886TrpAsp: 0.886 ± 0.494
2.215TrpGlu: 2.215 ± 1.232
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.443TrpHis: 0.443 ± 0.888
0.0TrpIle: 0.0 ± 0.0
1.329TrpLys: 1.329 ± 0.698
0.886TrpLeu: 0.886 ± 0.494
0.886TrpMet: 0.886 ± 0.494
0.443TrpAsn: 0.443 ± 0.767
0.443TrpPro: 0.443 ± 0.247
0.886TrpGln: 0.886 ± 1.14
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.886TrpThr: 0.886 ± 0.494
0.443TrpVal: 0.443 ± 0.247
0.443TrpTrp: 0.443 ± 0.247
0.443TrpTyr: 0.443 ± 0.767
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.988TyrAla: 3.988 ± 1.187
0.0TyrCys: 0.0 ± 0.0
2.658TyrAsp: 2.658 ± 1.17
1.772TyrGlu: 1.772 ± 1.381
1.329TyrPhe: 1.329 ± 1.132
0.443TyrGly: 0.443 ± 0.767
2.658TyrHis: 2.658 ± 1.119
0.886TyrIle: 0.886 ± 0.494
0.886TyrLys: 0.886 ± 0.494
2.658TyrLeu: 2.658 ± 1.238
1.329TyrMet: 1.329 ± 0.698
0.0TyrAsn: 0.0 ± 0.0
0.886TyrPro: 0.886 ± 0.494
1.329TyrGln: 1.329 ± 1.045
0.886TyrArg: 0.886 ± 1.131
2.215TyrSer: 2.215 ± 1.149
2.215TyrThr: 2.215 ± 0.833
1.329TyrVal: 1.329 ± 0.704
0.0TyrTrp: 0.0 ± 0.0
0.443TyrTyr: 0.443 ± 0.767
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2258 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski