Amino acid dipepetide frequency for Pseudooctadecabacter jejudonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.509AlaAla: 16.509 ± 0.201	1.152AlaCys: 1.152 ± 0.034	8.025AlaAsp: 8.025 ± 0.091	7.373AlaGlu: 7.373 ± 0.106	4.449AlaPhe: 4.449 ± 0.074	10.285AlaGly: 10.285 ± 0.097	2.313AlaHis: 2.313 ± 0.06	5.807AlaIle: 5.807 ± 0.083	4.103AlaLys: 4.103 ± 0.069	12.836AlaLeu: 12.836 ± 0.142	3.788AlaMet: 3.788 ± 0.073	2.948AlaAsn: 2.948 ± 0.054	5.873AlaPro: 5.873 ± 0.104	4.777AlaGln: 4.777 ± 0.074	7.855AlaArg: 7.855 ± 0.113	5.504AlaSer: 5.504 ± 0.075	6.607AlaThr: 6.607 ± 0.091	8.549AlaVal: 8.549 ± 0.109	1.365AlaTrp: 1.365 ± 0.04	2.558AlaTyr: 2.558 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.115CysAla: 1.115 ± 0.037	0.104CysCys: 0.104 ± 0.012	0.665CysAsp: 0.665 ± 0.028	0.427CysGlu: 0.427 ± 0.02	0.333CysPhe: 0.333 ± 0.02	0.959CysGly: 0.959 ± 0.038	0.27CysHis: 0.27 ± 0.017	0.447CysIle: 0.447 ± 0.021	0.209CysLys: 0.209 ± 0.014	0.833CysLeu: 0.833 ± 0.028	0.18CysMet: 0.18 ± 0.014	0.235CysAsn: 0.235 ± 0.015	0.475CysPro: 0.475 ± 0.023	0.218CysGln: 0.218 ± 0.013	0.479CysArg: 0.479 ± 0.022	0.445CysSer: 0.445 ± 0.021	0.494CysThr: 0.494 ± 0.027	0.721CysVal: 0.721 ± 0.03	0.114CysTrp: 0.114 ± 0.011	0.227CysTyr: 0.227 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.384AspAla: 8.384 ± 0.1	0.497AspCys: 0.497 ± 0.023	4.327AspAsp: 4.327 ± 0.122	3.638AspGlu: 3.638 ± 0.069	2.518AspPhe: 2.518 ± 0.051	6.055AspGly: 6.055 ± 0.112	1.636AspHis: 1.636 ± 0.042	3.638AspIle: 3.638 ± 0.062	1.811AspLys: 1.811 ± 0.051	6.956AspLeu: 6.956 ± 0.094	2.003AspMet: 2.003 ± 0.046	1.465AspAsn: 1.465 ± 0.044	3.76AspPro: 3.76 ± 0.067	2.274AspGln: 2.274 ± 0.043	4.454AspArg: 4.454 ± 0.07	2.158AspSer: 2.158 ± 0.049	3.814AspThr: 3.814 ± 0.095	5.278AspVal: 5.278 ± 0.087	1.201AspTrp: 1.201 ± 0.035	1.599AspTyr: 1.599 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.874GluAla: 7.874 ± 0.121	0.338GluCys: 0.338 ± 0.019	3.919GluAsp: 3.919 ± 0.072	3.057GluGlu: 3.057 ± 0.071	1.739GluPhe: 1.739 ± 0.049	4.717GluGly: 4.717 ± 0.072	0.969GluHis: 0.969 ± 0.033	3.228GluIle: 3.228 ± 0.066	1.885GluLys: 1.885 ± 0.05	4.314GluLeu: 4.314 ± 0.081	1.738GluMet: 1.738 ± 0.04	1.756GluAsn: 1.756 ± 0.05	2.042GluPro: 2.042 ± 0.047	1.68GluGln: 1.68 ± 0.048	3.373GluArg: 3.373 ± 0.069	1.718GluSer: 1.718 ± 0.041	3.684GluThr: 3.684 ± 0.061	4.362GluVal: 4.362 ± 0.067	0.689GluTrp: 0.689 ± 0.028	0.994GluTyr: 0.994 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.584PheAla: 4.584 ± 0.081	0.457PheCys: 0.457 ± 0.022	3.082PheAsp: 3.082 ± 0.059	2.419PheGlu: 2.419 ± 0.056	1.437PhePhe: 1.437 ± 0.053	3.808PheGly: 3.808 ± 0.069	0.713PheHis: 0.713 ± 0.03	1.746PheIle: 1.746 ± 0.046	1.122PheLys: 1.122 ± 0.037	3.307PheLeu: 3.307 ± 0.066	0.947PheMet: 0.947 ± 0.031	1.138PheAsn: 1.138 ± 0.03	1.487PhePro: 1.487 ± 0.045	1.057PheGln: 1.057 ± 0.035	2.018PheArg: 2.018 ± 0.048	2.05PheSer: 2.05 ± 0.047	2.213PheThr: 2.213 ± 0.053	2.952PheVal: 2.952 ± 0.06	0.584PheTrp: 0.584 ± 0.026	0.978PheTyr: 0.978 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.717GlyAla: 9.717 ± 0.102	0.887GlyCys: 0.887 ± 0.03	5.203GlyAsp: 5.203 ± 0.131	4.378GlyGlu: 4.378 ± 0.082	3.722GlyPhe: 3.722 ± 0.067	7.548GlyGly: 7.548 ± 0.143	1.979GlyHis: 1.979 ± 0.046	4.264GlyIle: 4.264 ± 0.073	2.819GlyLys: 2.819 ± 0.064	8.934GlyLeu: 8.934 ± 0.12	2.513GlyMet: 2.513 ± 0.056	2.169GlyAsn: 2.169 ± 0.079	3.651GlyPro: 3.651 ± 0.061	3.453GlyGln: 3.453 ± 0.058	5.231GlyArg: 5.231 ± 0.077	3.972GlySer: 3.972 ± 0.077	5.148GlyThr: 5.148 ± 0.094	6.739GlyVal: 6.739 ± 0.088	1.448GlyTrp: 1.448 ± 0.037	2.275GlyTyr: 2.275 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.344HisAla: 2.344 ± 0.048	0.215HisCys: 0.215 ± 0.015	1.394HisAsp: 1.394 ± 0.045	0.956HisGlu: 0.956 ± 0.03	0.843HisPhe: 0.843 ± 0.032	1.836HisGly: 1.836 ± 0.046	0.583HisHis: 0.583 ± 0.029	1.105HisIle: 1.105 ± 0.033	0.571HisLys: 0.571 ± 0.025	2.13HisLeu: 2.13 ± 0.05	0.586HisMet: 0.586 ± 0.024	0.469HisAsn: 0.469 ± 0.02	1.356HisPro: 1.356 ± 0.039	0.608HisGln: 0.608 ± 0.027	1.273HisArg: 1.273 ± 0.042	0.861HisSer: 0.861 ± 0.035	0.985HisThr: 0.985 ± 0.029	1.598HisVal: 1.598 ± 0.042	0.353HisTrp: 0.353 ± 0.019	0.55HisTyr: 0.55 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.998IleAla: 6.998 ± 0.089	0.611IleCys: 0.611 ± 0.026	3.725IleAsp: 3.725 ± 0.061	3.541IleGlu: 3.541 ± 0.066	1.793IlePhe: 1.793 ± 0.049	4.822IleGly: 4.822 ± 0.079	0.954IleHis: 0.954 ± 0.032	2.467IleIle: 2.467 ± 0.056	1.569IleLys: 1.569 ± 0.046	4.645IleLeu: 4.645 ± 0.079	1.213IleMet: 1.213 ± 0.033	1.607IleAsn: 1.607 ± 0.043	2.418IlePro: 2.418 ± 0.051	1.231IleGln: 1.231 ± 0.036	2.928IleArg: 2.928 ± 0.055	2.761IleSer: 2.761 ± 0.053	3.355IleThr: 3.355 ± 0.074	3.894IleVal: 3.894 ± 0.066	0.764IleTrp: 0.764 ± 0.031	1.199IleTyr: 1.199 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.844LysAla: 3.844 ± 0.069	0.177LysCys: 0.177 ± 0.014	2.081LysAsp: 2.081 ± 0.048	1.39LysGlu: 1.39 ± 0.044	0.94LysPhe: 0.94 ± 0.031	2.774LysGly: 2.774 ± 0.06	0.667LysHis: 0.667 ± 0.022	1.686LysIle: 1.686 ± 0.048	1.216LysLys: 1.216 ± 0.042	2.81LysLeu: 2.81 ± 0.057	0.967LysMet: 0.967 ± 0.031	0.806LysAsn: 0.806 ± 0.029	1.728LysPro: 1.728 ± 0.055	0.892LysGln: 0.892 ± 0.031	2.215LysArg: 2.215 ± 0.048	1.84LysSer: 1.84 ± 0.041	2.143LysThr: 2.143 ± 0.044	2.222LysVal: 2.222 ± 0.054	0.395LysTrp: 0.395 ± 0.021	0.639LysTyr: 0.639 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.797LeuAla: 11.797 ± 0.127	0.903LeuCys: 0.903 ± 0.032	6.212LeuAsp: 6.212 ± 0.092	4.782LeuGlu: 4.782 ± 0.074	3.46LeuPhe: 3.46 ± 0.07	8.054LeuGly: 8.054 ± 0.11	1.781LeuHis: 1.781 ± 0.046	5.427LeuIle: 5.427 ± 0.087	3.075LeuLys: 3.075 ± 0.057	7.924LeuLeu: 7.924 ± 0.11	2.803LeuMet: 2.803 ± 0.055	2.764LeuAsn: 2.764 ± 0.048	5.11LeuPro: 5.11 ± 0.082	2.808LeuGln: 2.808 ± 0.056	6.385LeuArg: 6.385 ± 0.085	6.33LeuSer: 6.33 ± 0.09	6.551LeuThr: 6.551 ± 0.094	6.324LeuVal: 6.324 ± 0.102	1.29LeuTrp: 1.29 ± 0.038	1.937LeuTyr: 1.937 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.607MetAla: 3.607 ± 0.06	0.242MetCys: 0.242 ± 0.014	1.702MetAsp: 1.702 ± 0.039	1.388MetGlu: 1.388 ± 0.036	0.921MetPhe: 0.921 ± 0.029	2.534MetGly: 2.534 ± 0.049	0.459MetHis: 0.459 ± 0.024	1.62MetIle: 1.62 ± 0.042	1.074MetLys: 1.074 ± 0.032	2.462MetLeu: 2.462 ± 0.044	0.898MetMet: 0.898 ± 0.029	0.878MetAsn: 0.878 ± 0.031	1.477MetPro: 1.477 ± 0.034	0.987MetGln: 0.987 ± 0.031	1.894MetArg: 1.894 ± 0.044	1.791MetSer: 1.791 ± 0.045	2.368MetThr: 2.368 ± 0.05	1.988MetVal: 1.988 ± 0.04	0.293MetTrp: 0.293 ± 0.017	0.378MetTyr: 0.378 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.385AsnAla: 3.385 ± 0.063	0.273AsnCys: 0.273 ± 0.02	1.742AsnAsp: 1.742 ± 0.077	1.269AsnGlu: 1.269 ± 0.037	1.068AsnPhe: 1.068 ± 0.032	2.625AsnGly: 2.625 ± 0.068	0.55AsnHis: 0.55 ± 0.026	1.493AsnIle: 1.493 ± 0.037	0.688AsnLys: 0.688 ± 0.026	2.549AsnLeu: 2.549 ± 0.054	0.781AsnMet: 0.781 ± 0.028	0.755AsnAsn: 0.755 ± 0.038	1.847AsnPro: 1.847 ± 0.046	0.71AsnGln: 0.71 ± 0.028	1.754AsnArg: 1.754 ± 0.04	1.205AsnSer: 1.205 ± 0.034	1.634AsnThr: 1.634 ± 0.047	2.044AsnVal: 2.044 ± 0.054	0.436AsnTrp: 0.436 ± 0.02	0.644AsnTyr: 0.644 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.646ProAla: 5.646 ± 0.083	0.364ProCys: 0.364 ± 0.019	4.233ProAsp: 4.233 ± 0.079	3.275ProGlu: 3.275 ± 0.06	2.042ProPhe: 2.042 ± 0.047	3.35ProGly: 3.35 ± 0.06	1.144ProHis: 1.144 ± 0.038	2.327ProIle: 2.327 ± 0.048	1.78ProLys: 1.78 ± 0.047	4.597ProLeu: 4.597 ± 0.073	1.37ProMet: 1.37 ± 0.038	1.567ProAsn: 1.567 ± 0.038	2.16ProPro: 2.16 ± 0.061	1.776ProGln: 1.776 ± 0.034	2.508ProArg: 2.508 ± 0.053	2.539ProSer: 2.539 ± 0.055	2.933ProThr: 2.933 ± 0.057	4.068ProVal: 4.068 ± 0.062	0.677ProTrp: 0.677 ± 0.03	1.132ProTyr: 1.132 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.132GlnAla: 4.132 ± 0.071	0.214GlnCys: 0.214 ± 0.015	2.049GlnAsp: 2.049 ± 0.048	1.465GlnGlu: 1.465 ± 0.041	1.136GlnPhe: 1.136 ± 0.032	2.711GlnGly: 2.711 ± 0.054	0.615GlnHis: 0.615 ± 0.027	2.146GlnIle: 2.146 ± 0.046	1.055GlnLys: 1.055 ± 0.029	2.886GlnLeu: 2.886 ± 0.059	1.163GlnMet: 1.163 ± 0.031	1.051GlnAsn: 1.051 ± 0.029	1.617GlnPro: 1.617 ± 0.041	1.14GlnGln: 1.14 ± 0.043	2.017GlnArg: 2.017 ± 0.049	1.858GlnSer: 1.858 ± 0.041	2.415GlnThr: 2.415 ± 0.052	2.43GlnVal: 2.43 ± 0.048	0.423GlnTrp: 0.423 ± 0.019	0.607GlnTyr: 0.607 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.549ArgAla: 7.549 ± 0.105	0.452ArgCys: 0.452 ± 0.021	4.301ArgAsp: 4.301 ± 0.071	3.114ArgGlu: 3.114 ± 0.062	2.44ArgPhe: 2.44 ± 0.051	4.43ArgGly: 4.43 ± 0.082	1.434ArgHis: 1.434 ± 0.039	3.494ArgIle: 3.494 ± 0.062	2.054ArgLys: 2.054 ± 0.057	6.327ArgLeu: 6.327 ± 0.09	1.943ArgMet: 1.943 ± 0.042	1.621ArgAsn: 1.621 ± 0.043	2.945ArgPro: 2.945 ± 0.055	2.22ArgGln: 2.22 ± 0.045	4.352ArgArg: 4.352 ± 0.073	2.956ArgSer: 2.956 ± 0.056	3.32ArgThr: 3.32 ± 0.065	4.473ArgVal: 4.473 ± 0.069	0.893ArgTrp: 0.893 ± 0.034	1.397ArgTyr: 1.397 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.447SerAla: 5.447 ± 0.072	0.432SerCys: 0.432 ± 0.021	3.584SerAsp: 3.584 ± 0.063	2.513SerGlu: 2.513 ± 0.056	2.176SerPhe: 2.176 ± 0.046	4.979SerGly: 4.979 ± 0.079	1.065SerHis: 1.065 ± 0.03	2.538SerIle: 2.538 ± 0.059	1.544SerLys: 1.544 ± 0.044	4.786SerLeu: 4.786 ± 0.073	1.4SerMet: 1.4 ± 0.036	1.449SerAsn: 1.449 ± 0.042	2.402SerPro: 2.402 ± 0.048	1.657SerGln: 1.657 ± 0.036	2.87SerArg: 2.87 ± 0.054	2.422SerSer: 2.422 ± 0.054	2.703SerThr: 2.703 ± 0.052	3.827SerVal: 3.827 ± 0.064	0.644SerTrp: 0.644 ± 0.027	1.281SerTyr: 1.281 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.918ThrAla: 6.918 ± 0.1	0.574ThrCys: 0.574 ± 0.029	3.948ThrAsp: 3.948 ± 0.08	2.784ThrGlu: 2.784 ± 0.049	2.491ThrPhe: 2.491 ± 0.056	5.718ThrGly: 5.718 ± 0.103	1.282ThrHis: 1.282 ± 0.04	3.041ThrIle: 3.041 ± 0.07	1.674ThrLys: 1.674 ± 0.035	6.536ThrLeu: 6.536 ± 0.086	1.457ThrMet: 1.457 ± 0.038	1.616ThrAsn: 1.616 ± 0.055	3.811ThrPro: 3.811 ± 0.07	2.086ThrGln: 2.086 ± 0.048	3.527ThrArg: 3.527 ± 0.06	3.112ThrSer: 3.112 ± 0.061	3.358ThrThr: 3.358 ± 0.066	4.84ThrVal: 4.84 ± 0.098	0.76ThrTrp: 0.76 ± 0.028	1.539ThrTyr: 1.539 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	8.802ValAla: 8.802 ± 0.115	0.705ValCys: 0.705 ± 0.024	4.594ValAsp: 4.594 ± 0.086	4.447ValGlu: 4.447 ± 0.072	3.077ValPhe: 3.077 ± 0.064	5.716ValGly: 5.716 ± 0.081	1.35ValHis: 1.35 ± 0.04	4.291ValIle: 4.291 ± 0.065	2.201ValLys: 2.201 ± 0.04	7.226ValLeu: 7.226 ± 0.088	2.253ValMet: 2.253 ± 0.055	2.1ValAsn: 2.1 ± 0.061	3.592ValPro: 3.592 ± 0.064	2.347ValGln: 2.347 ± 0.052	4.161ValArg: 4.161 ± 0.065	4.22ValSer: 4.22 ± 0.075	5.249ValThr: 5.249 ± 0.119	5.824ValVal: 5.824 ± 0.091	1.021ValTrp: 1.021 ± 0.031	1.533ValTyr: 1.533 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.504TrpAla: 1.504 ± 0.043	0.132TrpCys: 0.132 ± 0.012	0.924TrpAsp: 0.924 ± 0.031	0.625TrpGlu: 0.625 ± 0.026	0.583TrpPhe: 0.583 ± 0.026	1.031TrpGly: 1.031 ± 0.029	0.331TrpHis: 0.331 ± 0.018	0.733TrpIle: 0.733 ± 0.027	0.395TrpLys: 0.395 ± 0.02	1.492TrpLeu: 1.492 ± 0.042	0.449TrpMet: 0.449 ± 0.022	0.415TrpAsn: 0.415 ± 0.021	0.675TrpPro: 0.675 ± 0.026	0.499TrpGln: 0.499 ± 0.022	0.971TrpArg: 0.971 ± 0.033	0.811TrpSer: 0.811 ± 0.03	0.872TrpThr: 0.872 ± 0.027	1.016TrpVal: 1.016 ± 0.031	0.219TrpTrp: 0.219 ± 0.015	0.252TrpTyr: 0.252 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.518TyrAla: 2.518 ± 0.053	0.219TyrCys: 0.219 ± 0.015	1.758TyrAsp: 1.758 ± 0.041	1.237TyrGlu: 1.237 ± 0.042	0.927TyrPhe: 0.927 ± 0.033	2.097TyrGly: 2.097 ± 0.049	0.524TyrHis: 0.524 ± 0.021	0.997TyrIle: 0.997 ± 0.032	0.586TyrLys: 0.586 ± 0.024	2.168TyrLeu: 2.168 ± 0.044	0.511TyrMet: 0.511 ± 0.024	0.642TyrAsn: 0.642 ± 0.026	1.063TyrPro: 1.063 ± 0.032	0.709TyrGln: 0.709 ± 0.03	1.446TyrArg: 1.446 ± 0.035	1.166TyrSer: 1.166 ± 0.036	1.226TyrThr: 1.226 ± 0.037	1.56TyrVal: 1.56 ± 0.035	0.362TyrTrp: 0.362 ± 0.02	0.537TyrTyr: 0.537 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3340 proteins (1035149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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