Amino acid dipepetide frequency for Faecalibacterium phage FP_Taranis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.383AlaAla: 13.383 ± 1.475
1.651AlaCys: 1.651 ± 0.319
6.131AlaAsp: 6.131 ± 0.838
7.723AlaGlu: 7.723 ± 0.737
2.24AlaPhe: 2.24 ± 0.309
7.134AlaGly: 7.134 ± 0.797
1.415AlaHis: 1.415 ± 0.257
5.188AlaIle: 5.188 ± 0.594
5.896AlaLys: 5.896 ± 0.727
8.372AlaLeu: 8.372 ± 0.968
2.24AlaMet: 2.24 ± 0.342
3.832AlaAsn: 3.832 ± 0.427
3.419AlaPro: 3.419 ± 0.482
4.127AlaGln: 4.127 ± 0.521
4.186AlaArg: 4.186 ± 0.49
5.601AlaSer: 5.601 ± 0.89
6.131AlaThr: 6.131 ± 0.853
6.308AlaVal: 6.308 ± 0.62
1.061AlaTrp: 1.061 ± 0.264
3.36AlaTyr: 3.36 ± 0.522
0.0AlaXaa: 0.0 ± 0.0
Cys
1.533CysAla: 1.533 ± 0.265
0.413CysCys: 0.413 ± 0.161
1.002CysAsp: 1.002 ± 0.251
1.002CysGlu: 1.002 ± 0.26
0.531CysPhe: 0.531 ± 0.185
2.004CysGly: 2.004 ± 0.456
0.472CysHis: 0.472 ± 0.161
0.766CysIle: 0.766 ± 0.19
1.061CysLys: 1.061 ± 0.271
0.943CysLeu: 0.943 ± 0.213
0.59CysMet: 0.59 ± 0.233
0.295CysAsn: 0.295 ± 0.118
1.061CysPro: 1.061 ± 0.274
0.884CysGln: 0.884 ± 0.266
0.884CysArg: 0.884 ± 0.214
0.649CysSer: 0.649 ± 0.164
1.238CysThr: 1.238 ± 0.314
0.59CysVal: 0.59 ± 0.183
0.236CysTrp: 0.236 ± 0.112
1.002CysTyr: 1.002 ± 0.24
0.0CysXaa: 0.0 ± 0.0
Asp
6.249AspAla: 6.249 ± 0.656
0.943AspCys: 0.943 ± 0.214
4.716AspAsp: 4.716 ± 0.548
4.834AspGlu: 4.834 ± 0.617
2.358AspPhe: 2.358 ± 0.423
5.66AspGly: 5.66 ± 0.556
1.238AspHis: 1.238 ± 0.299
3.419AspIle: 3.419 ± 0.462
3.243AspLys: 3.243 ± 0.422
5.365AspLeu: 5.365 ± 0.468
0.943AspMet: 0.943 ± 0.21
2.299AspAsn: 2.299 ± 0.429
2.417AspPro: 2.417 ± 0.39
1.179AspGln: 1.179 ± 0.328
3.125AspArg: 3.125 ± 0.51
3.36AspSer: 3.36 ± 0.388
4.481AspThr: 4.481 ± 0.541
4.245AspVal: 4.245 ± 0.494
1.002AspTrp: 1.002 ± 0.228
1.828AspTyr: 1.828 ± 0.355
0.0AspXaa: 0.0 ± 0.0
Glu
7.723GluAla: 7.723 ± 0.973
1.002GluCys: 1.002 ± 0.225
4.422GluAsp: 4.422 ± 0.616
5.011GluGlu: 5.011 ± 0.685
2.535GluPhe: 2.535 ± 0.346
2.712GluGly: 2.712 ± 0.307
1.179GluHis: 1.179 ± 0.235
3.832GluIle: 3.832 ± 0.405
4.481GluLys: 4.481 ± 0.432
7.193GluLeu: 7.193 ± 0.804
3.301GluMet: 3.301 ± 0.415
3.066GluAsn: 3.066 ± 0.387
2.24GluPro: 2.24 ± 0.379
3.243GluGln: 3.243 ± 0.552
4.068GluArg: 4.068 ± 0.491
3.125GluSer: 3.125 ± 0.582
3.125GluThr: 3.125 ± 0.425
4.009GluVal: 4.009 ± 0.404
0.943GluTrp: 0.943 ± 0.228
