Amino acid dipepetide frequency for Neodiprion lecontei (Redheaded pine sawfly)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.011AlaAla: 6.011 ± 0.053	1.156AlaCys: 1.156 ± 0.023	3.328AlaAsp: 3.328 ± 0.024	4.455AlaGlu: 4.455 ± 0.032	2.154AlaPhe: 2.154 ± 0.02	4.045AlaGly: 4.045 ± 0.033	1.452AlaHis: 1.452 ± 0.016	3.442AlaIle: 3.442 ± 0.026	4.011AlaLys: 4.011 ± 0.055	5.993AlaLeu: 5.993 ± 0.042	1.55AlaMet: 1.55 ± 0.014	2.777AlaAsn: 2.777 ± 0.021	3.201AlaPro: 3.201 ± 0.034	2.618AlaGln: 2.618 ± 0.023	3.544AlaArg: 3.544 ± 0.027	5.327AlaSer: 5.327 ± 0.036	4.217AlaThr: 4.217 ± 0.027	4.607AlaVal: 4.607 ± 0.027	0.676AlaTrp: 0.676 ± 0.009	1.663AlaTyr: 1.663 ± 0.018	0.008AlaXaa: 0.008 ± 0.001
Cys	1.073CysAla: 1.073 ± 0.015	0.452CysCys: 0.452 ± 0.01	1.066CysAsp: 1.066 ± 0.02	1.086CysGlu: 1.086 ± 0.017	0.631CysPhe: 0.631 ± 0.009	1.293CysGly: 1.293 ± 0.032	0.475CysHis: 0.475 ± 0.009	0.969CysIle: 0.969 ± 0.025	1.028CysLys: 1.028 ± 0.017	1.665CysLeu: 1.665 ± 0.024	0.357CysMet: 0.357 ± 0.007	0.874CysAsn: 0.874 ± 0.019	0.965CysPro: 0.965 ± 0.026	0.768CysGln: 0.768 ± 0.019	1.079CysArg: 1.079 ± 0.025	1.522CysSer: 1.522 ± 0.029	1.033CysThr: 1.033 ± 0.022	1.158CysVal: 1.158 ± 0.022	0.208CysTrp: 0.208 ± 0.005	0.532CysTyr: 0.532 ± 0.01	0.003CysXaa: 0.003 ± 0.001
Asp	3.445AspAla: 3.445 ± 0.026	0.955AspCys: 0.955 ± 0.02	3.756AspAsp: 3.756 ± 0.032	4.359AspGlu: 4.359 ± 0.028	2.073AspPhe: 2.073 ± 0.017	3.48AspGly: 3.48 ± 0.036	1.208AspHis: 1.208 ± 0.012	3.158AspIle: 3.158 ± 0.023	3.286AspLys: 3.286 ± 0.035	4.997AspLeu: 4.997 ± 0.026	1.176AspMet: 1.176 ± 0.012	2.507AspAsn: 2.507 ± 0.022	2.745AspPro: 2.745 ± 0.032	1.878AspGln: 1.878 ± 0.015	2.85AspArg: 2.85 ± 0.029	4.492AspSer: 4.492 ± 0.032	2.996AspThr: 2.996 ± 0.026	3.708AspVal: 3.708 ± 0.024	0.644AspTrp: 0.644 ± 0.01	1.74AspTyr: 1.74 ± 0.018	0.008AspXaa: 0.008 ± 0.001
Glu	4.614GluAla: 4.614 ± 0.042	1.133GluCys: 1.133 ± 0.033	4.283GluAsp: 4.283 ± 0.029	6.124GluGlu: 6.124 ± 0.055	2.223GluPhe: 2.223 ± 0.016	3.397GluGly: 3.397 ± 0.031	1.409GluHis: 1.409 ± 0.015	3.847GluIle: 3.847 ± 0.029	5.046GluLys: 5.046 ± 0.054	5.983GluLeu: 5.983 ± 0.041	1.559GluMet: 1.559 ± 0.015	3.58GluAsn: 3.58 ± 0.028	2.93GluPro: 2.93 ± 0.038	2.669GluGln: 2.669 ± 0.027	4.011GluArg: 4.011 ± 0.035	4.86GluSer: 4.86 ± 0.033	3.918GluThr: 3.918 ± 0.029	4.119GluVal: 4.119 ± 0.026	0.684GluTrp: 0.684 ± 0.01	1.904GluTyr: 1.904 ± 0.019	0.011GluXaa: 0.011 ± 0.001
Phe	2.143PheAla: 2.143 ± 0.02	0.675PheCys: 0.675 ± 0.01	1.997PheAsp: 1.997 ± 0.017	2.085PheGlu: 2.085 ± 0.018	1.313PhePhe: 1.313 ± 0.018	2.321PheGly: 2.321 ± 0.023	0.928PheHis: 0.928 ± 0.012	1.803PheIle: 1.803 ± 0.017	1.896PheLys: 1.896 ± 0.019	3.283PheLeu: 3.283 ± 0.028	0.74PheMet: 0.74 ± 0.008	1.598PheAsn: 1.598 ± 0.015	1.598PhePro: 1.598 ± 0.016	1.331PheGln: 1.331 ± 0.015	1.849PheArg: 1.849 ± 0.023	2.728PheSer: 2.728 ± 0.023	2.074PheThr: 2.074 ± 0.018	2.353PheVal: 2.353 ± 0.021	0.428PheTrp: 0.428 ± 0.009	1.182PheTyr: 1.182 ± 0.014	0.01PheXaa: 0.01 ± 0.001
Gly	3.656GlyAla: 3.656 ± 0.03	1.024GlyCys: 1.024 ± 0.016	3.249GlyAsp: 3.249 ± 0.024	3.631GlyGlu: 3.631 ± 0.035	2.273GlyPhe: 2.273 ± 0.022	5.157GlyGly: 5.157 ± 0.066	1.494GlyHis: 1.494 ± 0.016	3.261GlyIle: 3.261 ± 0.028	3.582GlyLys: 3.582 ± 0.032	4.858GlyLeu: 4.858 ± 0.032	1.273GlyMet: 1.273 ± 0.015	2.946GlyAsn: 2.946 ± 0.027	2.837GlyPro: 2.837 ± 0.042	2.328GlyGln: 2.328 ± 0.025	3.27GlyArg: 3.27 ± 0.027	5.384GlySer: 5.384 ± 0.044	3.584GlyThr: 3.584 ± 0.025	3.709GlyVal: 3.709 ± 0.026	0.688GlyTrp: 0.688 ± 0.011	1.99GlyTyr: 1.99 ± 0.024	0.01GlyXaa: 0.01 ± 0.001
His	1.422HisAla: 1.422 ± 0.013	0.554HisCys: 0.554 ± 0.01	1.095HisAsp: 1.095 ± 0.012	1.358HisGlu: 1.358 ± 0.016	0.897HisPhe: 0.897 ± 0.011	1.483HisGly: 1.483 ± 0.016	1.09HisHis: 1.09 ± 0.024	1.26HisIle: 1.26 ± 0.013	1.256HisLys: 1.256 ± 0.013	2.278HisLeu: 2.278 ± 0.019	0.568HisMet: 0.568 ± 0.009	1.102HisAsn: 1.102 ± 0.012	1.495HisPro: 1.495 ± 0.015	1.235HisGln: 1.235 ± 0.016	1.551HisArg: 1.551 ± 0.017	2.002HisSer: 2.002 ± 0.019	1.313HisThr: 1.313 ± 0.013	1.514HisVal: 1.514 ± 0.014	0.299HisTrp: 0.299 ± 0.006	0.793HisTyr: 0.793 ± 0.01	0.004HisXaa: 0.004 ± 0.001
Ile	3.507IleAla: 3.507 ± 0.022	1.071IleCys: 1.071 ± 0.018	3.026IleAsp: 3.026 ± 0.024	3.605IleGlu: 3.605 ± 0.031	2.023IlePhe: 2.023 ± 0.023	2.986IleGly: 2.986 ± 0.022	1.285IleHis: 1.285 ± 0.014	2.863IleIle: 2.863 ± 0.024	3.119IleLys: 3.119 ± 0.027	4.898IleLeu: 4.898 ± 0.038	1.069IleMet: 1.069 ± 0.013	2.497IleAsn: 2.497 ± 0.021	2.932IlePro: 2.932 ± 0.019	2.223IleGln: 2.223 ± 0.02	2.704IleArg: 2.704 ± 0.019	4.233IleSer: 4.233 ± 0.025	3.218IleThr: 3.218 ± 0.031	3.442IleVal: 3.442 ± 0.025	0.532IleTrp: 0.532 ± 0.009	1.525IleTyr: 1.525 ± 0.016	0.012IleXaa: 0.012 ± 0.001
Lys	3.563LysAla: 3.563 ± 0.03	1.079LysCys: 1.079 ± 0.023	3.542LysAsp: 3.542 ± 0.052	4.513LysGlu: 4.513 ± 0.049	2.057LysPhe: 2.057 ± 0.017	2.777LysGly: 2.777 ± 0.028	1.457LysHis: 1.457 ± 0.017	3.488LysIle: 3.488 ± 0.028	4.845LysLys: 4.845 ± 0.042	5.646LysLeu: 5.646 ± 0.039	1.442LysMet: 1.442 ± 0.014	3.021LysAsn: 3.021 ± 0.021	3.206LysPro: 3.206 ± 0.054	2.501LysGln: 2.501 ± 0.022	3.588LysArg: 3.588 ± 0.031	4.64LysSer: 4.64 ± 0.037	3.505LysThr: 3.505 ± 0.033	3.635LysVal: 3.635 ± 0.035	0.674LysTrp: 0.674 ± 0.012	1.895LysTyr: 1.895 ± 0.02	0.007LysXaa: 0.007 ± 0.001
Leu	6.362LeuAla: 6.362 ± 0.036	1.66LeuCys: 1.66 ± 0.019	4.922LeuAsp: 4.922 ± 0.033	6.22LeuGlu: 6.22 ± 0.049	2.957LeuPhe: 2.957 ± 0.027	4.886LeuGly: 4.886 ± 0.029	2.367LeuHis: 2.367 ± 0.02	4.358LeuIle: 4.358 ± 0.031	5.617LeuLys: 5.617 ± 0.037	8.434LeuLeu: 8.434 ± 0.056	1.891LeuMet: 1.891 ± 0.019	4.075LeuAsn: 4.075 ± 0.028	4.804LeuPro: 4.804 ± 0.033	4.467LeuGln: 4.467 ± 0.037	5.478LeuArg: 5.478 ± 0.035	7.014LeuSer: 7.014 ± 0.038	5.24LeuThr: 5.24 ± 0.03	5.385LeuVal: 5.385 ± 0.031	0.928LeuTrp: 0.928 ± 0.012	2.473LeuTyr: 2.473 ± 0.024	0.015LeuXaa: 0.015 ± 0.002
Met	1.653MetAla: 1.653 ± 0.015	0.382MetCys: 0.382 ± 0.008	1.274MetAsp: 1.274 ± 0.012	1.592MetGlu: 1.592 ± 0.013	0.764MetPhe: 0.764 ± 0.011	1.225MetGly: 1.225 ± 0.016	0.488MetHis: 0.488 ± 0.007	1.063MetIle: 1.063 ± 0.012	1.35MetLys: 1.35 ± 0.013	1.916MetLeu: 1.916 ± 0.018	0.627MetMet: 0.627 ± 0.008	1.0MetAsn: 1.0 ± 0.011	1.103MetPro: 1.103 ± 0.014	0.964MetGln: 0.964 ± 0.014	1.156MetArg: 1.156 ± 0.012	1.739MetSer: 1.739 ± 0.015	1.273MetThr: 1.273 ± 0.012	1.327MetVal: 1.327 ± 0.014	0.243MetTrp: 0.243 ± 0.006	0.615MetTyr: 0.615 ± 0.009	0.003MetXaa: 0.003 ± 0.001
Asn	2.928AsnAla: 2.928 ± 0.024	0.882AsnCys: 0.882 ± 0.013	2.514AsnAsp: 2.514 ± 0.021	3.008AsnGlu: 3.008 ± 0.021	1.699AsnPhe: 1.699 ± 0.017	3.088AsnGly: 3.088 ± 0.03	1.184AsnHis: 1.184 ± 0.016	2.755AsnIle: 2.755 ± 0.02	2.716AsnLys: 2.716 ± 0.02	4.369AsnLeu: 4.369 ± 0.028	1.045AsnMet: 1.045 ± 0.012	2.8AsnAsn: 2.8 ± 0.03	2.463AsnPro: 2.463 ± 0.033	1.947AsnGln: 1.947 ± 0.02	2.346AsnArg: 2.346 ± 0.019	4.078AsnSer: 4.078 ± 0.036	2.65AsnThr: 2.65 ± 0.021	3.167AsnVal: 3.167 ± 0.019	0.5AsnTrp: 0.5 ± 0.008	1.497AsnTyr: 1.497 ± 0.015	0.008AsnXaa: 0.008 ± 0.001
Pro	3.637ProAla: 3.637 ± 0.031	0.796ProCys: 0.796 ± 0.043	2.829ProAsp: 2.829 ± 0.02	3.77ProGlu: 3.77 ± 0.035	1.569ProPhe: 1.569 ± 0.018	3.527ProGly: 3.527 ± 0.051	1.282ProHis: 1.282 ± 0.016	2.598ProIle: 2.598 ± 0.02	2.938ProLys: 2.938 ± 0.03	4.261ProLeu: 4.261 ± 0.03	1.056ProMet: 1.056 ± 0.014	2.342ProAsn: 2.342 ± 0.024	4.731ProPro: 4.731 ± 0.066	2.35ProGln: 2.35 ± 0.028	2.892ProArg: 2.892 ± 0.027	4.706ProSer: 4.706 ± 0.042	3.424ProThr: 3.424 ± 0.033	3.544ProVal: 3.544 ± 0.026	0.524ProTrp: 0.524 ± 0.009	1.497ProTyr: 1.497 ± 0.018	0.01ProXaa: 0.01 ± 0.001
Gln	2.69GlnAla: 2.69 ± 0.023	0.746GlnCys: 0.746 ± 0.02	2.025GlnAsp: 2.025 ± 0.014	2.907GlnGlu: 2.907 ± 0.025	1.369GlnPhe: 1.369 ± 0.015	2.259GlnGly: 2.259 ± 0.02	1.237GlnHis: 1.237 ± 0.016	2.173GlnIle: 2.173 ± 0.018	2.429GlnLys: 2.429 ± 0.022	4.051GlnLeu: 4.051 ± 0.034	0.953GlnMet: 0.953 ± 0.012	2.102GlnAsn: 2.102 ± 0.021	2.311GlnPro: 2.311 ± 0.028	3.549GlnGln: 3.549 ± 0.085	2.662GlnArg: 2.662 ± 0.025	3.188GlnSer: 3.188 ± 0.025	2.393GlnThr: 2.393 ± 0.022	2.494GlnVal: 2.494 ± 0.022	0.474GlnTrp: 0.474 ± 0.008	1.253GlnTyr: 1.253 ± 0.013	0.008GlnXaa: 0.008 ± 0.001
Arg	3.312ArgAla: 3.312 ± 0.022	1.029ArgCys: 1.029 ± 0.015	3.157ArgAsp: 3.157 ± 0.029	3.857ArgGlu: 3.857 ± 0.029	1.901ArgPhe: 1.901 ± 0.02	3.244ArgGly: 3.244 ± 0.029	1.526ArgHis: 1.526 ± 0.014	2.931ArgIle: 2.931 ± 0.02	3.716ArgLys: 3.716 ± 0.028	5.053ArgLeu: 5.053 ± 0.034	1.17ArgMet: 1.17 ± 0.013	2.781ArgAsn: 2.781 ± 0.021	2.802ArgPro: 2.802 ± 0.031	2.497ArgGln: 2.497 ± 0.021	4.308ArgArg: 4.308 ± 0.042	4.521ArgSer: 4.521 ± 0.046	2.949ArgThr: 2.949 ± 0.017	3.253ArgVal: 3.253 ± 0.024	0.628ArgTrp: 0.628 ± 0.011	1.689ArgTyr: 1.689 ± 0.015	0.008ArgXaa: 0.008 ± 0.001
Ser	5.08SerAla: 5.08 ± 0.033	1.425SerCys: 1.425 ± 0.03	4.524SerAsp: 4.524 ± 0.032	5.094SerGlu: 5.094 ± 0.034	2.595SerPhe: 2.595 ± 0.021	5.436SerGly: 5.436 ± 0.038	1.884SerHis: 1.884 ± 0.015	3.967SerIle: 3.967 ± 0.027	4.598SerLys: 4.598 ± 0.041	7.139SerLeu: 7.139 ± 0.041	1.688SerMet: 1.688 ± 0.017	3.933SerAsn: 3.933 ± 0.034	5.076SerPro: 5.076 ± 0.058	3.375SerGln: 3.375 ± 0.026	4.535SerArg: 4.535 ± 0.043	8.743SerSer: 8.743 ± 0.075	5.271SerThr: 5.271 ± 0.037	4.996SerVal: 4.996 ± 0.032	0.87SerTrp: 0.87 ± 0.012	2.194SerTyr: 2.194 ± 0.02	0.014SerXaa: 0.014 ± 0.001
Thr	4.173ThrAla: 4.173 ± 0.026	1.11ThrCys: 1.11 ± 0.022	3.115ThrAsp: 3.115 ± 0.022	3.85ThrGlu: 3.85 ± 0.034	2.0ThrPhe: 2.0 ± 0.018	3.684ThrGly: 3.684 ± 0.031	1.261ThrHis: 1.261 ± 0.015	3.22ThrIle: 3.22 ± 0.022	3.328ThrLys: 3.328 ± 0.041	5.381ThrLeu: 5.381 ± 0.031	1.271ThrMet: 1.271 ± 0.012	2.738ThrAsn: 2.738 ± 0.02	3.792ThrPro: 3.792 ± 0.034	2.203ThrGln: 2.203 ± 0.024	2.877ThrArg: 2.877 ± 0.022	5.287ThrSer: 5.287 ± 0.037	4.287ThrThr: 4.287 ± 0.044	4.116ThrVal: 4.116 ± 0.03	0.673ThrTrp: 0.673 ± 0.012	1.564ThrTyr: 1.564 ± 0.017	0.01ThrXaa: 0.01 ± 0.001
Val	4.537ValAla: 4.537 ± 0.033	1.254ValCys: 1.254 ± 0.021	3.521ValAsp: 3.521 ± 0.024	4.298ValGlu: 4.298 ± 0.035	2.22ValPhe: 2.22 ± 0.018	3.47ValGly: 3.47 ± 0.024	1.467ValHis: 1.467 ± 0.014	3.493ValIle: 3.493 ± 0.025	3.921ValLys: 3.921 ± 0.038	5.524ValLeu: 5.524 ± 0.037	1.383ValMet: 1.383 ± 0.013	2.969ValAsn: 2.969 ± 0.022	3.444ValPro: 3.444 ± 0.024	2.641ValGln: 2.641 ± 0.022	3.259ValArg: 3.259 ± 0.024	4.894ValSer: 4.894 ± 0.028	4.256ValThr: 4.256 ± 0.029	4.302ValVal: 4.302 ± 0.03	0.685ValTrp: 0.685 ± 0.008	1.762ValTyr: 1.762 ± 0.018	0.009ValXaa: 0.009 ± 0.001
Trp	0.648TrpAla: 0.648 ± 0.01	0.208TrpCys: 0.208 ± 0.005	0.615TrpAsp: 0.615 ± 0.011	0.679TrpGlu: 0.679 ± 0.01	0.429TrpPhe: 0.429 ± 0.009	0.607TrpGly: 0.607 ± 0.01	0.267TrpHis: 0.267 ± 0.007	0.641TrpIle: 0.641 ± 0.011	0.694TrpLys: 0.694 ± 0.011	1.112TrpLeu: 1.112 ± 0.012	0.287TrpMet: 0.287 ± 0.006	0.556TrpAsn: 0.556 ± 0.009	0.434TrpPro: 0.434 ± 0.008	0.46TrpGln: 0.46 ± 0.008	0.683TrpArg: 0.683 ± 0.009	0.828TrpSer: 0.828 ± 0.011	0.623TrpThr: 0.623 ± 0.011	0.628TrpVal: 0.628 ± 0.01	0.195TrpTrp: 0.195 ± 0.005	0.331TrpTyr: 0.331 ± 0.007	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.771TyrAla: 1.771 ± 0.018	0.641TyrCys: 0.641 ± 0.01	1.612TyrAsp: 1.612 ± 0.015	1.798TyrGlu: 1.798 ± 0.018	1.181TyrPhe: 1.181 ± 0.014	1.832TyrGly: 1.832 ± 0.02	0.806TyrHis: 0.806 ± 0.01	1.468TyrIle: 1.468 ± 0.017	1.694TyrLys: 1.694 ± 0.016	2.701TyrLeu: 2.701 ± 0.023	0.65TyrMet: 0.65 ± 0.009	1.438TyrAsn: 1.438 ± 0.016	1.402TyrPro: 1.402 ± 0.019	1.265TyrGln: 1.265 ± 0.014	1.678TyrArg: 1.678 ± 0.014	2.239TyrSer: 2.239 ± 0.02	1.71TyrThr: 1.71 ± 0.018	1.842TyrVal: 1.842 ± 0.018	0.372TyrTrp: 0.372 ± 0.008	1.075TyrTyr: 1.075 ± 0.011	0.005TyrXaa: 0.005 ± 0.001
Xaa	0.01XaaAla: 0.01 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.008XaaAsp: 0.008 ± 0.001	0.012XaaGlu: 0.012 ± 0.001	0.007XaaPhe: 0.007 ± 0.001	0.009XaaGly: 0.009 ± 0.001	0.004XaaHis: 0.004 ± 0.001	0.01XaaIle: 0.01 ± 0.001	0.011XaaLys: 0.011 ± 0.001	0.013XaaLeu: 0.013 ± 0.002	0.004XaaMet: 0.004 ± 0.001	0.01XaaAsn: 0.01 ± 0.001	0.009XaaPro: 0.009 ± 0.001	0.005XaaGln: 0.005 ± 0.001	0.009XaaArg: 0.009 ± 0.001	0.014XaaSer: 0.014 ± 0.002	0.011XaaThr: 0.011 ± 0.001	0.009XaaVal: 0.009 ± 0.001	0.002XaaTrp: 0.002 ± 0.0	0.006XaaTyr: 0.006 ± 0.001	0.008XaaXaa: 0.008 ± 0.001

Statistics based on 14458 proteins (9009225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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