Amino acid dipepetide frequency for Lachnospiraceae bacterium 9_1_43BFAA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.385AlaAla: 6.385 ± 0.115	1.065AlaCys: 1.065 ± 0.041	3.951AlaAsp: 3.951 ± 0.075	5.799AlaGlu: 5.799 ± 0.103	3.153AlaPhe: 3.153 ± 0.073	5.809AlaGly: 5.809 ± 0.09	1.089AlaHis: 1.089 ± 0.042	4.883AlaIle: 4.883 ± 0.087	5.077AlaLys: 5.077 ± 0.073	6.507AlaLeu: 6.507 ± 0.103	2.323AlaMet: 2.323 ± 0.056	2.49AlaAsn: 2.49 ± 0.061	1.799AlaPro: 1.799 ± 0.045	2.159AlaGln: 2.159 ± 0.052	2.724AlaArg: 2.724 ± 0.063	3.544AlaSer: 3.544 ± 0.075	2.917AlaThr: 2.917 ± 0.06	6.273AlaVal: 6.273 ± 0.093	0.602AlaTrp: 0.602 ± 0.026	2.692AlaTyr: 2.692 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.976CysAla: 0.976 ± 0.033	0.254CysCys: 0.254 ± 0.019	0.756CysAsp: 0.756 ± 0.031	1.032CysGlu: 1.032 ± 0.037	0.642CysPhe: 0.642 ± 0.025	1.531CysGly: 1.531 ± 0.051	0.299CysHis: 0.299 ± 0.02	1.128CysIle: 1.128 ± 0.038	0.857CysLys: 0.857 ± 0.033	1.157CysLeu: 1.157 ± 0.04	0.48CysMet: 0.48 ± 0.024	0.549CysAsn: 0.549 ± 0.026	0.637CysPro: 0.637 ± 0.031	0.454CysGln: 0.454 ± 0.02	0.751CysArg: 0.751 ± 0.028	0.907CysSer: 0.907 ± 0.036	0.805CysThr: 0.805 ± 0.032	1.021CysVal: 1.021 ± 0.041	0.115CysTrp: 0.115 ± 0.011	0.59CysTyr: 0.59 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.513AspAla: 3.513 ± 0.061	0.767AspCys: 0.767 ± 0.028	2.304AspAsp: 2.304 ± 0.07	4.084AspGlu: 4.084 ± 0.077	2.374AspPhe: 2.374 ± 0.059	4.183AspGly: 4.183 ± 0.08	0.923AspHis: 0.923 ± 0.036	3.924AspIle: 3.924 ± 0.084	3.039AspLys: 3.039 ± 0.062	4.423AspLeu: 4.423 ± 0.07	1.619AspMet: 1.619 ± 0.044	1.74AspAsn: 1.74 ± 0.047	1.65AspPro: 1.65 ± 0.046	1.599AspGln: 1.599 ± 0.041	2.414AspArg: 2.414 ± 0.053	2.639AspSer: 2.639 ± 0.057	2.863AspThr: 2.863 ± 0.057	3.775AspVal: 3.775 ± 0.076	0.509AspTrp: 0.509 ± 0.027	2.391AspTyr: 2.391 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	5.896GluAla: 5.896 ± 0.091	0.931GluCys: 0.931 ± 0.035	4.297GluAsp: 4.297 ± 0.072	9.767GluGlu: 9.767 ± 0.159	2.749GluPhe: 2.749 ± 0.065	4.942GluGly: 4.942 ± 0.084	1.556GluHis: 1.556 ± 0.044	6.578GluIle: 6.578 ± 0.097	8.325GluLys: 8.325 ± 0.105	7.232GluLeu: 7.232 ± 0.099	2.764GluMet: 2.764 ± 0.052	4.095GluAsn: 4.095 ± 0.073	1.914GluPro: 1.914 ± 0.052	3.885GluGln: 3.885 ± 0.094	3.951GluArg: 3.951 ± 0.072	3.463GluSer: 3.463 ± 0.07	3.967GluThr: 3.967 ± 0.075	5.33GluVal: 5.33 ± 0.081	0.727GluTrp: 0.727 ± 0.03	3.209GluTyr: 3.209 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	3.082PheAla: 3.082 ± 0.067	0.836PheCys: 0.836 ± 0.034	2.381PheAsp: 2.381 ± 0.048	2.912PheGlu: 2.912 ± 0.071	2.025PhePhe: 2.025 ± 0.062	3.197PheGly: 3.197 ± 0.072	0.942PheHis: 0.942 ± 0.036	2.695PheIle: 2.695 ± 0.06	1.848PheLys: 1.848 ± 0.053	4.402PheLeu: 4.402 ± 0.104	1.14PheMet: 1.14 ± 0.035	1.354PheAsn: 1.354 ± 0.038	1.452PhePro: 1.452 ± 0.045	1.615PheGln: 1.615 ± 0.047	1.756PheArg: 1.756 ± 0.048	2.845PheSer: 2.845 ± 0.062	2.235PheThr: 2.235 ± 0.051	3.016PheVal: 3.016 ± 0.065	0.411PheTrp: 0.411 ± 0.025	1.841PheTyr: 1.841 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.92GlyAla: 4.92 ± 0.092	1.233GlyCys: 1.233 ± 0.042	3.094GlyAsp: 3.094 ± 0.064	5.266GlyGlu: 5.266 ± 0.102	2.988GlyPhe: 2.988 ± 0.062	4.75GlyGly: 4.75 ± 0.093	1.196GlyHis: 1.196 ± 0.04	6.337GlyIle: 6.337 ± 0.087	6.026GlyLys: 6.026 ± 0.082	5.432GlyLeu: 5.432 ± 0.1	2.636GlyMet: 2.636 ± 0.058	3.039GlyAsn: 3.039 ± 0.067	1.195GlyPro: 1.195 ± 0.038	2.114GlyGln: 2.114 ± 0.055	2.997GlyArg: 2.997 ± 0.058	3.796GlySer: 3.796 ± 0.071	4.247GlyThr: 4.247 ± 0.077	5.122GlyVal: 5.122 ± 0.094	0.642GlyTrp: 0.642 ± 0.028	3.294GlyTyr: 3.294 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.215HisAla: 1.215 ± 0.035	0.299HisCys: 0.299 ± 0.02	0.869HisAsp: 0.869 ± 0.034	1.138HisGlu: 1.138 ± 0.037	0.856HisPhe: 0.856 ± 0.033	1.302HisGly: 1.302 ± 0.042	0.409HisHis: 0.409 ± 0.026	1.444HisIle: 1.444 ± 0.047	0.926HisLys: 0.926 ± 0.033	1.682HisLeu: 1.682 ± 0.036	0.582HisMet: 0.582 ± 0.026	0.695HisAsn: 0.695 ± 0.031	0.875HisPro: 0.875 ± 0.034	0.585HisGln: 0.585 ± 0.029	0.833HisArg: 0.833 ± 0.035	0.947HisSer: 0.947 ± 0.037	1.072HisThr: 1.072 ± 0.041	1.11HisVal: 1.11 ± 0.035	0.175HisTrp: 0.175 ± 0.016	0.739HisTyr: 0.739 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.702IleAla: 5.702 ± 0.089	1.469IleCys: 1.469 ± 0.044	3.856IleAsp: 3.856 ± 0.087	5.268IleGlu: 5.268 ± 0.098	3.217IlePhe: 3.217 ± 0.071	5.333IleGly: 5.333 ± 0.094	1.468IleHis: 1.468 ± 0.043	4.829IleIle: 4.829 ± 0.09	3.938IleLys: 3.938 ± 0.086	7.573IleLeu: 7.573 ± 0.105	1.919IleMet: 1.919 ± 0.049	2.455IleAsn: 2.455 ± 0.059	3.328IlePro: 3.328 ± 0.074	2.673IleGln: 2.673 ± 0.059	3.701IleArg: 3.701 ± 0.056	4.857IleSer: 4.857 ± 0.079	4.058IleThr: 4.058 ± 0.081	5.363IleVal: 5.363 ± 0.082	0.653IleTrp: 0.653 ± 0.029	2.804IleTyr: 2.804 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.672LysAla: 4.672 ± 0.082	0.746LysCys: 0.746 ± 0.027	3.805LysAsp: 3.805 ± 0.07	8.46LysGlu: 8.46 ± 0.122	2.094LysPhe: 2.094 ± 0.052	4.287LysGly: 4.287 ± 0.074	1.094LysHis: 1.094 ± 0.034	5.482LysIle: 5.482 ± 0.088	7.194LysLys: 7.194 ± 0.1	5.636LysLeu: 5.636 ± 0.081	2.439LysMet: 2.439 ± 0.046	3.6LysAsn: 3.6 ± 0.077	1.812LysPro: 1.812 ± 0.05	2.564LysGln: 2.564 ± 0.054	3.433LysArg: 3.433 ± 0.068	3.426LysSer: 3.426 ± 0.07	3.619LysThr: 3.619 ± 0.063	4.657LysVal: 4.657 ± 0.069	0.678LysTrp: 0.678 ± 0.029	3.072LysTyr: 3.072 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	6.596LeuAla: 6.596 ± 0.113	1.557LeuCys: 1.557 ± 0.044	4.507LeuAsp: 4.507 ± 0.078	7.21LeuGlu: 7.21 ± 0.11	4.168LeuPhe: 4.168 ± 0.078	5.971LeuGly: 5.971 ± 0.089	1.604LeuHis: 1.604 ± 0.049	6.134LeuIle: 6.134 ± 0.101	6.303LeuLys: 6.303 ± 0.074	8.998LeuLeu: 8.998 ± 0.136	2.502LeuMet: 2.502 ± 0.055	3.59LeuAsn: 3.59 ± 0.066	3.492LeuPro: 3.492 ± 0.06	3.17LeuGln: 3.17 ± 0.067	3.784LeuArg: 3.784 ± 0.074	6.032LeuSer: 6.032 ± 0.086	4.949LeuThr: 4.949 ± 0.083	5.506LeuVal: 5.506 ± 0.09	0.808LeuTrp: 0.808 ± 0.032	3.448LeuTyr: 3.448 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.324MetAla: 2.324 ± 0.052	0.357MetCys: 0.357 ± 0.023	1.663MetAsp: 1.663 ± 0.044	2.91MetGlu: 2.91 ± 0.063	1.091MetPhe: 1.091 ± 0.037	2.075MetGly: 2.075 ± 0.051	0.48MetHis: 0.48 ± 0.024	2.422MetIle: 2.422 ± 0.052	2.825MetLys: 2.825 ± 0.062	2.878MetLeu: 2.878 ± 0.058	0.973MetMet: 0.973 ± 0.037	1.489MetAsn: 1.489 ± 0.042	1.057MetPro: 1.057 ± 0.034	1.096MetGln: 1.096 ± 0.035	1.363MetArg: 1.363 ± 0.036	1.723MetSer: 1.723 ± 0.048	1.811MetThr: 1.811 ± 0.051	1.751MetVal: 1.751 ± 0.048	0.249MetTrp: 0.249 ± 0.018	0.97MetTyr: 0.97 ± 0.038	0.0MetXaa: 0.0 ± 0.0
Asn	2.752AsnAla: 2.752 ± 0.054	0.616AsnCys: 0.616 ± 0.03	1.846AsnAsp: 1.846 ± 0.042	2.961AsnGlu: 2.961 ± 0.062	1.543AsnPhe: 1.543 ± 0.037	3.246AsnGly: 3.246 ± 0.072	0.781AsnHis: 0.781 ± 0.035	3.153AsnIle: 3.153 ± 0.062	2.307AsnLys: 2.307 ± 0.056	3.705AsnLeu: 3.705 ± 0.061	1.281AsnMet: 1.281 ± 0.042	1.505AsnAsn: 1.505 ± 0.054	1.853AsnPro: 1.853 ± 0.052	1.484AsnGln: 1.484 ± 0.039	1.951AsnArg: 1.951 ± 0.044	1.975AsnSer: 1.975 ± 0.045	2.207AsnThr: 2.207 ± 0.052	2.686AsnVal: 2.686 ± 0.068	0.42AsnTrp: 0.42 ± 0.022	1.865AsnTyr: 1.865 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.24ProAla: 2.24 ± 0.058	0.43ProCys: 0.43 ± 0.022	1.962ProAsp: 1.962 ± 0.053	3.427ProGlu: 3.427 ± 0.071	1.538ProPhe: 1.538 ± 0.041	2.116ProGly: 2.116 ± 0.052	0.58ProHis: 0.58 ± 0.027	2.062ProIle: 2.062 ± 0.055	2.071ProLys: 2.071 ± 0.052	2.71ProLeu: 2.71 ± 0.058	0.909ProMet: 0.909 ± 0.033	1.196ProAsn: 1.196 ± 0.036	0.679ProPro: 0.679 ± 0.031	1.059ProGln: 1.059 ± 0.038	0.933ProArg: 0.933 ± 0.037	1.679ProSer: 1.679 ± 0.048	1.507ProThr: 1.507 ± 0.042	2.797ProVal: 2.797 ± 0.053	0.31ProTrp: 0.31 ± 0.022	1.452ProTyr: 1.452 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.325GlnAla: 2.325 ± 0.047	0.4GlnCys: 0.4 ± 0.021	1.361GlnAsp: 1.361 ± 0.042	3.17GlnGlu: 3.17 ± 0.068	1.327GlnPhe: 1.327 ± 0.043	2.094GlnGly: 2.094 ± 0.056	0.462GlnHis: 0.462 ± 0.026	2.983GlnIle: 2.983 ± 0.056	3.48GlnLys: 3.48 ± 0.073	2.978GlnLeu: 2.978 ± 0.062	1.429GlnMet: 1.429 ± 0.04	1.642GlnAsn: 1.642 ± 0.047	0.922GlnPro: 0.922 ± 0.036	1.267GlnGln: 1.267 ± 0.052	1.551GlnArg: 1.551 ± 0.04	1.755GlnSer: 1.755 ± 0.047	1.906GlnThr: 1.906 ± 0.047	2.151GlnVal: 2.151 ± 0.048	0.312GlnTrp: 0.312 ± 0.021	1.394GlnTyr: 1.394 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.783ArgAla: 2.783 ± 0.053	0.576ArgCys: 0.576 ± 0.028	1.907ArgAsp: 1.907 ± 0.051	4.354ArgGlu: 4.354 ± 0.086	1.838ArgPhe: 1.838 ± 0.053	2.627ArgGly: 2.627 ± 0.063	0.765ArgHis: 0.765 ± 0.031	3.445ArgIle: 3.445 ± 0.069	3.952ArgLys: 3.952 ± 0.071	3.762ArgLeu: 3.762 ± 0.077	1.648ArgMet: 1.648 ± 0.045	2.0ArgAsn: 2.0 ± 0.047	1.266ArgPro: 1.266 ± 0.04	1.822ArgGln: 1.822 ± 0.047	2.372ArgArg: 2.372 ± 0.058	2.052ArgSer: 2.052 ± 0.046	2.309ArgThr: 2.309 ± 0.052	2.683ArgVal: 2.683 ± 0.062	0.371ArgTrp: 0.371 ± 0.022	1.873ArgTyr: 1.873 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	3.91SerAla: 3.91 ± 0.069	0.818SerCys: 0.818 ± 0.036	2.845SerAsp: 2.845 ± 0.064	4.248SerGlu: 4.248 ± 0.082	2.622SerPhe: 2.622 ± 0.057	4.615SerGly: 4.615 ± 0.079	0.995SerHis: 0.995 ± 0.036	4.03SerIle: 4.03 ± 0.077	3.332SerLys: 3.332 ± 0.064	4.767SerLeu: 4.767 ± 0.083	1.768SerMet: 1.768 ± 0.045	1.963SerAsn: 1.963 ± 0.054	1.646SerPro: 1.646 ± 0.053	1.697SerGln: 1.697 ± 0.045	2.474SerArg: 2.474 ± 0.057	3.212SerSer: 3.212 ± 0.073	2.522SerThr: 2.522 ± 0.063	4.19SerVal: 4.19 ± 0.073	0.514SerTrp: 0.514 ± 0.022	2.444SerTyr: 2.444 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.0ThrAla: 4.0 ± 0.067	0.627ThrCys: 0.627 ± 0.029	2.882ThrAsp: 2.882 ± 0.059	4.328ThrGlu: 4.328 ± 0.084	2.316ThrPhe: 2.316 ± 0.054	4.193ThrGly: 4.193 ± 0.081	0.854ThrHis: 0.854 ± 0.033	3.945ThrIle: 3.945 ± 0.065	3.378ThrLys: 3.378 ± 0.064	4.815ThrLeu: 4.815 ± 0.074	1.555ThrMet: 1.555 ± 0.043	1.992ThrAsn: 1.992 ± 0.045	1.984ThrPro: 1.984 ± 0.065	1.341ThrGln: 1.341 ± 0.049	1.765ThrArg: 1.765 ± 0.047	2.762ThrSer: 2.762 ± 0.059	2.79ThrThr: 2.79 ± 0.068	4.399ThrVal: 4.399 ± 0.078	0.467ThrTrp: 0.467 ± 0.025	2.14ThrTyr: 2.14 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.679ValAla: 4.679 ± 0.08	1.17ValCys: 1.17 ± 0.038	3.584ValAsp: 3.584 ± 0.074	5.142ValGlu: 5.142 ± 0.078	3.15ValPhe: 3.15 ± 0.066	4.507ValGly: 4.507 ± 0.082	1.178ValHis: 1.178 ± 0.037	5.395ValIle: 5.395 ± 0.097	4.782ValLys: 4.782 ± 0.081	6.92ValLeu: 6.92 ± 0.102	2.071ValMet: 2.071 ± 0.049	2.566ValAsn: 2.566 ± 0.058	2.513ValPro: 2.513 ± 0.056	2.243ValGln: 2.243 ± 0.049	3.075ValArg: 3.075 ± 0.062	4.452ValSer: 4.452 ± 0.076	4.129ValThr: 4.129 ± 0.067	4.774ValVal: 4.774 ± 0.086	0.717ValTrp: 0.717 ± 0.034	2.749ValTyr: 2.749 ± 0.054	0.001ValXaa: 0.001 ± 0.001
Trp	0.488TrpAla: 0.488 ± 0.024	0.156TrpCys: 0.156 ± 0.014	0.5TrpAsp: 0.5 ± 0.027	0.734TrpGlu: 0.734 ± 0.029	0.379TrpPhe: 0.379 ± 0.022	0.621TrpGly: 0.621 ± 0.03	0.134TrpHis: 0.134 ± 0.013	0.704TrpIle: 0.704 ± 0.033	0.887TrpLys: 0.887 ± 0.034	0.799TrpLeu: 0.799 ± 0.032	0.38TrpMet: 0.38 ± 0.022	0.558TrpAsn: 0.558 ± 0.029	0.177TrpPro: 0.177 ± 0.017	0.344TrpGln: 0.344 ± 0.02	0.406TrpArg: 0.406 ± 0.022	0.447TrpSer: 0.447 ± 0.024	0.437TrpThr: 0.437 ± 0.026	0.525TrpVal: 0.525 ± 0.025	0.076TrpTrp: 0.076 ± 0.01	0.374TrpTyr: 0.374 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.785TyrAla: 2.785 ± 0.053	0.634TyrCys: 0.634 ± 0.027	2.361TyrAsp: 2.361 ± 0.063	3.368TyrGlu: 3.368 ± 0.067	1.916TyrPhe: 1.916 ± 0.052	2.925TyrGly: 2.925 ± 0.064	0.945TyrHis: 0.945 ± 0.032	2.892TyrIle: 2.892 ± 0.059	2.222TyrLys: 2.222 ± 0.051	3.95TyrLeu: 3.95 ± 0.079	1.088TyrMet: 1.088 ± 0.04	1.62TyrAsn: 1.62 ± 0.049	1.407TyrPro: 1.407 ± 0.042	1.737TyrGln: 1.737 ± 0.047	2.17TyrArg: 2.17 ± 0.054	2.1TyrSer: 2.1 ± 0.051	2.182TyrThr: 2.182 ± 0.064	2.671TyrVal: 2.671 ± 0.058	0.369TyrTrp: 0.369 ± 0.019	1.853TyrTyr: 1.853 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2717 proteins (842039 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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