Amino acid dipepetide frequency for Legionella quinlivanii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.231AlaAla: 7.231 ± 0.11	1.11AlaCys: 1.11 ± 0.036	3.828AlaAsp: 3.828 ± 0.055	4.945AlaGlu: 4.945 ± 0.076	3.303AlaPhe: 3.303 ± 0.062	5.44AlaGly: 5.44 ± 0.094	1.639AlaHis: 1.639 ± 0.044	5.962AlaIle: 5.962 ± 0.089	4.367AlaLys: 4.367 ± 0.077	9.253AlaLeu: 9.253 ± 0.097	2.131AlaMet: 2.131 ± 0.053	3.541AlaAsn: 3.541 ± 0.071	2.485AlaPro: 2.485 ± 0.052	3.408AlaGln: 3.408 ± 0.064	3.779AlaArg: 3.779 ± 0.063	5.449AlaSer: 5.449 ± 0.07	3.447AlaThr: 3.447 ± 0.071	5.09AlaVal: 5.09 ± 0.071	0.794AlaTrp: 0.794 ± 0.03	2.623AlaTyr: 2.623 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.757CysAla: 0.757 ± 0.03	0.199CysCys: 0.199 ± 0.014	0.556CysAsp: 0.556 ± 0.023	0.65CysGlu: 0.65 ± 0.024	0.679CysPhe: 0.679 ± 0.027	0.84CysGly: 0.84 ± 0.032	0.335CysHis: 0.335 ± 0.016	0.771CysIle: 0.771 ± 0.029	0.599CysLys: 0.599 ± 0.035	1.416CysLeu: 1.416 ± 0.041	0.267CysMet: 0.267 ± 0.015	0.513CysAsn: 0.513 ± 0.023	0.483CysPro: 0.483 ± 0.023	0.558CysGln: 0.558 ± 0.026	0.548CysArg: 0.548 ± 0.023	0.819CysSer: 0.819 ± 0.034	0.52CysThr: 0.52 ± 0.021	0.619CysVal: 0.619 ± 0.025	0.147CysTrp: 0.147 ± 0.013	0.449CysTyr: 0.449 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.674AspAla: 3.674 ± 0.068	0.651AspCys: 0.651 ± 0.026	2.437AspAsp: 2.437 ± 0.052	3.497AspGlu: 3.497 ± 0.067	2.5AspPhe: 2.5 ± 0.057	2.731AspGly: 2.731 ± 0.081	0.958AspHis: 0.958 ± 0.031	3.533AspIle: 3.533 ± 0.067	3.289AspLys: 3.289 ± 0.063	5.308AspLeu: 5.308 ± 0.082	1.04AspMet: 1.04 ± 0.028	2.425AspAsn: 2.425 ± 0.05	1.969AspPro: 1.969 ± 0.051	1.77AspGln: 1.77 ± 0.042	2.054AspArg: 2.054 ± 0.049	3.381AspSer: 3.381 ± 0.067	2.189AspThr: 2.189 ± 0.045	2.712AspVal: 2.712 ± 0.052	0.718AspTrp: 0.718 ± 0.027	2.174AspTyr: 2.174 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.901GluAla: 4.901 ± 0.086	0.568GluCys: 0.568 ± 0.027	2.654GluAsp: 2.654 ± 0.054	4.417GluGlu: 4.417 ± 0.078	2.496GluPhe: 2.496 ± 0.046	3.166GluGly: 3.166 ± 0.056	1.568GluHis: 1.568 ± 0.038	4.577GluIle: 4.577 ± 0.072	4.561GluLys: 4.561 ± 0.077	7.102GluLeu: 7.102 ± 0.095	1.521GluMet: 1.521 ± 0.037	3.133GluAsn: 3.133 ± 0.056	2.039GluPro: 2.039 ± 0.05	3.818GluGln: 3.818 ± 0.078	3.228GluArg: 3.228 ± 0.065	3.56GluSer: 3.56 ± 0.055	3.149GluThr: 3.149 ± 0.05	3.54GluVal: 3.54 ± 0.061	0.68GluTrp: 0.68 ± 0.022	1.79GluTyr: 1.79 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.331PheAla: 3.331 ± 0.064	0.647PheCys: 0.647 ± 0.025	2.431PheAsp: 2.431 ± 0.052	2.403PheGlu: 2.403 ± 0.049	2.398PhePhe: 2.398 ± 0.065	2.597PheGly: 2.597 ± 0.052	0.973PheHis: 0.973 ± 0.034	3.354PheIle: 3.354 ± 0.063	2.5PheLys: 2.5 ± 0.051	4.65PheLeu: 4.65 ± 0.081	0.932PheMet: 0.932 ± 0.031	2.499PheAsn: 2.499 ± 0.052	1.79PhePro: 1.79 ± 0.042	1.601PheGln: 1.601 ± 0.043	1.724PheArg: 1.724 ± 0.042	3.705PheSer: 3.705 ± 0.063	2.347PheThr: 2.347 ± 0.044	2.382PheVal: 2.382 ± 0.052	0.527PheTrp: 0.527 ± 0.022	1.689PheTyr: 1.689 ± 0.044	0.001PheXaa: 0.001 ± 0.001
Gly	4.306GlyAla: 4.306 ± 0.084	0.806GlyCys: 0.806 ± 0.03	2.77GlyAsp: 2.77 ± 0.071	3.443GlyGlu: 3.443 ± 0.059	3.165GlyPhe: 3.165 ± 0.07	4.078GlyGly: 4.078 ± 0.117	1.479GlyHis: 1.479 ± 0.04	4.782GlyIle: 4.782 ± 0.069	3.748GlyLys: 3.748 ± 0.063	6.772GlyLeu: 6.772 ± 0.097	1.697GlyMet: 1.697 ± 0.042	2.732GlyAsn: 2.732 ± 0.068	1.632GlyPro: 1.632 ± 0.044	2.661GlyGln: 2.661 ± 0.061	2.713GlyArg: 2.713 ± 0.059	3.954GlySer: 3.954 ± 0.092	2.913GlyThr: 2.913 ± 0.062	3.841GlyVal: 3.841 ± 0.075	0.771GlyTrp: 0.771 ± 0.031	2.32GlyTyr: 2.32 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.699HisAla: 1.699 ± 0.045	0.418HisCys: 0.418 ± 0.021	0.992HisAsp: 0.992 ± 0.032	1.262HisGlu: 1.262 ± 0.033	1.331HisPhe: 1.331 ± 0.042	1.394HisGly: 1.394 ± 0.039	0.787HisHis: 0.787 ± 0.026	1.401HisIle: 1.401 ± 0.038	1.004HisLys: 1.004 ± 0.032	2.808HisLeu: 2.808 ± 0.06	0.502HisMet: 0.502 ± 0.023	0.923HisAsn: 0.923 ± 0.035	1.366HisPro: 1.366 ± 0.04	1.264HisGln: 1.264 ± 0.032	1.145HisArg: 1.145 ± 0.03	1.685HisSer: 1.685 ± 0.035	0.989HisThr: 0.989 ± 0.029	1.213HisVal: 1.213 ± 0.036	0.417HisTrp: 0.417 ± 0.021	1.148HisTyr: 1.148 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.235IleAla: 6.235 ± 0.083	0.78IleCys: 0.78 ± 0.026	4.152IleAsp: 4.152 ± 0.069	4.668IleGlu: 4.668 ± 0.066	2.567IlePhe: 2.567 ± 0.062	4.165IleGly: 4.165 ± 0.075	1.718IleHis: 1.718 ± 0.042	4.885IleIle: 4.885 ± 0.088	4.303IleLys: 4.303 ± 0.07	6.753IleLeu: 6.753 ± 0.085	1.304IleMet: 1.304 ± 0.039	3.96IleAsn: 3.96 ± 0.066	3.306IlePro: 3.306 ± 0.059	2.918IleGln: 2.918 ± 0.058	3.223IleArg: 3.223 ± 0.059	5.21IleSer: 5.21 ± 0.078	3.568IleThr: 3.568 ± 0.08	3.792IleVal: 3.792 ± 0.063	0.584IleTrp: 0.584 ± 0.023	2.091IleTyr: 2.091 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.77LysAla: 4.77 ± 0.081	0.375LysCys: 0.375 ± 0.02	2.797LysAsp: 2.797 ± 0.052	4.436LysGlu: 4.436 ± 0.081	1.509LysPhe: 1.509 ± 0.037	3.145LysGly: 3.145 ± 0.067	1.34LysHis: 1.34 ± 0.036	3.979LysIle: 3.979 ± 0.066	4.139LysLys: 4.139 ± 0.085	5.948LysLeu: 5.948 ± 0.074	1.441LysMet: 1.441 ± 0.042	3.062LysAsn: 3.062 ± 0.058	2.781LysPro: 2.781 ± 0.052	3.293LysGln: 3.293 ± 0.06	2.946LysArg: 2.946 ± 0.067	3.602LysSer: 3.602 ± 0.064	3.465LysThr: 3.465 ± 0.063	2.884LysVal: 2.884 ± 0.058	0.541LysTrp: 0.541 ± 0.02	1.522LysTyr: 1.522 ± 0.041	0.001LysXaa: 0.001 ± 0.001
Leu	9.331LeuAla: 9.331 ± 0.099	1.396LeuCys: 1.396 ± 0.042	5.301LeuAsp: 5.301 ± 0.082	6.38LeuGlu: 6.38 ± 0.092	5.116LeuPhe: 5.116 ± 0.087	6.577LeuGly: 6.577 ± 0.096	2.52LeuHis: 2.52 ± 0.049	7.928LeuIle: 7.928 ± 0.107	6.776LeuLys: 6.776 ± 0.091	12.502LeuLeu: 12.502 ± 0.149	2.553LeuMet: 2.553 ± 0.048	5.738LeuAsn: 5.738 ± 0.086	5.181LeuPro: 5.181 ± 0.085	4.961LeuGln: 4.961 ± 0.079	4.871LeuArg: 4.871 ± 0.075	8.823LeuSer: 8.823 ± 0.115	5.717LeuThr: 5.717 ± 0.078	6.041LeuVal: 6.041 ± 0.09	1.054LeuTrp: 1.054 ± 0.035	3.164LeuTyr: 3.164 ± 0.058	0.001LeuXaa: 0.001 ± 0.001
Met	2.075MetAla: 2.075 ± 0.046	0.149MetCys: 0.149 ± 0.012	1.201MetAsp: 1.201 ± 0.031	1.193MetGlu: 1.193 ± 0.037	0.669MetPhe: 0.669 ± 0.028	1.464MetGly: 1.464 ± 0.04	0.491MetHis: 0.491 ± 0.021	1.52MetIle: 1.52 ± 0.041	1.435MetLys: 1.435 ± 0.041	2.527MetLeu: 2.527 ± 0.048	0.623MetMet: 0.623 ± 0.027	1.215MetAsn: 1.215 ± 0.033	1.184MetPro: 1.184 ± 0.033	1.167MetGln: 1.167 ± 0.031	1.181MetArg: 1.181 ± 0.034	1.596MetSer: 1.596 ± 0.041	1.371MetThr: 1.371 ± 0.04	1.353MetVal: 1.353 ± 0.036	0.164MetTrp: 0.164 ± 0.011	0.509MetTyr: 0.509 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.644AsnAla: 3.644 ± 0.065	0.59AsnCys: 0.59 ± 0.03	2.312AsnAsp: 2.312 ± 0.055	3.154AsnGlu: 3.154 ± 0.058	1.918AsnPhe: 1.918 ± 0.045	2.833AsnGly: 2.833 ± 0.098	1.303AsnHis: 1.303 ± 0.032	2.944AsnIle: 2.944 ± 0.048	2.725AsnLys: 2.725 ± 0.057	5.03AsnLeu: 5.03 ± 0.075	0.898AsnMet: 0.898 ± 0.027	2.542AsnAsn: 2.542 ± 0.064	2.757AsnPro: 2.757 ± 0.054	2.811AsnGln: 2.811 ± 0.06	2.226AsnArg: 2.226 ± 0.046	3.309AsnSer: 3.309 ± 0.065	2.486AsnThr: 2.486 ± 0.052	2.275AsnVal: 2.275 ± 0.06	0.605AsnTrp: 0.605 ± 0.023	1.899AsnTyr: 1.899 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.612ProAla: 3.612 ± 0.065	0.386ProCys: 0.386 ± 0.021	2.481ProAsp: 2.481 ± 0.044	3.395ProGlu: 3.395 ± 0.059	1.87ProPhe: 1.87 ± 0.042	2.924ProGly: 2.924 ± 0.054	0.938ProHis: 0.938 ± 0.029	2.425ProIle: 2.425 ± 0.058	1.901ProLys: 1.901 ± 0.044	4.652ProLeu: 4.652 ± 0.069	0.888ProMet: 0.888 ± 0.03	1.628ProAsn: 1.628 ± 0.041	1.627ProPro: 1.627 ± 0.047	1.893ProGln: 1.893 ± 0.046	1.574ProArg: 1.574 ± 0.038	2.614ProSer: 2.614 ± 0.056	1.661ProThr: 1.661 ± 0.045	3.45ProVal: 3.45 ± 0.077	0.5ProTrp: 0.5 ± 0.024	1.293ProTyr: 1.293 ± 0.038	0.001ProXaa: 0.001 ± 0.001
Gln	4.274GlnAla: 4.274 ± 0.077	0.487GlnCys: 0.487 ± 0.023	1.984GlnAsp: 1.984 ± 0.044	2.783GlnGlu: 2.783 ± 0.063	2.258GlnPhe: 2.258 ± 0.051	2.669GlnGly: 2.669 ± 0.053	1.133GlnHis: 1.133 ± 0.039	3.249GlnIle: 3.249 ± 0.059	2.797GlnLys: 2.797 ± 0.058	5.808GlnLeu: 5.808 ± 0.09	1.073GlnMet: 1.073 ± 0.036	2.073GlnAsn: 2.073 ± 0.047	1.696GlnPro: 1.696 ± 0.043	3.096GlnGln: 3.096 ± 0.074	2.249GlnArg: 2.249 ± 0.055	3.173GlnSer: 3.173 ± 0.055	2.413GlnThr: 2.413 ± 0.048	2.624GlnVal: 2.624 ± 0.057	0.677GlnTrp: 0.677 ± 0.026	1.608GlnTyr: 1.608 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.209ArgAla: 3.209 ± 0.056	0.477ArgCys: 0.477 ± 0.024	2.256ArgAsp: 2.256 ± 0.047	3.19ArgGlu: 3.19 ± 0.073	2.385ArgPhe: 2.385 ± 0.054	2.365ArgGly: 2.365 ± 0.053	1.226ArgHis: 1.226 ± 0.036	3.356ArgIle: 3.356 ± 0.066	2.621ArgLys: 2.621 ± 0.055	5.635ArgLeu: 5.635 ± 0.092	1.139ArgMet: 1.139 ± 0.032	2.05ArgAsn: 2.05 ± 0.048	1.589ArgPro: 1.589 ± 0.044	2.581ArgGln: 2.581 ± 0.062	2.174ArgArg: 2.174 ± 0.056	2.671ArgSer: 2.671 ± 0.046	1.904ArgThr: 1.904 ± 0.047	2.784ArgVal: 2.784 ± 0.057	0.587ArgTrp: 0.587 ± 0.023	1.867ArgTyr: 1.867 ± 0.041	0.001ArgXaa: 0.001 ± 0.001
Ser	5.077SerAla: 5.077 ± 0.078	0.899SerCys: 0.899 ± 0.035	3.241SerAsp: 3.241 ± 0.061	4.081SerGlu: 4.081 ± 0.059	3.333SerPhe: 3.333 ± 0.066	4.67SerGly: 4.67 ± 0.088	1.65SerHis: 1.65 ± 0.037	4.758SerIle: 4.758 ± 0.083	3.556SerLys: 3.556 ± 0.068	8.493SerLeu: 8.493 ± 0.092	1.677SerMet: 1.677 ± 0.036	3.082SerAsn: 3.082 ± 0.067	3.003SerPro: 3.003 ± 0.065	3.096SerGln: 3.096 ± 0.058	3.24SerArg: 3.24 ± 0.056	5.124SerSer: 5.124 ± 0.097	3.22SerThr: 3.22 ± 0.066	3.913SerVal: 3.913 ± 0.064	0.828SerTrp: 0.828 ± 0.028	2.269SerTyr: 2.269 ± 0.054	0.001SerXaa: 0.001 ± 0.001
Thr	4.347ThrAla: 4.347 ± 0.077	0.503ThrCys: 0.503 ± 0.023	2.349ThrAsp: 2.349 ± 0.056	2.772ThrGlu: 2.772 ± 0.053	1.73ThrPhe: 1.73 ± 0.047	3.665ThrGly: 3.665 ± 0.076	1.285ThrHis: 1.285 ± 0.037	3.578ThrIle: 3.578 ± 0.064	2.122ThrLys: 2.122 ± 0.044	5.49ThrLeu: 5.49 ± 0.076	1.023ThrMet: 1.023 ± 0.032	2.039ThrAsn: 2.039 ± 0.049	2.601ThrPro: 2.601 ± 0.052	2.195ThrGln: 2.195 ± 0.052	2.313ThrArg: 2.313 ± 0.054	3.079ThrSer: 3.079 ± 0.06	2.466ThrThr: 2.466 ± 0.062	3.359ThrVal: 3.359 ± 0.071	0.501ThrTrp: 0.501 ± 0.022	1.464ThrTyr: 1.464 ± 0.038	0.002ThrXaa: 0.002 ± 0.001
Val	4.322ValAla: 4.322 ± 0.078	0.686ValCys: 0.686 ± 0.027	3.143ValAsp: 3.143 ± 0.062	3.402ValGlu: 3.402 ± 0.063	2.768ValPhe: 2.768 ± 0.056	3.206ValGly: 3.206 ± 0.071	1.2ValHis: 1.2 ± 0.035	4.547ValIle: 4.547 ± 0.087	3.309ValLys: 3.309 ± 0.062	6.234ValLeu: 6.234 ± 0.083	1.478ValMet: 1.478 ± 0.039	3.133ValAsn: 3.133 ± 0.07	2.262ValPro: 2.262 ± 0.048	2.106ValGln: 2.106 ± 0.049	2.465ValArg: 2.465 ± 0.045	4.444ValSer: 4.444 ± 0.075	2.933ValThr: 2.933 ± 0.063	3.667ValVal: 3.667 ± 0.085	0.558ValTrp: 0.558 ± 0.022	1.939ValTyr: 1.939 ± 0.041	0.004ValXaa: 0.004 ± 0.002
Trp	0.691TrpAla: 0.691 ± 0.027	0.119TrpCys: 0.119 ± 0.009	0.491TrpAsp: 0.491 ± 0.022	0.592TrpGlu: 0.592 ± 0.023	0.59TrpPhe: 0.59 ± 0.026	0.665TrpGly: 0.665 ± 0.031	0.296TrpHis: 0.296 ± 0.017	0.76TrpIle: 0.76 ± 0.026	0.554TrpLys: 0.554 ± 0.022	1.58TrpLeu: 1.58 ± 0.04	0.311TrpMet: 0.311 ± 0.019	0.513TrpAsn: 0.513 ± 0.022	0.438TrpPro: 0.438 ± 0.022	0.788TrpGln: 0.788 ± 0.029	0.571TrpArg: 0.571 ± 0.025	0.646TrpSer: 0.646 ± 0.027	0.519TrpThr: 0.519 ± 0.021	0.628TrpVal: 0.628 ± 0.025	0.15TrpTrp: 0.15 ± 0.012	0.374TrpTyr: 0.374 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.338TyrAla: 2.338 ± 0.056	0.478TyrCys: 0.478 ± 0.019	1.635TyrAsp: 1.635 ± 0.082	1.805TyrGlu: 1.805 ± 0.043	1.898TyrPhe: 1.898 ± 0.043	1.988TyrGly: 1.988 ± 0.044	0.909TyrHis: 0.909 ± 0.032	1.87TyrIle: 1.87 ± 0.041	1.672TyrLys: 1.672 ± 0.042	3.969TyrLeu: 3.969 ± 0.073	0.586TyrMet: 0.586 ± 0.026	1.46TyrAsn: 1.46 ± 0.046	1.524TyrPro: 1.524 ± 0.037	2.136TyrGln: 2.136 ± 0.051	1.845TyrArg: 1.845 ± 0.046	2.364TyrSer: 2.364 ± 0.05	1.606TyrThr: 1.606 ± 0.04	1.636TyrVal: 1.636 ± 0.04	0.474TyrTrp: 0.474 ± 0.024	1.388TyrTyr: 1.388 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.039XaaXaa: 0.039 ± 0.014

Statistics based on 2989 proteins (1064207 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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