Amino acid dipepetide frequency for Mycolicibacterium brisbanense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.46AlaAla: 20.46 ± 0.128	1.024AlaCys: 1.024 ± 0.021	8.55AlaAsp: 8.55 ± 0.078	7.77AlaGlu: 7.77 ± 0.064	3.518AlaPhe: 3.518 ± 0.045	11.759AlaGly: 11.759 ± 0.078	2.718AlaHis: 2.718 ± 0.035	5.362AlaIle: 5.362 ± 0.048	3.106AlaLys: 3.106 ± 0.044	13.102AlaLeu: 13.102 ± 0.085	2.947AlaMet: 2.947 ± 0.038	2.631AlaAsn: 2.631 ± 0.034	6.406AlaPro: 6.406 ± 0.075	4.206AlaGln: 4.206 ± 0.047	8.366AlaArg: 8.366 ± 0.064	6.017AlaSer: 6.017 ± 0.049	7.46AlaThr: 7.46 ± 0.066	12.104AlaVal: 12.104 ± 0.079	1.646AlaTrp: 1.646 ± 0.031	2.388AlaTyr: 2.388 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.103CysAla: 1.103 ± 0.025	0.091CysCys: 0.091 ± 0.006	0.538CysAsp: 0.538 ± 0.016	0.411CysGlu: 0.411 ± 0.014	0.225CysPhe: 0.225 ± 0.011	0.949CysGly: 0.949 ± 0.022	0.2CysHis: 0.2 ± 0.009	0.276CysIle: 0.276 ± 0.012	0.124CysLys: 0.124 ± 0.007	0.661CysLeu: 0.661 ± 0.018	0.139CysMet: 0.139 ± 0.008	0.171CysAsn: 0.171 ± 0.008	0.519CysPro: 0.519 ± 0.018	0.22CysGln: 0.22 ± 0.011	0.584CysArg: 0.584 ± 0.019	0.46CysSer: 0.46 ± 0.015	0.534CysThr: 0.534 ± 0.018	0.67CysVal: 0.67 ± 0.016	0.13CysTrp: 0.13 ± 0.009	0.196CysTyr: 0.196 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.951AspAla: 7.951 ± 0.061	0.446AspCys: 0.446 ± 0.016	4.226AspAsp: 4.226 ± 0.053	4.021AspGlu: 4.021 ± 0.053	1.727AspPhe: 1.727 ± 0.028	5.859AspGly: 5.859 ± 0.047	1.465AspHis: 1.465 ± 0.03	2.7AspIle: 2.7 ± 0.039	1.334AspLys: 1.334 ± 0.029	5.895AspLeu: 5.895 ± 0.048	1.07AspMet: 1.07 ± 0.022	1.296AspAsn: 1.296 ± 0.027	4.336AspPro: 4.336 ± 0.043	1.846AspGln: 1.846 ± 0.03	4.523AspArg: 4.523 ± 0.048	2.794AspSer: 2.794 ± 0.038	3.379AspThr: 3.379 ± 0.039	5.334AspVal: 5.334 ± 0.058	1.002AspTrp: 1.002 ± 0.023	1.45AspTyr: 1.45 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	5.835GluAla: 5.835 ± 0.054	0.366GluCys: 0.366 ± 0.012	2.33GluAsp: 2.33 ± 0.035	2.266GluGlu: 2.266 ± 0.036	1.858GluPhe: 1.858 ± 0.027	3.081GluGly: 3.081 ± 0.038	1.548GluHis: 1.548 ± 0.026	2.556GluIle: 2.556 ± 0.034	1.232GluLys: 1.232 ± 0.027	6.571GluLeu: 6.571 ± 0.067	0.998GluMet: 0.998 ± 0.02	1.1GluAsn: 1.1 ± 0.021	3.0GluPro: 3.0 ± 0.044	2.298GluGln: 2.298 ± 0.031	4.176GluArg: 4.176 ± 0.05	2.741GluSer: 2.741 ± 0.038	2.651GluThr: 2.651 ± 0.042	4.107GluVal: 4.107 ± 0.048	0.723GluTrp: 0.723 ± 0.021	1.14GluTyr: 1.14 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.063PheAla: 4.063 ± 0.043	0.311PheCys: 0.311 ± 0.012	2.527PheAsp: 2.527 ± 0.032	1.556PheGlu: 1.556 ± 0.029	0.997PhePhe: 0.997 ± 0.025	3.492PheGly: 3.492 ± 0.043	0.673PheHis: 0.673 ± 0.017	1.162PheIle: 1.162 ± 0.023	0.541PheLys: 0.541 ± 0.015	2.537PheLeu: 2.537 ± 0.033	0.511PheMet: 0.511 ± 0.015	0.775PheAsn: 0.775 ± 0.021	1.408PhePro: 1.408 ± 0.028	0.711PheGln: 0.711 ± 0.018	1.621PheArg: 1.621 ± 0.027	1.704PheSer: 1.704 ± 0.028	2.151PheThr: 2.151 ± 0.034	2.628PheVal: 2.628 ± 0.033	0.439PheTrp: 0.439 ± 0.016	0.722PheTyr: 0.722 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.073GlyAla: 10.073 ± 0.077	0.793GlyCys: 0.793 ± 0.021	4.874GlyAsp: 4.874 ± 0.049	4.172GlyGlu: 4.172 ± 0.044	3.138GlyPhe: 3.138 ± 0.043	7.674GlyGly: 7.674 ± 0.094	2.09GlyHis: 2.09 ± 0.03	4.299GlyIle: 4.299 ± 0.044	2.297GlyLys: 2.297 ± 0.031	8.671GlyLeu: 8.671 ± 0.062	2.097GlyMet: 2.097 ± 0.032	2.044GlyAsn: 2.044 ± 0.034	4.437GlyPro: 4.437 ± 0.051	2.868GlyGln: 2.868 ± 0.038	6.029GlyArg: 6.029 ± 0.058	5.211GlySer: 5.211 ± 0.052	5.324GlyThr: 5.324 ± 0.051	7.67GlyVal: 7.67 ± 0.065	1.643GlyTrp: 1.643 ± 0.03	2.48GlyTyr: 2.48 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.51HisAla: 2.51 ± 0.035	0.221HisCys: 0.221 ± 0.011	1.486HisAsp: 1.486 ± 0.031	1.082HisGlu: 1.082 ± 0.025	0.686HisPhe: 0.686 ± 0.018	2.169HisGly: 2.169 ± 0.033	0.732HisHis: 0.732 ± 0.02	0.916HisIle: 0.916 ± 0.021	0.387HisLys: 0.387 ± 0.013	2.177HisLeu: 2.177 ± 0.036	0.408HisMet: 0.408 ± 0.014	0.519HisAsn: 0.519 ± 0.016	1.681HisPro: 1.681 ± 0.027	0.693HisGln: 0.693 ± 0.015	1.924HisArg: 1.924 ± 0.031	1.125HisSer: 1.125 ± 0.023	1.298HisThr: 1.298 ± 0.023	1.806HisVal: 1.806 ± 0.031	0.409HisTrp: 0.409 ± 0.014	0.574HisTyr: 0.574 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.543IleAla: 6.543 ± 0.054	0.416IleCys: 0.416 ± 0.015	3.427IleAsp: 3.427 ± 0.039	2.559IleGlu: 2.559 ± 0.037	1.082IlePhe: 1.082 ± 0.024	4.651IleGly: 4.651 ± 0.042	0.832IleHis: 0.832 ± 0.018	1.536IleIle: 1.536 ± 0.029	0.907IleLys: 0.907 ± 0.02	3.149IleLeu: 3.149 ± 0.039	0.634IleMet: 0.634 ± 0.019	1.144IleAsn: 1.144 ± 0.024	2.424IlePro: 2.424 ± 0.034	0.969IleGln: 0.969 ± 0.022	2.666IleArg: 2.666 ± 0.039	2.365IleSer: 2.365 ± 0.034	2.937IleThr: 2.937 ± 0.035	3.947IleVal: 3.947 ± 0.04	0.486IleTrp: 0.486 ± 0.016	0.847IleTyr: 0.847 