Amino acid dipepetide frequency for Lonchura striata domestica (Bengalese finch)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.838AlaAla: 7.838 ± 0.07	1.349AlaCys: 1.349 ± 0.015	3.063AlaAsp: 3.063 ± 0.021	5.299AlaGlu: 5.299 ± 0.04	2.582AlaPhe: 2.582 ± 0.023	5.002AlaGly: 5.002 ± 0.04	1.446AlaHis: 1.446 ± 0.013	2.836AlaIle: 2.836 ± 0.019	3.691AlaLys: 3.691 ± 0.032	7.244AlaLeu: 7.244 ± 0.044	1.59AlaMet: 1.59 ± 0.016	2.115AlaAsn: 2.115 ± 0.016	3.852AlaPro: 3.852 ± 0.036	3.106AlaGln: 3.106 ± 0.027	3.613AlaArg: 3.613 ± 0.028	5.403AlaSer: 5.403 ± 0.033	3.432AlaThr: 3.432 ± 0.026	5.15AlaVal: 5.15 ± 0.031	0.788AlaTrp: 0.788 ± 0.011	1.529AlaTyr: 1.529 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	1.299CysAla: 1.299 ± 0.017	0.656CysCys: 0.656 ± 0.012	1.042CysAsp: 1.042 ± 0.017	1.276CysGlu: 1.276 ± 0.018	0.874CysPhe: 0.874 ± 0.011	1.508CysGly: 1.508 ± 0.022	0.685CysHis: 0.685 ± 0.011	1.022CysIle: 1.022 ± 0.015	1.209CysLys: 1.209 ± 0.016	2.181CysLeu: 2.181 ± 0.025	0.443CysMet: 0.443 ± 0.008	0.832CysAsn: 0.832 ± 0.014	1.446CysPro: 1.446 ± 0.023	1.122CysGln: 1.122 ± 0.017	1.324CysArg: 1.324 ± 0.017	2.061CysSer: 2.061 ± 0.024	1.148CysThr: 1.148 ± 0.016	1.332CysVal: 1.332 ± 0.02	0.3CysTrp: 0.3 ± 0.006	0.626CysTyr: 0.626 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	2.973AspAla: 2.973 ± 0.023	1.072AspCys: 1.072 ± 0.016	2.735AspAsp: 2.735 ± 0.037	3.629AspGlu: 3.629 ± 0.029	2.173AspPhe: 2.173 ± 0.018	3.373AspGly: 3.373 ± 0.032	1.121AspHis: 1.121 ± 0.013	2.731AspIle: 2.731 ± 0.023	2.668AspLys: 2.668 ± 0.021	4.894AspLeu: 4.894 ± 0.027	1.161AspMet: 1.161 ± 0.012	1.829AspAsn: 1.829 ± 0.025	2.769AspPro: 2.769 ± 0.027	1.759AspGln: 1.759 ± 0.017	2.38AspArg: 2.38 ± 0.023	4.213AspSer: 4.213 ± 0.034	2.574AspThr: 2.574 ± 0.019	3.154AspVal: 3.154 ± 0.025	0.628AspTrp: 0.628 ± 0.011	1.531AspTyr: 1.531 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.07GluAla: 5.07 ± 0.034	1.294GluCys: 1.294 ± 0.021	4.468GluAsp: 4.468 ± 0.03	8.45GluGlu: 8.45 ± 0.086	2.144GluPhe: 2.144 ± 0.018	4.11GluGly: 4.11 ± 0.026	1.595GluHis: 1.595 ± 0.014	3.31GluIle: 3.31 ± 0.026	5.525GluLys: 5.525 ± 0.049	6.679GluLeu: 6.679 ± 0.045	1.815GluMet: 1.815 ± 0.017	3.28GluAsn: 3.28 ± 0.028	3.107GluPro: 3.107 ± 0.025	3.41GluGln: 3.41 ± 0.029	4.075GluArg: 4.075 ± 0.029	4.509GluSer: 4.509 ± 0.029	3.388GluThr: 3.388 ± 0.025	4.231GluVal: 4.231 ± 0.027	0.723GluTrp: 0.723 ± 0.01	1.705GluTyr: 1.705 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.12PheAla: 2.12 ± 0.016	0.939PheCys: 0.939 ± 0.012	1.714PheAsp: 1.714 ± 0.017	2.042PheGlu: 2.042 ± 0.016	1.631PhePhe: 1.631 ± 0.018	2.281PheGly: 2.281 ± 0.023	1.055PheHis: 1.055 ± 0.014	1.868PheIle: 1.868 ± 0.019	1.822PheLys: 1.822 ± 0.016	4.045PheLeu: 4.045 ± 0.028	0.791PheMet: 0.791 ± 0.01	1.367PheAsn: 1.367 ± 0.016	2.015PhePro: 2.015 ± 0.02	1.815PheGln: 1.815 ± 0.016	1.876PheArg: 1.876 ± 0.022	3.34PheSer: 3.34 ± 0.024	2.055PheThr: 2.055 ± 0.019	2.252PheVal: 2.252 ± 0.017	0.496PheTrp: 0.496 ± 0.008	1.222PheTyr: 1.222 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	4.433GlyAla: 4.433 ± 0.037	1.339GlyCys: 1.339 ± 0.018	3.169GlyAsp: 3.169 ± 0.024	3.937GlyGlu: 3.937 ± 0.025	2.432GlyPhe: 2.432 ± 0.022	4.755GlyGly: 4.755 ± 0.049	1.68GlyHis: 1.68 ± 0.017	2.885GlyIle: 2.885 ± 0.021	3.836GlyLys: 3.836 ± 0.025	5.477GlyLeu: 5.477 ± 0.035	1.404GlyMet: 1.404 ± 0.016	2.468GlyAsn: 2.468 ± 0.029	3.304GlyPro: 3.304 ± 0.041	2.715GlyGln: 2.715 ± 0.023	3.62GlyArg: 3.62 ± 0.027	5.683GlySer: 5.683 ± 0.035	3.638GlyThr: 3.638 ± 0.027	3.524GlyVal: 3.524 ± 0.03	0.818GlyTrp: 0.818 ± 0.013	1.825GlyTyr: 1.825 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.347HisAla: 1.347 ± 0.013	0.714HisCys: 0.714 ± 0.011	0.911HisAsp: 0.911 ± 0.011	1.339HisGlu: 1.339 ± 0.013	1.062HisPhe: 1.062 ± 0.013	1.64HisGly: 1.64 ± 0.017	0.907HisHis: 0.907 ± 0.016	1.269HisIle: 1.269 ± 0.013	1.314HisLys: 1.314 ± 0.014	2.792HisLeu: 2.792 ± 0.022	0.592HisMet: 0.592 ± 0.009	0.906HisAsn: 0.906 ± 0.011	1.611HisPro: 1.611 ± 0.018	1.214HisGln: 1.214 ± 0.013	1.53HisArg: 1.53 ± 0.016	2.232HisSer: 2.232 ± 0.019	1.267HisThr: 1.267 ± 0.014	1.461HisVal: 1.461 ± 0.014	0.344HisTrp: 0.344 ± 0.007	0.825HisTyr: 0.825 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	2.772IleAla: 2.772 ± 0.023	1.096IleCys: 1.096 ± 0.014	2.121IleAsp: 2.121 ± 0.019	2.653IleGlu: 2.653 ± 0.023	1.936IlePhe: 1.936 ± 0.019	2.252IleGly: 2.252 ± 0.021	1.262IleHis: 1.262 ± 0.015	2.451IleIle: 2.451 ± 0.025	2.73IleLys: 2.73 ± 0.023	4.576IleLeu: 4.576 ± 0.035	1.026IleMet: 1.026 ± 0.011	1.939IleAsn: 1.939 ± 0.018	2.744IlePro: 2.744 ± 0.027	2.314IleGln: 2.314 ± 0.019	2.36IleArg: 2.36 ± 0.019	3.811IleSer: 3.811 ± 0.025	2.638IleThr: 2.638 ± 0.023	2.615IleVal: 2.615 ± 0.021	0.52IleTrp: 0.52 ± 0.01	1.416IleTyr: 1.416 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.086LysAla: 4.086 ± 0.037	1.132LysCys: 1.132 ± 0.016	3.281LysAsp: 3.281 ± 0.027	5.397LysGlu: 5.397 ± 0.044	1.766LysPhe: 1.766 ± 0.018	3.285LysGly: 3.285 ± 0.028	1.474LysHis: 1.474 ± 0.015	2.889LysIle: 2.889 ± 0.024	5.014LysLys: 5.014 ± 0.049	5.336LysLeu: 5.336 ± 0.038	1.534LysMet: 1.534 ± 0.016	2.514LysAsn: 2.514 ± 0.023	3.0LysPro: 3.0 ± 0.031	2.82LysGln: 2.82 ± 0.026	3.386LysArg: 3.386 ± 0.025	4.093LysSer: 4.093 ± 0.032	3.096LysThr: 3.096 ± 0.022	3.566LysVal: 3.566 ± 0.026	0.643LysTrp: 0.643 ± 0.009	1.696LysTyr: 1.696 ± 0.019	0.001LysXaa: 0.001 ± 0.0
Leu	6.75LeuAla: 6.75 ± 0.041	2.309LeuCys: 2.309 ± 0.024	4.715LeuAsp: 4.715 ± 0.029	7.217LeuGlu: 7.217 ± 0.04	3.399LeuPhe: 3.399 ± 0.024	5.646LeuGly: 5.646 ± 0.035	2.689LeuHis: 2.689 ± 0.02	3.848LeuIle: 3.848 ± 0.026	5.965LeuLys: 5.965 ± 0.038	10.656LeuLeu: 10.656 ± 0.059	2.038LeuMet: 2.038 ± 0.016	3.557LeuAsn: 3.557 ± 0.025	5.79LeuPro: 5.79 ± 0.035	5.826LeuGln: 5.826 ± 0.04	5.736LeuArg: 5.736 ± 0.038	7.889LeuSer: 7.889 ± 0.041	4.708LeuThr: 4.708 ± 0.028	5.427LeuVal: 5.427 ± 0.037	1.124LeuTrp: 1.124 ± 0.015	2.637LeuTyr: 2.637 ± 0.023	0.001LeuXaa: 0.001 ± 0.0
Met	1.954MetAla: 1.954 ± 0.019	0.432MetCys: 0.432 ± 0.008	1.329MetAsp: 1.329 ± 0.015	1.968MetGlu: 1.968 ± 0.018	0.783MetPhe: 0.783 ± 0.009	1.316MetGly: 1.316 ± 0.016	0.488MetHis: 0.488 ± 0.008	0.877MetIle: 0.877 ± 0.012	1.533MetLys: 1.533 ± 0.014	2.016MetLeu: 2.016 ± 0.018	0.61MetMet: 0.61 ± 0.01	0.928MetAsn: 0.928 ± 0.012	1.083MetPro: 1.083 ± 0.015	1.02MetGln: 1.02 ± 0.013	1.093MetArg: 1.093 ± 0.013	1.627MetSer: 1.627 ± 0.015	1.093MetThr: 1.093 ± 0.013	1.403MetVal: 1.403 ± 0.012	0.251MetTrp: 0.251 ± 0.006	0.597MetTyr: 0.597 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.238AsnAla: 2.238 ± 0.018	0.891AsnCys: 0.891 ± 0.012	1.576AsnAsp: 1.576 ± 0.022	2.354AsnGlu: 2.354 ± 0.025	1.51AsnPhe: 1.51 ± 0.014	2.614AsnGly: 2.614 ± 0.031	0.915AsnHis: 0.915 ± 0.013	2.225AsnIle: 2.225 ± 0.02	2.313AsnLys: 2.313 ± 0.02	3.743AsnLeu: 3.743 ± 0.024	0.972AsnMet: 0.972 ± 0.011	1.657AsnAsn: 1.657 ± 0.018	2.186AsnPro: 2.186 ± 0.02	1.61AsnGln: 1.61 ± 0.019	1.863AsnArg: 1.863 ± 0.02	3.249AsnSer: 3.249 ± 0.028	2.056AsnThr: 2.056 ± 0.018	2.286AsnVal: 2.286 ± 0.018	0.451AsnTrp: 0.451 ± 0.009	1.177AsnTyr: 1.177 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	4.941ProAla: 4.941 ± 0.046	1.202ProCys: 1.202 ± 0.02	2.672ProAsp: 2.672 ± 0.021	4.307ProGlu: 4.307 ± 0.031	1.885ProPhe: 1.885 ± 0.018	4.659ProGly: 4.659 ± 0.052	1.339ProHis: 1.339 ± 0.017	1.818ProIle: 1.818 ± 0.017	2.769ProLys: 2.769 ± 0.031	4.919ProLeu: 4.919 ± 0.032	0.983ProMet: 0.983 ± 0.012	1.79ProAsn: 1.79 ± 0.02	5.222ProPro: 5.222 ± 0.06	2.578ProGln: 2.578 ± 0.026	3.088ProArg: 3.088 ± 0.026	5.211ProSer: 5.211 ± 0.039	2.663ProThr: 2.663 ± 0.024	3.804ProVal: 3.804 ± 0.028	0.651ProTrp: 0.651 ± 0.011	1.409ProTyr: 1.409 ± 0.015	0.001ProXaa: 0.001 ± 0.0
Gln	3.267GlnAla: 3.267 ± 0.026	0.994GlnCys: 0.994 ± 0.017	2.333GlnAsp: 2.333 ± 0.019	3.873GlnGlu: 3.873 ± 0.033	1.417GlnPhe: 1.417 ± 0.014	2.675GlnGly: 2.675 ± 0.023	1.362GlnHis: 1.362 ± 0.014	2.042GlnIle: 2.042 ± 0.02	3.03GlnLys: 3.03 ± 0.023	4.762GlnLeu: 4.762 ± 0.032	1.124GlnMet: 1.124 ± 0.013	1.957GlnAsn: 1.957 ± 0.019	2.659GlnPro: 2.659 ± 0.027	3.182GlnGln: 3.182 ± 0.046	2.86GlnArg: 2.86 ± 0.021	3.21GlnSer: 3.21 ± 0.025	2.244GlnThr: 2.244 ± 0.022	2.759GlnVal: 2.759 ± 0.02	0.547GlnTrp: 0.547 ± 0.009	1.211GlnTyr: 1.211 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	3.909ArgAla: 3.909 ± 0.029	1.256ArgCys: 1.256 ± 0.017	2.829ArgAsp: 2.829 ± 0.026	3.947ArgGlu: 3.947 ± 0.029	1.893ArgPhe: 1.893 ± 0.016	3.425ArgGly: 3.425 ± 0.03	1.486ArgHis: 1.486 ± 0.016	2.419ArgIle: 2.419 ± 0.019	3.669ArgLys: 3.669 ± 0.025	5.17ArgLeu: 5.17 ± 0.034	1.223ArgMet: 1.223 ± 0.014	2.148ArgAsn: 2.148 ± 0.019	2.777ArgPro: 2.777 ± 0.026	2.576ArgGln: 2.576 ± 0.021	4.33ArgArg: 4.33 ± 0.035	4.229ArgSer: 4.229 ± 0.035	2.654ArgThr: 2.654 ± 0.021	3.06ArgVal: 3.06 ± 0.023	0.677ArgTrp: 0.677 ± 0.01	1.527ArgTyr: 1.527 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	5.547SerAla: 5.547 ± 0.031	1.955SerCys: 1.955 ± 0.022	3.934SerAsp: 3.934 ± 0.032	5.115SerGlu: 5.115 ± 0.033	3.015SerPhe: 3.015 ± 0.022	5.231SerGly: 5.231 ± 0.033	2.051SerHis: 2.051 ± 0.019	3.387SerIle: 3.387 ± 0.024	4.266SerLys: 4.266 ± 0.034	8.027SerLeu: 8.027 ± 0.045	1.676SerMet: 1.676 ± 0.016	2.772SerAsn: 2.772 ± 0.026	5.66SerPro: 5.66 ± 0.048	3.73SerGln: 3.73 ± 0.028	4.382SerArg: 4.382 ± 0.031	9.38SerSer: 9.38 ± 0.073	4.428SerThr: 4.428 ± 0.032	5.019SerVal: 5.019 ± 0.031	1.002SerTrp: 1.002 ± 0.014	2.121SerTyr: 2.121 ± 0.017	0.001SerXaa: 0.001 ± 0.0
Thr	3.963ThrAla: 3.963 ± 0.025	1.278ThrCys: 1.278 ± 0.02	2.571ThrAsp: 2.571 ± 0.02	3.639ThrGlu: 3.639 ± 0.024	2.061ThrPhe: 2.061 ± 0.018	3.433ThrGly: 3.433 ± 0.025	1.12ThrHis: 1.12 ± 0.012	2.38ThrIle: 2.38 ± 0.022	2.708ThrLys: 2.708 ± 0.022	5.009ThrLeu: 5.009 ± 0.029	1.102ThrMet: 1.102 ± 0.012	1.79ThrAsn: 1.79 ± 0.02	3.18ThrPro: 3.18 ± 0.028	2.079ThrGln: 2.079 ± 0.016	2.316ThrArg: 2.316 ± 0.018	4.45ThrSer: 4.45 ± 0.031	2.839ThrThr: 2.839 ± 0.043	3.909ThrVal: 3.909 ± 0.028	0.68ThrTrp: 0.68 ± 0.011	1.41ThrTyr: 1.41 ± 0.014	0.001ThrXaa: 0.001 ± 0.0
Val	4.23ValAla: 4.23 ± 0.028	1.518ValCys: 1.518 ± 0.02	2.88ValAsp: 2.88 ± 0.023	3.915ValGlu: 3.915 ± 0.026	2.473ValPhe: 2.473 ± 0.022	3.3ValGly: 3.3 ± 0.021	1.521ValHis: 1.521 ± 0.012	2.935ValIle: 2.935 ± 0.023	3.565ValLys: 3.565 ± 0.028	6.436ValLeu: 6.436 ± 0.034	1.36ValMet: 1.36 ± 0.013	2.319ValAsn: 2.319 ± 0.021	3.739ValPro: 3.739 ± 0.029	2.837ValGln: 2.837 ± 0.019	3.031ValArg: 3.031 ± 0.023	4.92ValSer: 4.92 ± 0.028	3.837ValThr: 3.837 ± 0.033	4.069ValVal: 4.069 ± 0.027	0.721ValTrp: 0.721 ± 0.011	1.682ValTyr: 1.682 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.746TrpAla: 0.746 ± 0.012	0.253TrpCys: 0.253 ± 0.006	0.678TrpAsp: 0.678 ± 0.01	0.802TrpGlu: 0.802 ± 0.01	0.437TrpPhe: 0.437 ± 0.008	0.679TrpGly: 0.679 ± 0.01	0.317TrpHis: 0.317 ± 0.006	0.581TrpIle: 0.581 ± 0.011	0.835TrpLys: 0.835 ± 0.011	1.228TrpLeu: 1.228 ± 0.016	0.322TrpMet: 0.322 ± 0.007	0.546TrpAsn: 0.546 ± 0.009	0.475TrpPro: 0.475 ± 0.008	0.548TrpGln: 0.548 ± 0.009	0.712TrpArg: 0.712 ± 0.011	0.892TrpSer: 0.892 ± 0.013	0.657TrpThr: 0.657 ± 0.012	0.679TrpVal: 0.679 ± 0.011	0.195TrpTrp: 0.195 ± 0.005	0.348TrpTyr: 0.348 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.443TyrAla: 1.443 ± 0.014	0.706TyrCys: 0.706 ± 0.01	1.344TyrAsp: 1.344 ± 0.016	1.728TyrGlu: 1.728 ± 0.016	1.271TyrPhe: 1.271 ± 0.014	1.759TyrGly: 1.759 ± 0.014	0.765TyrHis: 0.765 ± 0.01	1.462TyrIle: 1.462 ± 0.017	1.546TyrLys: 1.546 ± 0.022	2.734TyrLeu: 2.734 ± 0.024	0.636TyrMet: 0.636 ± 0.009	1.176TyrAsn: 1.176 ± 0.014	1.292TyrPro: 1.292 ± 0.014	1.244TyrGln: 1.244 ± 0.015	1.63TyrArg: 1.63 ± 0.017	2.296TyrSer: 2.296 ± 0.021	1.502TyrThr: 1.502 ± 0.015	1.59TyrVal: 1.59 ± 0.017	0.373TyrTrp: 0.373 ± 0.008	0.996TyrTyr: 0.996 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.057XaaXaa: 0.057 ± 0.019

Statistics based on 15252 proteins (8504911 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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