Amino acid dipepetide frequency for Neptunomonas qingdaonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.067AlaAla: 9.067 ± 0.105
1.053AlaCys: 1.053 ± 0.031
5.204AlaAsp: 5.204 ± 0.083
5.986AlaGlu: 5.986 ± 0.077
3.436AlaPhe: 3.436 ± 0.056
6.744AlaGly: 6.744 ± 0.097
1.859AlaHis: 1.859 ± 0.04
5.833AlaIle: 5.833 ± 0.082
4.068AlaLys: 4.068 ± 0.06
10.273AlaLeu: 10.273 ± 0.111
2.557AlaMet: 2.557 ± 0.054
3.162AlaAsn: 3.162 ± 0.066
3.028AlaPro: 3.028 ± 0.058
3.755AlaGln: 3.755 ± 0.066
4.167AlaArg: 4.167 ± 0.069
5.543AlaSer: 5.543 ± 0.08
4.647AlaThr: 4.647 ± 0.082
6.444AlaVal: 6.444 ± 0.093
0.989AlaTrp: 0.989 ± 0.033
2.377AlaTyr: 2.377 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.825CysAla: 0.825 ± 0.029
0.168CysCys: 0.168 ± 0.012
0.609CysAsp: 0.609 ± 0.024
0.585CysGlu: 0.585 ± 0.023
0.447CysPhe: 0.447 ± 0.019
0.874CysGly: 0.874 ± 0.028
0.331CysHis: 0.331 ± 0.018
0.623CysIle: 0.623 ± 0.023
0.436CysLys: 0.436 ± 0.021
1.006CysLeu: 1.006 ± 0.031
0.24CysMet: 0.24 ± 0.013
0.366CysAsn: 0.366 ± 0.018
0.478CysPro: 0.478 ± 0.022
0.413CysGln: 0.413 ± 0.017
0.51CysArg: 0.51 ± 0.021
0.727CysSer: 0.727 ± 0.025
0.516CysThr: 0.516 ± 0.021
0.654CysVal: 0.654 ± 0.023
0.145CysTrp: 0.145 ± 0.012
0.324CysTyr: 0.324 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.932AspAla: 4.932 ± 0.109
0.526AspCys: 0.526 ± 0.023
3.252AspAsp: 3.252 ± 0.074
3.707AspGlu: 3.707 ± 0.049
2.333AspPhe: 2.333 ± 0.045
3.709AspGly: 3.709 ± 0.109
1.126AspHis: 1.126 ± 0.033
3.961AspIle: 3.961 ± 0.062
2.926AspLys: 2.926 ± 0.049
5.749AspLeu: 5.749 ± 0.067
1.429AspMet: 1.429 ± 0.036
2.257AspAsn: 2.257 ± 0.063
2.303AspPro: 2.303 ± 0.041
2.502AspGln: 2.502 ± 0.041
2.497AspArg: 2.497 ± 0.044
3.459AspSer: 3.459 ± 0.065
2.851AspThr: 2.851 ± 0.083
3.938AspVal: 3.938 ± 0.067
0.784AspTrp: 0.784 ± 0.027
1.867AspTyr: 1.867 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.601GluAla: 5.601 ± 0.078
0.495GluCys: 0.495 ± 0.023
2.832GluAsp: 2.832 ± 0.05
3.773GluGlu: 3.773 ± 0.069
2.104GluPhe: 2.104 ± 0.041
3.803GluGly: 3.803 ± 0.057
1.548GluHis: 1.548 ± 0.033
3.737GluIle: 3.737 ± 0.056
3.635GluLys: 3.635 ± 0.065
6.708GluLeu: 6.708 ± 0.088
1.682GluMet: 1.682 ± 0.037
2.461GluAsn: 2.461 ± 0.043
2.054GluPro: 2.054 ± 0.042
3.501GluGln: 3.501 ± 0.059
3.381GluArg: 3.381 ± 0.06
3.713GluSer: 3.713 ± 0.05
3.114GluThr: 3.114 ± 0.054
4.143GluVal: 4.143 ± 0.054
0.809GluTrp: 0.809 ± 0.026