2.712GluTyr: 2.712 ± 0.389
0.0GluXaa: 0.0 ± 0.0
Phe
2.417PheAla: 2.417 ± 0.367
0.531PheCys: 0.531 ± 0.189
2.24PheAsp: 2.24 ± 0.411
1.415PheGlu: 1.415 ± 0.272
1.415PhePhe: 1.415 ± 0.301
2.948PheGly: 2.948 ± 0.401
0.531PheHis: 0.531 ± 0.189
1.415PheIle: 1.415 ± 0.301
1.533PheLys: 1.533 ± 0.306
2.181PheLeu: 2.181 ± 0.495
0.943PheMet: 0.943 ± 0.277
0.825PheAsn: 0.825 ± 0.197
0.884PhePro: 0.884 ± 0.236
0.766PheGln: 0.766 ± 0.259
2.063PheArg: 2.063 ± 0.439
2.063PheSer: 2.063 ± 0.34
2.476PheThr: 2.476 ± 0.344
3.007PheVal: 3.007 ± 0.457
0.177PheTrp: 0.177 ± 0.104
1.592PheTyr: 1.592 ± 0.312
0.0PheXaa: 0.0 ± 0.0
Gly
4.54GlyAla: 4.54 ± 0.367
1.592GlyCys: 1.592 ± 0.339
4.009GlyAsp: 4.009 ± 0.436
4.363GlyGlu: 4.363 ± 0.494
2.889GlyPhe: 2.889 ± 0.407
5.778GlyGly: 5.778 ± 0.741
1.592GlyHis: 1.592 ± 0.401
4.834GlyIle: 4.834 ± 0.452
5.07GlyLys: 5.07 ± 0.589
5.188GlyLeu: 5.188 ± 0.557
1.946GlyMet: 1.946 ± 0.341
2.299GlyAsn: 2.299 ± 0.323
1.71GlyPro: 1.71 ± 0.371
2.063GlyGln: 2.063 ± 0.369
3.832GlyArg: 3.832 ± 0.531
5.011GlySer: 5.011 ± 0.777
6.19GlyThr: 6.19 ± 0.654
4.775GlyVal: 4.775 ± 0.535
1.238GlyTrp: 1.238 ± 0.248
2.948GlyTyr: 2.948 ± 0.339
0.0GlyXaa: 0.0 ± 0.0
His
1.592HisAla: 1.592 ± 0.31
0.413HisCys: 0.413 ± 0.131
1.12HisAsp: 1.12 ± 0.257
1.415HisGlu: 1.415 ± 0.275
0.884HisPhe: 0.884 ± 0.241
1.71HisGly: 1.71 ± 0.308
0.354HisHis: 0.354 ± 0.165
1.179HisIle: 1.179 ± 0.242
0.825HisLys: 0.825 ± 0.206
1.297HisLeu: 1.297 ± 0.241
0.236HisMet: 0.236 ± 0.112
0.707HisAsn: 0.707 ± 0.194
0.884HisPro: 0.884 ± 0.261
0.766HisGln: 0.766 ± 0.229
1.061HisArg: 1.061 ± 0.281
1.061HisSer: 1.061 ± 0.194
1.356HisThr: 1.356 ± 0.288
0.943HisVal: 0.943 ± 0.23
0.472HisTrp: 0.472 ± 0.168
0.884HisTyr: 0.884 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
4.893IleAla: 4.893 ± 0.55
1.002IleCys: 1.002 ± 0.229
3.714IleAsp: 3.714 ± 0.463
4.068IleGlu: 4.068 ± 0.523
1.356IlePhe: 1.356 ± 0.352
3.419IleGly: 3.419 ± 0.438
1.474IleHis: 1.474 ± 0.28
2.712IleIle: 2.712 ± 0.382
4.009IleLys: 4.009 ± 0.499
3.243IleLeu: 3.243 ± 0.449
1.179IleMet: 1.179 ± 0.257
2.417IleAsn: 2.417 ± 0.366
2.889IlePro: 2.889 ± 0.367
1.887IleGln: 1.887 ± 0.345
3.419IleArg: 3.419 ± 0.457
4.068IleSer: 4.068 ± 0.585
3.478IleThr: 3.478 ± 0.372
2.535IleVal: 2.535 ± 0.331
0.707IleTrp: 0.707 ± 0.206
2.476IleTyr: 2.476 ± 0.412
0.0IleXaa: 0.0 ± 0.0
Lys
7.369LysAla: 7.369 ± 0.646
1.179LysCys: 1.179 ± 0.289
2.889LysAsp: 2.889 ± 0.477
4.599LysGlu: 4.599 ± 0.444
1.828LysPhe: 1.828 ± 0.339
3.125LysGly: 3.125 ± 0.404
1.297LysHis: 1.297 ± 0.275
3.478LysIle: 3.478 ± 0.428
4.245LysLys: 4.245 ± 0.622
5.424LysLeu: 5.424 ± 0.524
2.24LysMet: 2.24 ± 0.279
2.535LysAsn: 2.535 ± 0.404
1.71LysPro: 1.71 ± 0.357
1.887LysGln: 1.887 ± 0.297
2.83LysArg: 2.83 ± 0.358
3.419LysSer: 3.419 ± 0.424
3.301LysThr: 3.301 ± 0.36
3.773LysVal: 3.773 ± 0.402
0.649LysTrp: 0.649 ± 0.226
2.122LysTyr: 2.122 ± 0.432
0.0LysXaa: 0.0 ± 0.0
Leu
7.075LeuAla: 7.075 ± 0.975
1.828LeuCys: 1.828 ± 0.404
4.422LeuAsp: 4.422 ± 0.611
4.952LeuGlu: 4.952 ± 0.557
2.299LeuPhe: 2.299 ± 0.357
6.131LeuGly: 6.131 ± 0.593
2.063LeuHis: 2.063 ± 0.378
2.889LeuIle: 2.889 ± 0.429
4.127LeuLys: 4.127 ± 0.442
6.308LeuLeu: 6.308 ± 0.779
2.417LeuMet: 2.417 ± 0.353
3.596LeuAsn: 3.596 ± 0.479
2.889LeuPro: 2.889 ± 0.413
2.83LeuGln: 2.83 ± 0.391
4.422LeuArg: 4.422 ± 0.54
5.483LeuSer: 5.483 ± 0.52
6.485LeuThr: 6.485 ± 0.615
4.481LeuVal: 4.481 ± 0.564
1.297LeuTrp: 1.297 ± 0.304
2.122LeuTyr: 2.122 ± 0.421
0.0LeuXaa: 0.0 ± 0.0
Met
3.537MetAla: 3.537 ± 0.513
0.413MetCys: 0.413 ± 0.19
1.828MetAsp: 1.828 ± 0.36
1.651MetGlu: 1.651 ± 0.291
1.002MetPhe: 1.002 ± 0.297
1.946MetGly: 1.946 ± 0.321
0.295MetHis: 0.295 ± 0.123
1.297MetIle: 1.297 ± 0.279
1.415MetLys: 1.415 ± 0.311
1.946MetLeu: 1.946 ± 0.289
0.943MetMet: 0.943 ± 0.262
1.002MetAsn: 1.002 ± 0.181
1.179MetPro: 1.179 ± 0.219
1.002MetGln: 1.002 ± 0.245
1.592MetArg: 1.592 ± 0.348
2.712MetSer: 2.712 ± 0.472
2.004MetThr: 2.004 ± 0.347
1.71MetVal: 1.71 ± 0.304
0.177MetTrp: 0.177 ± 0.109
0.825MetTyr: 0.825 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
4.304AsnAla: 4.304 ± 0.639
0.531AsnCys: 0.531 ± 0.165
2.299AsnAsp: 2.299 ± 0.446
2.358AsnGlu: 2.358 ± 0.38
1.946AsnPhe: 1.946 ± 0.341
3.596AsnGly: 3.596 ± 0.406
0.59AsnHis: 0.59 ± 0.182
1.592AsnIle: 1.592 ± 0.28
2.063AsnLys: 2.063 ± 0.342
2.063AsnLeu: 2.063 ± 0.36
1.061AsnMet: 1.061 ± 0.279
1.297AsnAsn: 1.297 ± 0.262
1.946AsnPro: 1.946 ± 0.308
1.002AsnGln: 1.002 ± 0.187
2.24AsnArg: 2.24 ± 0.443
2.299AsnSer: 2.299 ± 0.374
2.181AsnThr: 2.181 ± 0.346
2.712AsnVal: 2.712 ± 0.43
0.59AsnTrp: 0.59 ± 0.206
1.415AsnTyr: 1.415 ± 0.396
0.0AsnXaa: 0.0 ± 0.0
Pro
4.363ProAla: 4.363 ± 0.548
0.707ProCys: 0.707 ± 0.203
2.83ProAsp: 2.83 ± 0.422
3.243ProGlu: 3.243 ± 0.43
0.766ProPhe: 0.766 ± 0.183
3.243ProGly: 3.243 ± 0.427
0.413ProHis: 0.413 ± 0.146
1.533ProIle: 1.533 ± 0.23
2.476ProLys: 2.476 ± 0.348
2.358ProLeu: 2.358 ± 0.394
0.707ProMet: 0.707 ± 0.168
1.474ProAsn: 1.474 ± 0.338
1.415ProPro: 1.415 ± 0.39
1.061ProGln: 1.061 ± 0.268
1.238ProArg: 1.238 ± 0.307
1.71ProSer: 1.71 ± 0.276
2.181ProThr: 2.181 ± 0.439
2.653ProVal: 2.653 ± 0.396
0.531ProTrp: 0.531 ± 0.175
1.887ProTyr: 1.887 ± 0.392
0.0ProXaa: 0.0 ± 0.0
Gln
2.417GlnAla: 2.417 ± 0.355
0.413GlnCys: 0.413 ± 0.147
1.356GlnAsp: 1.356 ± 0.276
2.535GlnGlu: 2.535 ± 0.439
1.061GlnPhe: 1.061 ± 0.215
1.946GlnGly: 1.946 ± 0.331
0.766GlnHis: 0.766 ± 0.222
2.063GlnIle: 2.063 ± 0.307
2.181GlnLys: 2.181 ± 0.37
3.184GlnLeu: 3.184 ± 0.352
1.415GlnMet: 1.415 ± 0.295
2.358GlnAsn: 2.358 ± 0.329
1.769GlnPro: 1.769 ± 0.371
2.653GlnGln: 2.653 ± 0.551
2.417GlnArg: 2.417 ± 0.31
2.948GlnSer: 2.948 ± 0.493
2.299GlnThr: 2.299 ± 0.36
1.474GlnVal: 1.474 ± 0.271
0.354GlnTrp: 0.354 ± 0.148
1.179GlnTyr: 1.179 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
4.481ArgAla: 4.481 ± 0.54
1.356ArgCys: 1.356 ± 0.256
2.771ArgAsp: 2.771 ± 0.343
3.655ArgGlu: 3.655 ± 0.517
1.12ArgPhe: 1.12 ± 0.247
3.125ArgGly: 3.125 ± 0.528
0.943ArgHis: 0.943 ± 0.267
2.889ArgIle: 2.889 ± 0.544
3.007ArgLys: 3.007 ± 0.411
4.952ArgLeu: 4.952 ± 0.587
1.946ArgMet: 1.946 ± 0.38
2.063ArgAsn: 2.063 ± 0.418
1.533ArgPro: 1.533 ± 0.298
2.476ArgGln: 2.476 ± 0.345
4.009ArgArg: 4.009 ± 0.555
2.358ArgSer: 2.358 ± 0.405
2.24ArgThr: 2.24 ± 0.309
3.596ArgVal: 3.596 ± 0.613
1.474ArgTrp: 1.474 ± 0.363
2.417ArgTyr: 2.417 ± 0.326
0.0ArgXaa: 0.0 ± 0.0
Ser
6.485SerAla: 6.485 ± 1.095
0.59SerCys: 0.59 ± 0.173
4.068SerAsp: 4.068 ± 0.443
3.832SerGlu: 3.832 ± 0.553
1.887SerPhe: 1.887 ± 0.329
5.542SerGly: 5.542 ± 0.705
0.825SerHis: 0.825 ± 0.222
4.186SerIle: 4.186 ± 0.515
3.773SerLys: 3.773 ± 0.371
3.537SerLeu: 3.537 ± 0.5
1.179SerMet: 1.179 ± 0.31
2.535SerAsn: 2.535 ± 0.45
2.299SerPro: 2.299 ± 0.412
2.004SerGln: 2.004 ± 0.334
2.712SerArg: 2.712 ± 0.363
3.95SerSer: 3.95 ± 0.717
3.714SerThr: 3.714 ± 0.389
4.481SerVal: 4.481 ± 0.626
1.061SerTrp: 1.061 ± 0.287
2.358SerTyr: 2.358 ± 0.337
0.0SerXaa: 0.0 ± 0.0
Thr
7.782ThrAla: 7.782 ± 1.116
0.707ThrCys: 0.707 ± 0.197
4.186ThrAsp: 4.186 ± 0.563
4.716ThrGlu: 4.716 ± 0.591
1.651ThrPhe: 1.651 ± 0.355
3.95ThrGly: 3.95 ± 0.456
1.415ThrHis: 1.415 ± 0.242
4.834ThrIle: 4.834 ± 0.659
3.655ThrLys: 3.655 ± 0.41
4.363ThrLeu: 4.363 ± 0.668
1.651ThrMet: 1.651 ± 0.351
1.474ThrAsn: 1.474 ± 0.285
2.948ThrPro: 2.948 ± 0.398
2.181ThrGln: 2.181 ± 0.335
2.653ThrArg: 2.653 ± 0.394
3.125ThrSer: 3.125 ± 0.464
3.832ThrThr: 3.832 ± 0.591
5.66ThrVal: 5.66 ± 0.57
0.59ThrTrp: 0.59 ± 0.178
2.948ThrTyr: 2.948 ± 0.333
0.0ThrXaa: 0.0 ± 0.0
Val
5.188ValAla: 5.188 ± 0.609
0.825ValCys: 0.825 ± 0.227
4.834ValAsp: 4.834 ± 0.477
4.54ValGlu: 4.54 ± 0.507
2.063ValPhe: 2.063 ± 0.414
4.009ValGly: 4.009 ± 0.333
0.884ValHis: 0.884 ± 0.198
3.596ValIle: 3.596 ± 0.373
3.301ValLys: 3.301 ± 0.456
5.778ValLeu: 5.778 ± 0.577
1.71ValMet: 1.71 ± 0.311
1.946ValAsn: 1.946 ± 0.303
2.063ValPro: 2.063 ± 0.435
2.653ValGln: 2.653 ± 0.408
3.066ValArg: 3.066 ± 0.507
5.365ValSer: 5.365 ± 0.725
4.127ValThr: 4.127 ± 0.456
4.245ValVal: 4.245 ± 0.442
1.179ValTrp: 1.179 ± 0.287
2.712ValTyr: 2.712 ± 0.422
0.0ValXaa: 0.0 ± 0.0
Trp
1.533TrpAla: 1.533 ± 0.328
0.354TrpCys: 0.354 ± 0.136
1.002TrpAsp: 1.002 ± 0.229
1.061TrpGlu: 1.061 ± 0.261
0.472TrpPhe: 0.472 ± 0.247
0.59TrpGly: 0.59 ± 0.174
0.295TrpHis: 0.295 ± 0.156
0.707TrpIle: 0.707 ± 0.217
1.061TrpLys: 1.061 ± 0.278
1.474TrpLeu: 1.474 ± 0.283
0.472TrpMet: 0.472 ± 0.157
0.295TrpAsn: 0.295 ± 0.124
0.295TrpPro: 0.295 ± 0.141
0.707TrpGln: 0.707 ± 0.283
0.766TrpArg: 0.766 ± 0.205
1.002TrpSer: 1.002 ± 0.266
1.002TrpThr: 1.002 ± 0.27
0.884TrpVal: 0.884 ± 0.221
0.177TrpTrp: 0.177 ± 0.081
0.472TrpTyr: 0.472 ± 0.173
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.535TyrAla: 2.535 ± 0.388
0.707TyrCys: 0.707 ± 0.167
3.066TyrAsp: 3.066 ± 0.424
2.948TyrGlu: 2.948 ± 0.461
1.12TyrPhe: 1.12 ± 0.194
3.301TyrGly: 3.301 ± 0.358
1.12TyrHis: 1.12 ± 0.256
2.535TyrIle: 2.535 ± 0.344
2.535TyrLys: 2.535 ± 0.436
2.948TyrLeu: 2.948 ± 0.407
1.297TyrMet: 1.297 ± 0.282
1.769TyrAsn: 1.769 ± 0.265
1.238TyrPro: 1.238 ± 0.278
1.415TyrGln: 1.415 ± 0.225
1.828TyrArg: 1.828 ± 0.328
1.71TyrSer: 1.71 ± 0.278
2.476TyrThr: 2.476 ± 0.428
2.004TyrVal: 2.004 ± 0.368
0.707TyrTrp: 0.707 ± 0.172
1.356TyrTyr: 1.356 ± 0.285
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 85 proteins (16963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski