Amino acid dipepetide frequency for Avian metaavulavirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.766AlaAla: 6.766 ± 1.989
1.091AlaCys: 1.091 ± 0.332
3.71AlaAsp: 3.71 ± 0.92
3.71AlaGlu: 3.71 ± 1.164
2.619AlaPhe: 2.619 ± 0.527
3.928AlaGly: 3.928 ± 1.668
1.528AlaHis: 1.528 ± 0.295
4.583AlaIle: 4.583 ± 0.954
5.02AlaLys: 5.02 ± 1.111
8.73AlaLeu: 8.73 ± 2.19
3.055AlaMet: 3.055 ± 0.62
1.746AlaAsn: 1.746 ± 0.613
2.182AlaPro: 2.182 ± 0.381
3.928AlaGln: 3.928 ± 1.083
5.238AlaArg: 5.238 ± 0.73
7.857AlaSer: 7.857 ± 1.177
6.111AlaThr: 6.111 ± 0.761
5.456AlaVal: 5.456 ± 1.364
0.655AlaTrp: 0.655 ± 0.281
2.182AlaTyr: 2.182 ± 0.299
0.0AlaXaa: 0.0 ± 0.0
Cys
1.746CysAla: 1.746 ± 0.308
0.655CysCys: 0.655 ± 0.281
0.655CysAsp: 0.655 ± 0.216
0.873CysGlu: 0.873 ± 0.498
0.655CysPhe: 0.655 ± 0.273
0.218CysGly: 0.218 ± 0.257
0.218CysHis: 0.218 ± 0.125
0.873CysIle: 0.873 ± 0.296
1.964CysLys: 1.964 ± 0.44
1.528CysLeu: 1.528 ± 0.241
0.218CysMet: 0.218 ± 0.125
1.528CysAsn: 1.528 ± 0.487
0.873CysPro: 0.873 ± 0.468
1.309CysGln: 1.309 ± 0.419
1.964CysArg: 1.964 ± 0.604
1.309CysSer: 1.309 ± 0.411
0.0CysThr: 0.0 ± 0.0
1.746CysVal: 1.746 ± 0.485
0.0CysTrp: 0.0 ± 0.0
0.655CysTyr: 0.655 ± 0.273
0.0CysXaa: 0.0 ± 0.0
Asp
3.928AspAla: 3.928 ± 1.385
0.873AspCys: 0.873 ± 0.455
3.71AspAsp: 3.71 ± 1.471
2.401AspGlu: 2.401 ± 0.464
1.528AspPhe: 1.528 ± 0.369
1.746AspGly: 1.746 ± 0.308
0.873AspHis: 0.873 ± 0.262
3.274AspIle: 3.274 ± 1.121
1.964AspLys: 1.964 ± 0.557
6.329AspLeu: 6.329 ± 1.598
1.309AspMet: 1.309 ± 0.481
3.055AspAsn: 3.055 ± 0.312
4.583AspPro: 4.583 ± 0.754
1.964AspGln: 1.964 ± 0.76
2.619AspArg: 2.619 ± 0.965
2.837AspSer: 2.837 ± 0.927
3.274AspThr: 3.274 ± 1.377
3.274AspVal: 3.274 ± 0.56
0.436AspTrp: 0.436 ± 0.37
0.655AspTyr: 0.655 ± 0.216
0.0AspXaa: 0.0 ± 0.0
Glu
4.583GluAla: 4.583 ± 1.103
0.873GluCys: 0.873 ± 0.333
1.091GluAsp: 1.091 ± 0.611
2.837GluGlu: 2.837 ± 1.074
3.055GluPhe: 3.055 ± 1.098
2.619GluGly: 2.619 ± 0.674
1.091GluHis: 1.091 ± 0.294
3.492GluIle: 3.492 ± 0.654
2.837GluLys: 2.837 ± 0.754
4.801GluLeu: 4.801 ± 1.784
1.091GluMet: 1.091 ± 0.505
2.401GluAsn: 2.401 ± 0.337
0.655GluPro: 0.655 ± 0.305
1.091GluGln: 1.091 ± 0.431
2.182GluArg: 2.182 ± 0.847
5.02GluSer: 5.02 ± 0.832
4.365GluThr: 4.365 ± 0.759
4.147GluVal: 4.147 ± 0.886
0.873GluTrp: 0.873 ± 0.495
1.309GluTyr: 1.309 ± 0.442
0.0GluXaa: 0.0 ± 0.0
Phe
1.528PheAla: 1.528 ± 0.584
0.436PheCys: 0.436 ± 0.227
1.528PheAsp: 1.528 ± 0.667
0.873PheGlu: 0.873 ± 0.372
2.401PhePhe: 2.401 ± 0.646
1.964PheGly: 1.964 ± 0.406
0.873PheHis: 0.873 ± 0.743
2.837PheIle: 2.837 ± 0.954
1.964PheLys: 1.964 ± 0.734
3.71PheLeu: 3.71 ± 1.078
0.655PheMet: 0.655 ± 0.488
2.401PheAsn: 2.401 ± 0.758
1.091PhePro: 1.091 ± 0.603
1.746PheGln: 1.746 ± 0.375
2.182PheArg: 2.182 ± 0.796
3.274PheSer: 3.274 ± 0.549
1.964PheThr: 1.964 ± 0.454
2.619PheVal: 2.619 ± 0.71
0.218PheTrp: 0.218 ± 0.125
0.655PheTyr: 0.655 ± 0.293
0.0PheXaa: 0.0 ± 0.0
Gly
3.71GlyAla: 3.71 ± 0.994
1.528GlyCys: 1.528 ± 0.792
4.147GlyAsp: 4.147 ± 0.729
2.619GlyGlu: 2.619 ± 0.486
2.182GlyPhe: 2.182 ± 0.878
3.274GlyGly: 3.274 ± 0.511
0.873GlyHis: 0.873 ± 0.297
3.71GlyIle: 3.71 ± 0.764
2.837GlyLys: 2.837 ± 1.142
4.365GlyLeu: 4.365 ± 0.608
0.655GlyMet: 0.655 ± 0.281
1.746GlyAsn: 1.746 ± 0.756
1.964GlyPro: 1.964 ± 0.824
1.964GlyGln: 1.964 ± 0.364
2.401GlyArg: 2.401 ± 0.646
7.202GlySer: 7.202 ± 1.786
2.619GlyThr: 2.619 ± 0.957
5.893GlyVal: 5.893 ± 1.566
0.218GlyTrp: 0.218 ± 0.125
2.619GlyTyr: 2.619 ± 0.551
0.0GlyXaa: 0.0 ± 0.0
His
1.528HisAla: 1.528 ± 0.655
0.873HisCys: 0.873 ± 0.498
1.528HisAsp: 1.528 ± 0.655
0.655HisGlu: 0.655 ± 0.292
0.0HisPhe: 0.0 ± 0.0
0.873HisGly: 0.873 ± 0.297
0.436HisHis: 0.436 ± 0.246
0.873HisIle: 0.873 ± 0.34
0.0HisLys: 0.0 ± 0.0
2.619HisLeu: 2.619 ± 1.058
0.436HisMet: 0.436 ± 0.364
1.091HisAsn: 1.091 ± 0.417
1.528HisPro: 1.528 ± 0.487
0.436HisGln: 0.436 ± 0.249
1.091HisArg: 1.091 ± 0.466
1.964HisSer: 1.964 ± 0.444
1.091HisThr: 1.091 ± 0.294
1.309HisVal: 1.309 ± 0.282
0.218HisTrp: 0.218 ± 0.241
0.436HisTyr: 0.436 ± 0.233
0.0HisXaa: 0.0 ± 0.0
Ile
5.674IleAla: 5.674 ± 0.969
0.873IleCys: 0.873 ± 0.234
4.365IleAsp: 4.365 ± 0.818
3.928IleGlu: 3.928 ± 0.966
1.528IlePhe: 1.528 ± 0.503
5.02IleGly: 5.02 ± 0.999
1.528IleHis: 1.528 ± 0.872
5.893IleIle: 5.893 ± 1.437
4.147IleLys: 4.147 ± 0.737
5.674IleLeu: 5.674 ± 0.853
1.309IleMet: 1.309 ± 0.466
3.055IleAsn: 3.055 ± 0.886
2.401IlePro: 2.401 ± 0.521
3.492IleGln: 3.492 ± 0.632
2.182IleArg: 2.182 ± 0.546
6.547IleSer: 6.547 ± 1.15
4.365IleThr: 4.365 ± 0.904
6.111IleVal: 6.111 ± 1.068
0.873IleTrp: 0.873 ± 0.352
1.091IleTyr: 1.091 ± 0.294
0.0IleXaa: 0.0 ± 0.0
Lys
3.274LysAla: 3.274 ± 1.141
1.091LysCys: 1.091 ± 0.264
3.274LysAsp: 3.274 ± 1.069
3.492LysGlu: 3.492 ± 0.466
1.746LysPhe: 1.746 ± 0.375
2.837LysGly: 2.837 ± 0.564
0.436LysHis: 0.436 ± 0.249
2.401LysIle: 2.401 ± 0.676
2.401LysLys: 2.401 ± 0.855
5.02LysLeu: 5.02 ± 0.841
2.182LysMet: 2.182 ± 0.542
2.182LysAsn: 2.182 ± 0.399
1.746LysPro: 1.746 ± 0.879
1.964LysGln: 1.964 ± 0.263
2.182LysArg: 2.182 ± 0.728
4.365LysSer: 4.365 ± 0.704
2.401LysThr: 2.401 ± 0.407
3.71LysVal: 3.71 ± 1.284
0.218LysTrp: 0.218 ± 0.125
2.401LysTyr: 2.401 ± 0.401
0.0LysXaa: 0.0 ± 0.0
Leu
8.293LeuAla: 8.293 ± 0.727
2.401LeuCys: 2.401 ± 0.45
6.547LeuAsp: 6.547 ± 1.306
5.02LeuGlu: 5.02 ± 0.826
4.365LeuPhe: 4.365 ± 1.48
4.365LeuGly: 4.365 ± 0.955
1.746LeuHis: 1.746 ± 0.622
6.329LeuIle: 6.329 ± 1.118
4.801LeuLys: 4.801 ± 0.663
8.293LeuLeu: 8.293 ± 2.536
2.401LeuMet: 2.401 ± 0.67
4.801LeuAsn: 4.801 ± 1.069
3.492LeuPro: 3.492 ± 0.549
4.147LeuGln: 4.147 ± 0.295
5.02LeuArg: 5.02 ± 0.953
10.476LeuSer: 10.476 ± 1.939
7.639LeuThr: 7.639 ± 1.097
5.456LeuVal: 5.456 ± 0.593
1.528LeuTrp: 1.528 ± 0.329
4.583LeuTyr: 4.583 ± 1.208
0.0LeuXaa: 0.0 ± 0.0
Met
2.401MetAla: 2.401 ± 0.708
0.655MetCys: 0.655 ± 0.374
0.436MetAsp: 0.436 ± 0.192
1.746MetGlu: 1.746 ± 0.732
0.873MetPhe: 0.873 ± 0.262
2.401MetGly: 2.401 ± 1.29
0.436MetHis: 0.436 ± 0.249
1.528MetIle: 1.528 ± 0.329
0.873MetLys: 0.873 ± 0.297
1.309MetLeu: 1.309 ± 0.592
0.873MetMet: 0.873 ± 0.225
0.873MetAsn: 0.873 ± 0.28
0.873MetPro: 0.873 ± 0.333
0.436MetGln: 0.436 ± 0.233
1.964MetArg: 1.964 ± 0.552
2.401MetSer: 2.401 ± 0.896
1.309MetThr: 1.309 ± 0.218
1.091MetVal: 1.091 ± 0.477
0.218MetTrp: 0.218 ± 0.231
0.655MetTyr: 0.655 ± 0.216
0.0MetXaa: 0.0 ± 0.0
Asn
4.147AsnAla: 4.147 ± 1.062
0.218AsnCys: 0.218 ± 0.257
2.619AsnAsp: 2.619 ± 0.877
1.746AsnGlu: 1.746 ± 0.638
1.309AsnPhe: 1.309 ± 0.545
2.182AsnGly: 2.182 ± 0.458
0.655AsnHis: 0.655 ± 0.216
4.365AsnIle: 4.365 ± 0.896
0.436AsnLys: 0.436 ± 0.227
4.583AsnLeu: 4.583 ± 0.884
1.091AsnMet: 1.091 ± 0.29
2.182AsnAsn: 2.182 ± 0.591
2.401AsnPro: 2.401 ± 0.803
3.492AsnGln: 3.492 ± 0.449
1.528AsnArg: 1.528 ± 0.493
3.492AsnSer: 3.492 ± 0.835
3.274AsnThr: 3.274 ± 1.595
1.528AsnVal: 1.528 ± 0.369
0.436AsnTrp: 0.436 ± 0.249
1.528AsnTyr: 1.528 ± 0.63
0.0AsnXaa: 0.0 ± 0.0
Pro
3.492ProAla: 3.492 ± 0.486
0.436ProCys: 0.436 ± 0.249
2.401ProAsp: 2.401 ± 0.454
3.055ProGlu: 3.055 ± 0.673
0.873ProPhe: 0.873 ± 0.313
3.492ProGly: 3.492 ± 1.656
0.873ProHis: 0.873 ± 0.351
3.274ProIle: 3.274 ± 0.882
2.182ProLys: 2.182 ± 0.418
3.492ProLeu: 3.492 ± 0.251
0.655ProMet: 0.655 ± 0.488
0.873ProAsn: 0.873 ± 0.266
1.528ProPro: 1.528 ± 0.758
1.964ProGln: 1.964 ± 0.804
2.182ProArg: 2.182 ± 0.53
2.619ProSer: 2.619 ± 0.946
3.71ProThr: 3.71 ± 0.486
2.401ProVal: 2.401 ± 0.324
0.0ProTrp: 0.0 ± 0.0
1.309ProTyr: 1.309 ± 0.346
0.0ProXaa: 0.0 ± 0.0
Gln
4.365GlnAla: 4.365 ± 0.815
0.436GlnCys: 0.436 ± 0.374
2.401GlnAsp: 2.401 ± 0.961
1.746GlnGlu: 1.746 ± 0.932
2.401GlnPhe: 2.401 ± 0.824
4.365GlnGly: 4.365 ± 0.936
0.873GlnHis: 0.873 ± 0.333
3.71GlnIle: 3.71 ± 1.471
1.309GlnLys: 1.309 ± 0.328
6.111GlnLeu: 6.111 ± 0.64
0.655GlnMet: 0.655 ± 0.273
1.091GlnAsn: 1.091 ± 0.42
2.837GlnPro: 2.837 ± 0.803
2.837GlnGln: 2.837 ± 1.377
1.528GlnArg: 1.528 ± 0.496
2.182GlnSer: 2.182 ± 0.532
2.619GlnThr: 2.619 ± 0.591
3.928GlnVal: 3.928 ± 0.309
0.436GlnTrp: 0.436 ± 0.249
1.746GlnTyr: 1.746 ± 0.467
0.0GlnXaa: 0.0 ± 0.0
Arg
4.365ArgAla: 4.365 ± 1.442
0.655ArgCys: 0.655 ± 0.374
2.837ArgAsp: 2.837 ± 0.555
2.182ArgGlu: 2.182 ± 0.301
1.746ArgPhe: 1.746 ± 0.872
2.401ArgGly: 2.401 ± 0.899
0.873ArgHis: 0.873 ± 0.498
3.274ArgIle: 3.274 ± 1.081
3.71ArgLys: 3.71 ± 0.794
6.766ArgLeu: 6.766 ± 0.737
0.436ArgMet: 0.436 ± 0.249
1.964ArgAsn: 1.964 ± 0.456
2.619ArgPro: 2.619 ± 0.672
3.274ArgGln: 3.274 ± 0.945
2.401ArgArg: 2.401 ± 0.62
3.274ArgSer: 3.274 ± 1.067
1.964ArgThr: 1.964 ± 0.31
3.492ArgVal: 3.492 ± 0.462
0.873ArgTrp: 0.873 ± 0.466
1.309ArgTyr: 1.309 ± 0.413
0.0ArgXaa: 0.0 ± 0.0
Ser
5.674SerAla: 5.674 ± 0.412
1.746SerCys: 1.746 ± 0.219
2.401SerAsp: 2.401 ± 0.452
5.456SerGlu: 5.456 ± 1.972
2.401SerPhe: 2.401 ± 0.491
3.928SerGly: 3.928 ± 0.813
2.619SerHis: 2.619 ± 0.718
6.766SerIle: 6.766 ± 1.125
4.365SerLys: 4.365 ± 0.883
9.166SerLeu: 9.166 ± 0.652
2.837SerMet: 2.837 ± 0.787
5.456SerAsn: 5.456 ± 0.725
3.492SerPro: 3.492 ± 0.639
3.928SerGln: 3.928 ± 1.44
3.928SerArg: 3.928 ± 0.344
6.329SerSer: 6.329 ± 0.601
6.111SerThr: 6.111 ± 0.912
6.766SerVal: 6.766 ± 1.634
1.091SerTrp: 1.091 ± 0.4
2.182SerTyr: 2.182 ± 0.409
0.0SerXaa: 0.0 ± 0.0
Thr
4.365ThrAla: 4.365 ± 1.171
1.528ThrCys: 1.528 ± 0.407
2.401ThrAsp: 2.401 ± 0.955
3.492ThrGlu: 3.492 ± 1.173
1.964ThrPhe: 1.964 ± 0.572
4.583ThrGly: 4.583 ± 1.132
1.309ThrHis: 1.309 ± 0.273
5.893ThrIle: 5.893 ± 1.007
2.837ThrLys: 2.837 ± 1.106
7.42ThrLeu: 7.42 ± 0.698
0.218ThrMet: 0.218 ± 0.125
2.619ThrAsn: 2.619 ± 0.68
2.837ThrPro: 2.837 ± 0.623
3.274ThrGln: 3.274 ± 0.773
3.492ThrArg: 3.492 ± 1.094
5.238ThrSer: 5.238 ± 1.132
7.202ThrThr: 7.202 ± 2.045
3.71ThrVal: 3.71 ± 1.584
1.091ThrTrp: 1.091 ± 0.603
1.091ThrTyr: 1.091 ± 0.332
0.0ThrXaa: 0.0 ± 0.0
Val
6.984ValAla: 6.984 ± 1.196
1.528ValCys: 1.528 ± 0.57
3.71ValAsp: 3.71 ± 0.664
2.837ValGlu: 2.837 ± 0.843
1.964ValPhe: 1.964 ± 0.574
4.583ValGly: 4.583 ± 1.281
1.309ValHis: 1.309 ± 0.386
4.365ValIle: 4.365 ± 0.468
3.055ValLys: 3.055 ± 1.234
6.984ValLeu: 6.984 ± 1.484
1.964ValMet: 1.964 ± 0.871
2.837ValAsn: 2.837 ± 1.083
2.401ValPro: 2.401 ± 0.579
3.274ValGln: 3.274 ± 0.636
3.055ValArg: 3.055 ± 0.488
5.674ValSer: 5.674 ± 1.198
4.583ValThr: 4.583 ± 1.233
4.583ValVal: 4.583 ± 0.802
1.091ValTrp: 1.091 ± 0.256
2.401ValTyr: 2.401 ± 0.573
0.0ValXaa: 0.0 ± 0.0
Trp
0.655TrpAla: 0.655 ± 0.374
0.218TrpCys: 0.218 ± 0.241
0.0TrpAsp: 0.0 ± 0.0
0.873TrpGlu: 0.873 ± 0.366
0.436TrpPhe: 0.436 ± 0.225
0.436TrpGly: 0.436 ± 0.225
0.0TrpHis: 0.0 ± 0.0
0.655TrpIle: 0.655 ± 0.259
0.655TrpLys: 0.655 ± 0.293
1.309TrpLeu: 1.309 ± 0.445
0.436TrpMet: 0.436 ± 0.216
0.218TrpAsn: 0.218 ± 0.269
0.436TrpPro: 0.436 ± 0.192
0.218TrpGln: 0.218 ± 0.257
1.309TrpArg: 1.309 ± 0.328
0.873TrpSer: 0.873 ± 0.372
0.655TrpThr: 0.655 ± 0.216
0.873TrpVal: 0.873 ± 0.654
0.218TrpTrp: 0.218 ± 0.241
0.218TrpTyr: 0.218 ± 0.125
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.619TyrAla: 2.619 ± 0.779
0.873TyrCys: 0.873 ± 0.234
0.873TyrAsp: 0.873 ± 0.492
1.091TyrGlu: 1.091 ± 0.256
0.873TyrPhe: 0.873 ± 0.352
1.309TyrGly: 1.309 ± 0.554
0.436TyrHis: 0.436 ± 0.249
1.964TyrIle: 1.964 ± 0.503
1.964TyrLys: 1.964 ± 0.534
3.492TyrLeu: 3.492 ± 0.874
0.655TyrMet: 0.655 ± 0.259
1.091TyrAsn: 1.091 ± 0.345
0.873TyrPro: 0.873 ± 0.524
2.837TyrGln: 2.837 ± 0.997
1.964TyrArg: 1.964 ± 0.581
3.71TyrSer: 3.71 ± 0.671
1.309TyrThr: 1.309 ± 0.419
1.091TyrVal: 1.091 ± 0.458
0.0TyrTrp: 0.0 ± 0.0
0.873TyrTyr: 0.873 ± 0.333
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (4583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski