Amino acid dipepetide frequency for Micromonospora rosaria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.558AlaAla: 22.558 ± 0.189
0.971AlaCys: 0.971 ± 0.024
9.212AlaAsp: 9.212 ± 0.083
8.358AlaGlu: 8.358 ± 0.083
3.148AlaPhe: 3.148 ± 0.044
15.234AlaGly: 15.234 ± 0.115
2.734AlaHis: 2.734 ± 0.045
3.413AlaIle: 3.413 ± 0.047
1.917AlaLys: 1.917 ± 0.046
14.435AlaLeu: 14.435 ± 0.124
2.232AlaMet: 2.232 ± 0.041
2.001AlaAsn: 2.001 ± 0.034
7.207AlaPro: 7.207 ± 0.078
3.588AlaGln: 3.588 ± 0.047
10.89AlaArg: 10.89 ± 0.083
5.04AlaSer: 5.04 ± 0.054
8.612AlaThr: 8.612 ± 0.074
13.256AlaVal: 13.256 ± 0.099
1.939AlaTrp: 1.939 ± 0.037
2.761AlaTyr: 2.761 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
1.026CysAla: 1.026 ± 0.023
0.099CysCys: 0.099 ± 0.008
0.486CysAsp: 0.486 ± 0.017
0.311CysGlu: 0.311 ± 0.013
0.19CysPhe: 0.19 ± 0.01
0.877CysGly: 0.877 ± 0.023
0.21CysHis: 0.21 ± 0.01
0.136CysIle: 0.136 ± 0.008
0.071CysLys: 0.071 ± 0.006
0.718CysLeu: 0.718 ± 0.018
0.081CysMet: 0.081 ± 0.006
0.129CysAsn: 0.129 ± 0.009
0.496CysPro: 0.496 ± 0.017
0.193CysGln: 0.193 ± 0.009
0.65CysArg: 0.65 ± 0.019
0.333CysSer: 0.333 ± 0.012
0.443CysThr: 0.443 ± 0.015
0.648CysVal: 0.648 ± 0.018
0.153CysTrp: 0.153 ± 0.008
0.174CysTyr: 0.174 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.504AspAla: 7.504 ± 0.067
0.4AspCys: 0.4 ± 0.017
3.848AspAsp: 3.848 ± 0.046
3.645AspGlu: 3.645 ± 0.046
1.459AspPhe: 1.459 ± 0.027
6.434AspGly: 6.434 ± 0.067
1.382AspHis: 1.382 ± 0.028
1.474AspIle: 1.474 ± 0.03
0.763AspLys: 0.763 ± 0.022
7.376AspLeu: 7.376 ± 0.078
0.655AspMet: 0.655 ± 0.016
0.906AspAsn: 0.906 ± 0.023
5.265AspPro: 5.265 ± 0.066
1.772AspGln: 1.772 ± 0.029
6.149AspArg: 6.149 ± 0.067
2.167AspSer: 2.167 ± 0.036
3.024AspThr: 3.024 ± 0.041
5.042AspVal: 5.042 ± 0.052
1.014AspTrp: 1.014 ± 0.025
1.072AspTyr: 1.072 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
6.315GluAla: 6.315 ± 0.075
0.336GluCys: 0.336 ± 0.014
1.969GluAsp: 1.969 ± 0.039
2.558GluGlu: 2.558 ± 0.048
1.417GluPhe: 1.417 ± 0.028
3.121GluGly: 3.121 ± 0.042
1.371GluHis: 1.371 ± 0.029
2.138GluIle: 2.138 ± 0.037
0.945GluLys: 0.945 ± 0.03
6.063GluLeu: 6.063 ± 0.071
0.77GluMet: 0.77 ± 0.021
0.819GluAsn: 0.819 ± 0.021
3.472GluPro: 3.472 ± 0.052
2.179GluGln: 2.179 ± 0.034
4.933GluArg: 4.933 ± 0.062
2.108GluSer: 2.108 ± 0.032
2.457GluThr: 2.457 ± 0.038
4.921GluVal: 4.921 ± 0.048
0.696GluTrp: 0.696 ± 0.019
1.14GluTyr: 1.14 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.611PheAla: 3.611 ± 0.041
0.255PheCys: 0.255 ± 0.011
1.971PheAsp: 1.971 ± 0.035
1.172PheGlu: 1.172 ± 0.027
0.832PhePhe: 0.832 ± 0.027
2.922PheGly: 2.922 ± 0.041
0.584PheHis: 0.584 ± 0.017
0.587PheIle: 0.587 ± 0.017
0.332PheLys: 0.332 ± 0.014
2.497PheLeu: 2.497 ± 0.037
0.313PheMet: 0.313 ± 0.013
0.517PheAsn: 0.517 ± 0.018
1.312PhePro: 1.312 ± 0.025
0.603PheGln: 0.603 ± 0.018
1.804PheArg: 1.804 ± 0.031
1.209PheSer: 1.209 ± 0.024
1.963PheThr: 1.963 ± 0.032
2.487PheVal: 2.487 ± 0.044
0.425PheTrp: 0.425 ± 0.017
0.546PheTyr: 0.546 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
11.092GlyAla: 11.092 ± 0.089
0.83GlyCys: 0.83 ± 0.024
5.323GlyAsp: 5.323 ± 0.058
4.624GlyGlu: 4.624 ± 0.047
2.709GlyPhe: 2.709 ± 0.041
8.967GlyGly: 8.967 ± 0.096
2.211GlyHis: 2.211 ± 0.037
3.015GlyIle: 3.015 ± 0.039
1.646GlyLys: 1.646 ± 0.035
9.679GlyLeu: 9.679 ± 0.076
1.782GlyMet: 1.782 ± 0.03
1.727GlyAsn: 1.727 ± 0.038
5.799GlyPro: 5.799 ± 0.063
2.877GlyGln: 2.877 ± 0.043
8.468GlyArg: 8.468 ± 0.074
4.713GlySer: 4.713 ± 0.052
6.444GlyThr: 6.444 ± 0.076
8.271GlyVal: 8.271 ± 0.075
2.006GlyTrp: 2.006 ± 0.035
2.543GlyTyr: 2.543 ± 0.037
0.0GlyXaa: 0.0 ± 0.0
His
2.537HisAla: 2.537 ± 0.039
0.195HisCys: 0.195 ± 0.011
1.351HisAsp: 1.351 ± 0.026
1.035HisGlu: 1.035 ± 0.024
0.565HisPhe: 0.565 ± 0.018
2.112HisGly: 2.112 ± 0.035
0.671HisHis: 0.671 ± 0.021
0.501HisIle: 0.501 ± 0.017
0.234HisLys: 0.234 ± 0.011
2.77HisLeu: 2.77 ± 0.037
0.247HisMet: 0.247 ± 0.011
0.351HisAsn: 0.351 ± 0.013
1.843HisPro: 1.843 ± 0.032
0.693HisGln: 0.693 ± 0.019
2.386HisArg: 2.386 ± 0.035
0.834HisSer: 0.834 ± 0.023
1.171HisThr: 1.171 ± 0.026
1.716HisVal: 1.716 ± 0.032
0.352HisTrp: 0.352 ± 0.012
0.432HisTyr: 0.432 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.197IleAla: 4.197 ± 0.046
0.269IleCys: 0.269 ± 0.012
2.121IleAsp: 2.121 ± 0.039
1.787IleGlu: 1.787 ± 0.036
0.788IlePhe: 0.788 ± 0.021
3.258IleGly: 3.258 ± 0.042
0.539IleHis: 0.539 ± 0.018
0.811IleIle: 0.811 ± 0.025
0.514IleLys: 0.514 ± 0.015
2.36IleLeu: 2.36 ± 0.042
0.395IleMet: 0.395 ± 0.015
0.658IleAsn: 0.658 ± 0.02
1.515IlePro: 1.515 ± 0.031
0.665IleGln: 0.665 ± 0.018
2.44IleArg: 2.44 ± 0.038
1.488IleSer: 1.488 ± 0.031
2.005IleThr: 2.005 ± 0.031
2.616IleVal: 2.616 ± 0.041
0.38IleTrp: 0.38 ± 0.013
0.507IleTyr: 0.507 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
1.796LysAla: 1.796 ± 0.043
0.09LysCys: 0.09 ± 0.008
0.689LysAsp: 0.689 ± 0.02
0.699LysGlu: 0.699 ± 0.021
0.332LysPhe: 0.332 ± 0.016
1.13LysGly: 1.13 ± 0.028
0.279LysHis: 0.279 ± 0.012
0.686LysIle: 0.686 ± 0.021
0.405LysLys: 0.405 ± 0.02
1.582LysLeu: 1.582 ± 0.032
0.235LysMet: 0.235 ± 0.012
0.292LysAsn: 0.292 ± 0.012
0.935LysPro: 0.935 ± 0.025
0.503LysGln: 0.503 ± 0.017
1.103LysArg: 1.103 ± 0.028
0.736LysSer: 0.736 ± 0.021
0.871LysThr: 0.871 ± 0.022
1.342LysVal: 1.342 ± 0.032
0.191LysTrp: 0.191 ± 0.012
0.296LysTyr: 0.296 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
17.063LeuAla: 17.063 ± 0.129
0.721LeuCys: 0.721 ± 0.019
7.234LeuAsp: 7.234 ± 0.07
3.648LeuGlu: 3.648 ± 0.047
2.525LeuPhe: 2.525 ± 0.04
9.378LeuGly: 9.378 ± 0.09
2.334LeuHis: 2.334 ± 0.035
2.901LeuIle: 2.901 ± 0.041
1.246LeuLys: 1.246 ± 0.032
12.057LeuLeu: 12.057 ± 0.119
1.329LeuMet: 1.329 ± 0.027
1.538LeuAsn: 1.538 ± 0.032
6.909LeuPro: 6.909 ± 0.065
1.828LeuGln: 1.828 ± 0.034
9.675LeuArg: 9.675 ± 0.092
4.647LeuSer: 4.647 ± 0.056
7.447LeuThr: 7.447 ± 0.066
10.532LeuVal: 10.532 ± 0.087
1.278LeuTrp: 1.278 ± 0.029
1.722LeuTyr: 1.722 ± 0.032
0.0LeuXaa: 0.0 ± 0.0
Met
1.924MetAla: 1.924 ± 0.03
0.104MetCys: 0.104 ± 0.008
0.681MetAsp: 0.681 ± 0.021
0.548MetGlu: 0.548 ± 0.018
0.438MetPhe: 0.438 ± 0.017
1.056MetGly: 1.056 ± 0.024
0.284MetHis: 0.284 ± 0.013
0.593MetIle: 0.593 ± 0.02
0.283MetLys: 0.283 ± 0.012
1.59MetLeu: 1.59 ± 0.028
0.257MetMet: 0.257 ± 0.012
0.318MetAsn: 0.318 ± 0.011
0.998MetPro: 0.998 ± 0.026
0.398MetGln: 0.398 ± 0.014
1.323MetArg: 1.323 ± 0.026
1.119MetSer: 1.119 ± 0.024
1.469MetThr: 1.469 ± 0.028
1.299MetVal: 1.299 ± 0.026
0.191MetTrp: 0.191 ± 0.008
0.273MetTyr: 0.273 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
1.963AsnAla: 1.963 ± 0.033
0.15AsnCys: 0.15 ± 0.009
0.888AsnAsp: 0.888 ± 0.021
0.719AsnGlu: 0.719 ± 0.018
0.471AsnPhe: 0.471 ± 0.017
1.718AsnGly: 1.718 ± 0.039
0.364AsnHis: 0.364 ± 0.013
0.526AsnIle: 0.526 ± 0.021
0.296AsnLys: 0.296 ± 0.014
1.823AsnLeu: 1.823 ± 0.03
0.248AsnMet: 0.248 ± 0.012
0.455AsnAsn: 0.455 ± 0.022
1.418AsnPro: 1.418 ± 0.031
0.558AsnGln: 0.558 ± 0.02
1.387AsnArg: 1.387 ± 0.03
0.828AsnSer: 0.828 ± 0.023
1.039AsnThr: 1.039 ± 0.031
1.333AsnVal: 1.333 ± 0.028
0.297AsnTrp: 0.297 ± 0.013
0.408AsnTyr: 0.408 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
10.544ProAla: 10.544 ± 0.096
0.307ProCys: 0.307 ± 0.013
4.909ProAsp: 4.909 ± 0.063
3.865ProGlu: 3.865 ± 0.045
1.432ProPhe: 1.432 ± 0.03
6.965ProGly: 6.965 ± 0.076
1.256ProHis: 1.256 ± 0.028
1.507ProIle: 1.507 ± 0.031
0.819ProLys: 0.819 ± 0.022
5.388ProLeu: 5.388 ± 0.061
0.938ProMet: 0.938 ± 0.022
0.945ProAsn: 0.945 ± 0.024
4.615ProPro: 4.615 ± 0.076
1.628ProGln: 1.628 ± 0.029
4.079ProArg: 4.079 ± 0.05
2.773ProSer: 2.773 ± 0.041
4.439ProThr: 4.439 ± 0.065
6.337ProVal: 6.337 ± 0.058
0.952ProTrp: 0.952 ± 0.023
1.342ProTyr: 1.342 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.698GlnAla: 3.698 ± 0.044
0.154GlnCys: 0.154 ± 0.009
1.087GlnAsp: 1.087 ± 0.024
1.206GlnGlu: 1.206 ± 0.027
0.734GlnPhe: 0.734 ± 0.021
1.937GlnGly: 1.937 ± 0.034
0.638GlnHis: 0.638 ± 0.017
1.008GlnIle: 1.008 ± 0.025
0.388GlnLys: 0.388 ± 0.016
2.939GlnLeu: 2.939 ± 0.038
0.418GlnMet: 0.418 ± 0.015
0.471GlnAsn: 0.471 ± 0.017
1.933GlnPro: 1.933 ± 0.034
1.176GlnGln: 1.176 ± 0.029
2.853GlnArg: 2.853 ± 0.044
1.094GlnSer: 1.094 ± 0.026
1.358GlnThr: 1.358 ± 0.03
3.02GlnVal: 3.02 ± 0.039
0.52GlnTrp: 0.52 ± 0.015
0.552GlnTyr: 0.552 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
10.801ArgAla: 10.801 ± 0.097
0.651ArgCys: 0.651 ± 0.017
4.89ArgAsp: 4.89 ± 0.059
4.234ArgGlu: 4.234 ± 0.063
2.463ArgPhe: 2.463 ± 0.035
5.926ArgGly: 5.926 ± 0.063
2.375ArgHis: 2.375 ± 0.041
3.244ArgIle: 3.244 ± 0.04
1.137ArgLys: 1.137 ± 0.026
9.875ArgLeu: 9.875 ± 0.087
1.855ArgMet: 1.855 ± 0.03
1.398ArgAsn: 1.398 ± 0.026
5.767ArgPro: 5.767 ± 0.058
2.794ArgGln: 2.794 ± 0.04
9.101ArgArg: 9.101 ± 0.093
4.177ArgSer: 4.177 ± 0.053
5.195ArgThr: 5.195 ± 0.046
6.959ArgVal: 6.959 ± 0.062
1.741ArgTrp: 1.741 ± 0.03
2.257ArgTyr: 2.257 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
5.983SerAla: 5.983 ± 0.058
0.368SerCys: 0.368 ± 0.016
2.163SerAsp: 2.163 ± 0.036
1.708SerGlu: 1.708 ± 0.03
1.401SerPhe: 1.401 ± 0.028
5.209SerGly: 5.209 ± 0.061
0.849SerHis: 0.849 ± 0.02
1.385SerIle: 1.385 ± 0.032
0.652SerLys: 0.652 ± 0.02
4.146SerLeu: 4.146 ± 0.047
0.86SerMet: 0.86 ± 0.022
0.812SerAsn: 0.812 ± 0.021
2.978SerPro: 2.978 ± 0.046
1.034SerGln: 1.034 ± 0.025
3.629SerArg: 3.629 ± 0.043
2.206SerSer: 2.206 ± 0.039
3.138SerThr: 3.138 ± 0.05
3.975SerVal: 3.975 ± 0.05
0.859SerTrp: 0.859 ± 0.02
1.15SerTyr: 1.15 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
9.012ThrAla: 9.012 ± 0.082
0.459ThrCys: 0.459 ± 0.016
3.955ThrAsp: 3.955 ± 0.057
3.076ThrGlu: 3.076 ± 0.043
1.655ThrPhe: 1.655 ± 0.032
7.424ThrGly: 7.424 ± 0.073
1.12ThrHis: 1.12 ± 0.029
1.895ThrIle: 1.895 ± 0.036
0.823ThrLys: 0.823 ± 0.028
6.07ThrLeu: 6.07 ± 0.056
0.991ThrMet: 0.991 ± 0.024
1.111ThrAsn: 1.111 ± 0.028
4.534ThrPro: 4.534 ± 0.057
1.244ThrGln: 1.244 ± 0.028
4.435ThrArg: 4.435 ± 0.053
2.929ThrSer: 2.929 ± 0.048
4.115ThrThr: 4.115 ± 0.066
6.986ThrVal: 6.986 ± 0.066
1.015ThrTrp: 1.015 ± 0.024
1.347ThrTyr: 1.347 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
13.363ValAla: 13.363 ± 0.111
0.739ValCys: 0.739 ± 0.021
6.35ValAsp: 6.35 ± 0.059
4.914ValGlu: 4.914 ± 0.056
2.312ValPhe: 2.312 ± 0.037
7.956ValGly: 7.956 ± 0.083
1.882ValHis: 1.882 ± 0.032
2.594ValIle: 2.594 ± 0.039
1.244ValLys: 1.244 ± 0.029
10.209ValLeu: 10.209 ± 0.084
1.113ValMet: 1.113 ± 0.027
1.68ValAsn: 1.68 ± 0.032
5.844ValPro: 5.844 ± 0.061
2.065ValGln: 2.065 ± 0.034
7.72ValArg: 7.72 ± 0.063
4.187ValSer: 4.187 ± 0.043
6.809ValThr: 6.809 ± 0.074
9.61ValVal: 9.61 ± 0.085
1.142ValTrp: 1.142 ± 0.021
1.528ValTyr: 1.528 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.74TrpAla: 1.74 ± 0.033
0.152TrpCys: 0.152 ± 0.01
0.763TrpAsp: 0.763 ± 0.02
0.611TrpGlu: 0.611 ± 0.018
0.48TrpPhe: 0.48 ± 0.016
0.984TrpGly: 0.984 ± 0.022
0.418TrpHis: 0.418 ± 0.014
0.532TrpIle: 0.532 ± 0.017
0.23TrpLys: 0.23 ± 0.009
2.032TrpLeu: 2.032 ± 0.034
0.241TrpMet: 0.241 ± 0.011
0.381TrpAsn: 0.381 ± 0.016
0.933TrpPro: 0.933 ± 0.02
0.677TrpGln: 0.677 ± 0.02
1.704TrpArg: 1.704 ± 0.032
1.069TrpSer: 1.069 ± 0.026
1.05TrpThr: 1.05 ± 0.025
1.117TrpVal: 1.117 ± 0.024
0.409TrpTrp: 0.409 ± 0.013
0.392TrpTyr: 0.392 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.781TyrAla: 2.781 ± 0.037
0.176TyrCys: 0.176 ± 0.009
1.458TyrAsp: 1.458 ± 0.036
1.009TyrGlu: 1.009 ± 0.023
0.59TyrPhe: 0.59 ± 0.018
2.118TyrGly: 2.118 ± 0.034
0.495TyrHis: 0.495 ± 0.016
0.368TyrIle: 0.368 ± 0.015
0.248TyrLys: 0.248 ± 0.012
2.404TyrLeu: 2.404 ± 0.036
0.184TyrMet: 0.184 ± 0.01
0.38TyrAsn: 0.38 ± 0.016
1.266TyrPro: 1.266 ± 0.028
0.705TyrGln: 0.705 ± 0.02
2.112TyrArg: 2.112 ± 0.033
0.849TyrSer: 0.849 ± 0.02
1.15TyrThr: 1.15 ± 0.031
1.794TyrVal: 1.794 ± 0.031
0.356TyrTrp: 0.356 ± 0.013
0.434TyrTyr: 0.434 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5974 proteins (1999827 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski