Amino acid dipepetide frequency for Pogona vitticeps (central bearded dragon)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.064AlaAla: 6.064 ± 0.033	1.286AlaCys: 1.286 ± 0.009	2.909AlaAsp: 2.909 ± 0.013	4.924AlaGlu: 4.924 ± 0.028	2.462AlaPhe: 2.462 ± 0.014	4.044AlaGly: 4.044 ± 0.02	1.45AlaHis: 1.45 ± 0.01	2.869AlaIle: 2.869 ± 0.013	3.701AlaLys: 3.701 ± 0.019	6.402AlaLeu: 6.402 ± 0.028	1.481AlaMet: 1.481 ± 0.01	2.23AlaAsn: 2.23 ± 0.011	3.35AlaPro: 3.35 ± 0.023	2.999AlaGln: 2.999 ± 0.018	3.136AlaArg: 3.136 ± 0.015	5.719AlaSer: 5.719 ± 0.025	3.604AlaThr: 3.604 ± 0.019	4.55AlaVal: 4.55 ± 0.018	0.691AlaTrp: 0.691 ± 0.006	1.486AlaTyr: 1.486 ± 0.011	0.002AlaXaa: 0.002 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.009	0.584CysCys: 0.584 ± 0.008	0.994CysAsp: 0.994 ± 0.009	1.265CysGlu: 1.265 ± 0.011	0.944CysPhe: 0.944 ± 0.011	1.754CysGly: 1.754 ± 0.023	0.648CysHis: 0.648 ± 0.007	1.047CysIle: 1.047 ± 0.01	1.219CysLys: 1.219 ± 0.01	2.133CysLeu: 2.133 ± 0.015	0.536CysMet: 0.536 ± 0.011	0.839CysAsn: 0.839 ± 0.009	1.229CysPro: 1.229 ± 0.012	1.113CysGln: 1.113 ± 0.012	1.177CysArg: 1.177 ± 0.011	2.02CysSer: 2.02 ± 0.014	1.099CysThr: 1.099 ± 0.011	1.182CysVal: 1.182 ± 0.009	0.258CysTrp: 0.258 ± 0.004	0.596CysTyr: 0.596 ± 0.007	0.001CysXaa: 0.001 ± 0.0
Asp	2.835AspAla: 2.835 ± 0.015	1.051AspCys: 1.051 ± 0.01	2.818AspAsp: 2.818 ± 0.017	3.626AspGlu: 3.626 ± 0.018	2.108AspPhe: 2.108 ± 0.012	3.267AspGly: 3.267 ± 0.02	1.176AspHis: 1.176 ± 0.007	2.719AspIle: 2.719 ± 0.017	2.652AspLys: 2.652 ± 0.014	5.026AspLeu: 5.026 ± 0.018	1.132AspMet: 1.132 ± 0.008	1.842AspAsn: 1.842 ± 0.011	2.739AspPro: 2.739 ± 0.015	1.887AspGln: 1.887 ± 0.01	2.385AspArg: 2.385 ± 0.013	4.277AspSer: 4.277 ± 0.02	2.43AspThr: 2.43 ± 0.013	3.069AspVal: 3.069 ± 0.017	0.603AspTrp: 0.603 ± 0.006	1.55AspTyr: 1.55 ± 0.009	0.001AspXaa: 0.001 ± 0.0
Glu	5.121GluAla: 5.121 ± 0.029	1.632GluCys: 1.632 ± 0.022	4.516GluAsp: 4.516 ± 0.018	8.848GluGlu: 8.848 ± 0.057	2.096GluPhe: 2.096 ± 0.012	4.161GluGly: 4.161 ± 0.018	1.573GluHis: 1.573 ± 0.01	3.52GluIle: 3.52 ± 0.019	6.298GluLys: 6.298 ± 0.044	6.435GluLeu: 6.435 ± 0.036	1.908GluMet: 1.908 ± 0.012	3.459GluAsn: 3.459 ± 0.018	2.927GluPro: 2.927 ± 0.02	3.375GluGln: 3.375 ± 0.021	4.28GluArg: 4.28 ± 0.025	4.745GluSer: 4.745 ± 0.02	3.738GluThr: 3.738 ± 0.019	4.163GluVal: 4.163 ± 0.018	0.72GluTrp: 0.72 ± 0.007	1.716GluTyr: 1.716 ± 0.013	0.001GluXaa: 0.001 ± 0.0
Phe	2.063PheAla: 2.063 ± 0.014	0.93PheCys: 0.93 ± 0.008	1.687PheAsp: 1.687 ± 0.012	2.053PheGlu: 2.053 ± 0.01	1.532PhePhe: 1.532 ± 0.012	2.133PheGly: 2.133 ± 0.014	1.051PheHis: 1.051 ± 0.008	1.814PheIle: 1.814 ± 0.011	1.841PheLys: 1.841 ± 0.011	3.939PheLeu: 3.939 ± 0.019	0.761PheMet: 0.761 ± 0.007	1.392PheAsn: 1.392 ± 0.01	1.984PhePro: 1.984 ± 0.013	1.799PheGln: 1.799 ± 0.011	1.891PheArg: 1.891 ± 0.013	3.463PheSer: 3.463 ± 0.019	2.001PheThr: 2.001 ± 0.013	2.15PheVal: 2.15 ± 0.013	0.469PheTrp: 0.469 ± 0.006	1.149PheTyr: 1.149 ± 0.009	0.001PheXaa: 0.001 ± 0.0
Gly	3.714GlyAla: 3.714 ± 0.021	1.164GlyCys: 1.164 ± 0.011	2.953GlyAsp: 2.953 ± 0.015	4.27GlyGlu: 4.27 ± 0.027	2.327GlyPhe: 2.327 ± 0.015	4.481GlyGly: 4.481 ± 0.035	1.534GlyHis: 1.534 ± 0.011	2.828GlyIle: 2.828 ± 0.015	4.194GlyLys: 4.194 ± 0.025	5.097GlyLeu: 5.097 ± 0.021	1.361GlyMet: 1.361 ± 0.011	2.506GlyAsn: 2.506 ± 0.015	3.089GlyPro: 3.089 ± 0.033	2.62GlyGln: 2.62 ± 0.014	3.416GlyArg: 3.416 ± 0.017	5.513GlySer: 5.513 ± 0.024	3.447GlyThr: 3.447 ± 0.016	3.219GlyVal: 3.219 ± 0.018	0.717GlyTrp: 0.717 ± 0.007	1.728GlyTyr: 1.728 ± 0.013	0.002GlyXaa: 0.002 ± 0.0
His	1.322HisAla: 1.322 ± 0.009	0.688HisCys: 0.688 ± 0.007	0.938HisAsp: 0.938 ± 0.007	1.445HisGlu: 1.445 ± 0.01	1.066HisPhe: 1.066 ± 0.008	1.457HisGly: 1.457 ± 0.009	0.97HisHis: 0.97 ± 0.011	1.312HisIle: 1.312 ± 0.009	1.423HisLys: 1.423 ± 0.01	2.898HisLeu: 2.898 ± 0.015	0.592HisMet: 0.592 ± 0.006	0.966HisAsn: 0.966 ± 0.008	1.591HisPro: 1.591 ± 0.013	1.561HisGln: 1.561 ± 0.018	1.549HisArg: 1.549 ± 0.01	2.372HisSer: 2.372 ± 0.016	1.696HisThr: 1.696 ± 0.022	1.446HisVal: 1.446 ± 0.009	0.328HisTrp: 0.328 ± 0.004	0.826HisTyr: 0.826 ± 0.007	0.001HisXaa: 0.001 ± 0.0
Ile	2.763IleAla: 2.763 ± 0.013	1.128IleCys: 1.128 ± 0.008	2.177IleAsp: 2.177 ± 0.012	2.809IleGlu: 2.809 ± 0.017	1.877IlePhe: 1.877 ± 0.012	2.295IleGly: 2.295 ± 0.014	1.483IleHis: 1.483 ± 0.013	2.488IleIle: 2.488 ± 0.015	2.834IleLys: 2.834 ± 0.016	4.631IleLeu: 4.631 ± 0.02	1.053IleMet: 1.053 ± 0.008	2.004IleAsn: 2.004 ± 0.013	2.728IlePro: 2.728 ± 0.014	2.44IleGln: 2.44 ± 0.015	2.411IleArg: 2.411 ± 0.013	3.982IleSer: 3.982 ± 0.015	2.701IleThr: 2.701 ± 0.017	2.691IleVal: 2.691 ± 0.017	0.525IleTrp: 0.525 ± 0.005	1.43IleTyr: 1.43 ± 0.011	0.001IleXaa: 0.001 ± 0.0
Lys	4.086LysAla: 4.086 ± 0.022	1.557LysCys: 1.557 ± 0.023	3.376LysAsp: 3.376 ± 0.016	5.884LysGlu: 5.884 ± 0.034	1.7LysPhe: 1.7 ± 0.012	3.418LysGly: 3.418 ± 0.022	1.595LysHis: 1.595 ± 0.011	2.997LysIle: 2.997 ± 0.015	5.192LysLys: 5.192 ± 0.027	5.482LysLeu: 5.482 ± 0.028	1.598LysMet: 1.598 ± 0.01	2.687LysAsn: 2.687 ± 0.014	3.548LysPro: 3.548 ± 0.026	2.997LysGln: 2.997 ± 0.019	3.663LysArg: 3.663 ± 0.018	4.442LysSer: 4.442 ± 0.026	3.347LysThr: 3.347 ± 0.017	3.528LysVal: 3.528 ± 0.017	0.643LysTrp: 0.643 ± 0.006	1.658LysTyr: 1.658 ± 0.011	0.001LysXaa: 0.001 ± 0.0
Leu	6.29LeuAla: 6.29 ± 0.027	2.024LeuCys: 2.024 ± 0.013	4.7LeuAsp: 4.7 ± 0.018	7.289LeuGlu: 7.289 ± 0.037	3.22LeuPhe: 3.22 ± 0.02	5.006LeuGly: 5.006 ± 0.02	2.738LeuHis: 2.738 ± 0.015	3.9LeuIle: 3.9 ± 0.016	6.289LeuLys: 6.289 ± 0.029	9.883LeuLeu: 9.883 ± 0.039	2.039LeuMet: 2.039 ± 0.012	3.765LeuAsn: 3.765 ± 0.017	5.617LeuPro: 5.617 ± 0.026	5.751LeuGln: 5.751 ± 0.029	5.365LeuArg: 5.365 ± 0.021	7.931LeuSer: 7.931 ± 0.028	4.785LeuThr: 4.785 ± 0.016	5.094LeuVal: 5.094 ± 0.019	1.009LeuTrp: 1.009 ± 0.008	2.515LeuTyr: 2.515 ± 0.014	0.003LeuXaa: 0.003 ± 0.0
Met	1.825MetAla: 1.825 ± 0.011	0.407MetCys: 0.407 ± 0.005	1.345MetAsp: 1.345 ± 0.009	2.158MetGlu: 2.158 ± 0.015	0.756MetPhe: 0.756 ± 0.007	1.291MetGly: 1.291 ± 0.01	0.513MetHis: 0.513 ± 0.006	0.919MetIle: 0.919 ± 0.008	1.641MetLys: 1.641 ± 0.011	1.981MetLeu: 1.981 ± 0.011	0.621MetMet: 0.621 ± 0.007	0.981MetAsn: 0.981 ± 0.008	1.136MetPro: 1.136 ± 0.01	1.036MetGln: 1.036 ± 0.008	1.06MetArg: 1.06 ± 0.008	1.604MetSer: 1.604 ± 0.01	1.135MetThr: 1.135 ± 0.007	1.37MetVal: 1.37 ± 0.01	0.243MetTrp: 0.243 ± 0.004	0.61MetTyr: 0.61 ± 0.006	0.001MetXaa: 0.001 ± 0.0
Asn	2.297AsnAla: 2.297 ± 0.013	0.893AsnCys: 0.893 ± 0.008	1.676AsnAsp: 1.676 ± 0.011	2.58AsnGlu: 2.58 ± 0.016	1.482AsnPhe: 1.482 ± 0.009	2.712AsnGly: 2.712 ± 0.017	1.039AsnHis: 1.039 ± 0.008	2.331AsnIle: 2.331 ± 0.014	2.426AsnLys: 2.426 ± 0.013	3.934AsnLeu: 3.934 ± 0.017	1.018AsnMet: 1.018 ± 0.008	1.736AsnAsn: 1.736 ± 0.013	2.231AsnPro: 2.231 ± 0.015	1.843AsnGln: 1.843 ± 0.012	2.012AsnArg: 2.012 ± 0.012	3.508AsnSer: 3.508 ± 0.017	2.165AsnThr: 2.165 ± 0.013	2.337AsnVal: 2.337 ± 0.012	0.465AsnTrp: 0.465 ± 0.005	1.199AsnTyr: 1.199 ± 0.009	0.001AsnXaa: 0.001 ± 0.0
Pro	4.168ProAla: 4.168 ± 0.024	1.024ProCys: 1.024 ± 0.012	2.657ProAsp: 2.657 ± 0.014	4.119ProGlu: 4.119 ± 0.021	1.976ProPhe: 1.976 ± 0.014	4.008ProGly: 4.008 ± 0.038	1.379ProHis: 1.379 ± 0.011	1.966ProIle: 1.966 ± 0.012	2.923ProLys: 2.923 ± 0.019	4.933ProLeu: 4.933 ± 0.021	0.995ProMet: 0.995 ± 0.009	1.955ProAsn: 1.955 ± 0.012	5.423ProPro: 5.423 ± 0.043	2.589ProGln: 2.589 ± 0.02	2.723ProArg: 2.723 ± 0.017	5.616ProSer: 5.616 ± 0.03	2.883ProThr: 2.883 ± 0.016	3.791ProVal: 3.791 ± 0.021	0.584ProTrp: 0.584 ± 0.007	1.71ProTyr: 1.71 ± 0.019	0.002ProXaa: 0.002 ± 0.0
Gln	3.273GlnAla: 3.273 ± 0.018	0.933GlnCys: 0.933 ± 0.01	2.291GlnAsp: 2.291 ± 0.012	4.121GlnGlu: 4.121 ± 0.027	1.402GlnPhe: 1.402 ± 0.009	2.569GlnGly: 2.569 ± 0.013	1.342GlnHis: 1.342 ± 0.009	2.185GlnIle: 2.185 ± 0.013	3.313GlnLys: 3.313 ± 0.021	4.676GlnLeu: 4.676 ± 0.025	1.199GlnMet: 1.199 ± 0.009	2.171GlnAsn: 2.171 ± 0.014	2.662GlnPro: 2.662 ± 0.022	3.443GlnGln: 3.443 ± 0.033	3.049GlnArg: 3.049 ± 0.021	3.379GlnSer: 3.379 ± 0.019	2.455GlnThr: 2.455 ± 0.013	2.667GlnVal: 2.667 ± 0.015	0.533GlnTrp: 0.533 ± 0.005	1.224GlnTyr: 1.224 ± 0.008	0.001GlnXaa: 0.001 ± 0.0
Arg	3.148ArgAla: 3.148 ± 0.015	1.107ArgCys: 1.107 ± 0.01	2.605ArgAsp: 2.605 ± 0.015	3.958ArgGlu: 3.958 ± 0.022	1.803ArgPhe: 1.803 ± 0.01	3.065ArgGly: 3.065 ± 0.017	1.529ArgHis: 1.529 ± 0.012	2.669ArgIle: 2.669 ± 0.014	3.907ArgLys: 3.907 ± 0.019	4.996ArgLeu: 4.996 ± 0.024	1.241ArgMet: 1.241 ± 0.009	2.258ArgAsn: 2.258 ± 0.012	2.757ArgPro: 2.757 ± 0.019	2.65ArgGln: 2.65 ± 0.016	4.129ArgArg: 4.129 ± 0.025	4.363ArgSer: 4.363 ± 0.027	2.918ArgThr: 2.918 ± 0.015	2.853ArgVal: 2.853 ± 0.016	0.637ArgTrp: 0.637 ± 0.006	1.487ArgTyr: 1.487 ± 0.009	0.002ArgXaa: 0.002 ± 0.0
Ser	5.333SerAla: 5.333 ± 0.023	1.794SerCys: 1.794 ± 0.013	4.088SerAsp: 4.088 ± 0.019	5.532SerGlu: 5.532 ± 0.022	3.329SerPhe: 3.329 ± 0.02	5.355SerGly: 5.355 ± 0.02	2.339SerHis: 2.339 ± 0.017	3.46SerIle: 3.46 ± 0.016	4.528SerLys: 4.528 ± 0.019	8.152SerLeu: 8.152 ± 0.026	1.678SerMet: 1.678 ± 0.01	3.102SerAsn: 3.102 ± 0.016	5.873SerPro: 5.873 ± 0.031	4.008SerGln: 4.008 ± 0.022	4.425SerArg: 4.425 ± 0.025	10.232SerSer: 10.232 ± 0.052	4.728SerThr: 4.728 ± 0.021	4.96SerVal: 4.96 ± 0.02	0.969SerTrp: 0.969 ± 0.008	2.159SerTyr: 2.159 ± 0.013	0.002SerXaa: 0.002 ± 0.0
Thr	3.722ThrAla: 3.722 ± 0.015	1.229ThrCys: 1.229 ± 0.012	2.627ThrAsp: 2.627 ± 0.013	3.884ThrGlu: 3.884 ± 0.02	2.09ThrPhe: 2.09 ± 0.013	3.739ThrGly: 3.739 ± 0.023	1.387ThrHis: 1.387 ± 0.015	2.491ThrIle: 2.491 ± 0.014	2.828ThrLys: 2.828 ± 0.013	5.078ThrLeu: 5.078 ± 0.016	1.148ThrMet: 1.148 ± 0.008	1.877ThrAsn: 1.877 ± 0.01	3.358ThrPro: 3.358 ± 0.02	2.217ThrGln: 2.217 ± 0.012	2.345ThrArg: 2.345 ± 0.012	4.892ThrSer: 4.892 ± 0.026	3.166ThrThr: 3.166 ± 0.025	3.881ThrVal: 3.881 ± 0.019	0.642ThrTrp: 0.642 ± 0.007	1.451ThrTyr: 1.451 ± 0.01	0.001ThrXaa: 0.001 ± 0.0
Val	4.132ValAla: 4.132 ± 0.018	1.409ValCys: 1.409 ± 0.011	2.871ValAsp: 2.871 ± 0.014	3.955ValGlu: 3.955 ± 0.018	2.3ValPhe: 2.3 ± 0.014	3.134ValGly: 3.134 ± 0.015	1.633ValHis: 1.633 ± 0.012	2.893ValIle: 2.893 ± 0.016	3.588ValLys: 3.588 ± 0.017	5.764ValLeu: 5.764 ± 0.02	1.337ValMet: 1.337 ± 0.008	2.371ValAsn: 2.371 ± 0.013	3.433ValPro: 3.433 ± 0.019	2.752ValGln: 2.752 ± 0.015	2.814ValArg: 2.814 ± 0.015	4.853ValSer: 4.853 ± 0.019	3.608ValThr: 3.608 ± 0.018	3.85ValVal: 3.85 ± 0.022	0.651ValTrp: 0.651 ± 0.007	1.601ValTyr: 1.601 ± 0.01	0.002ValXaa: 0.002 ± 0.0
Trp	0.643TrpAla: 0.643 ± 0.006	0.235TrpCys: 0.235 ± 0.004	0.612TrpAsp: 0.612 ± 0.006	0.774TrpGlu: 0.774 ± 0.007	0.427TrpPhe: 0.427 ± 0.005	0.6TrpGly: 0.6 ± 0.007	0.297TrpHis: 0.297 ± 0.004	0.563TrpIle: 0.563 ± 0.007	0.825TrpLys: 0.825 ± 0.006	1.132TrpLeu: 1.132 ± 0.011	0.317TrpMet: 0.317 ± 0.004	0.541TrpAsn: 0.541 ± 0.005	0.464TrpPro: 0.464 ± 0.006	0.521TrpGln: 0.521 ± 0.006	0.658TrpArg: 0.658 ± 0.006	0.86TrpSer: 0.86 ± 0.008	0.62TrpThr: 0.62 ± 0.007	0.625TrpVal: 0.625 ± 0.006	0.173TrpTrp: 0.173 ± 0.003	0.32TrpTyr: 0.32 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.446TyrAla: 1.446 ± 0.009	0.674TyrCys: 0.674 ± 0.007	1.354TyrAsp: 1.354 ± 0.01	1.735TyrGlu: 1.735 ± 0.012	1.207TyrPhe: 1.207 ± 0.01	1.689TyrGly: 1.689 ± 0.013	0.766TyrHis: 0.766 ± 0.007	1.48TyrIle: 1.48 ± 0.012	1.777TyrLys: 1.777 ± 0.018	2.639TyrLeu: 2.639 ± 0.013	0.614TyrMet: 0.614 ± 0.006	1.201TyrAsn: 1.201 ± 0.009	1.284TyrPro: 1.284 ± 0.01	1.288TyrGln: 1.288 ± 0.009	1.594TyrArg: 1.594 ± 0.01	2.272TyrSer: 2.272 ± 0.014	1.526TyrThr: 1.526 ± 0.01	1.523TyrVal: 1.523 ± 0.01	0.35TyrTrp: 0.35 ± 0.005	0.961TyrTyr: 0.961 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.003XaaPro: 0.003 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.107XaaXaa: 0.107 ± 0.012

Statistics based on 31185 proteins (20298321 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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