Amino acid dipepetide frequency for Nitrosovibrio tenuis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.408AlaAla: 11.408 ± 0.15
1.006AlaCys: 1.006 ± 0.034
4.998AlaAsp: 4.998 ± 0.082
6.339AlaGlu: 6.339 ± 0.099
3.511AlaPhe: 3.511 ± 0.072
8.286AlaGly: 8.286 ± 0.133
2.205AlaHis: 2.205 ± 0.058
5.91AlaIle: 5.91 ± 0.092
3.987AlaLys: 3.987 ± 0.08
10.781AlaLeu: 10.781 ± 0.137
2.778AlaMet: 2.778 ± 0.061
3.175AlaAsn: 3.175 ± 0.056
3.951AlaPro: 3.951 ± 0.073
4.067AlaGln: 4.067 ± 0.084
6.576AlaArg: 6.576 ± 0.103
5.872AlaSer: 5.872 ± 0.096
4.821AlaThr: 4.821 ± 0.092
7.033AlaVal: 7.033 ± 0.103
1.31AlaTrp: 1.31 ± 0.04
2.545AlaTyr: 2.545 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.965CysAla: 0.965 ± 0.037
0.138CysCys: 0.138 ± 0.013
0.516CysAsp: 0.516 ± 0.024
0.521CysGlu: 0.521 ± 0.025
0.346CysPhe: 0.346 ± 0.018
0.967CysGly: 0.967 ± 0.037
0.38CysHis: 0.38 ± 0.025
0.554CysIle: 0.554 ± 0.025
0.326CysLys: 0.326 ± 0.02
0.892CysLeu: 0.892 ± 0.032
0.23CysMet: 0.23 ± 0.018
0.34CysAsn: 0.34 ± 0.021
0.504CysPro: 0.504 ± 0.023
0.265CysGln: 0.265 ± 0.017
0.675CysArg: 0.675 ± 0.028
0.556CysSer: 0.556 ± 0.026
0.462CysThr: 0.462 ± 0.028
0.619CysVal: 0.619 ± 0.028
0.143CysTrp: 0.143 ± 0.011
0.303CysTyr: 0.303 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.148AspAla: 5.148 ± 0.085
0.493AspCys: 0.493 ± 0.022
2.497AspAsp: 2.497 ± 0.05
3.522AspGlu: 3.522 ± 0.071
2.216AspPhe: 2.216 ± 0.056
3.844AspGly: 3.844 ± 0.079
1.222AspHis: 1.222 ± 0.036
3.246AspIle: 3.246 ± 0.064
2.322AspLys: 2.322 ± 0.065
5.111AspLeu: 5.111 ± 0.076
1.226AspMet: 1.226 ± 0.035
1.729AspAsn: 1.729 ± 0.046
2.661AspPro: 2.661 ± 0.051
1.716AspGln: 1.716 ± 0.047
3.05AspArg: 3.05 ± 0.072
2.935AspSer: 2.935 ± 0.06
2.522AspThr: 2.522 ± 0.053
3.625AspVal: 3.625 ± 0.07
0.809AspTrp: 0.809 ± 0.033
1.756AspTyr: 1.756 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.046GluAla: 6.046 ± 0.1
0.469GluCys: 0.469 ± 0.027
2.552GluAsp: 2.552 ± 0.055
3.546GluGlu: 3.546 ± 0.084
2.214GluPhe: 2.214 ± 0.052
3.74GluGly: 3.74 ± 0.064
1.494GluHis: 1.494 ± 0.047
4.168GluIle: 4.168 ± 0.08
3.316GluLys: 3.316 ± 0.081
6.222GluLeu: 6.222 ± 0.09
1.619GluMet: 1.619 ± 0.044
2.292GluAsn: 2.292 ± 0.047
2.537GluPro: 2.537 ± 0.056
2.697GluGln: 2.697 ± 0.068
4.319GluArg: 4.319 ± 0.084
3.19GluSer: 3.19 ± 0.066
3.1GluThr: 3.1 ± 0.069
3.903GluVal: 3.903 ± 0.078
0.793GluTrp: 0.793 ± 0.033
1.544GluTyr: 1.544 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.565PheAla: 3.565 ± 0.076
0.473PheCys: 0.473 ± 0.026
2.4PheAsp: 2.4 ± 0.058
2.244PheGlu: 2.244 ± 0.051
1.726PhePhe: 1.726 ± 0.052
3.099PheGly: 3.099 ± 0.072
0.914PheHis: 0.914 ± 0.033
2.325PheIle: 2.325 ± 0.053
1.34PheLys: 1.34 ± 0.046
3.56PheLeu: 3.56 ± 0.072
0.927PheMet: 0.927 ± 0.038
1.533PheAsn: 1.533 ± 0.041
1.786PhePro: 1.786 ± 0.048
1.21PheGln: 1.21 ± 0.037
2.216PheArg: 2.216 ± 0.049
2.796PheSer: 2.796 ± 0.062
2.109PheThr: 2.109 ± 0.062
2.536PheVal: 2.536 ± 0.055
0.537PheTrp: 0.537 ± 0.028
1.225PheTyr: 1.225 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
6.656GlyAla: 6.656 ± 0.103
0.862GlyCys: 0.862 ± 0.036
3.688GlyAsp: 3.688 ± 0.059
4.419GlyGlu: 4.419 ± 0.076
3.276GlyPhe: 3.276 ± 0.067
5.991GlyGly: 5.991 ± 0.115
1.886GlyHis: 1.886 ± 0.051
5.141GlyIle: 5.141 ± 0.076
4.106GlyLys: 4.106 ± 0.068
7.645GlyLeu: 7.645 ± 0.101
2.361GlyMet: 2.361 ± 0.057
2.798GlyAsn: 2.798 ± 0.068
2.577GlyPro: 2.577 ± 0.062
2.741GlyGln: 2.741 ± 0.058
4.622GlyArg: 4.622 ± 0.087
4.672GlySer: 4.672 ± 0.09
3.99GlyThr: 3.99 ± 0.068
5.401GlyVal: 5.401 ± 0.084
1.219GlyTrp: 1.219 ± 0.045
2.614GlyTyr: 2.614 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
2.369HisAla: 2.369 ± 0.059
0.307HisCys: 0.307 ± 0.02
1.274HisAsp: 1.274 ± 0.044
1.425HisGlu: 1.425 ± 0.038
0.96HisPhe: 0.96 ± 0.03
2.081HisGly: 2.081 ± 0.054
0.722HisHis: 0.722 ± 0.032
1.435HisIle: 1.435 ± 0.043
0.89HisLys: 0.89 ± 0.029
2.367HisLeu: 2.367 ± 0.05
0.56HisMet: 0.56 ± 0.026
0.78HisAsn: 0.78 ± 0.03
1.558HisPro: 1.558 ± 0.044
0.883HisGln: 0.883 ± 0.03
1.481HisArg: 1.481 ± 0.041
1.401HisSer: 1.401 ± 0.039
1.093HisThr: 1.093 ± 0.041
1.542HisVal: 1.542 ± 0.044
0.329HisTrp: 0.329 ± 0.02
0.825HisTyr: 0.825 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.668IleAla: 6.668 ± 0.092
0.593IleCys: 0.593 ± 0.026
3.497IleAsp: 3.497 ± 0.074
3.812IleGlu: 3.812 ± 0.067
2.238IlePhe: 2.238 ± 0.059
4.64IleGly: 4.64 ± 0.078
1.32IleHis: 1.32 ± 0.036
3.136IleIle: 3.136 ± 0.057
2.53IleLys: 2.53 ± 0.062
5.322IleLeu: 5.322 ± 0.091
1.234IleMet: 1.234 ± 0.038
2.275IleAsn: 2.275 ± 0.052
3.014IlePro: 3.014 ± 0.064
1.899IleGln: 1.899 ± 0.052
3.565IleArg: 3.565 ± 0.061
3.987IleSer: 3.987 ± 0.068
3.322IleThr: 3.322 ± 0.061
3.965IleVal: 3.965 ± 0.072
0.589IleTrp: 0.589 ± 0.028
1.589IleTyr: 1.589 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.052LysAla: 4.052 ± 0.076
0.305LysCys: 0.305 ± 0.019
2.135LysAsp: 2.135 ± 0.052
2.545LysGlu: 2.545 ± 0.063
1.347LysPhe: 1.347 ± 0.042
2.803LysGly: 2.803 ± 0.061
1.014LysHis: 1.014 ± 0.036
2.675LysIle: 2.675 ± 0.062
2.287LysLys: 2.287 ± 0.073
4.523LysLeu: 4.523 ± 0.077
1.165LysMet: 1.165 ± 0.035
1.776LysAsn: 1.776 ± 0.057
2.39LysPro: 2.39 ± 0.061
1.88LysGln: 1.88 ± 0.049
2.95LysArg: 2.95 ± 0.066
2.598LysSer: 2.598 ± 0.05
2.585LysThr: 2.585 ± 0.06
2.709LysVal: 2.709 ± 0.054
0.505LysTrp: 0.505 ± 0.027
1.075LysTyr: 1.075 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
11.244LeuAla: 11.244 ± 0.151
0.997LeuCys: 0.997 ± 0.03
5.569LeuAsp: 5.569 ± 0.095
5.91LeuGlu: 5.91 ± 0.094
3.869LeuPhe: 3.869 ± 0.073
7.6LeuGly: 7.6 ± 0.099
2.356LeuHis: 2.356 ± 0.053
5.938LeuIle: 5.938 ± 0.094
4.709LeuLys: 4.709 ± 0.09
11.103LeuLeu: 11.103 ± 0.138
2.418LeuMet: 2.418 ± 0.059
3.603LeuAsn: 3.603 ± 0.08
5.682LeuPro: 5.682 ± 0.091
3.725LeuGln: 3.725 ± 0.069
6.822LeuArg: 6.822 ± 0.118
6.867LeuSer: 6.867 ± 0.096
5.426LeuThr: 5.426 ± 0.087
6.55LeuVal: 6.55 ± 0.093
1.225LeuTrp: 1.225 ± 0.041
2.482LeuTyr: 2.482 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.539MetAla: 2.539 ± 0.058
0.173MetCys: 0.173 ± 0.015
1.25MetAsp: 1.25 ± 0.038
1.486MetGlu: 1.486 ± 0.04
0.745MetPhe: 0.745 ± 0.027
1.875MetGly: 1.875 ± 0.052
0.642MetHis: 0.642 ± 0.028
1.32MetIle: 1.32 ± 0.041
1.3MetLys: 1.3 ± 0.042
2.802MetLeu: 2.802 ± 0.055
0.613MetMet: 0.613 ± 0.028
1.023MetAsn: 1.023 ± 0.03
1.418MetPro: 1.418 ± 0.041
1.092MetGln: 1.092 ± 0.034
1.767MetArg: 1.767 ± 0.049
1.675MetSer: 1.675 ± 0.042
1.305MetThr: 1.305 ± 0.035
1.697MetVal: 1.697 ± 0.05
0.221MetTrp: 0.221 ± 0.015
0.397MetTyr: 0.397 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.399AsnAla: 3.399 ± 0.069
0.367AsnCys: 0.367 ± 0.021
1.687AsnAsp: 1.687 ± 0.046
1.851AsnGlu: 1.851 ± 0.048
1.478AsnPhe: 1.478 ± 0.047
2.776AsnGly: 2.776 ± 0.06
0.802AsnHis: 0.802 ± 0.03
2.155AsnIle: 2.155 ± 0.059
1.369AsnLys: 1.369 ± 0.042
3.818AsnLeu: 3.818 ± 0.061
0.822AsnMet: 0.822 ± 0.028
1.39AsnAsn: 1.39 ± 0.047
2.202AsnPro: 2.202 ± 0.053
1.257AsnGln: 1.257 ± 0.037
2.335AsnArg: 2.335 ± 0.046
1.998AsnSer: 1.998 ± 0.053
1.863AsnThr: 1.863 ± 0.05
2.318AsnVal: 2.318 ± 0.055
0.505AsnTrp: 0.505 ± 0.024
1.014AsnTyr: 1.014 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
4.993ProAla: 4.993 ± 0.078
0.435ProCys: 0.435 ± 0.025
3.12ProAsp: 3.12 ± 0.062
3.623ProGlu: 3.623 ± 0.069
1.787ProPhe: 1.787 ± 0.05
4.282ProGly: 4.282 ± 0.095
1.217ProHis: 1.217 ± 0.034
2.389ProIle: 2.389 ± 0.052
1.813ProLys: 1.813 ± 0.048
4.741ProLeu: 4.741 ± 0.07
1.126ProMet: 1.126 ± 0.036
1.529ProAsn: 1.529 ± 0.046
2.524ProPro: 2.524 ± 0.075
1.864ProGln: 1.864 ± 0.052
2.529ProArg: 2.529 ± 0.055
2.854ProSer: 2.854 ± 0.06
2.138ProThr: 2.138 ± 0.05
3.925ProVal: 3.925 ± 0.07
0.598ProTrp: 0.598 ± 0.026
1.307ProTyr: 1.307 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.178GlnAla: 4.178 ± 0.091
0.3GlnCys: 0.3 ± 0.018
1.599GlnAsp: 1.599 ± 0.047
2.043GlnGlu: 2.043 ± 0.053
1.365GlnPhe: 1.365 ± 0.041
2.64GlnGly: 2.64 ± 0.048
1.021GlnHis: 1.021 ± 0.04
2.243GlnIle: 2.243 ± 0.05
1.712GlnLys: 1.712 ± 0.05
4.076GlnLeu: 4.076 ± 0.071
0.986GlnMet: 0.986 ± 0.034
1.273GlnAsn: 1.273 ± 0.037
1.947GlnPro: 1.947 ± 0.045
1.727GlnGln: 1.727 ± 0.057
2.657GlnArg: 2.657 ± 0.062
2.124GlnSer: 2.124 ± 0.046
1.987GlnThr: 1.987 ± 0.054
2.573GlnVal: 2.573 ± 0.062
0.468GlnTrp: 0.468 ± 0.027
1.004GlnTyr: 1.004 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
5.628ArgAla: 5.628 ± 0.079
0.582ArgCys: 0.582 ± 0.029
3.435ArgAsp: 3.435 ± 0.061
4.191ArgGlu: 4.191 ± 0.068
2.8ArgPhe: 2.8 ± 0.063
4.157ArgGly: 4.157 ± 0.077
1.763ArgHis: 1.763 ± 0.05
4.108ArgIle: 4.108 ± 0.074
2.833ArgLys: 2.833 ± 0.061
7.059ArgLeu: 7.059 ± 0.107
1.839ArgMet: 1.839 ± 0.048
2.545ArgAsn: 2.545 ± 0.05
2.742ArgPro: 2.742 ± 0.056
2.731ArgGln: 2.731 ± 0.065
4.386ArgArg: 4.386 ± 0.083
3.408ArgSer: 3.408 ± 0.066
2.984ArgThr: 2.984 ± 0.056
4.152ArgVal: 4.152 ± 0.077
0.829ArgTrp: 0.829 ± 0.028
2.135ArgTyr: 2.135 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.999SerAla: 5.999 ± 0.094
0.598SerCys: 0.598 ± 0.033
3.113SerAsp: 3.113 ± 0.066
3.152SerGlu: 3.152 ± 0.063
2.379SerPhe: 2.379 ± 0.053
5.648SerGly: 5.648 ± 0.101
1.562SerHis: 1.562 ± 0.038
3.351SerIle: 3.351 ± 0.07
2.333SerLys: 2.333 ± 0.055
6.348SerLeu: 6.348 ± 0.083
1.589SerMet: 1.589 ± 0.044
2.027SerAsn: 2.027 ± 0.051
3.059SerPro: 3.059 ± 0.057
2.249SerGln: 2.249 ± 0.058
3.95SerArg: 3.95 ± 0.067
3.971SerSer: 3.971 ± 0.085
2.965SerThr: 2.965 ± 0.067
4.061SerVal: 4.061 ± 0.072
0.783SerTrp: 0.783 ± 0.034
1.579SerTyr: 1.579 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
5.094ThrAla: 5.094 ± 0.085
0.446ThrCys: 0.446 ± 0.025
2.69ThrAsp: 2.69 ± 0.056
2.759ThrGlu: 2.759 ± 0.057
1.887ThrPhe: 1.887 ± 0.046
4.682ThrGly: 4.682 ± 0.082
1.224ThrHis: 1.224 ± 0.042
2.767ThrIle: 2.767 ± 0.051
1.625ThrLys: 1.625 ± 0.049
5.92ThrLeu: 5.92 ± 0.093
1.124ThrMet: 1.124 ± 0.036
1.485ThrAsn: 1.485 ± 0.051
2.897ThrPro: 2.897 ± 0.061
1.802ThrGln: 1.802 ± 0.042
3.055ThrArg: 3.055 ± 0.06
3.082ThrSer: 3.082 ± 0.073
2.613ThrThr: 2.613 ± 0.062
3.913ThrVal: 3.913 ± 0.077
0.606ThrTrp: 0.606 ± 0.03
1.359ThrTyr: 1.359 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
6.947ValAla: 6.947 ± 0.103
0.69ValCys: 0.69 ± 0.025
3.552ValAsp: 3.552 ± 0.066
4.242ValGlu: 4.242 ± 0.069
2.609ValPhe: 2.609 ± 0.062
4.501ValGly: 4.501 ± 0.076
1.453ValHis: 1.453 ± 0.043
4.194ValIle: 4.194 ± 0.074
2.977ValLys: 2.977 ± 0.064
7.138ValLeu: 7.138 ± 0.091
1.878ValMet: 1.878 ± 0.047
2.524ValAsn: 2.524 ± 0.061
3.404ValPro: 3.404 ± 0.064
2.362ValGln: 2.362 ± 0.054
4.25ValArg: 4.25 ± 0.072
4.256ValSer: 4.256 ± 0.08
3.83ValThr: 3.83 ± 0.079
5.127ValVal: 5.127 ± 0.101
0.785ValTrp: 0.785 ± 0.027
1.57ValTyr: 1.57 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.976TrpAla: 0.976 ± 0.033
0.132TrpCys: 0.132 ± 0.012
0.616TrpAsp: 0.616 ± 0.027
0.675TrpGlu: 0.675 ± 0.035
0.496TrpPhe: 0.496 ± 0.026
0.811TrpGly: 0.811 ± 0.027
0.371TrpHis: 0.371 ± 0.022
0.753TrpIle: 0.753 ± 0.028
0.577TrpLys: 0.577 ± 0.027
1.706TrpLeu: 1.706 ± 0.049
0.339TrpMet: 0.339 ± 0.018
0.495TrpAsn: 0.495 ± 0.022
0.521TrpPro: 0.521 ± 0.022
0.636TrpGln: 0.636 ± 0.029
1.052TrpArg: 1.052 ± 0.035
0.753TrpSer: 0.753 ± 0.028
0.56TrpThr: 0.56 ± 0.023
0.846TrpVal: 0.846 ± 0.034
0.202TrpTrp: 0.202 ± 0.018
0.365TrpTyr: 0.365 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.683TyrAla: 2.683 ± 0.065
0.337TyrCys: 0.337 ± 0.02
1.463TyrAsp: 1.463 ± 0.047
1.456TyrGlu: 1.456 ± 0.04
1.271TyrPhe: 1.271 ± 0.039
2.243TyrGly: 2.243 ± 0.057
0.714TyrHis: 0.714 ± 0.029
1.387TyrIle: 1.387 ± 0.031
0.964TyrLys: 0.964 ± 0.043
2.962TyrLeu: 2.962 ± 0.062
0.506TyrMet: 0.506 ± 0.024
0.816TyrAsn: 0.816 ± 0.03
1.417TyrPro: 1.417 ± 0.053
1.119TyrGln: 1.119 ± 0.039
2.052TyrArg: 2.052 ± 0.046
1.719TyrSer: 1.719 ± 0.052
1.356TyrThr: 1.356 ± 0.046
1.793TyrVal: 1.793 ± 0.048
0.43TyrTrp: 0.43 ± 0.021
0.877TyrTyr: 0.877 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2863 proteins (876671 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski