Amino acid dipepetide frequency for Bordetella sp. N

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.511AlaAla: 18.511 ± 0.151	1.199AlaCys: 1.199 ± 0.029	7.215AlaAsp: 7.215 ± 0.065	6.033AlaGlu: 6.033 ± 0.071	3.776AlaPhe: 3.776 ± 0.047	11.832AlaGly: 11.832 ± 0.112	2.506AlaHis: 2.506 ± 0.039	5.594AlaIle: 5.594 ± 0.056	3.436AlaLys: 3.436 ± 0.047	14.534AlaLeu: 14.534 ± 0.115	3.409AlaMet: 3.409 ± 0.044	3.023AlaAsn: 3.023 ± 0.048	6.416AlaPro: 6.416 ± 0.074	5.427AlaGln: 5.427 ± 0.062	9.326AlaArg: 9.326 ± 0.091	6.716AlaSer: 6.716 ± 0.071	6.658AlaThr: 6.658 ± 0.071	9.198AlaVal: 9.198 ± 0.084	1.831AlaTrp: 1.831 ± 0.036	2.849AlaTyr: 2.849 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.109CysAla: 1.109 ± 0.025	0.105CysCys: 0.105 ± 0.007	0.467CysAsp: 0.467 ± 0.017	0.373CysGlu: 0.373 ± 0.015	0.258CysPhe: 0.258 ± 0.011	0.899CysGly: 0.899 ± 0.023	0.22CysHis: 0.22 ± 0.011	0.368CysIle: 0.368 ± 0.014	0.165CysLys: 0.165 ± 0.009	0.821CysLeu: 0.821 ± 0.02	0.185CysMet: 0.185 ± 0.01	0.201CysAsn: 0.201 ± 0.01	0.389CysPro: 0.389 ± 0.016	0.232CysGln: 0.232 ± 0.01	0.525CysArg: 0.525 ± 0.014	0.404CysSer: 0.404 ± 0.013	0.432CysThr: 0.432 ± 0.017	0.69CysVal: 0.69 ± 0.02	0.094CysTrp: 0.094 ± 0.008	0.211CysTyr: 0.211 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.243AspAla: 7.243 ± 0.078	0.446AspCys: 0.446 ± 0.016	3.083AspAsp: 3.083 ± 0.049	2.949AspGlu: 2.949 ± 0.041	2.066AspPhe: 2.066 ± 0.037	5.092AspGly: 5.092 ± 0.087	1.15AspHis: 1.15 ± 0.029	2.881AspIle: 2.881 ± 0.041	1.73AspLys: 1.73 ± 0.038	5.796AspLeu: 5.796 ± 0.053	1.384AspMet: 1.384 ± 0.027	1.349AspAsn: 1.349 ± 0.031	3.182AspPro: 3.182 ± 0.038	1.83AspGln: 1.83 ± 0.025	3.507AspArg: 3.507 ± 0.052	2.44AspSer: 2.44 ± 0.038	3.019AspThr: 3.019 ± 0.054	4.53AspVal: 4.53 ± 0.051	0.863AspTrp: 0.863 ± 0.021	1.551AspTyr: 1.551 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.904GluAla: 5.904 ± 0.062	0.326GluCys: 0.326 ± 0.014	2.363GluAsp: 2.363 ± 0.043	2.313GluGlu: 2.313 ± 0.042	1.573GluPhe: 1.573 ± 0.028	3.339GluGly: 3.339 ± 0.048	1.287GluHis: 1.287 ± 0.027	2.494GluIle: 2.494 ± 0.038	1.666GluLys: 1.666 ± 0.037	5.159GluLeu: 5.159 ± 0.059	1.185GluMet: 1.185 ± 0.027	1.37GluAsn: 1.37 ± 0.028	2.287GluPro: 2.287 ± 0.04	2.405GluGln: 2.405 ± 0.04	4.067GluArg: 4.067 ± 0.061	2.38GluSer: 2.38 ± 0.033	2.478GluThr: 2.478 ± 0.038	3.413GluVal: 3.413 ± 0.046	0.643GluTrp: 0.643 ± 0.02	1.115GluTyr: 1.115 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.755PheAla: 3.755 ± 0.048	0.33PheCys: 0.33 ± 0.014	2.398PheAsp: 2.398 ± 0.034	1.754PheGlu: 1.754 ± 0.036	1.227PhePhe: 1.227 ± 0.029	3.157PheGly: 3.157 ± 0.044	0.723PheHis: 0.723 ± 0.023	1.479PheIle: 1.479 ± 0.028	1.047PheLys: 1.047 ± 0.023	2.978PheLeu: 2.978 ± 0.052	0.782PheMet: 0.782 ± 0.021	1.083PheAsn: 1.083 ± 0.026	1.537PhePro: 1.537 ± 0.026	1.133PheGln: 1.133 ± 0.022	1.797PheArg: 1.797 ± 0.033	2.152PheSer: 2.152 ± 0.035	1.878PheThr: 1.878 ± 0.036	2.577PheVal: 2.577 ± 0.041	0.459PheTrp: 0.459 ± 0.017	0.795PheTyr: 0.795 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.138GlyAla: 10.138 ± 0.108	0.74GlyCys: 0.74 ± 0.021	4.122GlyAsp: 4.122 ± 0.065	3.871GlyGlu: 3.871 ± 0.042	3.063GlyPhe: 3.063 ± 0.044	7.709GlyGly: 7.709 ± 0.179	1.982GlyHis: 1.982 ± 0.035	4.203GlyIle: 4.203 ± 0.05	3.446GlyLys: 3.446 ± 0.049	9.053GlyLeu: 9.053 ± 0.083	2.414GlyMet: 2.414 ± 0.04	2.484GlyAsn: 2.484 ± 0.071	3.334GlyPro: 3.334 ± 0.042	3.469GlyGln: 3.469 ± 0.054	5.536GlyArg: 5.536 ± 0.05	4.978GlySer: 4.978 ± 0.093	5.231GlyThr: 5.231 ± 0.173	6.728GlyVal: 6.728 ± 0.062	1.328GlyTrp: 1.328 ± 0.028	2.66GlyTyr: 2.66 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.891HisAla: 2.891 ± 0.042	0.227HisCys: 0.227 ± 0.01	1.283HisAsp: 1.283 ± 0.027	0.993HisGlu: 0.993 ± 0.02	0.775HisPhe: 0.775 ± 0.02	2.073HisGly: 2.073 ± 0.039	0.529HisHis: 0.529 ± 0.016	1.031HisIle: 1.031 ± 0.024	0.498HisLys: 0.498 ± 0.015	2.091HisLeu: 2.091 ± 0.038	0.528HisMet: 0.528 ± 0.015	0.505HisAsn: 0.505 ± 0.016	1.466HisPro: 1.466 ± 0.029	0.661HisGln: 0.661 ± 0.019	1.291HisArg: 1.291 ± 0.027	0.938HisSer: 0.938 ± 0.023	1.051HisThr: 1.051 ± 0.022	1.641HisVal: 1.641 ± 0.029	0.352HisTrp: 0.352 ± 0.014	0.6HisTyr: 0.6 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.155IleAla: 6.155 ± 0.064	0.438IleCys: 0.438 ± 0.016	3.115IleAsp: 3.115 ± 0.042	2.738IleGlu: 2.738 ± 0.042	1.383IlePhe: 1.383 ± 0.03	4.219IleGly: 4.219 ± 0.056	0.85IleHis: 0.85 ± 0.022	1.783IleIle: 1.783 ± 0.033	1.448IleLys: 1.448 ± 0.032	3.864IleLeu: 3.864 ± 0.053	0.864IleMet: 0.864 ± 0.022	1.491IleAsn: 1.491 ± 0.035	2.217IlePro: 2.217 ± 0.032	1.417IleGln: 1.417 ± 0.024	2.686IleArg: 2.686 ± 0.044	2.671IleSer: 2.671 ± 0.044	2.602IleThr: 2.602 ± 0.053	3.817IleVal: 3.817 ± 0.04	0.481IleTrp: 0.481 ± 0.015	1.008IleTyr: 1.008 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.555LysAla: 3.555 ± 0.056	0.13LysCys: 0.13 ± 0.009	1.649LysAsp: 1.649 ± 0.031	1.377LysGlu: 1.377 ± 0.03	0.853LysPhe: 0.853 ± 0.024	2.336LysGly: 2.336 ± 0.043	0.61LysHis: 0.61 ± 0.017	1.3LysIle: 1.3 ± 0.028	1.111LysLys: 1.111 ± 0.035	3.3LysLeu: 3.3 ± 0.044	0.694LysMet: 0.694 ± 0.021	0.794LysAsn: 0.794 ± 0.022	1.923LysPro: 1.923 ± 0.035	1.304LysGln: 1.304 ± 0.026	2.09LysArg: 2.09 ± 0.037	1.649LysSer: 1.649 ± 0.031	1.763LysThr: 1.763 ± 0.033	2.375LysVal: 2.375 ± 0.039	0.408LysTrp: 0.408 ± 0.018	0.627LysTyr: 0.627 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.029LeuAla: 15.029 ± 0.114	0.904LeuCys: 0.904 ± 0.024	6.264LeuAsp: 6.264 ± 0.067	4.786LeuGlu: 4.786 ± 0.061	3.349LeuPhe: 3.349 ± 0.053	8.909LeuGly: 8.909 ± 0.087	2.266LeuHis: 2.266 ± 0.037	4.422LeuIle: 4.422 ± 0.057	3.11LeuLys: 3.11 ± 0.045	10.878LeuLeu: 10.878 ± 0.123	2.344LeuMet: 2.344 ± 0.035	2.887LeuAsn: 2.887 ± 0.045	6.229LeuPro: 6.229 ± 0.064	3.642LeuGln: 3.642 ± 0.048	8.059LeuArg: 8.059 ± 0.082	6.058LeuSer: 6.058 ± 0.064	5.954LeuThr: 5.954 ± 0.077	7.615LeuVal: 7.615 ± 0.074	1.12LeuTrp: 1.12 ± 0.025	2.158LeuTyr: 2.158 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.024MetAla: 3.024 ± 0.048	0.166MetCys: 0.166 ± 0.01	1.126MetAsp: 1.126 ± 0.024	0.973MetGlu: 0.973 ± 0.028	0.665MetPhe: 0.665 ± 0.02	1.805MetGly: 1.805 ± 0.033	0.511MetHis: 0.511 ± 0.015	0.995MetIle: 0.995 ± 0.022	0.868MetLys: 0.868 ± 0.021	2.671MetLeu: 2.671 ± 0.046	0.583MetMet: 0.583 ± 0.018	0.796MetAsn: 0.796 ± 0.02	1.487MetPro: 1.487 ± 0.026	1.011MetGln: 1.011 ± 0.025	1.775MetArg: 1.775 ± 0.032	1.602MetSer: 1.602 ± 0.027	1.635MetThr: 1.635 ± 0.031	1.7MetVal: 1.7 ± 0.034	0.193MetTrp: 0.193 ± 0.01	0.419MetTyr: 0.419 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.403AsnAla: 3.403 ± 0.063	0.213AsnCys: 0.213 ± 0.012	1.447AsnAsp: 1.447 ± 0.039	1.143AsnGlu: 1.143 ± 0.024	0.933AsnPhe: 0.933 ± 0.022	2.574AsnGly: 2.574 ± 0.077	0.487AsnHis: 0.487 ± 0.016	1.304AsnIle: 1.304 ± 0.028	0.81AsnLys: 0.81 ± 0.022	2.725AsnLeu: 2.725 ± 0.041	0.602AsnMet: 0.602 ± 0.017	0.863AsnAsn: 0.863 ± 0.032	1.801AsnPro: 1.801 ± 0.035	0.913AsnGln: 0.913 ± 0.024	1.717AsnArg: 1.717 ± 0.032	1.333AsnSer: 1.333 ± 0.032	1.628AsnThr: 1.628 ± 0.044	2.2AsnVal: 2.2 ± 0.043	0.378AsnTrp: 0.378 ± 0.017	0.713AsnTyr: 0.713 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.641ProAla: 7.641 ± 0.074	0.306ProCys: 0.306 ± 0.012	3.63ProAsp: 3.63 ± 0.05	2.945ProGlu: 2.945 ± 0.043	1.767ProPhe: 1.767 ± 0.033	4.758ProGly: 4.758 ± 0.052	1.079ProHis: 1.079 ± 0.025	2.023ProIle: 2.023 ± 0.034	1.378ProLys: 1.378 ± 0.028	5.27ProLeu: 5.27 ± 0.064	1.179ProMet: 1.179 ± 0.028	1.386ProAsn: 1.386 ± 0.027	2.629ProPro: 2.629 ± 0.041	2.009ProGln: 2.009 ± 0.034	3.132ProArg: 3.132 ± 0.048	2.765ProSer: 2.765 ± 0.043	2.692ProThr: 2.692 ± 0.035	4.3ProVal: 4.3 ± 0.05	0.747ProTrp: 0.747 ± 0.019	1.554ProTyr: 1.554 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.936GlnAla: 5.936 ± 0.066	0.232GlnCys: 0.232 ± 0.01	1.893GlnAsp: 1.893 ± 0.031	1.589GlnGlu: 1.589 ± 0.031	1.121GlnPhe: 1.121 ± 0.025	3.201GlnGly: 3.201 ± 0.041	0.84GlnHis: 0.84 ± 0.021	1.745GlnIle: 1.745 ± 0.032	0.972GlnLys: 0.972 ± 0.023	3.737GlnLeu: 3.737 ± 0.049	0.93GlnMet: 0.93 ± 0.023	0.897GlnAsn: 0.897 ± 0.024	2.096GlnPro: 2.096 ± 0.033	1.835GlnGln: 1.835 ± 0.07	3.165GlnArg: 3.165 ± 0.046	1.933GlnSer: 1.933 ± 0.036	2.02GlnThr: 2.02 ± 0.041	2.939GlnVal: 2.939 ± 0.047	0.574GlnTrp: 0.574 ± 0.017	0.875GlnTyr: 0.875 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.191ArgAla: 8.191 ± 0.082	0.534ArgCys: 0.534 ± 0.017	3.917ArgAsp: 3.917 ± 0.05	3.814ArgGlu: 3.814 ± 0.056	2.372ArgPhe: 2.372 ± 0.034	4.842ArgGly: 4.842 ± 0.05	1.776ArgHis: 1.776 ± 0.031	3.597ArgIle: 3.597 ± 0.04	2.1ArgLys: 2.1 ± 0.037	7.811ArgLeu: 7.811 ± 0.082	1.827ArgMet: 1.827 ± 0.036	1.898ArgAsn: 1.898 ± 0.028	3.314ArgPro: 3.314 ± 0.045	3.004ArgGln: 3.004 ± 0.04	5.154ArgArg: 5.154 ± 0.068	3.28ArgSer: 3.28 ± 0.044	3.192ArgThr: 3.192 ± 0.042	5.205ArgVal: 5.205 ± 0.062	1.071ArgTrp: 1.071 ± 0.027	2.072ArgTyr: 2.072 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.532SerAla: 6.532 ± 0.073	0.392SerCys: 0.392 ± 0.014	2.674SerAsp: 2.674 ± 0.036	2.182SerGlu: 2.182 ± 0.037	1.991SerPhe: 1.991 ± 0.034	5.565SerGly: 5.565 ± 0.089	1.125SerHis: 1.125 ± 0.023	2.47SerIle: 2.47 ± 0.046	1.493SerLys: 1.493 ± 0.033	5.701SerLeu: 5.701 ± 0.071	1.318SerMet: 1.318 ± 0.026	1.505SerAsn: 1.505 ± 0.032	2.753SerPro: 2.753 ± 0.039	1.829SerGln: 1.829 ± 0.032	3.423SerArg: 3.423 ± 0.043	3.333SerSer: 3.333 ± 0.049	3.197SerThr: 3.197 ± 0.056	4.37SerVal: 4.37 ± 0.056	0.761SerTrp: 0.761 ± 0.02	1.384SerTyr: 1.384 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.342ThrAla: 6.342 ± 0.069	0.374ThrCys: 0.374 ± 0.014	2.861ThrAsp: 2.861 ± 0.055	2.383ThrGlu: 2.383 ± 0.04	1.839ThrPhe: 1.839 ± 0.031	5.074ThrGly: 5.074 ± 0.101	1.229ThrHis: 1.229 ± 0.024	2.462ThrIle: 2.462 ± 0.05	1.157ThrLys: 1.157 ± 0.031	7.016ThrLeu: 7.016 ± 0.1	1.136ThrMet: 1.136 ± 0.025	1.355ThrAsn: 1.355 ± 0.048	3.812ThrPro: 3.812 ± 0.043	2.039ThrGln: 2.039 ± 0.033	3.526ThrArg: 3.526 ± 0.035	2.979ThrSer: 2.979 ± 0.058	3.123ThrThr: 3.123 ± 0.071	4.701ThrVal: 4.701 ± 0.087	0.779ThrTrp: 0.779 ± 0.026	1.291ThrTyr: 1.291 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	9.897ValAla: 9.897 ± 0.077	0.711ValCys: 0.711 ± 0.021	4.438ValAsp: 4.438 ± 0.065	3.836ValGlu: 3.836 ± 0.045	2.607ValPhe: 2.607 ± 0.033	5.857ValGly: 5.857 ± 0.062	1.444ValHis: 1.444 ± 0.028	3.622ValIle: 3.622 ± 0.049	2.285ValLys: 2.285 ± 0.045	8.285ValLeu: 8.285 ± 0.076	1.827ValMet: 1.827 ± 0.032	2.258ValAsn: 2.258 ± 0.038	4.226ValPro: 4.226 ± 0.053	2.831ValGln: 2.831 ± 0.037	5.168ValArg: 5.168 ± 0.059	4.385ValSer: 4.385 ± 0.052	4.539ValThr: 4.539 ± 0.072	6.392ValVal: 6.392 ± 0.067	0.874ValTrp: 0.874 ± 0.021	1.647ValTyr: 1.647 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.214TrpAla: 1.214 ± 0.026	0.127TrpCys: 0.127 ± 0.008	0.598TrpAsp: 0.598 ± 0.018	0.518TrpGlu: 0.518 ± 0.018	0.507TrpPhe: 0.507 ± 0.016	0.914TrpGly: 0.914 ± 0.024	0.369TrpHis: 0.369 ± 0.012	0.599TrpIle: 0.599 ± 0.017	0.397TrpLys: 0.397 ± 0.014	1.877TrpLeu: 1.877 ± 0.039	0.352TrpMet: 0.352 ± 0.014	0.434TrpAsn: 0.434 ± 0.015	0.686TrpPro: 0.686 ± 0.021	0.667TrpGln: 0.667 ± 0.018	1.285TrpArg: 1.285 ± 0.025	0.764TrpSer: 0.764 ± 0.021	0.796TrpThr: 0.796 ± 0.036	0.871TrpVal: 0.871 ± 0.024	0.217TrpTrp: 0.217 ± 0.009	0.32TrpTyr: 0.32 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.018TyrAla: 3.018 ± 0.034	0.248TyrCys: 0.248 ± 0.012	1.549TyrAsp: 1.549 ± 0.029	1.199TyrGlu: 1.199 ± 0.027	0.917TyrPhe: 0.917 ± 0.021	2.334TyrGly: 2.334 ± 0.038	0.443TyrHis: 0.443 ± 0.015	0.875TyrIle: 0.875 ± 0.021	0.729TyrLys: 0.729 ± 0.021	2.416TyrLeu: 2.416 ± 0.04	0.459TyrMet: 0.459 ± 0.016	0.608TyrAsn: 0.608 ± 0.021	1.405TyrPro: 1.405 ± 0.031	0.872TyrGln: 0.872 ± 0.026	1.739TyrArg: 1.739 ± 0.031	1.24TyrSer: 1.24 ± 0.028	1.591TyrThr: 1.591 ± 0.042	1.867TyrVal: 1.867 ± 0.033	0.34TyrTrp: 0.34 ± 0.013	0.631TyrTyr: 0.631 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5821 proteins (2020596 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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