Amino acid dipepetide frequency for Thioploca ingrica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.875AlaAla: 6.875 ± 0.104	0.926AlaCys: 0.926 ± 0.033	3.926AlaAsp: 3.926 ± 0.07	5.075AlaGlu: 5.075 ± 0.081	2.678AlaPhe: 2.678 ± 0.05	5.261AlaGly: 5.261 ± 0.075	1.861AlaHis: 1.861 ± 0.041	5.942AlaIle: 5.942 ± 0.066	4.083AlaLys: 4.083 ± 0.059	8.326AlaLeu: 8.326 ± 0.106	1.762AlaMet: 1.762 ± 0.043	3.516AlaAsn: 3.516 ± 0.061	2.655AlaPro: 2.655 ± 0.056	4.709AlaGln: 4.709 ± 0.079	3.336AlaArg: 3.336 ± 0.059	3.85AlaSer: 3.85 ± 0.058	5.111AlaThr: 5.111 ± 0.081	5.077AlaVal: 5.077 ± 0.071	1.089AlaTrp: 1.089 ± 0.031	2.334AlaTyr: 2.334 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.708CysAla: 0.708 ± 0.024	0.142CysCys: 0.142 ± 0.01	0.533CysAsp: 0.533 ± 0.025	0.548CysGlu: 0.548 ± 0.023	0.404CysPhe: 0.404 ± 0.017	0.854CysGly: 0.854 ± 0.033	0.388CysHis: 0.388 ± 0.02	0.535CysIle: 0.535 ± 0.023	0.35CysLys: 0.35 ± 0.016	1.094CysLeu: 1.094 ± 0.031	0.149CysMet: 0.149 ± 0.01	0.415CysAsn: 0.415 ± 0.018	0.642CysPro: 0.642 ± 0.026	0.728CysGln: 0.728 ± 0.025	0.47CysArg: 0.47 ± 0.02	0.676CysSer: 0.676 ± 0.028	0.58CysThr: 0.58 ± 0.028	0.579CysVal: 0.579 ± 0.019	0.162CysTrp: 0.162 ± 0.013	0.404CysTyr: 0.404 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.937AspAla: 2.937 ± 0.056	0.56AspCys: 0.56 ± 0.024	2.282AspAsp: 2.282 ± 0.052	2.985AspGlu: 2.985 ± 0.058	2.248AspPhe: 2.248 ± 0.037	3.068AspGly: 3.068 ± 0.09	0.866AspHis: 0.866 ± 0.024	3.675AspIle: 3.675 ± 0.055	2.977AspLys: 2.977 ± 0.055	5.068AspLeu: 5.068 ± 0.08	0.984AspMet: 0.984 ± 0.028	2.643AspAsn: 2.643 ± 0.061	2.412AspPro: 2.412 ± 0.055	1.949AspGln: 1.949 ± 0.038	1.965AspArg: 1.965 ± 0.041	2.877AspSer: 2.877 ± 0.059	2.702AspThr: 2.702 ± 0.052	2.406AspVal: 2.406 ± 0.05	0.834AspTrp: 0.834 ± 0.029	2.039AspTyr: 2.039 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	4.673GluAla: 4.673 ± 0.073	0.463GluCys: 0.463 ± 0.02	2.37GluAsp: 2.37 ± 0.046	4.011GluGlu: 4.011 ± 0.091	2.136GluPhe: 2.136 ± 0.041	3.415GluGly: 3.415 ± 0.066	1.272GluHis: 1.272 ± 0.033	4.92GluIle: 4.92 ± 0.065	3.49GluLys: 3.49 ± 0.059	6.491GluLeu: 6.491 ± 0.086	1.599GluMet: 1.599 ± 0.037	2.667GluAsn: 2.667 ± 0.049	2.47GluPro: 2.47 ± 0.047	4.317GluGln: 4.317 ± 0.083	3.135GluArg: 3.135 ± 0.063	2.999GluSer: 2.999 ± 0.051	3.637GluThr: 3.637 ± 0.063	4.119GluVal: 4.119 ± 0.059	0.781GluTrp: 0.781 ± 0.024	1.71GluTyr: 1.71 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.924PheAla: 2.924 ± 0.05	0.438PheCys: 0.438 ± 0.019	2.15PheAsp: 2.15 ± 0.047	2.238PheGlu: 2.238 ± 0.045	1.689PhePhe: 1.689 ± 0.041	2.402PheGly: 2.402 ± 0.049	0.872PheHis: 0.872 ± 0.025	2.931PheIle: 2.931 ± 0.058	2.048PheLys: 2.048 ± 0.042	3.82PheLeu: 3.82 ± 0.063	0.792PheMet: 0.792 ± 0.023	2.134PheAsn: 2.134 ± 0.042	1.621PhePro: 1.621 ± 0.037	1.685PheGln: 1.685 ± 0.041	1.529PheArg: 1.529 ± 0.035	2.846PheSer: 2.846 ± 0.052	2.591PheThr: 2.591 ± 0.049	2.094PheVal: 2.094 ± 0.044	0.563PheTrp: 0.563 ± 0.024	1.435PheTyr: 1.435 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	3.918GlyAla: 3.918 ± 0.073	0.812GlyCys: 0.812 ± 0.026	3.063GlyAsp: 3.063 ± 0.066	3.94GlyGlu: 3.94 ± 0.061	2.525GlyPhe: 2.525 ± 0.044	4.613GlyGly: 4.613 ± 0.122	1.608GlyHis: 1.608 ± 0.038	5.089GlyIle: 5.089 ± 0.066	3.831GlyLys: 3.831 ± 0.062	6.506GlyLeu: 6.506 ± 0.088	1.59GlyMet: 1.59 ± 0.083	3.002GlyAsn: 3.002 ± 0.058	1.62GlyPro: 1.62 ± 0.048	3.589GlyGln: 3.589 ± 0.069	2.686GlyArg: 2.686 ± 0.056	3.467GlySer: 3.467 ± 0.078	3.975GlyThr: 3.975 ± 0.081	3.938GlyVal: 3.938 ± 0.061	1.111GlyTrp: 1.111 ± 0.029	2.462GlyTyr: 2.462 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.456HisAla: 1.456 ± 0.032	0.379HisCys: 0.379 ± 0.017	1.057HisAsp: 1.057 ± 0.031	1.251HisGlu: 1.251 ± 0.035	1.285HisPhe: 1.285 ± 0.034	1.296HisGly: 1.296 ± 0.035	0.902HisHis: 0.902 ± 0.029	1.41HisIle: 1.41 ± 0.029	0.818HisLys: 0.818 ± 0.025	3.106HisLeu: 3.106 ± 0.055	0.348HisMet: 0.348 ± 0.017	0.935HisAsn: 0.935 ± 0.028	1.436HisPro: 1.436 ± 0.035	1.55HisGln: 1.55 ± 0.037	1.171HisArg: 1.171 ± 0.03	1.341HisSer: 1.341 ± 0.03	1.243HisThr: 1.243 ± 0.033	1.021HisVal: 1.021 ± 0.028	0.474HisTrp: 0.474 ± 0.018	1.221HisTyr: 1.221 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.105IleAla: 6.105 ± 0.075	0.664IleCys: 0.664 ± 0.025	3.812IleAsp: 3.812 ± 0.05	4.711IleGlu: 4.711 ± 0.07	2.515IlePhe: 2.515 ± 0.059	4.304IleGly: 4.304 ± 0.066	1.636IleHis: 1.636 ± 0.037	4.821IleIle: 4.821 ± 0.076	3.612IleLys: 3.612 ± 0.062	7.065IleLeu: 7.065 ± 0.09	1.289IleMet: 1.289 ± 0.038	3.418IleAsn: 3.418 ± 0.058	3.541IlePro: 3.541 ± 0.053	3.37IleGln: 3.37 ± 0.052	3.08IleArg: 3.08 ± 0.056	4.32IleSer: 4.32 ± 0.06	4.747IleThr: 4.747 ± 0.069	4.186IleVal: 4.186 ± 0.059	0.837IleTrp: 0.837 ± 0.028	2.234IleTyr: 2.234 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	3.587LysAla: 3.587 ± 0.052	0.349LysCys: 0.349 ± 0.016	1.988LysAsp: 1.988 ± 0.041	2.889LysGlu: 2.889 ± 0.051	1.437LysPhe: 1.437 ± 0.036	2.708LysGly: 2.708 ± 0.048	0.952LysHis: 0.952 ± 0.029	3.812LysIle: 3.812 ± 0.063	2.753LysLys: 2.753 ± 0.062	5.213LysLeu: 5.213 ± 0.072	1.215LysMet: 1.215 ± 0.029	2.41LysAsn: 2.41 ± 0.053	2.572LysPro: 2.572 ± 0.045	3.012LysGln: 3.012 ± 0.062	2.387LysArg: 2.387 ± 0.05	2.7LysSer: 2.7 ± 0.045	3.103LysThr: 3.103 ± 0.063	3.147LysVal: 3.147 ± 0.053	0.641LysTrp: 0.641 ± 0.027	1.385LysTyr: 1.385 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	10.075LeuAla: 10.075 ± 0.11	0.948LeuCys: 0.948 ± 0.031	5.206LeuAsp: 5.206 ± 0.069	7.116LeuGlu: 7.116 ± 0.086	4.355LeuPhe: 4.355 ± 0.071	6.57LeuGly: 6.57 ± 0.07	2.225LeuHis: 2.225 ± 0.043	7.359LeuIle: 7.359 ± 0.088	5.505LeuLys: 5.505 ± 0.074	12.352LeuLeu: 12.352 ± 0.156	2.102LeuMet: 2.102 ± 0.042	4.974LeuAsn: 4.974 ± 0.065	5.882LeuPro: 5.882 ± 0.072	5.531LeuGln: 5.531 ± 0.095	5.225LeuArg: 5.225 ± 0.074	7.541LeuSer: 7.541 ± 0.097	7.568LeuThr: 7.568 ± 0.094	6.721LeuVal: 6.721 ± 0.081	1.457LeuTrp: 1.457 ± 0.047	3.047LeuTyr: 3.047 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.853MetAla: 1.853 ± 0.043	0.127MetCys: 0.127 ± 0.01	0.975MetAsp: 0.975 ± 0.029	1.079MetGlu: 1.079 ± 0.033	0.527MetPhe: 0.527 ± 0.021	1.554MetGly: 1.554 ± 0.058	0.33MetHis: 0.33 ± 0.016	1.34MetIle: 1.34 ± 0.036	1.112MetLys: 1.112 ± 0.033	2.024MetLeu: 2.024 ± 0.043	0.575MetMet: 0.575 ± 0.024	1.033MetAsn: 1.033 ± 0.025	1.082MetPro: 1.082 ± 0.031	0.927MetGln: 0.927 ± 0.03	0.964MetArg: 0.964 ± 0.026	1.389MetSer: 1.389 ± 0.037	1.523MetThr: 1.523 ± 0.039	1.405MetVal: 1.405 ± 0.035	0.166MetTrp: 0.166 ± 0.012	0.425MetTyr: 0.425 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	2.936AsnAla: 2.936 ± 0.052	0.564AsnCys: 0.564 ± 0.029	2.031AsnAsp: 2.031 ± 0.055	2.424AsnGlu: 2.424 ± 0.045	1.651AsnPhe: 1.651 ± 0.037	2.771AsnGly: 2.771 ± 0.052	1.234AsnHis: 1.234 ± 0.032	2.775AsnIle: 2.775 ± 0.05	2.077AsnLys: 2.077 ± 0.046	5.268AsnLeu: 5.268 ± 0.076	0.846AsnMet: 0.846 ± 0.024	2.4AsnAsn: 2.4 ± 0.063	2.66AsnPro: 2.66 ± 0.055	3.25AsnGln: 3.25 ± 0.062	2.212AsnArg: 2.212 ± 0.045	2.743AsnSer: 2.743 ± 0.061	2.675AsnThr: 2.675 ± 0.051	2.096AsnVal: 2.096 ± 0.046	0.687AsnTrp: 0.687 ± 0.024	1.632AsnTyr: 1.632 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.595ProAla: 3.595 ± 0.061	0.426ProCys: 0.426 ± 0.019	2.644ProAsp: 2.644 ± 0.044	3.208ProGlu: 3.208 ± 0.051	1.796ProPhe: 1.796 ± 0.038	2.673ProGly: 2.673 ± 0.053	1.216ProHis: 1.216 ± 0.03	3.345ProIle: 3.345 ± 0.057	1.912ProLys: 1.912 ± 0.043	5.271ProLeu: 5.271 ± 0.078	0.826ProMet: 0.826 ± 0.027	2.223ProAsn: 2.223 ± 0.045	2.811ProPro: 2.811 ± 0.07	2.652ProGln: 2.652 ± 0.051	1.688ProArg: 1.688 ± 0.039	2.695ProSer: 2.695 ± 0.053	3.295ProThr: 3.295 ± 0.064	3.404ProVal: 3.404 ± 0.06	0.622ProTrp: 0.622 ± 0.024	1.452ProTyr: 1.452 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.689GlnAla: 5.689 ± 0.077	0.519GlnCys: 0.519 ± 0.021	2.017GlnAsp: 2.017 ± 0.038	3.117GlnGlu: 3.117 ± 0.063	2.135GlnPhe: 2.135 ± 0.044	3.576GlnGly: 3.576 ± 0.07	1.291GlnHis: 1.291 ± 0.029	3.742GlnIle: 3.742 ± 0.055	2.133GlnLys: 2.133 ± 0.048	7.4GlnLeu: 7.4 ± 0.095	1.079GlnMet: 1.079 ± 0.031	1.861GlnAsn: 1.861 ± 0.041	2.955GlnPro: 2.955 ± 0.066	4.353GlnGln: 4.353 ± 0.102	3.133GlnArg: 3.133 ± 0.058	2.913GlnSer: 2.913 ± 0.049	3.119GlnThr: 3.119 ± 0.055	4.041GlnVal: 4.041 ± 0.066	0.96GlnTrp: 0.96 ± 0.034	1.447GlnTyr: 1.447 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.139ArgAla: 3.139 ± 0.055	0.526ArgCys: 0.526 ± 0.023	2.164ArgAsp: 2.164 ± 0.049	2.956ArgGlu: 2.956 ± 0.055	2.264ArgPhe: 2.264 ± 0.042	2.541ArgGly: 2.541 ± 0.047	1.292ArgHis: 1.292 ± 0.035	3.168ArgIle: 3.168 ± 0.047	1.918ArgLys: 1.918 ± 0.044	5.892ArgLeu: 5.892 ± 0.081	1.02ArgMet: 1.02 ± 0.03	1.701ArgAsn: 1.701 ± 0.036	1.696ArgPro: 1.696 ± 0.035	2.977ArgGln: 2.977 ± 0.053	2.52ArgArg: 2.52 ± 0.053	2.261ArgSer: 2.261 ± 0.041	2.196ArgThr: 2.196 ± 0.049	2.805ArgVal: 2.805 ± 0.051	0.87ArgTrp: 0.87 ± 0.027	1.93ArgTyr: 1.93 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.485SerAla: 4.485 ± 0.066	0.658SerCys: 0.658 ± 0.028	2.538SerAsp: 2.538 ± 0.058	3.131SerGlu: 3.131 ± 0.051	2.258SerPhe: 2.258 ± 0.042	4.346SerGly: 4.346 ± 0.076	1.579SerHis: 1.579 ± 0.038	3.704SerIle: 3.704 ± 0.063	2.475SerLys: 2.475 ± 0.044	6.844SerLeu: 6.844 ± 0.081	1.107SerMet: 1.107 ± 0.033	2.495SerAsn: 2.495 ± 0.057	3.156SerPro: 3.156 ± 0.053	3.224SerGln: 3.224 ± 0.052	2.56SerArg: 2.56 ± 0.05	3.869SerSer: 3.869 ± 0.071	3.587SerThr: 3.587 ± 0.068	3.49SerVal: 3.49 ± 0.061	0.849SerTrp: 0.849 ± 0.028	1.942SerTyr: 1.942 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.039ThrAla: 5.039 ± 0.081	0.647ThrCys: 0.647 ± 0.03	3.215ThrAsp: 3.215 ± 0.06	3.535ThrGlu: 3.535 ± 0.057	2.344ThrPhe: 2.344 ± 0.045	4.409ThrGly: 4.409 ± 0.079	1.583ThrHis: 1.583 ± 0.039	4.304ThrIle: 4.304 ± 0.07	2.193ThrLys: 2.193 ± 0.044	7.71ThrLeu: 7.71 ± 0.094	0.981ThrMet: 0.981 ± 0.03	2.239ThrAsn: 2.239 ± 0.049	3.71ThrPro: 3.71 ± 0.069	3.586ThrGln: 3.586 ± 0.058	2.534ThrArg: 2.534 ± 0.046	3.31ThrSer: 3.31 ± 0.064	4.404ThrThr: 4.404 ± 0.084	4.622ThrVal: 4.622 ± 0.092	0.802ThrTrp: 0.802 ± 0.03	1.766ThrTyr: 1.766 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.259ValAla: 5.259 ± 0.071	0.637ValCys: 0.637 ± 0.022	3.294ValAsp: 3.294 ± 0.05	3.888ValGlu: 3.888 ± 0.06	2.362ValPhe: 2.362 ± 0.048	4.04ValGly: 4.04 ± 0.074	1.212ValHis: 1.212 ± 0.03	4.848ValIle: 4.848 ± 0.065	3.276ValLys: 3.276 ± 0.051	6.153ValLeu: 6.153 ± 0.068	1.424ValMet: 1.424 ± 0.034	3.02ValAsn: 3.02 ± 0.052	2.601ValPro: 2.601 ± 0.049	2.442ValGln: 2.442 ± 0.045	2.581ValArg: 2.581 ± 0.051	3.685ValSer: 3.685 ± 0.064	4.5ValThr: 4.5 ± 0.093	4.49ValVal: 4.49 ± 0.071	0.796ValTrp: 0.796 ± 0.028	1.858ValTyr: 1.858 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.891TrpAla: 0.891 ± 0.027	0.18TrpCys: 0.18 ± 0.011	0.635TrpAsp: 0.635 ± 0.029	0.823TrpGlu: 0.823 ± 0.029	0.606TrpPhe: 0.606 ± 0.021	0.876TrpGly: 0.876 ± 0.036	0.367TrpHis: 0.367 ± 0.017	0.937TrpIle: 0.937 ± 0.032	0.566TrpLys: 0.566 ± 0.024	2.1TrpLeu: 2.1 ± 0.051	0.261TrpMet: 0.261 ± 0.015	0.598TrpAsn: 0.598 ± 0.025	0.474TrpPro: 0.474 ± 0.025	1.246TrpGln: 1.246 ± 0.033	0.785TrpArg: 0.785 ± 0.026	0.851TrpSer: 0.851 ± 0.026	0.56TrpThr: 0.56 ± 0.025	1.0TrpVal: 1.0 ± 0.03	0.264TrpTrp: 0.264 ± 0.016	0.459TrpTyr: 0.459 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.25TyrAla: 2.25 ± 0.039	0.396TyrCys: 0.396 ± 0.018	1.576TyrAsp: 1.576 ± 0.037	1.75TyrGlu: 1.75 ± 0.037	1.586TyrPhe: 1.586 ± 0.032	2.07TyrGly: 2.07 ± 0.048	1.012TyrHis: 1.012 ± 0.028	1.612TyrIle: 1.612 ± 0.037	1.133TyrLys: 1.133 ± 0.034	4.056TyrLeu: 4.056 ± 0.065	0.462TyrMet: 0.462 ± 0.018	1.245TyrAsn: 1.245 ± 0.035	1.757TyrPro: 1.757 ± 0.041	2.382TyrGln: 2.382 ± 0.044	1.872TyrArg: 1.872 ± 0.035	1.966TyrSer: 1.966 ± 0.045	1.814TyrThr: 1.814 ± 0.054	1.728TyrVal: 1.728 ± 0.041	0.517TyrTrp: 0.517 ± 0.02	1.293TyrTyr: 1.293 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3951 proteins (1382316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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