Amino acid dipepetide frequency for Micromonospora craniellae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.546AlaAla: 21.546 ± 0.172	0.966AlaCys: 0.966 ± 0.027	9.059AlaAsp: 9.059 ± 0.089	8.515AlaGlu: 8.515 ± 0.082	3.168AlaPhe: 3.168 ± 0.051	13.458AlaGly: 13.458 ± 0.102	2.737AlaHis: 2.737 ± 0.039	3.928AlaIle: 3.928 ± 0.06	2.089AlaLys: 2.089 ± 0.046	13.859AlaLeu: 13.859 ± 0.116	2.423AlaMet: 2.423 ± 0.045	2.104AlaAsn: 2.104 ± 0.042	6.963AlaPro: 6.963 ± 0.082	3.716AlaGln: 3.716 ± 0.045	10.536AlaArg: 10.536 ± 0.097	5.529AlaSer: 5.529 ± 0.059	8.069AlaThr: 8.069 ± 0.081	12.683AlaVal: 12.683 ± 0.118	1.911AlaTrp: 1.911 ± 0.039	2.812AlaTyr: 2.812 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.974CysAla: 0.974 ± 0.024	0.091CysCys: 0.091 ± 0.007	0.515CysAsp: 0.515 ± 0.018	0.339CysGlu: 0.339 ± 0.016	0.213CysPhe: 0.213 ± 0.01	0.937CysGly: 0.937 ± 0.026	0.203CysHis: 0.203 ± 0.012	0.143CysIle: 0.143 ± 0.009	0.081CysLys: 0.081 ± 0.006	0.699CysLeu: 0.699 ± 0.02	0.093CysMet: 0.093 ± 0.007	0.12CysAsn: 0.12 ± 0.008	0.511CysPro: 0.511 ± 0.017	0.204CysGln: 0.204 ± 0.012	0.661CysArg: 0.661 ± 0.02	0.362CysSer: 0.362 ± 0.015	0.445CysThr: 0.445 ± 0.017	0.665CysVal: 0.665 ± 0.019	0.127CysTrp: 0.127 ± 0.01	0.172CysTyr: 0.172 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.638AspAla: 7.638 ± 0.076	0.424AspCys: 0.424 ± 0.016	3.954AspAsp: 3.954 ± 0.058	3.931AspGlu: 3.931 ± 0.05	1.521AspPhe: 1.521 ± 0.029	6.416AspGly: 6.416 ± 0.077	1.414AspHis: 1.414 ± 0.029	1.789AspIle: 1.789 ± 0.033	0.887AspLys: 0.887 ± 0.025	7.078AspLeu: 7.078 ± 0.07	0.761AspMet: 0.761 ± 0.021	0.968AspAsn: 0.968 ± 0.027	4.876AspPro: 4.876 ± 0.064	1.767AspGln: 1.767 ± 0.033	5.812AspArg: 5.812 ± 0.069	2.399AspSer: 2.399 ± 0.036	3.139AspThr: 3.139 ± 0.045	5.064AspVal: 5.064 ± 0.052	1.012AspTrp: 1.012 ± 0.023	1.126AspTyr: 1.126 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.593GluAla: 6.593 ± 0.064	0.334GluCys: 0.334 ± 0.013	2.098GluAsp: 2.098 ± 0.038	2.441GluGlu: 2.441 ± 0.049	1.5GluPhe: 1.5 ± 0.025	3.159GluGly: 3.159 ± 0.046	1.414GluHis: 1.414 ± 0.03	2.297GluIle: 2.297 ± 0.035	0.96GluLys: 0.96 ± 0.028	6.463GluLeu: 6.463 ± 0.072	0.899GluMet: 0.899 ± 0.022	0.858GluAsn: 0.858 ± 0.024	3.386GluPro: 3.386 ± 0.058	2.319GluGln: 2.319 ± 0.039	5.057GluArg: 5.057 ± 0.061	2.419GluSer: 2.419 ± 0.044	2.617GluThr: 2.617 ± 0.044	4.801GluVal: 4.801 ± 0.054	0.727GluTrp: 0.727 ± 0.021	1.092GluTyr: 1.092 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.588PheAla: 3.588 ± 0.051	0.261PheCys: 0.261 ± 0.013	1.988PheAsp: 1.988 ± 0.033	1.206PheGlu: 1.206 ± 0.027	0.78PhePhe: 0.78 ± 0.028	2.942PheGly: 2.942 ± 0.043	0.59PheHis: 0.59 ± 0.018	0.685PheIle: 0.685 ± 0.022	0.375PheLys: 0.375 ± 0.015	2.443PheLeu: 2.443 ± 0.042	0.294PheMet: 0.294 ± 0.014	0.548PheAsn: 0.548 ± 0.019	1.289PhePro: 1.289 ± 0.028	0.633PheGln: 0.633 ± 0.018	1.816PheArg: 1.816 ± 0.032	1.287PheSer: 1.287 ± 0.029	1.935PheThr: 1.935 ± 0.034	2.441PheVal: 2.441 ± 0.041	0.435PheTrp: 0.435 ± 0.014	0.591PheTyr: 0.591 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.308GlyAla: 10.308 ± 0.091	0.799GlyCys: 0.799 ± 0.025	5.334GlyAsp: 5.334 ± 0.062	4.715GlyGlu: 4.715 ± 0.055	2.699GlyPhe: 2.699 ± 0.034	8.62GlyGly: 8.62 ± 0.107	2.164GlyHis: 2.164 ± 0.038	3.085GlyIle: 3.085 ± 0.049	1.791GlyLys: 1.791 ± 0.031	9.197GlyLeu: 9.197 ± 0.09	1.793GlyMet: 1.793 ± 0.038	1.662GlyAsn: 1.662 ± 0.04	5.265GlyPro: 5.265 ± 0.077	2.864GlyGln: 2.864 ± 0.045	8.143GlyArg: 8.143 ± 0.081	4.704GlySer: 4.704 ± 0.062	5.87GlyThr: 5.87 ± 0.072	7.978GlyVal: 7.978 ± 0.074	1.872GlyTrp: 1.872 ± 0.037	2.342GlyTyr: 2.342 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.618HisAla: 2.618 ± 0.04	0.187HisCys: 0.187 ± 0.01	1.458HisAsp: 1.458 ± 0.025	1.068HisGlu: 1.068 ± 0.023	0.572HisPhe: 0.572 ± 0.016	2.139HisGly: 2.139 ± 0.038	0.736HisHis: 0.736 ± 0.023	0.594HisIle: 0.594 ± 0.02	0.244HisLys: 0.244 ± 0.011	2.674HisLeu: 2.674 ± 0.041	0.268HisMet: 0.268 ± 0.013	0.389HisAsn: 0.389 ± 0.015	1.779HisPro: 1.779 ± 0.034	0.764HisGln: 0.764 ± 0.02	2.415HisArg: 2.415 ± 0.037	0.928HisSer: 0.928 ± 0.022	1.204HisThr: 1.204 ± 0.028	1.743HisVal: 1.743 ± 0.028	0.361HisTrp: 0.361 ± 0.014	0.452HisTyr: 0.452 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.782IleAla: 4.782 ± 0.059	0.309IleCys: 0.309 ± 0.012	2.454IleAsp: 2.454 ± 0.04	2.015IleGlu: 2.015 ± 0.034	0.86IlePhe: 0.86 ± 0.024	3.545IleGly: 3.545 ± 0.04	0.565IleHis: 0.565 ± 0.016	0.971IleIle: 0.971 ± 0.026	0.607IleLys: 0.607 ± 0.021	2.462IleLeu: 2.462 ± 0.045	0.429IleMet: 0.429 ± 0.017	0.703IleAsn: 0.703 ± 0.02	1.651IlePro: 1.651 ± 0.032	0.712IleGln: 0.712 ± 0.022	2.621IleArg: 2.621 ± 0.042	1.762IleSer: 1.762 ± 0.03	2.162IleThr: 2.162 ± 0.035	2.887IleVal: 2.887 ± 0.051	0.414IleTrp: 0.414 ± 0.016	0.594IleTyr: 0.594 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.008LysAla: 2.008 ± 0.037	0.09LysCys: 0.09 ± 0.008	0.731LysAsp: 0.731 ± 0.022	0.743LysGlu: 0.743 ± 0.022	0.342LysPhe: 0.342 ± 0.013	1.196LysGly: 1.196 ± 0.027	0.314LysHis: 0.314 ± 0.013	0.765LysIle: 0.765 ± 0.021	0.442LysLys: 0.442 ± 0.018	1.681LysLeu: 1.681 ± 0.035	0.277LysMet: 0.277 ± 0.012	0.329LysAsn: 0.329 ± 0.015	1.016LysPro: 1.016 ± 0.024	0.6LysGln: 0.6 ± 0.018	1.212LysArg: 1.212 ± 0.027	0.859LysSer: 0.859 ± 0.023	1.006LysThr: 1.006 ± 0.03	1.459LysVal: 1.459 ± 0.032	0.191LysTrp: 0.191 ± 0.011	0.327LysTyr: 0.327 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.075LeuAla: 16.075 ± 0.11	0.756LeuCys: 0.756 ± 0.02	7.202LeuAsp: 7.202 ± 0.061	3.725LeuGlu: 3.725 ± 0.048	2.49LeuPhe: 2.49 ± 0.044	9.068LeuGly: 9.068 ± 0.077	2.408LeuHis: 2.408 ± 0.041	3.325LeuIle: 3.325 ± 0.047	1.328LeuLys: 1.328 ± 0.031	11.592LeuLeu: 11.592 ± 0.1	1.376LeuMet: 1.376 ± 0.031	1.664LeuAsn: 1.664 ± 0.032	6.772LeuPro: 6.772 ± 0.078	1.937LeuGln: 1.937 ± 0.033	9.638LeuArg: 9.638 ± 0.083	4.994LeuSer: 4.994 ± 0.058	7.114LeuThr: 7.114 ± 0.063	9.934LeuVal: 9.934 ± 0.088	1.223LeuTrp: 1.223 ± 0.025	1.626LeuTyr: 1.626 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.111MetAla: 2.111 ± 0.032	0.107MetCys: 0.107 ± 0.008	0.743MetAsp: 0.743 ± 0.02	0.616MetGlu: 0.616 ± 0.02	0.446MetPhe: 0.446 ± 0.015	1.071MetGly: 1.071 ± 0.028	0.307MetHis: 0.307 ± 0.012	0.687MetIle: 0.687 ± 0.02	0.299MetLys: 0.299 ± 0.013	1.79MetLeu: 1.79 ± 0.034	0.297MetMet: 0.297 ± 0.013	0.336MetAsn: 0.336 ± 0.015	1.11MetPro: 1.11 ± 0.029	0.426MetGln: 0.426 ± 0.016	1.463MetArg: 1.463 ± 0.03	1.237MetSer: 1.237 ± 0.025	1.506MetThr: 1.506 ± 0.03	1.361MetVal: 1.361 ± 0.027	0.204MetTrp: 0.204 ± 0.011	0.267MetTyr: 0.267 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.15AsnAla: 2.15 ± 0.041	0.16AsnCys: 0.16 ± 0.011	0.948AsnAsp: 0.948 ± 0.024	0.785AsnGlu: 0.785 ± 0.021	0.476AsnPhe: 0.476 ± 0.016	1.788AsnGly: 1.788 ± 0.039	0.35AsnHis: 0.35 ± 0.013	0.603AsnIle: 0.603 ± 0.021	0.305AsnLys: 0.305 ± 0.014	1.853AsnLeu: 1.853 ± 0.033	0.295AsnMet: 0.295 ± 0.013	0.446AsnAsn: 0.446 ± 0.017	1.423AsnPro: 1.423 ± 0.033	0.583AsnGln: 0.583 ± 0.02	1.447AsnArg: 1.447 ± 0.033	0.9AsnSer: 0.9 ± 0.027	1.037AsnThr: 1.037 ± 0.027	1.362AsnVal: 1.362 ± 0.036	0.312AsnTrp: 0.312 ± 0.014	0.403AsnTyr: 0.403 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.256ProAla: 9.256 ± 0.099	0.322ProCys: 0.322 ± 0.015	4.876ProAsp: 4.876 ± 0.069	3.93ProGlu: 3.93 ± 0.055	1.413ProPhe: 1.413 ± 0.025	6.584ProGly: 6.584 ± 0.083	1.312ProHis: 1.312 ± 0.03	1.659ProIle: 1.659 ± 0.035	0.895ProLys: 0.895 ± 0.023	5.241ProLeu: 5.241 ± 0.05	1.026ProMet: 1.026 ± 0.022	1.029ProAsn: 1.029 ± 0.027	4.504ProPro: 4.504 ± 0.097	1.743ProGln: 1.743 ± 0.034	4.055ProArg: 4.055 ± 0.052	3.166ProSer: 3.166 ± 0.052	4.358ProThr: 4.358 ± 0.067	6.04ProVal: 6.04 ± 0.069	0.942ProTrp: 0.942 ± 0.024	1.307ProTyr: 1.307 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.848GlnAla: 3.848 ± 0.055	0.168GlnCys: 0.168 ± 0.01	1.176GlnAsp: 1.176 ± 0.026	1.233GlnGlu: 1.233 ± 0.026	0.72GlnPhe: 0.72 ± 0.018	1.944GlnGly: 1.944 ± 0.039	0.685GlnHis: 0.685 ± 0.019	1.165GlnIle: 1.165 ± 0.026	0.404GlnLys: 0.404 ± 0.014	3.135GlnLeu: 3.135 ± 0.049	0.508GlnMet: 0.508 ± 0.017	0.478GlnAsn: 0.478 ± 0.017	1.997GlnPro: 1.997 ± 0.043	1.251GlnGln: 1.251 ± 0.036	2.929GlnArg: 2.929 ± 0.041	1.248GlnSer: 1.248 ± 0.026	1.408GlnThr: 1.408 ± 0.029	3.143GlnVal: 3.143 ± 0.042	0.538GlnTrp: 0.538 ± 0.019	0.539GlnTyr: 0.539 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.255ArgAla: 10.255 ± 0.09	0.702ArgCys: 0.702 ± 0.022	4.883ArgAsp: 4.883 ± 0.05	4.289ArgGlu: 4.289 ± 0.052	2.464ArgPhe: 2.464 ± 0.035	5.71ArgGly: 5.71 ± 0.058	2.5ArgHis: 2.5 ± 0.043	3.3ArgIle: 3.3 ± 0.047	1.345ArgLys: 1.345 ± 0.028	9.761ArgLeu: 9.761 ± 0.088	1.924ArgMet: 1.924 ± 0.035	1.53ArgAsn: 1.53 ± 0.032	5.671ArgPro: 5.671 ± 0.076	2.937ArgGln: 2.937 ± 0.04	9.036ArgArg: 9.036 ± 0.091	4.352ArgSer: 4.352 ± 0.051	5.244ArgThr: 5.244 ± 0.05	6.7ArgVal: 6.7 ± 0.069	1.773ArgTrp: 1.773 ± 0.035	2.056ArgTyr: 2.056 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.43SerAla: 6.43 ± 0.067	0.372SerCys: 0.372 ± 0.016	2.488SerAsp: 2.488 ± 0.043	2.088SerGlu: 2.088 ± 0.035	1.396SerPhe: 1.396 ± 0.03	5.575SerGly: 5.575 ± 0.055	0.961SerHis: 0.961 ± 0.026	1.566SerIle: 1.566 ± 0.036	0.767SerLys: 0.767 ± 0.023	4.277SerLeu: 4.277 ± 0.051	1.0SerMet: 1.0 ± 0.023	0.891SerAsn: 0.891 ± 0.025	3.164SerPro: 3.164 ± 0.049	1.154SerGln: 1.154 ± 0.023	3.901SerArg: 3.901 ± 0.04	2.493SerSer: 2.493 ± 0.039	3.338SerThr: 3.338 ± 0.042	4.178SerVal: 4.178 ± 0.047	0.906SerTrp: 0.906 ± 0.026	1.133SerTyr: 1.133 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.83ThrAla: 8.83 ± 0.084	0.439ThrCys: 0.439 ± 0.016	3.866ThrAsp: 3.866 ± 0.049	3.2ThrGlu: 3.2 ± 0.047	1.639ThrPhe: 1.639 ± 0.034	6.673ThrGly: 6.673 ± 0.071	1.129ThrHis: 1.129 ± 0.026	2.039ThrIle: 2.039 ± 0.04	0.881ThrLys: 0.881 ± 0.022	5.911ThrLeu: 5.911 ± 0.059	1.008ThrMet: 1.008 ± 0.023	1.084ThrAsn: 1.084 ± 0.028	4.488ThrPro: 4.488 ± 0.068	1.346ThrGln: 1.346 ± 0.028	4.431ThrArg: 4.431 ± 0.05	3.125ThrSer: 3.125 ± 0.044	4.064ThrThr: 4.064 ± 0.058	6.605ThrVal: 6.605 ± 0.067	0.953ThrTrp: 0.953 ± 0.026	1.245ThrTyr: 1.245 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	12.627ValAla: 12.627 ± 0.109	0.733ValCys: 0.733 ± 0.023	6.144ValAsp: 6.144 ± 0.07	4.916ValGlu: 4.916 ± 0.063	2.336ValPhe: 2.336 ± 0.04	7.396ValGly: 7.396 ± 0.073	1.898ValHis: 1.898 ± 0.033	2.961ValIle: 2.961 ± 0.045	1.364ValLys: 1.364 ± 0.032	9.791ValLeu: 9.791 ± 0.095	1.233ValMet: 1.233 ± 0.029	1.732ValAsn: 1.732 ± 0.037	5.658ValPro: 5.658 ± 0.072	2.134ValGln: 2.134 ± 0.035	7.559ValArg: 7.559 ± 0.073	4.403ValSer: 4.403 ± 0.056	6.289ValThr: 6.289 ± 0.065	9.039ValVal: 9.039 ± 0.09	1.153ValTrp: 1.153 ± 0.029	1.517ValTyr: 1.517 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.664TrpAla: 1.664 ± 0.035	0.161TrpCys: 0.161 ± 0.009	0.7TrpAsp: 0.7 ± 0.022	0.64TrpGlu: 0.64 ± 0.021	0.5TrpPhe: 0.5 ± 0.014	0.961TrpGly: 0.961 ± 0.021	0.431TrpHis: 0.431 ± 0.016	0.55TrpIle: 0.55 ± 0.017	0.255TrpLys: 0.255 ± 0.013	1.965TrpLeu: 1.965 ± 0.037	0.289TrpMet: 0.289 ± 0.013	0.403TrpAsn: 0.403 ± 0.016	0.938TrpPro: 0.938 ± 0.022	0.711TrpGln: 0.711 ± 0.023	1.706TrpArg: 1.706 ± 0.036	1.047TrpSer: 1.047 ± 0.029	1.021TrpThr: 1.021 ± 0.025	1.088TrpVal: 1.088 ± 0.022	0.391TrpTrp: 0.391 ± 0.015	0.361TrpTyr: 0.361 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.775TyrAla: 2.775 ± 0.046	0.174TyrCys: 0.174 ± 0.011	1.36TyrAsp: 1.36 ± 0.035	1.042TyrGlu: 1.042 ± 0.022	0.592TyrPhe: 0.592 ± 0.019	2.023TyrGly: 2.023 ± 0.041	0.477TyrHis: 0.477 ± 0.017	0.393TyrIle: 0.393 ± 0.015	0.267TyrLys: 0.267 ± 0.013	2.375TyrLeu: 2.375 ± 0.037	0.193TyrMet: 0.193 ± 0.01	0.351TyrAsn: 0.351 ± 0.016	1.197TyrPro: 1.197 ± 0.028	0.715TyrGln: 0.715 ± 0.019	1.992TyrArg: 1.992 ± 0.03	0.863TyrSer: 0.863 ± 0.022	1.128TyrThr: 1.128 ± 0.026	1.711TyrVal: 1.711 ± 0.032	0.336TyrTrp: 0.336 ± 0.015	0.416TyrTyr: 0.416 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5663 proteins (1872375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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