Amino acid dipepetide frequency for Nesterenkonia sp. PF2B19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.611AlaAla: 18.611 ± 0.258
0.85AlaCys: 0.85 ± 0.032
7.99AlaAsp: 7.99 ± 0.11
10.169AlaGlu: 10.169 ± 0.136
3.292AlaPhe: 3.292 ± 0.066
12.246AlaGly: 12.246 ± 0.132
2.677AlaHis: 2.677 ± 0.06
3.95AlaIle: 3.95 ± 0.086
1.924AlaLys: 1.924 ± 0.06
12.605AlaLeu: 12.605 ± 0.146
2.791AlaMet: 2.791 ± 0.061
1.66AlaAsn: 1.66 ± 0.052
6.189AlaPro: 6.189 ± 0.085
4.399AlaGln: 4.399 ± 0.074
8.679AlaArg: 8.679 ± 0.118
6.451AlaSer: 6.451 ± 0.096
5.923AlaThr: 5.923 ± 0.082
11.439AlaVal: 11.439 ± 0.145
1.744AlaTrp: 1.744 ± 0.046
2.03AlaTyr: 2.03 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.815CysAla: 0.815 ± 0.032
0.113CysCys: 0.113 ± 0.013
0.361CysAsp: 0.361 ± 0.02
0.366CysGlu: 0.366 ± 0.021
0.187CysPhe: 0.187 ± 0.014
0.834CysGly: 0.834 ± 0.032
0.162CysHis: 0.162 ± 0.013
0.187CysIle: 0.187 ± 0.015
0.057CysLys: 0.057 ± 0.008
0.63CysLeu: 0.63 ± 0.025
0.098CysMet: 0.098 ± 0.01
0.085CysAsn: 0.085 ± 0.009
0.405CysPro: 0.405 ± 0.025
0.154CysGln: 0.154 ± 0.014
0.542CysArg: 0.542 ± 0.026
0.405CysSer: 0.405 ± 0.022
0.377CysThr: 0.377 ± 0.022
0.468CysVal: 0.468 ± 0.025
0.126CysTrp: 0.126 ± 0.015
0.108CysTyr: 0.108 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.114AspAla: 8.114 ± 0.124
0.319AspCys: 0.319 ± 0.022
4.584AspAsp: 4.584 ± 0.102
4.666AspGlu: 4.666 ± 0.095
1.644AspPhe: 1.644 ± 0.047
6.547AspGly: 6.547 ± 0.109
1.769AspHis: 1.769 ± 0.047
2.079AspIle: 2.079 ± 0.06
0.761AspLys: 0.761 ± 0.039
6.231AspLeu: 6.231 ± 0.096
1.057AspMet: 1.057 ± 0.039
0.71AspAsn: 0.71 ± 0.029
4.404AspPro: 4.404 ± 0.081
2.154AspGln: 2.154 ± 0.054
4.224AspArg: 4.224 ± 0.07
3.006AspSer: 3.006 ± 0.067
2.855AspThr: 2.855 ± 0.06
5.693AspVal: 5.693 ± 0.088
0.985AspTrp: 0.985 ± 0.039
1.229AspTyr: 1.229 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
8.493GluAla: 8.493 ± 0.117
0.277GluCys: 0.277 ± 0.019
4.948GluAsp: 4.948 ± 0.102
5.159GluGlu: 5.159 ± 0.095
1.789GluPhe: 1.789 ± 0.049
4.8GluGly: 4.8 ± 0.085
2.172GluHis: 2.172 ± 0.052
3.037GluIle: 3.037 ± 0.065
1.439GluLys: 1.439 ± 0.043
7.093GluLeu: 7.093 ± 0.11
1.174GluMet: 1.174 ± 0.043
1.273GluAsn: 1.273 ± 0.041
3.561GluPro: 3.561 ± 0.079
2.999GluGln: 2.999 ± 0.063
4.71GluArg: 4.71 ± 0.088
3.468GluSer: 3.468 ± 0.073
3.69GluThr: 3.69 ± 0.07
5.324GluVal: 5.324 ± 0.084
0.705GluTrp: 0.705 ± 0.03
1.093GluTyr: 1.093 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.437PheAla: 3.437 ± 0.071
0.222PheCys: 0.222 ± 0.015
2.033PheAsp: 2.033 ± 0.05
1.634PheGlu: 1.634 ± 0.052
1.099PhePhe: 1.099 ± 0.044
2.974PheGly: 2.974 ± 0.069
0.635PheHis: 0.635 ± 0.027
1.169PheIle: 1.169 ± 0.043
0.391PheLys: 0.391 ± 0.022
2.834PheLeu: 2.834 ± 0.068
0.506PheMet: 0.506 ± 0.028
0.589PheAsn: 0.589 ± 0.026
1.351PhePro: 1.351 ± 0.04
0.75PheGln: 0.75 ± 0.033
1.706PheArg: 1.706 ± 0.051
1.917PheSer: 1.917 ± 0.05
2.088PheThr: 2.088 ± 0.052
2.224PheVal: 2.224 ± 0.064
0.475PheTrp: 0.475 ± 0.027
0.63PheTyr: 0.63 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.506GlyAla: 10.506 ± 0.122
0.669GlyCys: 0.669 ± 0.024
5.105GlyAsp: 5.105 ± 0.098
5.875GlyGlu: 5.875 ± 0.105
2.913GlyPhe: 2.913 ± 0.061
7.697GlyGly: 7.697 ± 0.111
2.333GlyHis: 2.333 ± 0.059
4.005GlyIle: 4.005 ± 0.081
1.641GlyLys: 1.641 ± 0.05
9.352GlyLeu: 9.352 ± 0.119
2.246GlyMet: 2.246 ± 0.047
1.35GlyAsn: 1.35 ± 0.041
4.495GlyPro: 4.495 ± 0.086
2.934GlyGln: 2.934 ± 0.055
6.948GlyArg: 6.948 ± 0.095
5.19GlySer: 5.19 ± 0.089
5.418GlyThr: 5.418 ± 0.092
7.513GlyVal: 7.513 ± 0.091
1.652GlyTrp: 1.652 ± 0.047
1.944GlyTyr: 1.944 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.613HisAla: 2.613 ± 0.061
0.186HisCys: 0.186 ± 0.014
1.646HisAsp: 1.646 ± 0.051
1.394HisGlu: 1.394 ± 0.045
0.633HisPhe: 0.633 ± 0.027
2.505HisGly: 2.505 ± 0.057
0.853HisHis: 0.853 ± 0.036
0.848HisIle: 0.848 ± 0.032
0.316HisLys: 0.316 ± 0.019
2.818HisLeu: 2.818 ± 0.067
0.422HisMet: 0.422 ± 0.024
0.38HisAsn: 0.38 ± 0.023
1.819HisPro: 1.819 ± 0.046
0.937HisGln: 0.937 ± 0.03
2.357HisArg: 2.357 ± 0.052
1.136HisSer: 1.136 ± 0.037
1.277HisThr: 1.277 ± 0.037
1.935HisVal: 1.935 ± 0.048
0.346HisTrp: 0.346 ± 0.017
0.462HisTyr: 0.462 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.325IleAla: 5.325 ± 0.096
0.313IleCys: 0.313 ± 0.02
2.725IleAsp: 2.725 ± 0.065
2.27IleGlu: 2.27 ± 0.052
1.26IlePhe: 1.26 ± 0.04
4.078IleGly: 4.078 ± 0.088
0.856IleHis: 0.856 ± 0.035
1.908IleIle: 1.908 ± 0.054
0.599IleLys: 0.599 ± 0.028
3.665IleLeu: 3.665 ± 0.073
0.758IleMet: 0.758 ± 0.032
0.854IleAsn: 0.854 ± 0.034
2.233IlePro: 2.233 ± 0.062
0.884IleGln: 0.884 ± 0.038
2.635IleArg: 2.635 ± 0.058
2.6IleSer: 2.6 ± 0.058
2.792IleThr: 2.792 ± 0.062
3.097IleVal: 3.097 ± 0.073
0.502IleTrp: 0.502 ± 0.025
0.752IleTyr: 0.752 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
1.943LysAla: 1.943 ± 0.062
0.056LysCys: 0.056 ± 0.008
0.974LysAsp: 0.974 ± 0.036
1.006LysGlu: 1.006 ± 0.042
0.391LysPhe: 0.391 ± 0.021
1.204LysGly: 1.204 ± 0.044
0.448LysHis: 0.448 ± 0.021
0.807LysIle: 0.807 ± 0.034
0.674LysLys: 0.674 ± 0.039
1.544LysLeu: 1.544 ± 0.052
0.355LysMet: 0.355 ± 0.025
0.426LysAsn: 0.426 ± 0.023
0.934LysPro: 0.934 ± 0.037
0.61LysGln: 0.61 ± 0.031
1.107LysArg: 1.107 ± 0.043
0.91LysSer: 0.91 ± 0.031
1.046LysThr: 1.046 ± 0.036
1.43LysVal: 1.43 ± 0.043
0.181LysTrp: 0.181 ± 0.018
0.342LysTyr: 0.342 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
13.138LeuAla: 13.138 ± 0.171
0.625LeuCys: 0.625 ± 0.027
6.649LeuAsp: 6.649 ± 0.094
6.062LeuGlu: 6.062 ± 0.101
2.827LeuPhe: 2.827 ± 0.07
9.22LeuGly: 9.22 ± 0.117
2.387LeuHis: 2.387 ± 0.052
4.435LeuIle: 4.435 ± 0.084
1.637LeuLys: 1.637 ± 0.045
10.73LeuLeu: 10.73 ± 0.172
2.095LeuMet: 2.095 ± 0.047
1.819LeuAsn: 1.819 ± 0.046
5.63LeuPro: 5.63 ± 0.081
3.013LeuGln: 3.013 ± 0.057
7.893LeuArg: 7.893 ± 0.103
5.777LeuSer: 5.777 ± 0.088
6.758LeuThr: 6.758 ± 0.085
8.421LeuVal: 8.421 ± 0.126
1.381LeuTrp: 1.381 ± 0.052
1.637LeuTyr: 1.637 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.588MetAla: 2.588 ± 0.06
0.114MetCys: 0.114 ± 0.01
1.137MetAsp: 1.137 ± 0.036
1.046MetGlu: 1.046 ± 0.035
0.573MetPhe: 0.573 ± 0.031
1.541MetGly: 1.541 ± 0.046
0.447MetHis: 0.447 ± 0.022
1.052MetIle: 1.052 ± 0.037
0.396MetLys: 0.396 ± 0.022
2.249MetLeu: 2.249 ± 0.055
0.442MetMet: 0.442 ± 0.022
0.46MetAsn: 0.46 ± 0.026
1.36MetPro: 1.36 ± 0.033
0.514MetGln: 0.514 ± 0.026
1.494MetArg: 1.494 ± 0.04
1.458MetSer: 1.458 ± 0.042
1.87MetThr: 1.87 ± 0.046
1.722MetVal: 1.722 ± 0.051
0.206MetTrp: 0.206 ± 0.015
0.295MetTyr: 0.295 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
1.892AsnAla: 1.892 ± 0.051
0.109AsnCys: 0.109 ± 0.012
0.841AsnAsp: 0.841 ± 0.033
0.823AsnGlu: 0.823 ± 0.032
0.553AsnPhe: 0.553 ± 0.027
1.408AsnGly: 1.408 ± 0.043
0.404AsnHis: 0.404 ± 0.022
0.795AsnIle: 0.795 ± 0.033
0.274AsnLys: 0.274 ± 0.02
1.707AsnLeu: 1.707 ± 0.044
0.32AsnMet: 0.32 ± 0.017
0.348AsnAsn: 0.348 ± 0.021
1.365AsnPro: 1.365 ± 0.044
0.535AsnGln: 0.535 ± 0.025
1.151AsnArg: 1.151 ± 0.039
0.931AsnSer: 0.931 ± 0.036
0.99AsnThr: 0.99 ± 0.038
1.328AsnVal: 1.328 ± 0.04
0.314AsnTrp: 0.314 ± 0.018
0.408AsnTyr: 0.408 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.17ProAla: 7.17 ± 0.108
0.284ProCys: 0.284 ± 0.021
3.931ProAsp: 3.931 ± 0.072
5.15ProGlu: 5.15 ± 0.092
1.476ProPhe: 1.476 ± 0.043
5.668ProGly: 5.668 ± 0.094
1.408ProHis: 1.408 ± 0.038
1.56ProIle: 1.56 ± 0.045
0.854ProLys: 0.854 ± 0.033
4.885ProLeu: 4.885 ± 0.088
1.113ProMet: 1.113 ± 0.039
0.85ProAsn: 0.85 ± 0.034
2.631ProPro: 2.631 ± 0.064
2.115ProGln: 2.115 ± 0.048
3.857ProArg: 3.857 ± 0.07
3.275ProSer: 3.275 ± 0.058
3.214ProThr: 3.214 ± 0.064
4.938ProVal: 4.938 ± 0.076
0.951ProTrp: 0.951 ± 0.036
1.003ProTyr: 1.003 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.178GlnAla: 4.178 ± 0.083
0.152GlnCys: 0.152 ± 0.015
2.087GlnAsp: 2.087 ± 0.05
2.276GlnGlu: 2.276 ± 0.049
0.81GlnPhe: 0.81 ± 0.034
2.415GlnGly: 2.415 ± 0.061
0.963GlnHis: 0.963 ± 0.033
1.533GlnIle: 1.533 ± 0.04
0.63GlnLys: 0.63 ± 0.029
3.58GlnLeu: 3.58 ± 0.074
0.719GlnMet: 0.719 ± 0.029
0.627GlnAsn: 0.627 ± 0.029
1.695GlnPro: 1.695 ± 0.044
1.513GlnGln: 1.513 ± 0.047
2.644GlnArg: 2.644 ± 0.057
1.443GlnSer: 1.443 ± 0.04
1.653GlnThr: 1.653 ± 0.047
2.893GlnVal: 2.893 ± 0.054
0.568GlnTrp: 0.568 ± 0.024
0.548GlnTyr: 0.548 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
8.126ArgAla: 8.126 ± 0.115
0.549ArgCys: 0.549 ± 0.025
4.073ArgAsp: 4.073 ± 0.066
4.698ArgGlu: 4.698 ± 0.08
2.09ArgPhe: 2.09 ± 0.048
5.538ArgGly: 5.538 ± 0.082
2.179ArgHis: 2.179 ± 0.052
3.378ArgIle: 3.378 ± 0.071
1.202ArgLys: 1.202 ± 0.044
7.953ArgLeu: 7.953 ± 0.12
1.915ArgMet: 1.915 ± 0.048
1.118ArgAsn: 1.118 ± 0.037
4.451ArgPro: 4.451 ± 0.081
2.633ArgGln: 2.633 ± 0.054
8.694ArgArg: 8.694 ± 0.152
4.346ArgSer: 4.346 ± 0.078
4.422ArgThr: 4.422 ± 0.063
4.957ArgVal: 4.957 ± 0.07
1.38ArgTrp: 1.38 ± 0.038
1.436ArgTyr: 1.436 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
7.216SerAla: 7.216 ± 0.1
0.397SerCys: 0.397 ± 0.023
2.849SerAsp: 2.849 ± 0.059
3.182SerGlu: 3.182 ± 0.058
1.727SerPhe: 1.727 ± 0.048
5.826SerGly: 5.826 ± 0.087
1.179SerHis: 1.179 ± 0.038
2.091SerIle: 2.091 ± 0.05
0.809SerLys: 0.809 ± 0.035
5.46SerLeu: 5.46 ± 0.091
1.309SerMet: 1.309 ± 0.033
0.808SerAsn: 0.808 ± 0.031
3.644SerPro: 3.644 ± 0.08
1.693SerGln: 1.693 ± 0.046
4.351SerArg: 4.351 ± 0.081
3.795SerSer: 3.795 ± 0.078
3.722SerThr: 3.722 ± 0.073
4.337SerVal: 4.337 ± 0.064
1.063SerTrp: 1.063 ± 0.034
1.056SerTyr: 1.056 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.648ThrAla: 7.648 ± 0.099
0.368ThrCys: 0.368 ± 0.018
3.43ThrAsp: 3.43 ± 0.071
3.542ThrGlu: 3.542 ± 0.075
1.735ThrPhe: 1.735 ± 0.044
5.878ThrGly: 5.878 ± 0.091
1.267ThrHis: 1.267 ± 0.037
2.255ThrIle: 2.255 ± 0.054
0.87ThrLys: 0.87 ± 0.035
5.8ThrLeu: 5.8 ± 0.078
1.197ThrMet: 1.197 ± 0.035
0.94ThrAsn: 0.94 ± 0.033
3.859ThrPro: 3.859 ± 0.067
1.615ThrGln: 1.615 ± 0.045
3.722ThrArg: 3.722 ± 0.063
3.506ThrSer: 3.506 ± 0.07
3.847ThrThr: 3.847 ± 0.078
5.824ThrVal: 5.824 ± 0.089
0.928ThrTrp: 0.928 ± 0.038
1.172ThrTyr: 1.172 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
10.081ValAla: 10.081 ± 0.125
0.597ValCys: 0.597 ± 0.027
5.632ValAsp: 5.632 ± 0.089
5.893ValGlu: 5.893 ± 0.088
2.443ValPhe: 2.443 ± 0.059
6.644ValGly: 6.644 ± 0.101
2.01ValHis: 2.01 ± 0.051
3.698ValIle: 3.698 ± 0.075
1.367ValLys: 1.367 ± 0.046
9.442ValLeu: 9.442 ± 0.136
1.756ValMet: 1.756 ± 0.049
1.439ValAsn: 1.439 ± 0.041
4.561ValPro: 4.561 ± 0.073
2.277ValGln: 2.277 ± 0.06
5.673ValArg: 5.673 ± 0.084
4.904ValSer: 4.904 ± 0.07
5.37ValThr: 5.37 ± 0.086
8.406ValVal: 8.406 ± 0.108
0.98ValTrp: 0.98 ± 0.037
1.34ValTyr: 1.34 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.617TrpAla: 1.617 ± 0.048
0.137TrpCys: 0.137 ± 0.012
0.812TrpAsp: 0.812 ± 0.03
0.922TrpGlu: 0.922 ± 0.033
0.576TrpPhe: 0.576 ± 0.028
1.011TrpGly: 1.011 ± 0.034
0.369TrpHis: 0.369 ± 0.02
0.679TrpIle: 0.679 ± 0.031
0.281TrpLys: 0.281 ± 0.02
1.695TrpLeu: 1.695 ± 0.053
0.397TrpMet: 0.397 ± 0.02
0.383TrpAsn: 0.383 ± 0.024
0.738TrpPro: 0.738 ± 0.031
0.549TrpGln: 0.549 ± 0.024
1.263TrpArg: 1.263 ± 0.04
0.949TrpSer: 0.949 ± 0.036
0.966TrpThr: 0.966 ± 0.036
1.111TrpVal: 1.111 ± 0.036
0.388TrpTrp: 0.388 ± 0.019
0.323TrpTyr: 0.323 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.106TyrAla: 2.106 ± 0.053
0.143TyrCys: 0.143 ± 0.014
1.222TyrAsp: 1.222 ± 0.04
1.069TyrGlu: 1.069 ± 0.035
0.646TyrPhe: 0.646 ± 0.027
1.751TyrGly: 1.751 ± 0.047
0.366TyrHis: 0.366 ± 0.024
0.643TyrIle: 0.643 ± 0.03
0.266TyrLys: 0.266 ± 0.019
1.866TyrLeu: 1.866 ± 0.042
0.293TyrMet: 0.293 ± 0.016
0.376TyrAsn: 0.376 ± 0.02
1.009TyrPro: 1.009 ± 0.034
0.649TyrGln: 0.649 ± 0.029
1.488TyrArg: 1.488 ± 0.044
1.046TyrSer: 1.046 ± 0.037
1.124TyrThr: 1.124 ± 0.034
1.452TyrVal: 1.452 ± 0.038
0.293TyrTrp: 0.293 ± 0.021
0.449TyrTyr: 0.449 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2886 proteins (891083 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski