Amino acid dipepetide frequency for Clostridium frigidicarnis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.173AlaAla: 3.173 ± 0.07	0.692AlaCys: 0.692 ± 0.021	2.237AlaAsp: 2.237 ± 0.048	2.866AlaGlu: 2.866 ± 0.055	2.4AlaPhe: 2.4 ± 0.047	3.295AlaGly: 3.295 ± 0.069	0.772AlaHis: 0.772 ± 0.027	5.554AlaIle: 5.554 ± 0.075	4.288AlaLys: 4.288 ± 0.068	5.709AlaLeu: 5.709 ± 0.08	1.608AlaMet: 1.608 ± 0.043	2.469AlaAsn: 2.469 ± 0.044	1.346AlaPro: 1.346 ± 0.033	1.255AlaGln: 1.255 ± 0.029	1.696AlaArg: 1.696 ± 0.037	2.995AlaSer: 2.995 ± 0.05	2.777AlaThr: 2.777 ± 0.083	3.428AlaVal: 3.428 ± 0.061	0.346AlaTrp: 0.346 ± 0.016	2.054AlaTyr: 2.054 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.59CysAla: 0.59 ± 0.019	0.255CysCys: 0.255 ± 0.018	0.779CysAsp: 0.779 ± 0.026	0.908CysGlu: 0.908 ± 0.028	0.535CysPhe: 0.535 ± 0.023	1.137CysGly: 1.137 ± 0.041	0.233CysHis: 0.233 ± 0.015	1.253CysIle: 1.253 ± 0.035	1.197CysLys: 1.197 ± 0.034	0.994CysLeu: 0.994 ± 0.034	0.298CysMet: 0.298 ± 0.018	0.905CysAsn: 0.905 ± 0.026	0.483CysPro: 0.483 ± 0.025	0.215CysGln: 0.215 ± 0.013	0.391CysArg: 0.391 ± 0.018	0.816CysSer: 0.816 ± 0.027	0.645CysThr: 0.645 ± 0.026	0.753CysVal: 0.753 ± 0.027	0.076CysTrp: 0.076 ± 0.009	0.494CysTyr: 0.494 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.431AspAla: 2.431 ± 0.048	0.647AspCys: 0.647 ± 0.029	2.974AspAsp: 2.974 ± 0.054	4.751AspGlu: 4.751 ± 0.068	2.95AspPhe: 2.95 ± 0.053	3.334AspGly: 3.334 ± 0.059	0.597AspHis: 0.597 ± 0.023	6.32AspIle: 6.32 ± 0.088	5.851AspLys: 5.851 ± 0.077	5.308AspLeu: 5.308 ± 0.078	1.566AspMet: 1.566 ± 0.038	3.758AspAsn: 3.758 ± 0.067	1.242AspPro: 1.242 ± 0.035	0.775AspGln: 0.775 ± 0.028	1.693AspArg: 1.693 ± 0.038	3.128AspSer: 3.128 ± 0.055	2.541AspThr: 2.541 ± 0.063	3.642AspVal: 3.642 ± 0.057	0.328AspTrp: 0.328 ± 0.017	2.523AspTyr: 2.523 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	3.761GluAla: 3.761 ± 0.065	0.768GluCys: 0.768 ± 0.029	4.545GluAsp: 4.545 ± 0.073	7.041GluGlu: 7.041 ± 0.103	3.277GluPhe: 3.277 ± 0.057	3.912GluGly: 3.912 ± 0.06	0.872GluHis: 0.872 ± 0.026	7.278GluIle: 7.278 ± 0.094	7.979GluLys: 7.979 ± 0.105	6.674GluLeu: 6.674 ± 0.084	1.872GluMet: 1.872 ± 0.038	5.783GluAsn: 5.783 ± 0.089	1.427GluPro: 1.427 ± 0.036	1.592GluGln: 1.592 ± 0.043	2.544GluArg: 2.544 ± 0.051	3.731GluSer: 3.731 ± 0.061	2.996GluThr: 2.996 ± 0.051	4.923GluVal: 4.923 ± 0.066	0.402GluTrp: 0.402 ± 0.021	3.067GluTyr: 3.067 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.134PheAla: 2.134 ± 0.051	0.558PheCys: 0.558 ± 0.022	2.529PheAsp: 2.529 ± 0.051	2.718PheGlu: 2.718 ± 0.052	2.038PhePhe: 2.038 ± 0.058	2.819PheGly: 2.819 ± 0.05	0.549PheHis: 0.549 ± 0.022	5.026PheIle: 5.026 ± 0.076	4.344PheLys: 4.344 ± 0.072	3.994PheLeu: 3.994 ± 0.078	1.193PheMet: 1.193 ± 0.035	3.383PheAsn: 3.383 ± 0.057	1.096PhePro: 1.096 ± 0.032	1.061PheGln: 1.061 ± 0.032	1.237PheArg: 1.237 ± 0.031	3.204PheSer: 3.204 ± 0.057	2.245PheThr: 2.245 ± 0.046	2.678PheVal: 2.678 ± 0.06	0.314PheTrp: 0.314 ± 0.018	1.819PheTyr: 1.819 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	3.971GlyAla: 3.971 ± 0.093	0.979GlyCys: 0.979 ± 0.038	3.37GlyAsp: 3.37 ± 0.068	4.414GlyGlu: 4.414 ± 0.063	3.181GlyPhe: 3.181 ± 0.059	4.135GlyGly: 4.135 ± 0.07	0.967GlyHis: 0.967 ± 0.029	6.499GlyIle: 6.499 ± 0.094	5.549GlyLys: 5.549 ± 0.074	5.426GlyLeu: 5.426 ± 0.082	1.775GlyMet: 1.775 ± 0.042	3.481GlyAsn: 3.481 ± 0.059	1.202GlyPro: 1.202 ± 0.036	1.434GlyGln: 1.434 ± 0.035	2.023GlyArg: 2.023 ± 0.04	3.59GlySer: 3.59 ± 0.063	3.289GlyThr: 3.289 ± 0.064	4.695GlyVal: 4.695 ± 0.088	0.507GlyTrp: 0.507 ± 0.029	2.919GlyTyr: 2.919 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.603HisAla: 0.603 ± 0.025	0.214HisCys: 0.214 ± 0.015	0.728HisAsp: 0.728 ± 0.028	0.921HisGlu: 0.921 ± 0.032	0.543HisPhe: 0.543 ± 0.021	1.016HisGly: 1.016 ± 0.035	0.283HisHis: 0.283 ± 0.015	1.382HisIle: 1.382 ± 0.034	1.097HisLys: 1.097 ± 0.029	1.112HisLeu: 1.112 ± 0.037	0.409HisMet: 0.409 ± 0.019	0.8HisAsn: 0.8 ± 0.028	0.561HisPro: 0.561 ± 0.023	0.274HisGln: 0.274 ± 0.016	0.551HisArg: 0.551 ± 0.024	0.883HisSer: 0.883 ± 0.029	0.615HisThr: 0.615 ± 0.024	0.782HisVal: 0.782 ± 0.025	0.109HisTrp: 0.109 ± 0.01	0.559HisTyr: 0.559 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.371IleAla: 5.371 ± 0.07	1.395IleCys: 1.395 ± 0.04	6.095IleAsp: 6.095 ± 0.076	7.417IleGlu: 7.417 ± 0.105	4.319IlePhe: 4.319 ± 0.073	6.32IleGly: 6.32 ± 0.083	1.299IleHis: 1.299 ± 0.034	9.514IleIle: 9.514 ± 0.109	9.173IleLys: 9.173 ± 0.095	9.567IleLeu: 9.567 ± 0.104	2.416IleMet: 2.416 ± 0.056	6.932IleAsn: 6.932 ± 0.102	3.252IlePro: 3.252 ± 0.057	2.166IleGln: 2.166 ± 0.051	2.944IleArg: 2.944 ± 0.055	7.087IleSer: 7.087 ± 0.083	4.924IleThr: 4.924 ± 0.065	6.262IleVal: 6.262 ± 0.076	0.547IleTrp: 0.547 ± 0.022	3.639IleTyr: 3.639 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	4.42LysAla: 4.42 ± 0.064	1.034LysCys: 1.034 ± 0.03	6.554LysAsp: 6.554 ± 0.083	9.241LysGlu: 9.241 ± 0.119	3.494LysPhe: 3.494 ± 0.055	5.261LysGly: 5.261 ± 0.07	1.176LysHis: 1.176 ± 0.029	8.475LysIle: 8.475 ± 0.098	8.175LysLys: 8.175 ± 0.102	7.68LysLeu: 7.68 ± 0.083	2.273LysMet: 2.273 ± 0.048	7.044LysAsn: 7.044 ± 0.103	2.109LysPro: 2.109 ± 0.042	2.155LysGln: 2.155 ± 0.038	2.955LysArg: 2.955 ± 0.051	5.596LysSer: 5.596 ± 0.078	4.242LysThr: 4.242 ± 0.066	6.093LysVal: 6.093 ± 0.072	0.575LysTrp: 0.575 ± 0.022	4.034LysTyr: 4.034 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	4.734LeuAla: 4.734 ± 0.08	1.232LeuCys: 1.232 ± 0.032	5.216LeuAsp: 5.216 ± 0.078	6.344LeuGlu: 6.344 ± 0.079	3.724LeuPhe: 3.724 ± 0.06	6.063LeuGly: 6.063 ± 0.083	1.045LeuHis: 1.045 ± 0.034	8.666LeuIle: 8.666 ± 0.099	9.153LeuLys: 9.153 ± 0.103	7.724LeuLeu: 7.724 ± 0.1	2.35LeuMet: 2.35 ± 0.041	6.886LeuAsn: 6.886 ± 0.082	2.651LeuPro: 2.651 ± 0.052	2.04LeuGln: 2.04 ± 0.049	3.093LeuArg: 3.093 ± 0.056	6.862LeuSer: 6.862 ± 0.088	4.602LeuThr: 4.602 ± 0.063	5.36LeuVal: 5.36 ± 0.073	0.58LeuTrp: 0.58 ± 0.022	3.259LeuTyr: 3.259 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.734MetAla: 1.734 ± 0.046	0.312MetCys: 0.312 ± 0.016	1.67MetAsp: 1.67 ± 0.037	1.959MetGlu: 1.959 ± 0.037	1.173MetPhe: 1.173 ± 0.034	1.799MetGly: 1.799 ± 0.047	0.339MetHis: 0.339 ± 0.017	2.301MetIle: 2.301 ± 0.048	2.503MetLys: 2.503 ± 0.045	2.141MetLeu: 2.141 ± 0.052	0.606MetMet: 0.606 ± 0.025	1.763MetAsn: 1.763 ± 0.039	0.9MetPro: 0.9 ± 0.028	0.569MetGln: 0.569 ± 0.02	0.827MetArg: 0.827 ± 0.029	1.634MetSer: 1.634 ± 0.035	1.165MetThr: 1.165 ± 0.029	1.736MetVal: 1.736 ± 0.039	0.157MetTrp: 0.157 ± 0.012	0.894MetTyr: 0.894 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.78AsnAla: 2.78 ± 0.056	0.827AsnCys: 0.827 ± 0.031	3.378AsnAsp: 3.378 ± 0.064	4.844AsnGlu: 4.844 ± 0.081	2.899AsnPhe: 2.899 ± 0.063	4.09AsnGly: 4.09 ± 0.071	0.914AsnHis: 0.914 ± 0.033	7.831AsnIle: 7.831 ± 0.093	6.803AsnLys: 6.803 ± 0.088	6.194AsnLeu: 6.194 ± 0.091	1.729AsnMet: 1.729 ± 0.048	5.199AsnAsn: 5.199 ± 0.078	2.131AsnPro: 2.131 ± 0.045	1.404AsnGln: 1.404 ± 0.034	2.054AsnArg: 2.054 ± 0.044	4.386AsnSer: 4.386 ± 0.071	3.076AsnThr: 3.076 ± 0.055	3.827AsnVal: 3.827 ± 0.056	0.448AsnTrp: 0.448 ± 0.02	2.777AsnTyr: 2.777 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	1.215ProAla: 1.215 ± 0.036	0.354ProCys: 0.354 ± 0.02	1.228ProAsp: 1.228 ± 0.039	2.009ProGlu: 2.009 ± 0.044	1.348ProPhe: 1.348 ± 0.037	1.599ProGly: 1.599 ± 0.042	0.496ProHis: 0.496 ± 0.02	2.686ProIle: 2.686 ± 0.057	2.273ProLys: 2.273 ± 0.044	2.517ProLeu: 2.517 ± 0.047	0.745ProMet: 0.745 ± 0.025	1.602ProAsn: 1.602 ± 0.04	0.577ProPro: 0.577 ± 0.027	0.741ProGln: 0.741 ± 0.025	0.86ProArg: 0.86 ± 0.027	1.801ProSer: 1.801 ± 0.048	1.443ProThr: 1.443 ± 0.038	1.91ProVal: 1.91 ± 0.044	0.228ProTrp: 0.228 ± 0.016	1.229ProTyr: 1.229 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	1.116GlnAla: 1.116 ± 0.034	0.413GlnCys: 0.413 ± 0.019	1.168GlnAsp: 1.168 ± 0.032	1.638GlnGlu: 1.638 ± 0.041	0.885GlnPhe: 0.885 ± 0.025	1.739GlnGly: 1.739 ± 0.037	0.304GlnHis: 0.304 ± 0.016	1.905GlnIle: 1.905 ± 0.046	1.786GlnLys: 1.786 ± 0.039	1.994GlnLeu: 1.994 ± 0.04	0.558GlnMet: 0.558 ± 0.023	1.326GlnAsn: 1.326 ± 0.038	0.494GlnPro: 0.494 ± 0.019	0.603GlnGln: 0.603 ± 0.024	0.886GlnArg: 0.886 ± 0.028	1.361GlnSer: 1.361 ± 0.041	0.94GlnThr: 0.94 ± 0.029	1.478GlnVal: 1.478 ± 0.037	0.276GlnTrp: 0.276 ± 0.013	1.078GlnTyr: 1.078 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.699ArgAla: 1.699 ± 0.039	0.412ArgCys: 0.412 ± 0.02	1.86ArgAsp: 1.86 ± 0.04	2.773ArgGlu: 2.773 ± 0.047	1.449ArgPhe: 1.449 ± 0.036	1.986ArgGly: 1.986 ± 0.045	0.458ArgHis: 0.458 ± 0.019	3.034ArgIle: 3.034 ± 0.051	2.928ArgLys: 2.928 ± 0.055	2.767ArgLeu: 2.767 ± 0.054	0.823ArgMet: 0.823 ± 0.027	2.092ArgAsn: 2.092 ± 0.049	0.771ArgPro: 0.771 ± 0.027	0.826ArgGln: 0.826 ± 0.027	1.3ArgArg: 1.3 ± 0.039	1.557ArgSer: 1.557 ± 0.042	1.493ArgThr: 1.493 ± 0.036	2.267ArgVal: 2.267 ± 0.045	0.236ArgTrp: 0.236 ± 0.013	1.332ArgTyr: 1.332 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	2.79SerAla: 2.79 ± 0.049	0.731SerCys: 0.731 ± 0.026	3.08SerAsp: 3.08 ± 0.052	3.945SerGlu: 3.945 ± 0.06	3.136SerPhe: 3.136 ± 0.06	4.151SerGly: 4.151 ± 0.07	0.89SerHis: 0.89 ± 0.028	6.934SerIle: 6.934 ± 0.087	6.062SerLys: 6.062 ± 0.084	6.281SerLeu: 6.281 ± 0.093	1.84SerMet: 1.84 ± 0.041	4.154SerAsn: 4.154 ± 0.065	1.582SerPro: 1.582 ± 0.042	1.514SerGln: 1.514 ± 0.041	2.085SerArg: 2.085 ± 0.046	4.441SerSer: 4.441 ± 0.088	3.184SerThr: 3.184 ± 0.052	3.771SerVal: 3.771 ± 0.057	0.444SerTrp: 0.444 ± 0.022	2.745SerTyr: 2.745 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	2.535ThrAla: 2.535 ± 0.056	0.559ThrCys: 0.559 ± 0.021	2.195ThrAsp: 2.195 ± 0.038	2.94ThrGlu: 2.94 ± 0.052	2.282ThrPhe: 2.282 ± 0.048	3.523ThrGly: 3.523 ± 0.156	0.777ThrHis: 0.777 ± 0.023	5.005ThrIle: 5.005 ± 0.069	3.726ThrLys: 3.726 ± 0.054	5.31ThrLeu: 5.31 ± 0.07	1.189ThrMet: 1.189 ± 0.034	2.777ThrAsn: 2.777 ± 0.056	1.792ThrPro: 1.792 ± 0.046	1.076ThrGln: 1.076 ± 0.03	1.381ThrArg: 1.381 ± 0.039	3.204ThrSer: 3.204 ± 0.054	2.627ThrThr: 2.627 ± 0.064	3.248ThrVal: 3.248 ± 0.064	0.339ThrTrp: 0.339 ± 0.018	1.96ThrTyr: 1.96 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	3.78ValAla: 3.78 ± 0.063	0.896ValCys: 0.896 ± 0.032	3.846ValAsp: 3.846 ± 0.056	4.49ValGlu: 4.49 ± 0.061	2.958ValPhe: 2.958 ± 0.058	4.099ValGly: 4.099 ± 0.07	0.815ValHis: 0.815 ± 0.025	6.259ValIle: 6.259 ± 0.079	5.395ValLys: 5.395 ± 0.068	5.932ValLeu: 5.932 ± 0.082	1.67ValMet: 1.67 ± 0.041	3.842ValAsn: 3.842 ± 0.059	1.909ValPro: 1.909 ± 0.043	1.357ValGln: 1.357 ± 0.033	1.899ValArg: 1.899 ± 0.045	4.332ValSer: 4.332 ± 0.058	3.325ValThr: 3.325 ± 0.071	4.425ValVal: 4.425 ± 0.075	0.422ValTrp: 0.422 ± 0.02	2.447ValTyr: 2.447 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.359TrpAla: 0.359 ± 0.02	0.101TrpCys: 0.101 ± 0.009	0.383TrpAsp: 0.383 ± 0.017	0.418TrpGlu: 0.418 ± 0.018	0.339TrpPhe: 0.339 ± 0.019	0.49TrpGly: 0.49 ± 0.021	0.114TrpHis: 0.114 ± 0.01	0.669TrpIle: 0.669 ± 0.026	0.482TrpLys: 0.482 ± 0.02	0.55TrpLeu: 0.55 ± 0.02	0.205TrpMet: 0.205 ± 0.012	0.479TrpAsn: 0.479 ± 0.02	0.15TrpPro: 0.15 ± 0.013	0.212TrpGln: 0.212 ± 0.015	0.227TrpArg: 0.227 ± 0.015	0.403TrpSer: 0.403 ± 0.018	0.299TrpThr: 0.299 ± 0.017	0.442TrpVal: 0.442 ± 0.017	0.076TrpTrp: 0.076 ± 0.008	0.305TrpTyr: 0.305 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.765TyrAla: 1.765 ± 0.046	0.576TyrCys: 0.576 ± 0.023	2.525TyrAsp: 2.525 ± 0.064	2.808TyrGlu: 2.808 ± 0.056	2.009TyrPhe: 2.009 ± 0.049	2.637TyrGly: 2.637 ± 0.044	0.539TyrHis: 0.539 ± 0.02	4.049TyrIle: 4.049 ± 0.072	3.82TyrLys: 3.82 ± 0.065	3.712TyrLeu: 3.712 ± 0.059	1.055TyrMet: 1.055 ± 0.03	2.92TyrAsn: 2.92 ± 0.053	1.19TyrPro: 1.19 ± 0.036	0.68TyrGln: 0.68 ± 0.026	1.418TyrArg: 1.418 ± 0.035	2.748TyrSer: 2.748 ± 0.055	2.017TyrThr: 2.017 ± 0.048	2.375TyrVal: 2.375 ± 0.046	0.293TyrTrp: 0.293 ± 0.015	1.901TyrTyr: 1.901 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3915 proteins (1178405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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