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.733LysAla: 2.733 ± 0.046	0.118LysCys: 0.118 ± 0.007	1.153LysAsp: 1.153 ± 0.025	0.934LysGlu: 0.934 ± 0.019	0.639LysPhe: 0.639 ± 0.018	1.537LysGly: 1.537 ± 0.027	0.512LysHis: 0.512 ± 0.015	1.04LysIle: 1.04 ± 0.022	0.627LysLys: 0.627 ± 0.022	2.257LysLeu: 2.257 ± 0.035	0.475LysMet: 0.475 ± 0.017	0.539LysAsn: 0.539 ± 0.017	1.539LysPro: 1.539 ± 0.029	0.756LysGln: 0.756 ± 0.021	1.572LysArg: 1.572 ± 0.025	1.222LysSer: 1.222 ± 0.024	1.411LysThr: 1.411 ± 0.024	1.902LysVal: 1.902 ± 0.033	0.318LysTrp: 0.318 ± 0.013	0.495LysTyr: 0.495 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.213LeuAla: 14.213 ± 0.095	0.817LeuCys: 0.817 ± 0.016	6.506LeuAsp: 6.506 ± 0.057	4.181LeuGlu: 4.181 ± 0.051	2.718LeuPhe: 2.718 ± 0.042	8.734LeuGly: 8.734 ± 0.062	2.129LeuHis: 2.129 ± 0.031	4.265LeuIle: 4.265 ± 0.046	1.857LeuLys: 1.857 ± 0.028	9.637LeuLeu: 9.637 ± 0.08	1.768LeuMet: 1.768 ± 0.026	2.136LeuAsn: 2.136 ± 0.035	5.755LeuPro: 5.755 ± 0.054	2.71LeuGln: 2.71 ± 0.035	7.462LeuArg: 7.462 ± 0.074	5.664LeuSer: 5.664 ± 0.057	6.563LeuThr: 6.563 ± 0.05	8.348LeuVal: 8.348 ± 0.067	1.239LeuTrp: 1.239 ± 0.027	1.704LeuTyr: 1.704 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.665MetAla: 2.665 ± 0.035	0.191MetCys: 0.191 ± 0.009	0.864MetAsp: 0.864 ± 0.02	0.645MetGlu: 0.645 ± 0.018	0.644MetPhe: 0.644 ± 0.019	1.509MetGly: 1.509 ± 0.027	0.429MetHis: 0.429 ± 0.014	0.905MetIle: 0.905 ± 0.023	0.463MetLys: 0.463 ± 0.017	2.06MetLeu: 2.06 ± 0.032	0.403MetMet: 0.403 ± 0.015	0.5MetAsn: 0.5 ± 0.016	1.213MetPro: 1.213 ± 0.023	0.578MetGln: 0.578 ± 0.017	1.515MetArg: 1.515 ± 0.024	1.583MetSer: 1.583 ± 0.026	1.922MetThr: 1.922 ± 0.028	1.679MetVal: 1.679 ± 0.032	0.26MetTrp: 0.26 ± 0.011	0.351MetTyr: 0.351 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.719AsnAla: 2.719 ± 0.039	0.21AsnCys: 0.21 ± 0.009	1.266AsnAsp: 1.266 ± 0.027	0.953AsnGlu: 0.953 ± 0.02	0.661AsnPhe: 0.661 ± 0.018	2.129AsnGly: 2.129 ± 0.035	0.519AsnHis: 0.519 ± 0.014	1.012AsnIle: 1.012 ± 0.022	0.487AsnLys: 0.487 ± 0.016	2.121AsnLeu: 2.121 ± 0.029	0.435AsnMet: 0.435 ± 0.013	0.617AsnAsn: 0.617 ± 0.018	1.834AsnPro: 1.834 ± 0.032	0.668AsnGln: 0.668 ± 0.019	1.576AsnArg: 1.576 ± 0.03	1.2AsnSer: 1.2 ± 0.024	1.41AsnThr: 1.41 ± 0.031	1.842AsnVal: 1.842 ± 0.033	0.397AsnTrp: 0.397 ± 0.013	0.595AsnTyr: 0.595 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.561ProAla: 7.561 ± 0.08	0.323ProCys: 0.323 ± 0.012	4.4ProAsp: 4.4 ± 0.048	3.54ProGlu: 3.54 ± 0.046	1.675ProPhe: 1.675 ± 0.026	5.596ProGly: 5.596 ± 0.053	1.269ProHis: 1.269 ± 0.027	2.204ProIle: 2.204 ± 0.031	1.278ProLys: 1.278 ± 0.023	4.867ProLeu: 4.867 ± 0.049	1.205ProMet: 1.205 ± 0.022	1.33ProAsn: 1.33 ± 0.024	3.492ProPro: 3.492 ± 0.065	1.965ProGln: 1.965 ± 0.03	3.291ProArg: 3.291 ± 0.045	3.021ProSer: 3.021 ± 0.035	3.467ProThr: 3.467 ± 0.04	5.123ProVal: 5.123 ± 0.053	0.893ProTrp: 0.893 ± 0.021	1.21ProTyr: 1.21 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.763GlnAla: 3.763 ± 0.044	0.232GlnCys: 0.232 ± 0.01	1.297GlnAsp: 1.297 ± 0.027	1.094GlnGlu: 1.094 ± 0.021	1.038GlnPhe: 1.038 ± 0.023	2.06GlnGly: 2.06 ± 0.031	0.81GlnHis: 0.81 ± 0.023	1.586GlnIle: 1.586 ± 0.029	0.639GlnLys: 0.639 ± 0.019	3.694GlnLeu: 3.694 ± 0.041	0.709GlnMet: 0.709 ± 0.019	0.662GlnAsn: 0.662 ± 0.02	1.991GlnPro: 1.991 ± 0.03	1.404GlnGln: 1.404 ± 0.033	2.837GlnArg: 2.837 ± 0.039	1.589GlnSer: 1.589 ± 0.026	1.703GlnThr: 1.703 ± 0.027	2.499GlnVal: 2.499 ± 0.034	0.627GlnTrp: 0.627 ± 0.017	0.686GlnTyr: 0.686 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.022ArgAla: 8.022 ± 0.062	0.578ArgCys: 0.578 ± 0.015	4.226ArgAsp: 4.226 ± 0.044	3.706ArgGlu: 3.706 ± 0.043	2.379ArgPhe: 2.379 ± 0.03	4.901ArgGly: 4.901 ± 0.05	1.79ArgHis: 1.79 ± 0.032	3.459ArgIle: 3.459 ± 0.035	1.568ArgLys: 1.568 ± 0.027	7.314ArgLeu: 7.314 ± 0.064	1.754ArgMet: 1.754 ± 0.025	1.668ArgAsn: 1.668 ± 0.03	3.77ArgPro: 3.77 ± 0.042	2.264ArgGln: 2.264 ± 0.034	6.256ArgArg: 6.256 ± 0.076	3.92ArgSer: 3.92 ± 0.044	4.202ArgThr: 4.202 ± 0.045	5.429ArgVal: 5.429 ± 0.057	1.284ArgTrp: 1.284 ± 0.027	1.928ArgTyr: 1.928 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.124SerAla: 7.124 ± 0.049	0.442SerCys: 0.442 ± 0.014	3.199SerAsp: 3.199 ± 0.034	2.525SerGlu: 2.525 ± 0.036	1.679SerPhe: 1.679 ± 0.03	5.685SerGly: 5.685 ± 0.063	1.12SerHis: 1.12 ± 0.021	2.249SerIle: 2.249 ± 0.035	1.168SerLys: 1.168 ± 0.024	4.743SerLeu: 4.743 ± 0.048	1.289SerMet: 1.289 ± 0.025	1.157SerAsn: 1.157 ± 0.021	3.047SerPro: 3.047 ± 0.043	1.52SerGln: 1.52 ± 0.025	3.553SerArg: 3.553 ± 0.046	3.105SerSer: 3.105 ± 0.048	3.434SerThr: 3.434 ± 0.038	4.594SerVal: 4.594 ± 0.05	0.94SerTrp: 0.94 ± 0.02	1.279SerTyr: 1.279 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.327ThrAla: 8.327 ± 0.062	0.449ThrCys: 0.449 ± 0.016	3.876ThrAsp: 3.876 ± 0.048	3.156ThrGlu: 3.156 ± 0.039	1.897ThrPhe: 1.897 ± 0.03	5.98ThrGly: 5.98 ± 0.054	1.234ThrHis: 1.234 ± 0.023	2.509ThrIle: 2.509 ± 0.034	1.294ThrLys: 1.294 ± 0.024	5.711ThrLeu: 5.711 ± 0.054	1.252ThrMet: 1.252 ± 0.025	1.277ThrAsn: 1.277 ± 0.026	3.995ThrPro: 3.995 ± 0.043	1.586ThrGln: 1.586 ± 0.026	3.615ThrArg: 3.615 ± 0.039	3.229ThrSer: 3.229 ± 0.039	4.111ThrThr: 4.111 ± 0.056	6.13ThrVal: 6.13 ± 0.058	0.863ThrTrp: 0.863 ± 0.02	1.344ThrTyr: 1.344 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.769ValAla: 11.769 ± 0.085	0.77ValCys: 0.77 ± 0.02	5.671ValAsp: 5.671 ± 0.053	4.374ValGlu: 4.374 ± 0.048	2.657ValPhe: 2.657 ± 0.039	6.982ValGly: 6.982 ± 0.063	1.85ValHis: 1.85 ± 0.027	4.082ValIle: 4.082 ± 0.042	1.749ValLys: 1.749 ± 0.032	9.092ValLeu: 9.092 ± 0.066	1.646ValMet: 1.646 ± 0.029	2.128ValAsn: 2.128 ± 0.034	4.693ValPro: 4.693 ± 0.047	2.228ValGln: 2.228 ± 0.031	5.715ValArg: 5.715 ± 0.053	4.84ValSer: 4.84 ± 0.046	5.725ValThr: 5.725 ± 0.048	8.663ValVal: 8.663 ± 0.068	1.064ValTrp: 1.064 ± 0.022	1.662ValTyr: 1.662 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.598TrpAla: 1.598 ± 0.029	0.154TrpCys: 0.154 ± 0.009	0.813TrpAsp: 0.813 ± 0.018	0.613TrpGlu: 0.613 ± 0.016	0.541TrpPhe: 0.541 ± 0.016	1.033TrpGly: 1.033 ± 0.024	0.399TrpHis: 0.399 ± 0.013	0.686TrpIle: 0.686 ± 0.018	0.324TrpLys: 0.324 ± 0.013	1.707TrpLeu: 1.707 ± 0.031	0.34TrpMet: 0.34 ± 0.014	0.447TrpAsn: 0.447 ± 0.013	0.846TrpPro: 0.846 ± 0.017	0.684TrpGln: 0.684 ± 0.018	1.238TrpArg: 1.238 ± 0.026	0.922TrpSer: 0.922 ± 0.019	0.897TrpThr: 0.897 ± 0.023	1.16TrpVal: 1.16 ± 0.025	0.333TrpTrp: 0.333 ± 0.013	0.334TrpTyr: 0.334 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.035	0.248TyrCys: 0.248 ± 0.009	1.423TyrAsp: 1.423 ± 0.027	1.018TyrGlu: 1.018 ± 0.022	0.772TyrPhe: 0.772 ± 0.02	2.105TyrGly: 2.105 ± 0.033	0.486TyrHis: 0.486 ± 0.015	0.719TyrIle: 0.719 ± 0.018	0.394TyrLys: 0.394 ± 0.014	2.443TyrLeu: 2.443 ± 0.035	0.299TyrMet: 0.299 ± 0.012	0.51TyrAsn: 0.51 ± 0.016	1.321TyrPro: 1.321 ± 0.024	0.744TyrGln: 0.744 ± 0.02	1.9TyrArg: 1.9 ± 0.03	1.142TyrSer: 1.142 ± 0.022	1.255TyrThr: 1.255 ± 0.025	1.723TyrVal: 1.723 ± 0.026	0.374TyrTrp: 0.374 ± 0.011	0.519TyrTyr: 0.519 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7125 proteins (2269745 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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