Amino acid dipepetide frequency for Sulfolobus sp. SCGC AB-777_G05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.146AlaAla: 2.146 ± 0.241
0.508AlaCys: 0.508 ± 0.08
2.436AlaAsp: 2.436 ± 0.202
4.176AlaGlu: 4.176 ± 0.238
2.683AlaPhe: 2.683 ± 0.18
3.176AlaGly: 3.176 ± 0.257
0.624AlaHis: 0.624 ± 0.097
5.336AlaIle: 5.336 ± 0.319
4.162AlaLys: 4.162 ± 0.235
6.134AlaLeu: 6.134 ± 0.342
0.885AlaMet: 0.885 ± 0.113
2.001AlaAsn: 2.001 ± 0.18
1.508AlaPro: 1.508 ± 0.167
1.088AlaGln: 1.088 ± 0.137
2.088AlaArg: 2.088 ± 0.198
3.408AlaSer: 3.408 ± 0.227
2.146AlaThr: 2.146 ± 0.194
3.611AlaVal: 3.611 ± 0.242
0.682AlaTrp: 0.682 ± 0.099
2.61AlaTyr: 2.61 ± 0.216
0.0AlaXaa: 0.0 ± 0.0
Cys
0.421CysAla: 0.421 ± 0.086
0.102CysCys: 0.102 ± 0.04
0.406CysAsp: 0.406 ± 0.078
0.725CysGlu: 0.725 ± 0.113
0.276CysPhe: 0.276 ± 0.064
0.609CysGly: 0.609 ± 0.123
0.174CysHis: 0.174 ± 0.054
0.711CysIle: 0.711 ± 0.102
0.812CysLys: 0.812 ± 0.116
0.522CysLeu: 0.522 ± 0.094
0.116CysMet: 0.116 ± 0.043
0.377CysAsn: 0.377 ± 0.075
0.551CysPro: 0.551 ± 0.099
0.174CysGln: 0.174 ± 0.054
0.189CysArg: 0.189 ± 0.05
0.435CysSer: 0.435 ± 0.09
0.392CysThr: 0.392 ± 0.094
0.421CysVal: 0.421 ± 0.087
0.087CysTrp: 0.087 ± 0.042
0.319CysTyr: 0.319 ± 0.069
0.0CysXaa: 0.0 ± 0.0
Asp
2.407AspAla: 2.407 ± 0.185
0.479AspCys: 0.479 ± 0.094
2.117AspAsp: 2.117 ± 0.165
4.191AspGlu: 4.191 ± 0.27
2.407AspPhe: 2.407 ± 0.208
2.233AspGly: 2.233 ± 0.183
0.508AspHis: 0.508 ± 0.078
4.916AspIle: 4.916 ± 0.259
4.278AspLys: 4.278 ± 0.272
5.409AspLeu: 5.409 ± 0.302
0.914AspMet: 0.914 ± 0.122
1.827AspAsn: 1.827 ± 0.183
2.161AspPro: 2.161 ± 0.175
0.798AspGln: 0.798 ± 0.108
1.581AspArg: 1.581 ± 0.125
2.393AspSer: 2.393 ± 0.167
1.842AspThr: 1.842 ± 0.149
3.886AspVal: 3.886 ± 0.216
0.624AspTrp: 0.624 ± 0.107
2.886AspTyr: 2.886 ± 0.184
0.0AspXaa: 0.0 ± 0.0
Glu
4.22GluAla: 4.22 ± 0.313
0.711GluCys: 0.711 ± 0.11
3.944GluAsp: 3.944 ± 0.236
7.903GluGlu: 7.903 ± 0.439
3.321GluPhe: 3.321 ± 0.211
5.09GluGly: 5.09 ± 0.313
0.87GluHis: 0.87 ± 0.106
8.28GluIle: 8.28 ± 0.405
7.685GluLys: 7.685 ± 0.426
8.033GluLeu: 8.033 ± 0.398
1.61GluMet: 1.61 ± 0.161
3.48GluAsn: 3.48 ± 0.212
1.595GluPro: 1.595 ± 0.149
1.523GluGln: 1.523 ± 0.16
3.785GluArg: 3.785 ± 0.251
2.958GluSer: 2.958 ± 0.193
2.436GluThr: 2.436 ± 0.177
6.641GluVal: 6.641 ± 0.3
0.711GluTrp: 0.711 ± 0.095
3.161GluTyr: 3.161 ± 0.193
0.0GluXaa: 0.0 ± 0.0
Phe
1.987PheAla: 1.987 ± 0.212
0.377PheCys: 0.377 ± 0.078
2.03PheAsp: 2.03 ± 0.167
3.103PheGlu: 3.103 ± 0.184
2.088PhePhe: 2.088 ± 0.186
2.451PheGly: 2.451 ± 0.196
0.812PheHis: 0.812 ± 0.105
4.162PheIle: 4.162 ± 0.261
3.422PheLys: 3.422 ± 0.227
5.148PheLeu: 5.148 ± 0.364
1.03PheMet: 1.03 ± 0.129
1.987PheAsn: 1.987 ± 0.201
1.61PhePro: 1.61 ± 0.145
0.986PheGln: 0.986 ± 0.125
1.653PheArg: 1.653 ± 0.135
3.35PheSer: 3.35 ± 0.265
2.248PheThr: 2.248 ± 0.196
2.929PheVal: 2.929 ± 0.205
0.392PheTrp: 0.392 ± 0.074
2.32PheTyr: 2.32 ± 0.186
0.0PheXaa: 0.0 ± 0.0
Gly
3.176GlyAla: 3.176 ± 0.287
0.595GlyCys: 0.595 ± 0.101
3.234GlyAsp: 3.234 ± 0.237
4.553GlyGlu: 4.553 ± 0.259
3.031GlyPhe: 3.031 ± 0.238
4.365GlyGly: 4.365 ± 0.329
0.943GlyHis: 0.943 ± 0.143
6.351GlyIle: 6.351 ± 0.318
5.496GlyLys: 5.496 ± 0.267
6.293GlyLeu: 6.293 ± 0.36
1.334GlyMet: 1.334 ± 0.119
2.712GlyAsn: 2.712 ± 0.207
1.291GlyPro: 1.291 ± 0.156
0.841GlyGln: 0.841 ± 0.125
2.683GlyArg: 2.683 ± 0.189
3.64GlySer: 3.64 ± 0.234
2.422GlyThr: 2.422 ± 0.209
5.09GlyVal: 5.09 ± 0.263
0.798GlyTrp: 0.798 ± 0.104
3.219GlyTyr: 3.219 ± 0.262
0.0GlyXaa: 0.0 ± 0.0
His
0.711HisAla: 0.711 ± 0.094
0.116HisCys: 0.116 ± 0.037
0.74HisAsp: 0.74 ± 0.104
0.899HisGlu: 0.899 ± 0.108
0.754HisPhe: 0.754 ± 0.11
0.914HisGly: 0.914 ± 0.125
0.363HisHis: 0.363 ± 0.071
1.059HisIle: 1.059 ± 0.137
0.87HisLys: 0.87 ± 0.099
1.392HisLeu: 1.392 ± 0.133
0.189HisMet: 0.189 ± 0.055
0.537HisAsn: 0.537 ± 0.077
0.856HisPro: 0.856 ± 0.131
0.189HisGln: 0.189 ± 0.046
0.406HisArg: 0.406 ± 0.079
0.682HisSer: 0.682 ± 0.091
0.537HisThr: 0.537 ± 0.096
1.015HisVal: 1.015 ± 0.145
0.16HisTrp: 0.16 ± 0.047
0.827HisTyr: 0.827 ± 0.122
0.0HisXaa: 0.0 ± 0.0
Ile
5.177IleAla: 5.177 ± 0.289
0.537IleCys: 0.537 ± 0.089
4.887IleAsp: 4.887 ± 0.246
6.598IleGlu: 6.598 ± 0.329
3.567IlePhe: 3.567 ± 0.224
5.655IleGly: 5.655 ± 0.382
1.291IleHis: 1.291 ± 0.145
9.106IleIle: 9.106 ± 0.482
7.932IleLys: 7.932 ± 0.367
9.266IleLeu: 9.266 ± 0.399
1.885IleMet: 1.885 ± 0.167
5.626IleAsn: 5.626 ± 0.316
3.712IlePro: 3.712 ± 0.237
1.581IleGln: 1.581 ± 0.126
4.713IleArg: 4.713 ± 0.266
7.091IleSer: 7.091 ± 0.263
4.452IleThr: 4.452 ± 0.235
6.902IleVal: 6.902 ± 0.33
0.711IleTrp: 0.711 ± 0.099
3.799IleTyr: 3.799 ± 0.244
0.0IleXaa: 0.0 ± 0.0
Lys
4.263LysAla: 4.263 ± 0.258
0.711LysCys: 0.711 ± 0.118
4.553LysAsp: 4.553 ± 0.28
8.062LysGlu: 8.062 ± 0.366
3.074LysPhe: 3.074 ± 0.161
5.858LysGly: 5.858 ± 0.325
0.885LysHis: 0.885 ± 0.123
8.091LysIle: 8.091 ± 0.431
6.525LysLys: 6.525 ± 0.391
8.555LysLeu: 8.555 ± 0.421
1.972LysMet: 1.972 ± 0.164
3.466LysAsn: 3.466 ± 0.22
3.306LysPro: 3.306 ± 0.212
1.421LysGln: 1.421 ± 0.131
4.191LysArg: 4.191 ± 0.253
4.394LysSer: 4.394 ± 0.25
2.697LysThr: 2.697 ± 0.205
7.584LysVal: 7.584 ± 0.362
0.841LysTrp: 0.841 ± 0.109
3.814LysTyr: 3.814 ± 0.239
0.0LysXaa: 0.0 ± 0.0
Leu
6.453LeuAla: 6.453 ± 0.362
0.45LeuCys: 0.45 ± 0.075
4.437LeuAsp: 4.437 ± 0.255
7.584LeuGlu: 7.584 ± 0.351
3.973LeuPhe: 3.973 ± 0.252
7.004LeuGly: 7.004 ± 0.386
1.407LeuHis: 1.407 ± 0.172
8.99LeuIle: 8.99 ± 0.396
9.28LeuLys: 9.28 ± 0.356
10.498LeuLeu: 10.498 ± 0.491
2.451LeuMet: 2.451 ± 0.181
4.988LeuAsn: 4.988 ± 0.266
4.466LeuPro: 4.466 ± 0.275
2.364LeuGln: 2.364 ± 0.188
5.177LeuArg: 5.177 ± 0.299
8.251LeuSer: 8.251 ± 0.346
4.887LeuThr: 4.887 ± 0.293
6.844LeuVal: 6.844 ± 0.266
1.059LeuTrp: 1.059 ± 0.128
4.655LeuTyr: 4.655 ± 0.263
0.0LeuXaa: 0.0 ± 0.0
Met
1.218MetAla: 1.218 ± 0.145
0.087MetCys: 0.087 ± 0.037
1.001MetAsp: 1.001 ± 0.111
1.218MetGlu: 1.218 ± 0.119
0.798MetPhe: 0.798 ± 0.112
1.581MetGly: 1.581 ± 0.161
0.203MetHis: 0.203 ± 0.046
1.639MetIle: 1.639 ± 0.199
2.001MetLys: 2.001 ± 0.179
2.161MetLeu: 2.161 ± 0.168
0.435MetMet: 0.435 ± 0.085
0.943MetAsn: 0.943 ± 0.121
0.841MetPro: 0.841 ± 0.118
0.406MetGln: 0.406 ± 0.069
1.334MetArg: 1.334 ± 0.138
1.494MetSer: 1.494 ± 0.156
0.798MetThr: 0.798 ± 0.097
1.32MetVal: 1.32 ± 0.124
0.174MetTrp: 0.174 ± 0.056
0.609MetTyr: 0.609 ± 0.093
0.0MetXaa: 0.0 ± 0.0
Asn
2.407AsnAla: 2.407 ± 0.204
0.45AsnCys: 0.45 ± 0.092
2.219AsnAsp: 2.219 ± 0.156
4.031AsnGlu: 4.031 ± 0.27
1.856AsnPhe: 1.856 ± 0.173
3.292AsnGly: 3.292 ± 0.284
0.58AsnHis: 0.58 ± 0.083
3.77AsnIle: 3.77 ± 0.256
3.669AsnLys: 3.669 ± 0.218
4.437AsnLeu: 4.437 ± 0.227
0.769AsnMet: 0.769 ± 0.101
2.19AsnAsn: 2.19 ± 0.207
2.19AsnPro: 2.19 ± 0.207
0.798AsnGln: 0.798 ± 0.093
1.61AsnArg: 1.61 ± 0.133
3.335AsnSer: 3.335 ± 0.222
2.03AsnThr: 2.03 ± 0.174
4.249AsnVal: 4.249 ± 0.276
0.479AsnTrp: 0.479 ± 0.089
2.596AsnTyr: 2.596 ± 0.255
0.0AsnXaa: 0.0 ± 0.0
Pro
1.74ProAla: 1.74 ± 0.152
0.261ProCys: 0.261 ± 0.056
1.639ProAsp: 1.639 ± 0.146
2.668ProGlu: 2.668 ± 0.215
1.871ProPhe: 1.871 ± 0.177
1.711ProGly: 1.711 ± 0.16
0.653ProHis: 0.653 ± 0.1
3.292ProIle: 3.292 ± 0.216
2.871ProLys: 2.871 ± 0.204
4.307ProLeu: 4.307 ± 0.286
0.537ProMet: 0.537 ± 0.096
1.726ProAsn: 1.726 ± 0.174
1.929ProPro: 1.929 ± 0.183
1.131ProGln: 1.131 ± 0.131
1.436ProArg: 1.436 ± 0.148
2.799ProSer: 2.799 ± 0.197
2.074ProThr: 2.074 ± 0.163
2.625ProVal: 2.625 ± 0.211
0.421ProTrp: 0.421 ± 0.079
2.407ProTyr: 2.407 ± 0.185
0.0ProXaa: 0.0 ± 0.0
Gln
1.189GlnAla: 1.189 ± 0.12
0.247GlnCys: 0.247 ± 0.066
0.74GlnAsp: 0.74 ± 0.105
1.508GlnGlu: 1.508 ± 0.164
0.914GlnPhe: 0.914 ± 0.113
1.175GlnGly: 1.175 ± 0.134
0.16GlnHis: 0.16 ± 0.052
1.972GlnIle: 1.972 ± 0.185
1.508GlnLys: 1.508 ± 0.142
2.277GlnLeu: 2.277 ± 0.193
0.406GlnMet: 0.406 ± 0.079
0.827GlnAsn: 0.827 ± 0.113
0.667GlnPro: 0.667 ± 0.096
0.58GlnGln: 0.58 ± 0.085
0.856GlnArg: 0.856 ± 0.108
0.986GlnSer: 0.986 ± 0.127
1.015GlnThr: 1.015 ± 0.105
1.291GlnVal: 1.291 ± 0.142
0.189GlnTrp: 0.189 ± 0.057
1.015GlnTyr: 1.015 ± 0.119
0.0GlnXaa: 0.0 ± 0.0
Arg
2.117ArgAla: 2.117 ± 0.203
0.377ArgCys: 0.377 ± 0.079
2.494ArgAsp: 2.494 ± 0.205
3.857ArgGlu: 3.857 ± 0.251
2.219ArgPhe: 2.219 ± 0.175
3.277ArgGly: 3.277 ± 0.208
0.522ArgHis: 0.522 ± 0.09
4.075ArgIle: 4.075 ± 0.223
3.799ArgLys: 3.799 ± 0.228
4.249ArgLeu: 4.249 ± 0.237
0.87ArgMet: 0.87 ± 0.114
2.291ArgAsn: 2.291 ± 0.19
1.349ArgPro: 1.349 ± 0.147
0.943ArgGln: 0.943 ± 0.119
2.422ArgArg: 2.422 ± 0.208
1.958ArgSer: 1.958 ± 0.157
1.61ArgThr: 1.61 ± 0.166
3.321ArgVal: 3.321 ± 0.194
0.638ArgTrp: 0.638 ± 0.097
1.639ArgTyr: 1.639 ± 0.157
0.0ArgXaa: 0.0 ± 0.0
Ser
2.77SerAla: 2.77 ± 0.226
0.493SerCys: 0.493 ± 0.086
2.828SerAsp: 2.828 ± 0.202
4.611SerGlu: 4.611 ± 0.294
3.422SerPhe: 3.422 ± 0.253
3.524SerGly: 3.524 ± 0.203
0.87SerHis: 0.87 ± 0.096
5.786SerIle: 5.786 ± 0.297
5.104SerLys: 5.104 ± 0.295
7.888SerLeu: 7.888 ± 0.438
1.218SerMet: 1.218 ± 0.123
2.871SerAsn: 2.871 ± 0.266
2.697SerPro: 2.697 ± 0.219
1.624SerGln: 1.624 ± 0.142
2.639SerArg: 2.639 ± 0.195
4.887SerSer: 4.887 ± 0.309
3.335SerThr: 3.335 ± 0.206
3.959SerVal: 3.959 ± 0.229
0.986SerTrp: 0.986 ± 0.123
2.958SerTyr: 2.958 ± 0.179
0.0SerXaa: 0.0 ± 0.0
Thr
2.335ThrAla: 2.335 ± 0.167
0.232ThrCys: 0.232 ± 0.056
1.61ThrAsp: 1.61 ± 0.133
2.538ThrGlu: 2.538 ± 0.175
2.103ThrPhe: 2.103 ± 0.206
2.77ThrGly: 2.77 ± 0.186
0.551ThrHis: 0.551 ± 0.09
4.423ThrIle: 4.423 ± 0.231
2.784ThrLys: 2.784 ± 0.156
4.901ThrLeu: 4.901 ± 0.29
0.899ThrMet: 0.899 ± 0.123
1.842ThrAsn: 1.842 ± 0.141
2.422ThrPro: 2.422 ± 0.192
0.827ThrGln: 0.827 ± 0.113
1.74ThrArg: 1.74 ± 0.18
3.132ThrSer: 3.132 ± 0.235
2.625ThrThr: 2.625 ± 0.185
3.959ThrVal: 3.959 ± 0.258
0.348ThrTrp: 0.348 ± 0.082
2.016ThrTyr: 2.016 ± 0.184
0.0ThrXaa: 0.0 ± 0.0
Val
3.509ValAla: 3.509 ± 0.274
0.537ValCys: 0.537 ± 0.095
3.828ValAsp: 3.828 ± 0.265
5.67ValGlu: 5.67 ± 0.33
2.871ValPhe: 2.871 ± 0.204
3.973ValGly: 3.973 ± 0.266
0.885ValHis: 0.885 ± 0.104
7.946ValIle: 7.946 ± 0.314
7.279ValLys: 7.279 ± 0.308
7.265ValLeu: 7.265 ± 0.323
1.436ValMet: 1.436 ± 0.136
4.307ValAsn: 4.307 ± 0.261
2.697ValPro: 2.697 ± 0.188
1.262ValGln: 1.262 ± 0.134
3.408ValArg: 3.408 ± 0.23
5.264ValSer: 5.264 ± 0.264
3.582ValThr: 3.582 ± 0.198
5.612ValVal: 5.612 ± 0.36
0.754ValTrp: 0.754 ± 0.105
3.785ValTyr: 3.785 ± 0.26
0.0ValXaa: 0.0 ± 0.0
Trp
0.653TrpAla: 0.653 ± 0.108
0.058TrpCys: 0.058 ± 0.033
0.537TrpAsp: 0.537 ± 0.074
0.711TrpGlu: 0.711 ± 0.108
0.435TrpPhe: 0.435 ± 0.069
0.783TrpGly: 0.783 ± 0.112
0.16TrpHis: 0.16 ± 0.049
0.899TrpIle: 0.899 ± 0.101
0.87TrpLys: 0.87 ± 0.103
1.204TrpLeu: 1.204 ± 0.131
0.232TrpMet: 0.232 ± 0.053
0.479TrpAsn: 0.479 ± 0.09
0.319TrpPro: 0.319 ± 0.058
0.145TrpGln: 0.145 ± 0.046
0.595TrpArg: 0.595 ± 0.098
0.696TrpSer: 0.696 ± 0.11
0.522TrpThr: 0.522 ± 0.101
0.769TrpVal: 0.769 ± 0.11
0.102TrpTrp: 0.102 ± 0.031
0.464TrpTyr: 0.464 ± 0.094
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.509TyrAla: 2.509 ± 0.174
0.493TyrCys: 0.493 ± 0.083
2.175TyrAsp: 2.175 ± 0.205
3.35TyrGlu: 3.35 ± 0.227
2.422TyrPhe: 2.422 ± 0.196
2.625TyrGly: 2.625 ± 0.22
0.754TyrHis: 0.754 ± 0.102
3.683TyrIle: 3.683 ± 0.228
3.915TyrLys: 3.915 ± 0.258
5.278TyrLeu: 5.278 ± 0.327
1.059TyrMet: 1.059 ± 0.113
2.48TyrAsn: 2.48 ± 0.165
1.929TyrPro: 1.929 ± 0.168
0.841TyrGln: 0.841 ± 0.11
1.523TyrArg: 1.523 ± 0.136
3.321TyrSer: 3.321 ± 0.215
2.407TyrThr: 2.407 ± 0.173
3.857TyrVal: 3.857 ± 0.256
0.479TyrTrp: 0.479 ± 0.097
2.726TyrTyr: 2.726 ± 0.231
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 297 proteins (68966 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski