Amino acid dipepetide frequency for Xylella phage Prado

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.624AlaAla: 16.624 ± 1.67
0.799AlaCys: 0.799 ± 0.168
6.461AlaAsp: 6.461 ± 0.727
7.84AlaGlu: 7.84 ± 0.653
2.904AlaPhe: 2.904 ± 0.5
7.477AlaGly: 7.477 ± 1.091
1.452AlaHis: 1.452 ± 0.451
4.574AlaIle: 4.574 ± 0.622
4.864AlaLys: 4.864 ± 0.789
8.421AlaLeu: 8.421 ± 0.767
3.848AlaMet: 3.848 ± 0.667
4.283AlaAsn: 4.283 ± 0.504
4.574AlaPro: 4.574 ± 0.851
4.428AlaGln: 4.428 ± 0.697
6.461AlaArg: 6.461 ± 0.716
4.936AlaSer: 4.936 ± 0.649
5.808AlaThr: 5.808 ± 0.618
7.55AlaVal: 7.55 ± 0.716
2.033AlaTrp: 2.033 ± 0.39
2.831AlaTyr: 2.831 ± 0.362
0.0AlaXaa: 0.0 ± 0.0
Cys
0.653CysAla: 0.653 ± 0.258
0.0CysCys: 0.0 ± 0.0
0.363CysAsp: 0.363 ± 0.212
0.436CysGlu: 0.436 ± 0.168
0.218CysPhe: 0.218 ± 0.125
0.944CysGly: 0.944 ± 0.315
0.145CysHis: 0.145 ± 0.112
0.726CysIle: 0.726 ± 0.227
0.29CysLys: 0.29 ± 0.177
0.508CysLeu: 0.508 ± 0.205
0.145CysMet: 0.145 ± 0.112
0.508CysAsn: 0.508 ± 0.19
0.145CysPro: 0.145 ± 0.106
0.363CysGln: 0.363 ± 0.225
0.436CysArg: 0.436 ± 0.19
0.29CysSer: 0.29 ± 0.159
0.653CysThr: 0.653 ± 0.232
0.581CysVal: 0.581 ± 0.208
0.073CysTrp: 0.073 ± 0.063
0.29CysTyr: 0.29 ± 0.14
0.0CysXaa: 0.0 ± 0.0
Asp
5.517AspAla: 5.517 ± 0.639
0.363AspCys: 0.363 ± 0.177
4.574AspAsp: 4.574 ± 0.53
4.864AspGlu: 4.864 ± 0.688
2.541AspPhe: 2.541 ± 0.438
5.227AspGly: 5.227 ± 0.671
0.581AspHis: 0.581 ± 0.206
3.122AspIle: 3.122 ± 0.424
3.339AspLys: 3.339 ± 0.595
3.848AspLeu: 3.848 ± 0.412
1.452AspMet: 1.452 ± 0.351
2.396AspAsn: 2.396 ± 0.445
3.485AspPro: 3.485 ± 0.407
2.613AspGln: 2.613 ± 0.405
3.63AspArg: 3.63 ± 0.48
2.25AspSer: 2.25 ± 0.385
3.412AspThr: 3.412 ± 0.453
4.356AspVal: 4.356 ± 0.606
1.234AspTrp: 1.234 ± 0.305
2.468AspTyr: 2.468 ± 0.527
0.0AspXaa: 0.0 ± 0.0
Glu
6.824GluAla: 6.824 ± 0.755
0.436GluCys: 0.436 ± 0.191
2.759GluAsp: 2.759 ± 0.468
4.138GluGlu: 4.138 ± 0.619
2.904GluPhe: 2.904 ± 0.483
4.646GluGly: 4.646 ± 0.596
1.742GluHis: 1.742 ± 0.385
2.033GluIle: 2.033 ± 0.296
2.976GluLys: 2.976 ± 0.624
6.534GluLeu: 6.534 ± 0.683
1.525GluMet: 1.525 ± 0.254
2.323GluAsn: 2.323 ± 0.583
1.67GluPro: 1.67 ± 0.372
3.412GluGln: 3.412 ± 0.393
3.339GluArg: 3.339 ± 0.531
3.412GluSer: 3.412 ± 0.485
3.267GluThr: 3.267 ± 0.434
4.138GluVal: 4.138 ± 0.676
1.452GluTrp: 1.452 ± 0.298
2.613GluTyr: 2.613 ± 0.437
0.0GluXaa: 0.0 ± 0.0
Phe
2.759PheAla: 2.759 ± 0.447
0.508PheCys: 0.508 ± 0.212
2.831PheAsp: 2.831 ± 0.462
1.234PheGlu: 1.234 ± 0.343
0.508PhePhe: 0.508 ± 0.214
2.613PheGly: 2.613 ± 0.498
0.799PheHis: 0.799 ± 0.243
1.452PheIle: 1.452 ± 0.385
1.162PheLys: 1.162 ± 0.271
2.468PheLeu: 2.468 ± 0.387
0.508PheMet: 0.508 ± 0.204
1.379PheAsn: 1.379 ± 0.36
1.887PhePro: 1.887 ± 0.403
1.307PheGln: 1.307 ± 0.328
1.815PheArg: 1.815 ± 0.384
2.25PheSer: 2.25 ± 0.331
1.96PheThr: 1.96 ± 0.512
2.759PheVal: 2.759 ± 0.585
0.29PheTrp: 0.29 ± 0.145
1.525PheTyr: 1.525 ± 0.286
0.0PheXaa: 0.0 ± 0.0
Gly
7.623GlyAla: 7.623 ± 0.685
0.508GlyCys: 0.508 ± 0.197
5.88GlyAsp: 5.88 ± 0.634
4.936GlyGlu: 4.936 ± 0.703
2.686GlyPhe: 2.686 ± 0.362
7.913GlyGly: 7.913 ± 0.771
0.799GlyHis: 0.799 ± 0.298
3.339GlyIle: 3.339 ± 0.577
4.501GlyLys: 4.501 ± 0.582
5.009GlyLeu: 5.009 ± 0.713
2.468GlyMet: 2.468 ± 0.382
3.702GlyAsn: 3.702 ± 0.357
2.396GlyPro: 2.396 ± 0.549
3.267GlyGln: 3.267 ± 0.608
5.227GlyArg: 5.227 ± 0.821
5.662GlySer: 5.662 ± 0.686
5.372GlyThr: 5.372 ± 0.715
5.735GlyVal: 5.735 ± 0.507
1.379GlyTrp: 1.379 ± 0.346
2.468GlyTyr: 2.468 ± 0.391
0.0GlyXaa: 0.0 ± 0.0
His
1.597HisAla: 1.597 ± 0.461
0.073HisCys: 0.073 ± 0.092
1.234HisAsp: 1.234 ± 0.307
1.234HisGlu: 1.234 ± 0.304
0.799HisPhe: 0.799 ± 0.217
1.234HisGly: 1.234 ± 0.259
0.29HisHis: 0.29 ± 0.135
0.799HisIle: 0.799 ± 0.293
0.944HisLys: 0.944 ± 0.329
1.234HisLeu: 1.234 ± 0.313
0.653HisMet: 0.653 ± 0.217
0.871HisAsn: 0.871 ± 0.254
1.162HisPro: 1.162 ± 0.267
0.508HisGln: 0.508 ± 0.192
1.67HisArg: 1.67 ± 0.39
1.089HisSer: 1.089 ± 0.252
0.653HisThr: 0.653 ± 0.19
1.452HisVal: 1.452 ± 0.361
0.145HisTrp: 0.145 ± 0.096
0.218HisTyr: 0.218 ± 0.121
0.0HisXaa: 0.0 ± 0.0
Ile
5.227IleAla: 5.227 ± 0.805
0.29IleCys: 0.29 ± 0.153
3.63IleAsp: 3.63 ± 0.49
2.976IleGlu: 2.976 ± 0.546
1.089IlePhe: 1.089 ± 0.279
3.412IleGly: 3.412 ± 0.435
1.016IleHis: 1.016 ± 0.25
1.887IleIle: 1.887 ± 0.413
2.686IleLys: 2.686 ± 0.569
2.759IleLeu: 2.759 ± 0.472
0.726IleMet: 0.726 ± 0.242
1.815IleAsn: 1.815 ± 0.368
2.396IlePro: 2.396 ± 0.395
1.67IleGln: 1.67 ± 0.322
2.541IleArg: 2.541 ± 0.437
2.178IleSer: 2.178 ± 0.314
3.485IleThr: 3.485 ± 0.49
2.831IleVal: 2.831 ± 0.502
0.436IleTrp: 0.436 ± 0.162
1.379IleTyr: 1.379 ± 0.295
0.0IleXaa: 0.0 ± 0.0
Lys
6.388LysAla: 6.388 ± 0.845
0.145LysCys: 0.145 ± 0.115
2.686LysAsp: 2.686 ± 0.49
3.194LysGlu: 3.194 ± 0.591
1.452LysPhe: 1.452 ± 0.349
3.339LysGly: 3.339 ± 0.548
1.162LysHis: 1.162 ± 0.313
2.033LysIle: 2.033 ± 0.359
2.178LysLys: 2.178 ± 0.466
5.154LysLeu: 5.154 ± 0.8
1.162LysMet: 1.162 ± 0.323
1.597LysAsn: 1.597 ± 0.293
2.468LysPro: 2.468 ± 0.499
2.033LysGln: 2.033 ± 0.423
3.485LysArg: 3.485 ± 0.625
2.323LysSer: 2.323 ± 0.351
2.468LysThr: 2.468 ± 0.443
2.831LysVal: 2.831 ± 0.567
1.234LysTrp: 1.234 ± 0.291
2.033LysTyr: 2.033 ± 0.338
0.0LysXaa: 0.0 ± 0.0
Leu
7.768LeuAla: 7.768 ± 0.824
1.234LeuCys: 1.234 ± 0.333
5.082LeuAsp: 5.082 ± 0.567
5.735LeuGlu: 5.735 ± 0.596
1.597LeuPhe: 1.597 ± 0.371
5.009LeuGly: 5.009 ± 0.601
1.815LeuHis: 1.815 ± 0.38
3.485LeuIle: 3.485 ± 0.587
4.138LeuLys: 4.138 ± 0.676
6.969LeuLeu: 6.969 ± 0.649
2.033LeuMet: 2.033 ± 0.319
3.339LeuAsn: 3.339 ± 0.469
4.065LeuPro: 4.065 ± 0.523
3.485LeuGln: 3.485 ± 0.707
6.969LeuArg: 6.969 ± 0.733
5.808LeuSer: 5.808 ± 0.541
4.791LeuThr: 4.791 ± 0.629
4.791LeuVal: 4.791 ± 0.497
1.016LeuTrp: 1.016 ± 0.226
2.976LeuTyr: 2.976 ± 0.566
0.0LeuXaa: 0.0 ± 0.0
Met
2.831MetAla: 2.831 ± 0.389
0.218MetCys: 0.218 ± 0.147
2.25MetAsp: 2.25 ± 0.376
0.944MetGlu: 0.944 ± 0.256
0.944MetPhe: 0.944 ± 0.277
2.323MetGly: 2.323 ± 0.627
0.29MetHis: 0.29 ± 0.134
0.726MetIle: 0.726 ± 0.219
1.234MetLys: 1.234 ± 0.414
1.742MetLeu: 1.742 ± 0.282
0.436MetMet: 0.436 ± 0.197
0.944MetAsn: 0.944 ± 0.3
0.653MetPro: 0.653 ± 0.284
1.379MetGln: 1.379 ± 0.301
2.105MetArg: 2.105 ± 0.361
2.613MetSer: 2.613 ± 0.447
1.597MetThr: 1.597 ± 0.336
1.525MetVal: 1.525 ± 0.36
0.29MetTrp: 0.29 ± 0.153
0.799MetTyr: 0.799 ± 0.284
0.0MetXaa: 0.0 ± 0.0
Asn
4.065AsnAla: 4.065 ± 0.694
0.218AsnCys: 0.218 ± 0.118
2.105AsnAsp: 2.105 ± 0.335
2.613AsnGlu: 2.613 ± 0.527
1.307AsnPhe: 1.307 ± 0.303
4.428AsnGly: 4.428 ± 0.484
0.653AsnHis: 0.653 ± 0.271
1.742AsnIle: 1.742 ± 0.392
1.815AsnLys: 1.815 ± 0.427
3.775AsnLeu: 3.775 ± 0.477
0.944AsnMet: 0.944 ± 0.27
2.105AsnAsn: 2.105 ± 0.392
2.396AsnPro: 2.396 ± 0.385
1.379AsnGln: 1.379 ± 0.335
2.904AsnArg: 2.904 ± 0.544
2.25AsnSer: 2.25 ± 0.34
2.613AsnThr: 2.613 ± 0.539
2.759AsnVal: 2.759 ± 0.467
0.653AsnTrp: 0.653 ± 0.197
1.525AsnTyr: 1.525 ± 0.295
0.0AsnXaa: 0.0 ± 0.0
Pro
4.428ProAla: 4.428 ± 0.974
0.363ProCys: 0.363 ± 0.157
3.122ProAsp: 3.122 ± 0.488
3.557ProGlu: 3.557 ± 0.568
0.944ProPhe: 0.944 ± 0.342
3.194ProGly: 3.194 ± 0.536
0.871ProHis: 0.871 ± 0.252
1.742ProIle: 1.742 ± 0.493
1.96ProLys: 1.96 ± 0.351
3.92ProLeu: 3.92 ± 0.48
1.525ProMet: 1.525 ± 0.409
2.396ProAsn: 2.396 ± 0.467
2.033ProPro: 2.033 ± 0.45
1.887ProGln: 1.887 ± 0.438
1.815ProArg: 1.815 ± 0.329
2.396ProSer: 2.396 ± 0.421
2.105ProThr: 2.105 ± 0.477
3.049ProVal: 3.049 ± 0.486
0.726ProTrp: 0.726 ± 0.228
1.016ProTyr: 1.016 ± 0.315
0.0ProXaa: 0.0 ± 0.0
Gln
5.227GlnAla: 5.227 ± 0.669
0.218GlnCys: 0.218 ± 0.178
1.67GlnAsp: 1.67 ± 0.379
1.815GlnGlu: 1.815 ± 0.295
1.379GlnPhe: 1.379 ± 0.35
2.759GlnGly: 2.759 ± 0.297
0.726GlnHis: 0.726 ± 0.226
2.105GlnIle: 2.105 ± 0.278
1.67GlnLys: 1.67 ± 0.32
3.702GlnLeu: 3.702 ± 0.457
1.67GlnMet: 1.67 ± 0.344
1.379GlnAsn: 1.379 ± 0.256
2.25GlnPro: 2.25 ± 0.694
3.049GlnGln: 3.049 ± 0.52
3.194GlnArg: 3.194 ± 0.568
2.396GlnSer: 2.396 ± 0.397
2.904GlnThr: 2.904 ± 0.531
2.323GlnVal: 2.323 ± 0.49
0.871GlnTrp: 0.871 ± 0.308
1.742GlnTyr: 1.742 ± 0.446
0.0GlnXaa: 0.0 ± 0.0
Arg
7.114ArgAla: 7.114 ± 0.952
0.726ArgCys: 0.726 ± 0.258
3.339ArgAsp: 3.339 ± 0.524
3.194ArgGlu: 3.194 ± 0.498
2.033ArgPhe: 2.033 ± 0.329
4.719ArgGly: 4.719 ± 0.749
1.525ArgHis: 1.525 ± 0.328
3.412ArgIle: 3.412 ± 0.587
4.574ArgLys: 4.574 ± 0.633
5.517ArgLeu: 5.517 ± 0.543
2.25ArgMet: 2.25 ± 0.318
2.396ArgAsn: 2.396 ± 0.414
1.742ArgPro: 1.742 ± 0.393
2.033ArgGln: 2.033 ± 0.415
3.63ArgArg: 3.63 ± 0.628
3.339ArgSer: 3.339 ± 0.532
3.63ArgThr: 3.63 ± 0.623
5.082ArgVal: 5.082 ± 0.674
0.871ArgTrp: 0.871 ± 0.3
2.033ArgTyr: 2.033 ± 0.412
0.0ArgXaa: 0.0 ± 0.0
Ser
5.372SerAla: 5.372 ± 0.58
0.436SerCys: 0.436 ± 0.189
3.122SerAsp: 3.122 ± 0.391
3.993SerGlu: 3.993 ± 0.506
2.178SerPhe: 2.178 ± 0.725
6.171SerGly: 6.171 ± 0.939
0.871SerHis: 0.871 ± 0.288
3.412SerIle: 3.412 ± 0.476
2.831SerLys: 2.831 ± 0.462
5.082SerLeu: 5.082 ± 0.56
0.944SerMet: 0.944 ± 0.224
2.178SerAsn: 2.178 ± 0.454
2.105SerPro: 2.105 ± 0.339
1.815SerGln: 1.815 ± 0.329
3.267SerArg: 3.267 ± 0.399
4.138SerSer: 4.138 ± 0.825
3.049SerThr: 3.049 ± 0.371
4.065SerVal: 4.065 ± 0.546
1.089SerTrp: 1.089 ± 0.268
1.597SerTyr: 1.597 ± 0.344
0.0SerXaa: 0.0 ± 0.0
Thr
5.735ThrAla: 5.735 ± 0.808
0.363ThrCys: 0.363 ± 0.175
2.759ThrAsp: 2.759 ± 0.428
2.976ThrGlu: 2.976 ± 0.551
1.815ThrPhe: 1.815 ± 0.426
6.824ThrGly: 6.824 ± 0.606
1.016ThrHis: 1.016 ± 0.281
2.323ThrIle: 2.323 ± 0.386
3.557ThrLys: 3.557 ± 0.552
3.993ThrLeu: 3.993 ± 0.356
1.162ThrMet: 1.162 ± 0.329
2.976ThrAsn: 2.976 ± 0.392
2.25ThrPro: 2.25 ± 0.325
2.831ThrGln: 2.831 ± 0.48
2.976ThrArg: 2.976 ± 0.469
3.557ThrSer: 3.557 ± 0.558
3.92ThrThr: 3.92 ± 0.613
4.356ThrVal: 4.356 ± 0.51
0.799ThrTrp: 0.799 ± 0.211
2.541ThrTyr: 2.541 ± 0.523
0.0ThrXaa: 0.0 ± 0.0
Val
7.768ValAla: 7.768 ± 0.843
0.29ValCys: 0.29 ± 0.156
4.065ValAsp: 4.065 ± 0.578
3.775ValGlu: 3.775 ± 0.454
2.178ValPhe: 2.178 ± 0.404
5.227ValGly: 5.227 ± 0.534
0.944ValHis: 0.944 ± 0.29
2.976ValIle: 2.976 ± 0.417
2.613ValLys: 2.613 ± 0.427
6.824ValLeu: 6.824 ± 0.662
1.089ValMet: 1.089 ± 0.361
3.267ValAsn: 3.267 ± 0.553
3.702ValPro: 3.702 ± 0.489
3.412ValGln: 3.412 ± 0.443
4.356ValArg: 4.356 ± 0.692
4.211ValSer: 4.211 ± 0.653
4.501ValThr: 4.501 ± 0.624
5.517ValVal: 5.517 ± 0.79
1.162ValTrp: 1.162 ± 0.267
1.887ValTyr: 1.887 ± 0.422
0.0ValXaa: 0.0 ± 0.0
Trp
1.089TrpAla: 1.089 ± 0.288
0.363TrpCys: 0.363 ± 0.148
0.653TrpAsp: 0.653 ± 0.216
0.799TrpGlu: 0.799 ± 0.184
0.944TrpPhe: 0.944 ± 0.194
1.089TrpGly: 1.089 ± 0.343
0.653TrpHis: 0.653 ± 0.236
0.944TrpIle: 0.944 ± 0.207
0.726TrpLys: 0.726 ± 0.213
1.815TrpLeu: 1.815 ± 0.34
0.581TrpMet: 0.581 ± 0.242
0.653TrpAsn: 0.653 ± 0.203
0.581TrpPro: 0.581 ± 0.206
0.871TrpGln: 0.871 ± 0.234
0.871TrpArg: 0.871 ± 0.247
0.944TrpSer: 0.944 ± 0.339
0.799TrpThr: 0.799 ± 0.24
1.234TrpVal: 1.234 ± 0.315
0.218TrpTrp: 0.218 ± 0.115
0.871TrpTyr: 0.871 ± 0.247
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.557TyrAla: 3.557 ± 0.505
0.218TyrCys: 0.218 ± 0.141
2.686TyrAsp: 2.686 ± 0.336
1.887TyrGlu: 1.887 ± 0.427
1.597TyrPhe: 1.597 ± 0.412
2.396TyrGly: 2.396 ± 0.393
0.508TyrHis: 0.508 ± 0.19
1.597TyrIle: 1.597 ± 0.33
1.307TyrLys: 1.307 ± 0.293
2.831TyrLeu: 2.831 ± 0.459
0.653TyrMet: 0.653 ± 0.221
1.742TyrAsn: 1.742 ± 0.33
1.089TyrPro: 1.089 ± 0.332
1.307TyrGln: 1.307 ± 0.387
2.468TyrArg: 2.468 ± 0.419
1.67TyrSer: 1.67 ± 0.327
1.742TyrThr: 1.742 ± 0.335
2.831TyrVal: 2.831 ± 0.699
0.726TyrTrp: 0.726 ± 0.241
0.944TyrTyr: 0.944 ± 0.282
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (13776 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski