Amino acid dipepetide frequency for Streptococcus satellite phage Javan98

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.353AlaAla: 0.353 ± 0.375
1.059AlaCys: 1.059 ± 0.527
6.704AlaAsp: 6.704 ± 2.267
6.351AlaGlu: 6.351 ± 1.478
2.117AlaPhe: 2.117 ± 0.789
2.823AlaGly: 2.823 ± 1.024
1.411AlaHis: 1.411 ± 0.926
4.587AlaIle: 4.587 ± 1.534
4.587AlaLys: 4.587 ± 1.347
6.351AlaLeu: 6.351 ± 1.388
2.47AlaMet: 2.47 ± 1.252
1.411AlaAsn: 1.411 ± 0.679
1.764AlaPro: 1.764 ± 0.623
1.059AlaGln: 1.059 ± 0.554
2.47AlaArg: 2.47 ± 0.854
4.234AlaSer: 4.234 ± 1.011
4.234AlaThr: 4.234 ± 1.523
1.059AlaVal: 1.059 ± 0.643
0.0AlaTrp: 0.0 ± 0.0
1.411AlaTyr: 1.411 ± 0.511
0.0AlaXaa: 0.0 ± 0.0
Cys
0.706CysAla: 0.706 ± 0.439
0.0CysCys: 0.0 ± 0.0
1.411CysAsp: 1.411 ± 0.589
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.706CysGly: 0.706 ± 0.74
0.0CysHis: 0.0 ± 0.0
0.706CysIle: 0.706 ± 0.644
0.353CysLys: 0.353 ± 0.406
0.706CysLeu: 0.706 ± 0.448
0.0CysMet: 0.0 ± 0.0
0.353CysAsn: 0.353 ± 0.322
0.353CysPro: 0.353 ± 0.37
0.706CysGln: 0.706 ± 0.74
0.706CysArg: 0.706 ± 0.446
0.0CysSer: 0.0 ± 0.0
0.353CysThr: 0.353 ± 0.347
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.706CysTyr: 0.706 ± 0.425
0.0CysXaa: 0.0 ± 0.0
Asp
1.411AspAla: 1.411 ± 0.957
1.059AspCys: 1.059 ± 0.797
3.881AspAsp: 3.881 ± 1.34
3.176AspGlu: 3.176 ± 1.099
3.176AspPhe: 3.176 ± 1.072
2.117AspGly: 2.117 ± 0.842
0.0AspHis: 0.0 ± 0.0
5.293AspIle: 5.293 ± 1.254
8.469AspLys: 8.469 ± 1.584
5.293AspLeu: 5.293 ± 1.306
2.47AspMet: 2.47 ± 0.73
2.823AspAsn: 2.823 ± 0.789
1.411AspPro: 1.411 ± 0.562
1.059AspGln: 1.059 ± 0.415
1.059AspArg: 1.059 ± 0.514
2.823AspSer: 2.823 ± 1.072
3.529AspThr: 3.529 ± 1.115
2.117AspVal: 2.117 ± 0.845
0.353AspTrp: 0.353 ± 0.379
3.881AspTyr: 3.881 ± 1.008
0.0AspXaa: 0.0 ± 0.0
Glu
3.176GluAla: 3.176 ± 0.9
0.353GluCys: 0.353 ± 0.352
3.529GluAsp: 3.529 ± 0.627
3.881GluGlu: 3.881 ± 1.302
1.764GluPhe: 1.764 ± 0.916
1.411GluGly: 1.411 ± 0.561
1.411GluHis: 1.411 ± 0.567
5.999GluIle: 5.999 ± 1.148
5.999GluLys: 5.999 ± 1.323
13.409GluLeu: 13.409 ± 1.898
1.411GluMet: 1.411 ± 0.704
3.881GluAsn: 3.881 ± 1.096
2.823GluPro: 2.823 ± 0.756
3.176GluGln: 3.176 ± 1.084
4.587GluArg: 4.587 ± 1.728
3.529GluSer: 3.529 ± 1.026
3.529GluThr: 3.529 ± 0.976
5.293GluVal: 5.293 ± 1.225
1.059GluTrp: 1.059 ± 0.453
3.529GluTyr: 3.529 ± 1.282
0.0GluXaa: 0.0 ± 0.0
Phe
1.059PheAla: 1.059 ± 0.635
0.353PheCys: 0.353 ± 0.345
2.117PheAsp: 2.117 ± 1.264
3.529PheGlu: 3.529 ± 1.217
1.411PhePhe: 1.411 ± 0.627
2.823PheGly: 2.823 ± 0.844
0.353PheHis: 0.353 ± 0.277
3.881PheIle: 3.881 ± 1.405
1.764PheLys: 1.764 ± 0.738
1.764PheLeu: 1.764 ± 0.867
0.0PheMet: 0.0 ± 0.0
3.176PheAsn: 3.176 ± 1.184
0.706PhePro: 0.706 ± 0.51
0.706PheGln: 0.706 ± 0.644
1.764PheArg: 1.764 ± 0.887
2.47PheSer: 2.47 ± 0.699
1.764PheThr: 1.764 ± 0.918
1.411PheVal: 1.411 ± 0.792
0.0PheTrp: 0.0 ± 0.0
2.823PheTyr: 2.823 ± 0.849
0.0PheXaa: 0.0 ± 0.0
Gly
3.529GlyAla: 3.529 ± 1.368
0.706GlyCys: 0.706 ± 0.446
1.764GlyAsp: 1.764 ± 0.906
3.529GlyGlu: 3.529 ± 0.945
3.176GlyPhe: 3.176 ± 1.544
2.117GlyGly: 2.117 ± 0.852
1.411GlyHis: 1.411 ± 0.723
4.234GlyIle: 4.234 ± 0.904
4.234GlyLys: 4.234 ± 1.002
5.293GlyLeu: 5.293 ± 1.719
1.059GlyMet: 1.059 ± 0.613
2.47GlyAsn: 2.47 ± 1.185
0.0GlyPro: 0.0 ± 0.0
1.411GlyGln: 1.411 ± 0.956
2.117GlyArg: 2.117 ± 0.771
2.117GlySer: 2.117 ± 0.981
4.587GlyThr: 4.587 ± 1.518
4.587GlyVal: 4.587 ± 1.199
1.411GlyTrp: 1.411 ± 0.966
3.176GlyTyr: 3.176 ± 0.864
0.0GlyXaa: 0.0 ± 0.0
His
1.764HisAla: 1.764 ± 0.916
0.0HisCys: 0.0 ± 0.0
0.353HisAsp: 0.353 ± 0.352
0.706HisGlu: 0.706 ± 0.486
0.353HisPhe: 0.353 ± 0.439
1.764HisGly: 1.764 ± 1.215
0.706HisHis: 0.706 ± 0.547
0.353HisIle: 0.353 ± 0.388
1.059HisLys: 1.059 ± 0.703
2.823HisLeu: 2.823 ± 0.982
0.0HisMet: 0.0 ± 0.0
0.706HisAsn: 0.706 ± 0.407
1.059HisPro: 1.059 ± 0.633
0.353HisGln: 0.353 ± 0.406
0.706HisArg: 0.706 ± 0.381
1.059HisSer: 1.059 ± 0.454
1.764HisThr: 1.764 ± 0.556
1.411HisVal: 1.411 ± 0.721
0.0HisTrp: 0.0 ± 0.0
1.059HisTyr: 1.059 ± 0.597
0.0HisXaa: 0.0 ± 0.0
Ile
7.763IleAla: 7.763 ± 1.626
0.0IleCys: 0.0 ± 0.0
3.529IleAsp: 3.529 ± 1.156
4.234IleGlu: 4.234 ± 1.203
2.117IlePhe: 2.117 ± 1.009
2.117IleGly: 2.117 ± 0.874
1.059IleHis: 1.059 ± 0.8
3.881IleIle: 3.881 ± 1.446
7.41IleLys: 7.41 ± 1.465
5.999IleLeu: 5.999 ± 1.799
0.0IleMet: 0.0 ± 0.0
5.646IleAsn: 5.646 ± 1.388
5.646IlePro: 5.646 ± 0.983
1.411IleGln: 1.411 ± 0.593
2.823IleArg: 2.823 ± 1.486
5.646IleSer: 5.646 ± 1.365
7.41IleThr: 7.41 ± 1.405
2.47IleVal: 2.47 ± 0.86
0.353IleTrp: 0.353 ± 0.388
2.117IleTyr: 2.117 ± 1.044
0.0IleXaa: 0.0 ± 0.0
Lys
5.293LysAla: 5.293 ± 1.635
0.0LysCys: 0.0 ± 0.0
3.176LysAsp: 3.176 ± 1.207
10.939LysGlu: 10.939 ± 1.853
2.117LysPhe: 2.117 ± 0.771
6.351LysGly: 6.351 ± 1.608
2.47LysHis: 2.47 ± 0.786
4.94LysIle: 4.94 ± 1.262
8.821LysLys: 8.821 ± 1.948
8.116LysLeu: 8.116 ± 1.736
1.764LysMet: 1.764 ± 0.722
5.293LysAsn: 5.293 ± 1.452
5.293LysPro: 5.293 ± 1.295
5.293LysGln: 5.293 ± 1.053
5.646LysArg: 5.646 ± 1.356
2.823LysSer: 2.823 ± 1.037
6.351LysThr: 6.351 ± 1.289
4.234LysVal: 4.234 ± 0.96
1.059LysTrp: 1.059 ± 0.619
1.059LysTyr: 1.059 ± 0.566
0.0LysXaa: 0.0 ± 0.0
Leu
5.999LeuAla: 5.999 ± 1.876
1.411LeuCys: 1.411 ± 0.717
7.763LeuAsp: 7.763 ± 1.284
8.821LeuGlu: 8.821 ± 2.277
1.411LeuPhe: 1.411 ± 0.662
7.057LeuGly: 7.057 ± 1.55
1.411LeuHis: 1.411 ± 0.557
8.116LeuIle: 8.116 ± 1.986
8.821LeuLys: 8.821 ± 1.642
13.056LeuLeu: 13.056 ± 1.933
2.823LeuMet: 2.823 ± 0.739
5.999LeuAsn: 5.999 ± 1.043
3.881LeuPro: 3.881 ± 1.223
5.646LeuGln: 5.646 ± 1.325
2.47LeuArg: 2.47 ± 0.618
7.41LeuSer: 7.41 ± 2.18
7.057LeuThr: 7.057 ± 1.279
3.881LeuVal: 3.881 ± 1.504
1.411LeuTrp: 1.411 ± 0.448
4.234LeuTyr: 4.234 ± 1.296
0.0LeuXaa: 0.0 ± 0.0
Met
4.234MetAla: 4.234 ± 1.077
0.353MetCys: 0.353 ± 0.37
0.706MetAsp: 0.706 ± 0.439
1.059MetGlu: 1.059 ± 0.557
0.706MetPhe: 0.706 ± 0.53
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.059MetIle: 1.059 ± 0.618
1.059MetLys: 1.059 ± 0.495
1.411MetLeu: 1.411 ± 0.507
0.353MetMet: 0.353 ± 0.336
3.176MetAsn: 3.176 ± 0.878
0.353MetPro: 0.353 ± 0.474
0.353MetGln: 0.353 ± 0.322
0.706MetArg: 0.706 ± 0.487
1.411MetSer: 1.411 ± 0.66
3.529MetThr: 3.529 ± 1.168
2.117MetVal: 2.117 ± 1.07
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.881AsnAla: 3.881 ± 1.042
0.706AsnCys: 0.706 ± 0.486
2.117AsnAsp: 2.117 ± 0.76
3.176AsnGlu: 3.176 ± 0.658
1.059AsnPhe: 1.059 ± 0.584
5.999AsnGly: 5.999 ± 1.743
0.706AsnHis: 0.706 ± 0.396
3.881AsnIle: 3.881 ± 1.473
3.529AsnLys: 3.529 ± 1.261
5.293AsnLeu: 5.293 ± 1.225
2.117AsnMet: 2.117 ± 0.444
2.47AsnAsn: 2.47 ± 0.666
3.529AsnPro: 3.529 ± 1.301
1.764AsnGln: 1.764 ± 0.916
2.823AsnArg: 2.823 ± 0.668
1.764AsnSer: 1.764 ± 0.723
1.411AsnThr: 1.411 ± 0.728
0.706AsnVal: 0.706 ± 0.528
0.353AsnTrp: 0.353 ± 0.375
2.117AsnTyr: 2.117 ± 0.779
0.0AsnXaa: 0.0 ± 0.0
Pro
1.764ProAla: 1.764 ± 0.755
0.0ProCys: 0.0 ± 0.0
2.117ProAsp: 2.117 ± 0.763
2.823ProGlu: 2.823 ± 0.837
2.823ProPhe: 2.823 ± 0.842
0.353ProGly: 0.353 ± 0.37
0.353ProHis: 0.353 ± 0.474
3.176ProIle: 3.176 ± 0.803
7.41ProLys: 7.41 ± 1.498
2.823ProLeu: 2.823 ± 1.062
1.059ProMet: 1.059 ± 0.597
1.059ProAsn: 1.059 ± 0.967
1.764ProPro: 1.764 ± 0.692
1.764ProGln: 1.764 ± 0.636
2.47ProArg: 2.47 ± 0.698
2.47ProSer: 2.47 ± 1.038
2.47ProThr: 2.47 ± 0.857
2.823ProVal: 2.823 ± 0.632
0.0ProTrp: 0.0 ± 0.0
2.117ProTyr: 2.117 ± 0.965
0.0ProXaa: 0.0 ± 0.0
Gln
5.293GlnAla: 5.293 ± 1.865
0.353GlnCys: 0.353 ± 0.322
1.411GlnAsp: 1.411 ± 0.702
4.234GlnGlu: 4.234 ± 1.158
0.706GlnPhe: 0.706 ± 0.425
2.823GlnGly: 2.823 ± 0.953
1.411GlnHis: 1.411 ± 0.739
2.117GlnIle: 2.117 ± 0.72
4.234GlnLys: 4.234 ± 1.337
4.94GlnLeu: 4.94 ± 1.229
0.706GlnMet: 0.706 ± 0.536
1.059GlnAsn: 1.059 ± 0.515
1.059GlnPro: 1.059 ± 0.465
2.823GlnGln: 2.823 ± 1.2
3.176GlnArg: 3.176 ± 1.148
1.764GlnSer: 1.764 ± 0.8
1.059GlnThr: 1.059 ± 0.545
2.47GlnVal: 2.47 ± 0.619
0.0GlnTrp: 0.0 ± 0.0
2.117GlnTyr: 2.117 ± 1.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.117ArgAla: 2.117 ± 0.744
0.706ArgCys: 0.706 ± 0.446
3.529ArgAsp: 3.529 ± 0.969
1.764ArgGlu: 1.764 ± 0.735
1.764ArgPhe: 1.764 ± 0.578
2.823ArgGly: 2.823 ± 1.168
0.706ArgHis: 0.706 ± 0.424
1.411ArgIle: 1.411 ± 0.726
4.94ArgLys: 4.94 ± 1.155
7.763ArgLeu: 7.763 ± 1.473
1.764ArgMet: 1.764 ± 0.695
2.117ArgAsn: 2.117 ± 1.134
1.411ArgPro: 1.411 ± 0.717
3.529ArgGln: 3.529 ± 1.36
2.117ArgArg: 2.117 ± 0.743
1.411ArgSer: 1.411 ± 0.507
2.823ArgThr: 2.823 ± 0.952
3.176ArgVal: 3.176 ± 0.771
0.706ArgTrp: 0.706 ± 0.488
2.823ArgTyr: 2.823 ± 1.135
0.0ArgXaa: 0.0 ± 0.0
Ser
1.059SerAla: 1.059 ± 0.754
0.0SerCys: 0.0 ± 0.0
4.234SerAsp: 4.234 ± 1.277
2.823SerGlu: 2.823 ± 1.174
1.059SerPhe: 1.059 ± 0.669
2.47SerGly: 2.47 ± 0.68
0.706SerHis: 0.706 ± 0.555
3.881SerIle: 3.881 ± 0.928
3.176SerLys: 3.176 ± 0.813
7.41SerLeu: 7.41 ± 1.709
0.706SerMet: 0.706 ± 0.548
1.764SerAsn: 1.764 ± 0.568
1.059SerPro: 1.059 ± 0.558
4.234SerGln: 4.234 ± 1.081
3.881SerArg: 3.881 ± 1.25
1.764SerSer: 1.764 ± 0.812
2.47SerThr: 2.47 ± 0.953
4.234SerVal: 4.234 ± 1.526
0.0SerTrp: 0.0 ± 0.0
6.351SerTyr: 6.351 ± 1.407
0.0SerXaa: 0.0 ± 0.0
Thr
2.823ThrAla: 2.823 ± 0.876
0.0ThrCys: 0.0 ± 0.0
3.529ThrAsp: 3.529 ± 0.926
5.999ThrGlu: 5.999 ± 1.527
2.47ThrPhe: 2.47 ± 0.741
4.587ThrGly: 4.587 ± 1.259
1.059ThrHis: 1.059 ± 0.55
5.999ThrIle: 5.999 ± 1.262
4.587ThrLys: 4.587 ± 1.491
7.41ThrLeu: 7.41 ± 1.412
1.059ThrMet: 1.059 ± 0.453
1.411ThrAsn: 1.411 ± 0.709
3.881ThrPro: 3.881 ± 1.316
2.823ThrGln: 2.823 ± 1.347
3.529ThrArg: 3.529 ± 0.95
2.117ThrSer: 2.117 ± 0.788
3.529ThrThr: 3.529 ± 1.097
3.176ThrVal: 3.176 ± 0.69
1.411ThrTrp: 1.411 ± 0.488
3.176ThrTyr: 3.176 ± 0.766
0.0ThrXaa: 0.0 ± 0.0
Val
3.529ValAla: 3.529 ± 0.988
0.353ValCys: 0.353 ± 0.322
2.117ValAsp: 2.117 ± 0.705
2.117ValGlu: 2.117 ± 0.688
1.764ValPhe: 1.764 ± 0.877
2.117ValGly: 2.117 ± 0.881
1.411ValHis: 1.411 ± 0.595
3.881ValIle: 3.881 ± 1.203
4.94ValLys: 4.94 ± 1.374
2.47ValLeu: 2.47 ± 1.074
1.411ValMet: 1.411 ± 0.615
2.117ValAsn: 2.117 ± 0.668
3.176ValPro: 3.176 ± 1.385
2.117ValGln: 2.117 ± 1.032
2.117ValArg: 2.117 ± 0.669
4.94ValSer: 4.94 ± 1.198
4.234ValThr: 4.234 ± 1.274
2.823ValVal: 2.823 ± 1.135
0.353ValTrp: 0.353 ± 0.352
1.764ValTyr: 1.764 ± 0.731
0.0ValXaa: 0.0 ± 0.0
Trp
1.059TrpAla: 1.059 ± 0.656
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.411TrpGlu: 1.411 ± 0.667
0.706TrpPhe: 0.706 ± 0.476
0.0TrpGly: 0.0 ± 0.0
0.353TrpHis: 0.353 ± 0.322
0.0TrpIle: 0.0 ± 0.0
0.353TrpLys: 0.353 ± 0.37
1.764TrpLeu: 1.764 ± 0.578
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.353TrpGln: 0.353 ± 0.322
0.706TrpArg: 0.706 ± 0.417
0.706TrpSer: 0.706 ± 0.396
0.706TrpThr: 0.706 ± 0.547
0.706TrpVal: 0.706 ± 0.448
0.0TrpTrp: 0.0 ± 0.0
0.353TrpTyr: 0.353 ± 0.322
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.353TyrCys: 0.353 ± 0.336
1.411TyrAsp: 1.411 ± 0.856
3.176TyrGlu: 3.176 ± 0.86
3.176TyrPhe: 3.176 ± 1.002
2.47TyrGly: 2.47 ± 0.992
1.059TyrHis: 1.059 ± 0.598
4.234TyrIle: 4.234 ± 0.736
5.293TyrLys: 5.293 ± 1.678
4.587TyrLeu: 4.587 ± 1.02
1.059TyrMet: 1.059 ± 0.554
2.47TyrAsn: 2.47 ± 0.991
2.47TyrPro: 2.47 ± 1.124
3.176TyrGln: 3.176 ± 1.326
3.529TyrArg: 3.529 ± 0.761
2.823TyrSer: 2.823 ± 1.015
1.764TyrThr: 1.764 ± 0.784
1.059TyrVal: 1.059 ± 0.58
0.706TyrTrp: 0.706 ± 0.74
2.117TyrTyr: 2.117 ± 0.818
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (2835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski