Amino acid dipepetide frequency for Psychromonas sp. psych-6C06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.577AlaAla: 5.577 ± 0.104	0.941AlaCys: 0.941 ± 0.033	4.369AlaAsp: 4.369 ± 0.071	4.868AlaGlu: 4.868 ± 0.084	3.566AlaPhe: 3.566 ± 0.067	5.609AlaGly: 5.609 ± 0.085	1.545AlaHis: 1.545 ± 0.038	6.39AlaIle: 6.39 ± 0.09	5.001AlaLys: 5.001 ± 0.09	9.757AlaLeu: 9.757 ± 0.101	2.284AlaMet: 2.284 ± 0.058	3.704AlaAsn: 3.704 ± 0.073	2.676AlaPro: 2.676 ± 0.059	4.01AlaGln: 4.01 ± 0.067	3.012AlaArg: 3.012 ± 0.052	5.478AlaSer: 5.478 ± 0.064	4.817AlaThr: 4.817 ± 0.082	5.311AlaVal: 5.311 ± 0.079	0.86AlaTrp: 0.86 ± 0.032	2.373AlaTyr: 2.373 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.853CysAla: 0.853 ± 0.033	0.172CysCys: 0.172 ± 0.012	0.651CysAsp: 0.651 ± 0.025	0.635CysGlu: 0.635 ± 0.024	0.499CysPhe: 0.499 ± 0.023	0.786CysGly: 0.786 ± 0.026	0.316CysHis: 0.316 ± 0.018	0.681CysIle: 0.681 ± 0.028	0.512CysLys: 0.512 ± 0.022	1.061CysLeu: 1.061 ± 0.035	0.214CysMet: 0.214 ± 0.016	0.413CysAsn: 0.413 ± 0.022	0.44CysPro: 0.44 ± 0.022	0.472CysGln: 0.472 ± 0.023	0.401CysArg: 0.401 ± 0.021	0.748CysSer: 0.748 ± 0.027	0.462CysThr: 0.462 ± 0.023	0.619CysVal: 0.619 ± 0.024	0.137CysTrp: 0.137 ± 0.025	0.392CysTyr: 0.392 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.375AspAla: 4.375 ± 0.07	0.588AspCys: 0.588 ± 0.027	3.188AspAsp: 3.188 ± 0.108	3.765AspGlu: 3.765 ± 0.07	2.59AspPhe: 2.59 ± 0.055	3.503AspGly: 3.503 ± 0.119	1.111AspHis: 1.111 ± 0.04	4.41AspIle: 4.41 ± 0.072	3.788AspLys: 3.788 ± 0.064	5.302AspLeu: 5.302 ± 0.079	1.313AspMet: 1.313 ± 0.037	3.086AspAsn: 3.086 ± 0.098	1.876AspPro: 1.876 ± 0.052	2.039AspGln: 2.039 ± 0.045	1.879AspArg: 1.879 ± 0.049	3.362AspSer: 3.362 ± 0.068	2.617AspThr: 2.617 ± 0.076	3.48AspVal: 3.48 ± 0.067	0.741AspTrp: 0.741 ± 0.025	2.019AspTyr: 2.019 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.985GluAla: 4.985 ± 0.083	0.491GluCys: 0.491 ± 0.022	2.68GluAsp: 2.68 ± 0.052	3.468GluGlu: 3.468 ± 0.07	2.404GluPhe: 2.404 ± 0.057	3.366GluGly: 3.366 ± 0.053	1.521GluHis: 1.521 ± 0.053	4.246GluIle: 4.246 ± 0.079	4.367GluLys: 4.367 ± 0.07	6.657GluLeu: 6.657 ± 0.083	1.684GluMet: 1.684 ± 0.045	3.205GluAsn: 3.205 ± 0.059	1.674GluPro: 1.674 ± 0.043	4.207GluGln: 4.207 ± 0.075	2.642GluArg: 2.642 ± 0.057	3.861GluSer: 3.861 ± 0.06	3.208GluThr: 3.208 ± 0.057	4.264GluVal: 4.264 ± 0.071	0.61GluTrp: 0.61 ± 0.024	1.67GluTyr: 1.67 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.637PheAla: 3.637 ± 0.068	0.491PheCys: 0.491 ± 0.022	2.775PheAsp: 2.775 ± 0.059	2.647PheGlu: 2.647 ± 0.048	1.854PhePhe: 1.854 ± 0.055	2.628PheGly: 2.628 ± 0.058	0.796PheHis: 0.796 ± 0.026	3.518PheIle: 3.518 ± 0.063	2.488PheLys: 2.488 ± 0.053	3.781PheLeu: 3.781 ± 0.074	1.017PheMet: 1.017 ± 0.033	2.472PheAsn: 2.472 ± 0.048	1.48PhePro: 1.48 ± 0.039	1.338PheGln: 1.338 ± 0.043	1.27PheArg: 1.27 ± 0.035	3.846PheSer: 3.846 ± 0.069	2.609PheThr: 2.609 ± 0.06	2.816PheVal: 2.816 ± 0.054	0.498PheTrp: 0.498 ± 0.023	1.501PheTyr: 1.501 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	5.052GlyAla: 5.052 ± 0.086	0.823GlyCys: 0.823 ± 0.029	3.703GlyAsp: 3.703 ± 0.082	4.288GlyGlu: 4.288 ± 0.067	3.109GlyPhe: 3.109 ± 0.053	4.374GlyGly: 4.374 ± 0.118	1.425GlyHis: 1.425 ± 0.047	4.647GlyIle: 4.647 ± 0.064	4.031GlyLys: 4.031 ± 0.064	6.579GlyLeu: 6.579 ± 0.092	1.73GlyMet: 1.73 ± 0.055	2.575GlyAsn: 2.575 ± 0.063	1.384GlyPro: 1.384 ± 0.037	2.504GlyGln: 2.504 ± 0.057	2.576GlyArg: 2.576 ± 0.048	3.779GlySer: 3.779 ± 0.082	3.133GlyThr: 3.133 ± 0.072	4.569GlyVal: 4.569 ± 0.077	0.817GlyTrp: 0.817 ± 0.031	2.463GlyTyr: 2.463 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.567HisAla: 1.567 ± 0.043	0.356HisCys: 0.356 ± 0.022	1.12HisAsp: 1.12 ± 0.042	1.121HisGlu: 1.121 ± 0.053	1.23HisPhe: 1.23 ± 0.035	1.378HisGly: 1.378 ± 0.045	0.686HisHis: 0.686 ± 0.03	1.499HisIle: 1.499 ± 0.035	1.094HisLys: 1.094 ± 0.031	2.336HisLeu: 2.336 ± 0.05	0.381HisMet: 0.381 ± 0.021	0.961HisAsn: 0.961 ± 0.034	1.069HisPro: 1.069 ± 0.03	1.222HisGln: 1.222 ± 0.033	0.923HisArg: 0.923 ± 0.029	1.436HisSer: 1.436 ± 0.036	0.939HisThr: 0.939 ± 0.034	1.109HisVal: 1.109 ± 0.031	0.322HisTrp: 0.322 ± 0.019	0.905HisTyr: 0.905 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.87IleAla: 6.87 ± 0.095	0.791IleCys: 0.791 ± 0.029	4.704IleAsp: 4.704 ± 0.072	5.297IleGlu: 5.297 ± 0.075	2.705IlePhe: 2.705 ± 0.064	4.712IleGly: 4.712 ± 0.073	1.313IleHis: 1.313 ± 0.032	4.713IleIle: 4.713 ± 0.077	4.445IleLys: 4.445 ± 0.066	5.81IleLeu: 5.81 ± 0.082	1.371IleMet: 1.371 ± 0.039	4.151IleAsn: 4.151 ± 0.068	2.679IlePro: 2.679 ± 0.054	2.365IleGln: 2.365 ± 0.047	2.492IleArg: 2.492 ± 0.043	5.456IleSer: 5.456 ± 0.076	4.274IleThr: 4.274 ± 0.076	4.308IleVal: 4.308 ± 0.073	0.612IleTrp: 0.612 ± 0.024	2.041IleTyr: 2.041 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.911LysAla: 4.911 ± 0.073	0.38LysCys: 0.38 ± 0.02	2.705LysAsp: 2.705 ± 0.051	3.737LysGlu: 3.737 ± 0.076	1.754LysPhe: 1.754 ± 0.04	3.43LysGly: 3.43 ± 0.058	1.383LysHis: 1.383 ± 0.035	3.892LysIle: 3.892 ± 0.075	4.037LysLys: 4.037 ± 0.078	6.086LysLeu: 6.086 ± 0.086	1.599LysMet: 1.599 ± 0.037	3.03LysAsn: 3.03 ± 0.055	2.144LysPro: 2.144 ± 0.042	3.783LysGln: 3.783 ± 0.07	2.904LysArg: 2.904 ± 0.06	3.85LysSer: 3.85 ± 0.063	3.219LysThr: 3.219 ± 0.059	4.072LysVal: 4.072 ± 0.068	0.579LysTrp: 0.579 ± 0.024	1.498LysTyr: 1.498 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.455LeuAla: 9.455 ± 0.125	1.064LeuCys: 1.064 ± 0.031	5.717LeuAsp: 5.717 ± 0.093	5.508LeuGlu: 5.508 ± 0.081	4.877LeuPhe: 4.877 ± 0.088	6.358LeuGly: 6.358 ± 0.092	2.187LeuHis: 2.187 ± 0.05	7.378LeuIle: 7.378 ± 0.091	5.987LeuLys: 5.987 ± 0.08	12.121LeuLeu: 12.121 ± 0.153	2.579LeuMet: 2.579 ± 0.056	5.271LeuAsn: 5.271 ± 0.081	4.613LeuPro: 4.613 ± 0.069	4.793LeuGln: 4.793 ± 0.077	3.981LeuArg: 3.981 ± 0.065	8.381LeuSer: 8.381 ± 0.11	6.393LeuThr: 6.393 ± 0.091	6.54LeuVal: 6.54 ± 0.085	0.984LeuTrp: 0.984 ± 0.035	2.907LeuTyr: 2.907 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.162MetAla: 2.162 ± 0.05	0.187MetCys: 0.187 ± 0.014	1.205MetAsp: 1.205 ± 0.035	1.048MetGlu: 1.048 ± 0.033	0.887MetPhe: 0.887 ± 0.029	1.602MetGly: 1.602 ± 0.043	0.442MetHis: 0.442 ± 0.022	1.591MetIle: 1.591 ± 0.037	1.463MetLys: 1.463 ± 0.038	2.766MetLeu: 2.766 ± 0.06	0.706MetMet: 0.706 ± 0.029	1.16MetAsn: 1.16 ± 0.035	1.125MetPro: 1.125 ± 0.037	1.307MetGln: 1.307 ± 0.038	1.044MetArg: 1.044 ± 0.026	1.782MetSer: 1.782 ± 0.037	1.322MetThr: 1.322 ± 0.035	1.62MetVal: 1.62 ± 0.035	0.189MetTrp: 0.189 ± 0.013	0.435MetTyr: 0.435 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.92AsnAla: 3.92 ± 0.068	0.514AsnCys: 0.514 ± 0.026	2.768AsnAsp: 2.768 ± 0.084	3.076AsnGlu: 3.076 ± 0.057	1.832AsnPhe: 1.832 ± 0.04	3.114AsnGly: 3.114 ± 0.079	1.019AsnHis: 1.019 ± 0.035	3.727AsnIle: 3.727 ± 0.071	3.233AsnLys: 3.233 ± 0.052	4.382AsnLeu: 4.382 ± 0.073	1.015AsnMet: 1.015 ± 0.031	2.857AsnAsn: 2.857 ± 0.064	1.975AsnPro: 1.975 ± 0.053	2.224AsnGln: 2.224 ± 0.048	1.961AsnArg: 1.961 ± 0.046	3.302AsnSer: 3.302 ± 0.069	2.423AsnThr: 2.423 ± 0.047	2.823AsnVal: 2.823 ± 0.054	0.622AsnTrp: 0.622 ± 0.025	1.647AsnTyr: 1.647 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.838ProAla: 2.838 ± 0.061	0.33ProCys: 0.33 ± 0.019	2.04ProAsp: 2.04 ± 0.048	2.849ProGlu: 2.849 ± 0.056	1.779ProPhe: 1.779 ± 0.043	1.883ProGly: 1.883 ± 0.047	0.76ProHis: 0.76 ± 0.024	2.672ProIle: 2.672 ± 0.053	1.885ProLys: 1.885 ± 0.044	4.089ProLeu: 4.089 ± 0.07	0.917ProMet: 0.917 ± 0.031	1.606ProAsn: 1.606 ± 0.04	0.951ProPro: 0.951 ± 0.032	1.418ProGln: 1.418 ± 0.037	1.15ProArg: 1.15 ± 0.032	2.309ProSer: 2.309 ± 0.046	2.185ProThr: 2.185 ± 0.067	2.69ProVal: 2.69 ± 0.058	0.409ProTrp: 0.409 ± 0.022	1.22ProTyr: 1.22 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.296GlnAla: 4.296 ± 0.079	0.457GlnCys: 0.457 ± 0.025	2.005GlnAsp: 2.005 ± 0.045	2.269GlnGlu: 2.269 ± 0.047	2.04GlnPhe: 2.04 ± 0.044	3.014GlnGly: 3.014 ± 0.053	1.257GlnHis: 1.257 ± 0.039	2.915GlnIle: 2.915 ± 0.056	2.702GlnLys: 2.702 ± 0.063	5.944GlnLeu: 5.944 ± 0.1	1.032GlnMet: 1.032 ± 0.03	1.791GlnAsn: 1.791 ± 0.047	1.585GlnPro: 1.585 ± 0.041	3.741GlnGln: 3.741 ± 0.085	2.215GlnArg: 2.215 ± 0.047	3.068GlnSer: 3.068 ± 0.056	2.427GlnThr: 2.427 ± 0.049	3.084GlnVal: 3.084 ± 0.051	0.662GlnTrp: 0.662 ± 0.025	1.506GlnTyr: 1.506 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.886ArgAla: 2.886 ± 0.056	0.438ArgCys: 0.438 ± 0.024	2.167ArgAsp: 2.167 ± 0.045	2.404ArgGlu: 2.404 ± 0.051	2.126ArgPhe: 2.126 ± 0.05	2.243ArgGly: 2.243 ± 0.05	0.909ArgHis: 0.909 ± 0.026	2.864ArgIle: 2.864 ± 0.049	2.142ArgLys: 2.142 ± 0.05	4.607ArgLeu: 4.607 ± 0.076	0.9ArgMet: 0.9 ± 0.031	1.751ArgAsn: 1.751 ± 0.045	1.311ArgPro: 1.311 ± 0.035	1.66ArgGln: 1.66 ± 0.04	1.66ArgArg: 1.66 ± 0.049	2.316ArgSer: 2.316 ± 0.054	1.797ArgThr: 1.797 ± 0.048	2.607ArgVal: 2.607 ± 0.05	0.486ArgTrp: 0.486 ± 0.023	1.605ArgTyr: 1.605 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.423SerAla: 5.423 ± 0.08	0.708SerCys: 0.708 ± 0.028	3.992SerAsp: 3.992 ± 0.088	4.514SerGlu: 4.514 ± 0.071	3.123SerPhe: 3.123 ± 0.052	4.906SerGly: 4.906 ± 0.081	1.527SerHis: 1.527 ± 0.047	4.697SerIle: 4.697 ± 0.071	3.582SerLys: 3.582 ± 0.068	7.565SerLeu: 7.565 ± 0.091	1.62SerMet: 1.62 ± 0.04	3.117SerAsn: 3.117 ± 0.059	2.394SerPro: 2.394 ± 0.047	3.052SerGln: 3.052 ± 0.061	2.553SerArg: 2.553 ± 0.054	4.624SerSer: 4.624 ± 0.099	3.484SerThr: 3.484 ± 0.059	4.56SerVal: 4.56 ± 0.072	0.776SerTrp: 0.776 ± 0.031	2.197SerTyr: 2.197 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.282ThrAla: 4.282 ± 0.079	0.476ThrCys: 0.476 ± 0.021	3.001ThrAsp: 3.001 ± 0.084	3.29ThrGlu: 3.29 ± 0.051	2.314ThrPhe: 2.314 ± 0.057	3.9ThrGly: 3.9 ± 0.075	1.209ThrHis: 1.209 ± 0.035	3.771ThrIle: 3.771 ± 0.073	2.425ThrLys: 2.425 ± 0.045	6.867ThrLeu: 6.867 ± 0.098	1.06ThrMet: 1.06 ± 0.032	2.143ThrAsn: 2.143 ± 0.047	2.685ThrPro: 2.685 ± 0.074	2.652ThrGln: 2.652 ± 0.063	1.972ThrArg: 1.972 ± 0.042	3.278ThrSer: 3.278 ± 0.063	3.057ThrThr: 3.057 ± 0.065	3.654ThrVal: 3.654 ± 0.071	0.554ThrTrp: 0.554 ± 0.022	1.547ThrTyr: 1.547 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	5.998ValAla: 5.998 ± 0.088	0.692ValCys: 0.692 ± 0.028	4.067ValAsp: 4.067 ± 0.076	4.346ValGlu: 4.346 ± 0.064	2.642ValPhe: 2.642 ± 0.05	4.096ValGly: 4.096 ± 0.071	1.15ValHis: 1.15 ± 0.036	4.917ValIle: 4.917 ± 0.08	3.677ValLys: 3.677 ± 0.062	6.34ValLeu: 6.34 ± 0.083	1.713ValMet: 1.713 ± 0.045	3.329ValAsn: 3.329 ± 0.067	2.18ValPro: 2.18 ± 0.045	2.233ValGln: 2.233 ± 0.045	2.254ValArg: 2.254 ± 0.046	4.655ValSer: 4.655 ± 0.068	3.825ValThr: 3.825 ± 0.086	4.757ValVal: 4.757 ± 0.078	0.598ValTrp: 0.598 ± 0.024	1.742ValTyr: 1.742 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.745TrpAla: 0.745 ± 0.029	0.149TrpCys: 0.149 ± 0.013	0.542TrpAsp: 0.542 ± 0.024	0.5TrpGlu: 0.5 ± 0.023	0.544TrpPhe: 0.544 ± 0.023	0.748TrpGly: 0.748 ± 0.03	0.281TrpHis: 0.281 ± 0.016	0.643TrpIle: 0.643 ± 0.026	0.553TrpLys: 0.553 ± 0.023	1.518TrpLeu: 1.518 ± 0.045	0.278TrpMet: 0.278 ± 0.015	0.446TrpAsn: 0.446 ± 0.02	0.412TrpPro: 0.412 ± 0.019	0.822TrpGln: 0.822 ± 0.035	0.487TrpArg: 0.487 ± 0.023	0.742TrpSer: 0.742 ± 0.03	0.47TrpThr: 0.47 ± 0.021	0.709TrpVal: 0.709 ± 0.03	0.165TrpTrp: 0.165 ± 0.012	0.321TrpTyr: 0.321 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.313TyrAla: 2.313 ± 0.046	0.415TyrCys: 0.415 ± 0.021	1.637TyrAsp: 1.637 ± 0.037	1.579TyrGlu: 1.579 ± 0.038	1.591TyrPhe: 1.591 ± 0.046	1.911TyrGly: 1.911 ± 0.039	0.814TyrHis: 0.814 ± 0.026	1.938TyrIle: 1.938 ± 0.049	1.578TyrLys: 1.578 ± 0.038	3.525TyrLeu: 3.525 ± 0.062	0.628TyrMet: 0.628 ± 0.024	1.367TyrAsn: 1.367 ± 0.037	1.328TyrPro: 1.328 ± 0.041	2.169TyrGln: 2.169 ± 0.05	1.5TyrArg: 1.5 ± 0.041	2.142TyrSer: 2.142 ± 0.046	1.475TyrThr: 1.475 ± 0.039	1.621TyrVal: 1.621 ± 0.036	0.456TyrTrp: 0.456 ± 0.024	1.108TyrTyr: 1.108 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3200 proteins (1074385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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