1.709GluTyr: 1.709 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.25PheAla: 3.25 ± 0.057
0.531PheCys: 0.531 ± 0.022
2.539PheAsp: 2.539 ± 0.04
2.337PheGlu: 2.337 ± 0.048
1.714PhePhe: 1.714 ± 0.05
2.897PheGly: 2.897 ± 0.055
0.768PheHis: 0.768 ± 0.027
2.705PheIle: 2.705 ± 0.057
1.744PheLys: 1.744 ± 0.038
3.591PheLeu: 3.591 ± 0.06
1.027PheMet: 1.027 ± 0.032
1.73PheAsn: 1.73 ± 0.036
1.485PhePro: 1.485 ± 0.035
1.283PheGln: 1.283 ± 0.032
1.705PheArg: 1.705 ± 0.041
3.293PheSer: 3.293 ± 0.054
2.264PheThr: 2.264 ± 0.05
2.669PheVal: 2.669 ± 0.048
0.53PheTrp: 0.53 ± 0.019
1.248PheTyr: 1.248 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
5.692GlyAla: 5.692 ± 0.087
0.925GlyCys: 0.925 ± 0.031
3.831GlyAsp: 3.831 ± 0.092
4.162GlyGlu: 4.162 ± 0.055
3.27GlyPhe: 3.27 ± 0.054
5.093GlyGly: 5.093 ± 0.105
1.642GlyHis: 1.642 ± 0.035
4.799GlyIle: 4.799 ± 0.065
3.661GlyLys: 3.661 ± 0.058
7.398GlyLeu: 7.398 ± 0.086
2.086GlyMet: 2.086 ± 0.041
2.519GlyAsn: 2.519 ± 0.076
1.801GlyPro: 1.801 ± 0.042
2.772GlyGln: 2.772 ± 0.049
3.386GlyArg: 3.386 ± 0.054
4.469GlySer: 4.469 ± 0.094
3.635GlyThr: 3.635 ± 0.102
5.433GlyVal: 5.433 ± 0.077
1.061GlyTrp: 1.061 ± 0.035
2.374GlyTyr: 2.374 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.781HisAla: 1.781 ± 0.033
0.308HisCys: 0.308 ± 0.017
1.166HisAsp: 1.166 ± 0.036
1.208HisGlu: 1.208 ± 0.033
1.052HisPhe: 1.052 ± 0.029
1.506HisGly: 1.506 ± 0.041
0.701HisHis: 0.701 ± 0.024
1.456HisIle: 1.456 ± 0.034
1.01HisLys: 1.01 ± 0.029
2.397HisLeu: 2.397 ± 0.048
0.548HisMet: 0.548 ± 0.02
0.831HisAsn: 0.831 ± 0.028
1.263HisPro: 1.263 ± 0.034
1.185HisGln: 1.185 ± 0.03
1.158HisArg: 1.158 ± 0.032
1.431HisSer: 1.431 ± 0.038
1.133HisThr: 1.133 ± 0.032
1.286HisVal: 1.286 ± 0.033
0.379HisTrp: 0.379 ± 0.017
0.841HisTyr: 0.841 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.194IleAla: 6.194 ± 0.074
0.705IleCys: 0.705 ± 0.023
4.178IleAsp: 4.178 ± 0.055
4.376IleGlu: 4.376 ± 0.066
2.204IlePhe: 2.204 ± 0.051
4.521IleGly: 4.521 ± 0.066
1.327IleHis: 1.327 ± 0.034
3.938IleIle: 3.938 ± 0.064
3.277IleLys: 3.277 ± 0.054
5.603IleLeu: 5.603 ± 0.074
1.363IleMet: 1.363 ± 0.033
3.104IleAsn: 3.104 ± 0.05
2.828IlePro: 2.828 ± 0.053
2.424IleGln: 2.424 ± 0.043
3.294IleArg: 3.294 ± 0.045
4.784IleSer: 4.784 ± 0.065
3.743IleThr: 3.743 ± 0.072
4.037IleVal: 4.037 ± 0.062
0.67IleTrp: 0.67 ± 0.025
1.73IleTyr: 1.73 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.542LysAla: 4.542 ± 0.068
0.298LysCys: 0.298 ± 0.016
2.547LysAsp: 2.547 ± 0.046
3.091LysGlu: 3.091 ± 0.055
1.217LysPhe: 1.217 ± 0.031
3.224LysGly: 3.224 ± 0.049
1.133LysHis: 1.133 ± 0.032
2.893LysIle: 2.893 ± 0.058
2.85LysLys: 2.85 ± 0.058
4.661LysLeu: 4.661 ± 0.073
1.326LysMet: 1.326 ± 0.03
2.138LysAsn: 2.138 ± 0.047
2.298LysPro: 2.298 ± 0.046
2.566LysGln: 2.566 ± 0.049
2.727LysArg: 2.727 ± 0.051
2.972LysSer: 2.972 ± 0.053
2.73LysThr: 2.73 ± 0.049
3.395LysVal: 3.395 ± 0.066
0.46LysTrp: 0.46 ± 0.019
1.173LysTyr: 1.173 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
9.956LeuAla: 9.956 ± 0.105
1.088LeuCys: 1.088 ± 0.034
5.914LeuAsp: 5.914 ± 0.069
6.182LeuGlu: 6.182 ± 0.075
4.322LeuPhe: 4.322 ± 0.075
7.044LeuGly: 7.044 ± 0.079
2.262LeuHis: 2.262 ± 0.047
6.872LeuIle: 6.872 ± 0.085
5.515LeuLys: 5.515 ± 0.079
11.872LeuLeu: 11.872 ± 0.141
2.784LeuMet: 2.784 ± 0.059
4.475LeuAsn: 4.475 ± 0.066
4.99LeuPro: 4.99 ± 0.072
4.367LeuGln: 4.367 ± 0.073
5.05LeuArg: 5.05 ± 0.07
8.199LeuSer: 8.199 ± 0.082
5.967LeuThr: 5.967 ± 0.094
6.761LeuVal: 6.761 ± 0.062
1.132LeuTrp: 1.132 ± 0.029
2.594LeuTyr: 2.594 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.492MetAla: 2.492 ± 0.048
0.211MetCys: 0.211 ± 0.013
1.318MetAsp: 1.318 ± 0.035
1.245MetGlu: 1.245 ± 0.03
0.859MetPhe: 0.859 ± 0.026
1.846MetGly: 1.846 ± 0.051
0.574MetHis: 0.574 ± 0.021
1.585MetIle: 1.585 ± 0.037
1.38MetLys: 1.38 ± 0.036
2.918MetLeu: 2.918 ± 0.052
0.765MetMet: 0.765 ± 0.023
1.092MetAsn: 1.092 ± 0.031
1.305MetPro: 1.305 ± 0.035
1.251MetGln: 1.251 ± 0.033
1.342MetArg: 1.342 ± 0.037
2.008MetSer: 2.008 ± 0.043
1.541MetThr: 1.541 ± 0.034
1.603MetVal: 1.603 ± 0.042
0.189MetTrp: 0.189 ± 0.013
0.439MetTyr: 0.439 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.426AsnAla: 3.426 ± 0.075
0.379AsnCys: 0.379 ± 0.02
2.219AsnAsp: 2.219 ± 0.07
2.217AsnGlu: 2.217 ± 0.047
1.342AsnPhe: 1.342 ± 0.035
2.759AsnGly: 2.759 ± 0.081
0.913AsnHis: 0.913 ± 0.032
2.713AsnIle: 2.713 ± 0.058
2.024AsnLys: 2.024 ± 0.044
3.688AsnLeu: 3.688 ± 0.061
0.894AsnMet: 0.894 ± 0.027
1.863AsnAsn: 1.863 ± 0.048
2.017AsnPro: 2.017 ± 0.041
1.817AsnGln: 1.817 ± 0.043
2.035AsnArg: 2.035 ± 0.041
2.504AsnSer: 2.504 ± 0.065
2.322AsnThr: 2.322 ± 0.058
2.398AsnVal: 2.398 ± 0.044
0.561AsnTrp: 0.561 ± 0.023
1.128AsnTyr: 1.128 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
3.746ProAla: 3.746 ± 0.061
0.353ProCys: 0.353 ± 0.017
2.854ProAsp: 2.854 ± 0.051
3.35ProGlu: 3.35 ± 0.056
1.73ProPhe: 1.73 ± 0.039
2.874ProGly: 2.874 ± 0.046
0.918ProHis: 0.918 ± 0.033
2.373ProIle: 2.373 ± 0.047
1.626ProLys: 1.626 ± 0.044
4.458ProLeu: 4.458 ± 0.069
0.995ProMet: 0.995 ± 0.03
1.385ProAsn: 1.385 ± 0.034
1.363ProPro: 1.363 ± 0.043
1.628ProGln: 1.628 ± 0.041
1.53ProArg: 1.53 ± 0.033
2.385ProSer: 2.385 ± 0.047
2.032ProThr: 2.032 ± 0.044
3.532ProVal: 3.532 ± 0.053
0.517ProTrp: 0.517 ± 0.021
1.158ProTyr: 1.158 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.248GlnAla: 4.248 ± 0.069
0.387GlnCys: 0.387 ± 0.017
1.916GlnAsp: 1.916 ± 0.039
2.3GlnGlu: 2.3 ± 0.045
1.522GlnPhe: 1.522 ± 0.034
2.994GlnGly: 2.994 ± 0.046
1.302GlnHis: 1.302 ± 0.036
2.614GlnIle: 2.614 ± 0.042
1.999GlnLys: 1.999 ± 0.045
5.299GlnLeu: 5.299 ± 0.072
1.082GlnMet: 1.082 ± 0.032
1.498GlnAsn: 1.498 ± 0.036
1.867GlnPro: 1.867 ± 0.043
3.204GlnGln: 3.204 ± 0.067
2.726GlnArg: 2.726 ± 0.05
2.74GlnSer: 2.74 ± 0.05
2.226GlnThr: 2.226 ± 0.053
3.056GlnVal: 3.056 ± 0.049
0.641GlnTrp: 0.641 ± 0.023
1.146GlnTyr: 1.146 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.775ArgAla: 3.775 ± 0.056
0.518ArgCys: 0.518 ± 0.024
2.551ArgAsp: 2.551 ± 0.049
2.971ArgGlu: 2.971 ± 0.057
2.379ArgPhe: 2.379 ± 0.046
2.845ArgGly: 2.845 ± 0.053
1.249ArgHis: 1.249 ± 0.038
3.43ArgIle: 3.43 ± 0.052
2.419ArgLys: 2.419 ± 0.053
5.929ArgLeu: 5.929 ± 0.085
1.401ArgMet: 1.401 ± 0.038
1.896ArgAsn: 1.896 ± 0.037
1.823ArgPro: 1.823 ± 0.032
2.424ArgGln: 2.424 ± 0.052
2.702ArgArg: 2.702 ± 0.048
3.062ArgSer: 3.062 ± 0.057
2.265ArgThr: 2.265 ± 0.042
3.443ArgVal: 3.443 ± 0.052
0.742ArgTrp: 0.742 ± 0.028
1.817ArgTyr: 1.817 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.031SerAla: 6.031 ± 0.083
0.66SerCys: 0.66 ± 0.027
3.897SerAsp: 3.897 ± 0.083
3.927SerGlu: 3.927 ± 0.059
2.775SerPhe: 2.775 ± 0.047
5.62SerGly: 5.62 ± 0.101
1.485SerHis: 1.485 ± 0.034
4.306SerIle: 4.306 ± 0.064
2.756SerLys: 2.756 ± 0.051
7.134SerLeu: 7.134 ± 0.076
1.771SerMet: 1.771 ± 0.039
2.368SerAsn: 2.368 ± 0.058
2.61SerPro: 2.61 ± 0.044
2.762SerGln: 2.762 ± 0.055
3.347SerArg: 3.347 ± 0.055
4.684SerSer: 4.684 ± 0.076
3.384SerThr: 3.384 ± 0.064
4.872SerVal: 4.872 ± 0.072
0.858SerTrp: 0.858 ± 0.03
1.891SerTyr: 1.891 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.037ThrAla: 5.037 ± 0.102
0.462ThrCys: 0.462 ± 0.021
3.125ThrAsp: 3.125 ± 0.056
3.086ThrGlu: 3.086 ± 0.043
2.013ThrPhe: 2.013 ± 0.043
4.169ThrGly: 4.169 ± 0.098
1.229ThrHis: 1.229 ± 0.033
3.097ThrIle: 3.097 ± 0.061
1.857ThrLys: 1.857 ± 0.039
6.588ThrLeu: 6.588 ± 0.116
1.022ThrMet: 1.022 ± 0.029
1.829ThrAsn: 1.829 ± 0.051
2.81ThrPro: 2.81 ± 0.05
2.317ThrGln: 2.317 ± 0.047
2.507ThrArg: 2.507 ± 0.048
3.385ThrSer: 3.385 ± 0.072
2.881ThrThr: 2.881 ± 0.076
3.782ThrVal: 3.782 ± 0.092
0.542ThrTrp: 0.542 ± 0.022
1.475ThrTyr: 1.475 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
6.483ValAla: 6.483 ± 0.087
0.728ValCys: 0.728 ± 0.025
4.037ValAsp: 4.037 ± 0.075
4.191ValGlu: 4.191 ± 0.058
2.782ValPhe: 2.782 ± 0.049
4.658ValGly: 4.658 ± 0.079
1.273ValHis: 1.273 ± 0.035
4.944ValIle: 4.944 ± 0.067
3.252ValLys: 3.252 ± 0.055
7.125ValLeu: 7.125 ± 0.076
1.97ValMet: 1.97 ± 0.042
2.817ValAsn: 2.817 ± 0.074
2.626ValPro: 2.626 ± 0.046
2.303ValGln: 2.303 ± 0.042
3.137ValArg: 3.137 ± 0.054
5.023ValSer: 5.023 ± 0.078
4.054ValThr: 4.054 ± 0.086
5.311ValVal: 5.311 ± 0.077
0.784ValTrp: 0.784 ± 0.026
1.782ValTyr: 1.782 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.839TrpAla: 0.839 ± 0.023
0.154TrpCys: 0.154 ± 0.011
0.593TrpAsp: 0.593 ± 0.024
0.564TrpGlu: 0.564 ± 0.024
0.542TrpPhe: 0.542 ± 0.021
0.843TrpGly: 0.843 ± 0.026
0.314TrpHis: 0.314 ± 0.015
0.785TrpIle: 0.785 ± 0.029
0.599TrpLys: 0.599 ± 0.022
1.707TrpLeu: 1.707 ± 0.04
0.394TrpMet: 0.394 ± 0.02
0.464TrpAsn: 0.464 ± 0.017
0.491TrpPro: 0.491 ± 0.022
0.753TrpGln: 0.753 ± 0.026
0.681TrpArg: 0.681 ± 0.023
0.805TrpSer: 0.805 ± 0.024
0.519TrpThr: 0.519 ± 0.022
0.852TrpVal: 0.852 ± 0.025
0.181TrpTrp: 0.181 ± 0.012
0.334TrpTyr: 0.334 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.274TyrAla: 2.274 ± 0.044
0.325TyrCys: 0.325 ± 0.017
1.529TyrAsp: 1.529 ± 0.037
1.542TyrGlu: 1.542 ± 0.038
1.268TyrPhe: 1.268 ± 0.035
1.985TyrGly: 1.985 ± 0.046
0.682TyrHis: 0.682 ± 0.025
1.64TyrIle: 1.64 ± 0.038
1.208TyrLys: 1.208 ± 0.033
3.243TyrLeu: 3.243 ± 0.058
0.63TyrMet: 0.63 ± 0.024
0.965TyrAsn: 0.965 ± 0.028
1.368TyrPro: 1.368 ± 0.034
1.539TyrGln: 1.539 ± 0.036
1.757TyrArg: 1.757 ± 0.038
1.949TyrSer: 1.949 ± 0.039
1.392TyrThr: 1.392 ± 0.044
1.673TyrVal: 1.673 ± 0.043
0.44TyrTrp: 0.44 ± 0.019
0.928TyrTyr: 0.928 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4011 proteins (1312960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski