Amino acid dipepetide frequency for Chrysochloris asiatica (Cape golden mole)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.528AlaAla: 6.528 ± 0.036	1.371AlaCys: 1.371 ± 0.012	2.851AlaAsp: 2.851 ± 0.015	4.617AlaGlu: 4.617 ± 0.03	2.681AlaPhe: 2.681 ± 0.018	4.477AlaGly: 4.477 ± 0.026	1.538AlaHis: 1.538 ± 0.011	2.905AlaIle: 2.905 ± 0.013	3.347AlaLys: 3.347 ± 0.02	7.069AlaLeu: 7.069 ± 0.034	1.503AlaMet: 1.503 ± 0.011	2.057AlaAsn: 2.057 ± 0.013	3.922AlaPro: 3.922 ± 0.027	3.152AlaGln: 3.152 ± 0.021	3.502AlaArg: 3.502 ± 0.02	5.571AlaSer: 5.571 ± 0.027	3.558AlaThr: 3.558 ± 0.017	4.634AlaVal: 4.634 ± 0.021	0.755AlaTrp: 0.755 ± 0.007	1.577AlaTyr: 1.577 ± 0.011	0.006AlaXaa: 0.006 ± 0.001
Cys	1.244CysAla: 1.244 ± 0.013	0.647CysCys: 0.647 ± 0.013	1.03CysAsp: 1.03 ± 0.012	1.254CysGlu: 1.254 ± 0.015	0.858CysPhe: 0.858 ± 0.009	1.793CysGly: 1.793 ± 0.022	0.656CysHis: 0.656 ± 0.009	0.988CysIle: 0.988 ± 0.011	1.185CysLys: 1.185 ± 0.013	2.145CysLeu: 2.145 ± 0.017	0.436CysMet: 0.436 ± 0.006	0.821CysAsn: 0.821 ± 0.009	1.317CysPro: 1.317 ± 0.014	1.053CysGln: 1.053 ± 0.012	1.251CysArg: 1.251 ± 0.013	1.977CysSer: 1.977 ± 0.016	1.113CysThr: 1.113 ± 0.01	1.303CysVal: 1.303 ± 0.013	0.28CysTrp: 0.28 ± 0.005	0.603CysTyr: 0.603 ± 0.006	0.003CysXaa: 0.003 ± 0.001
Asp	2.775AspAla: 2.775 ± 0.015	1.047AspCys: 1.047 ± 0.011	2.641AspAsp: 2.641 ± 0.022	3.414AspGlu: 3.414 ± 0.021	2.107AspPhe: 2.107 ± 0.012	3.243AspGly: 3.243 ± 0.021	1.168AspHis: 1.168 ± 0.009	2.616AspIle: 2.616 ± 0.015	2.549AspLys: 2.549 ± 0.014	4.982AspLeu: 4.982 ± 0.022	1.139AspMet: 1.139 ± 0.01	1.75AspAsn: 1.75 ± 0.015	2.908AspPro: 2.908 ± 0.019	1.822AspGln: 1.822 ± 0.012	2.43AspArg: 2.43 ± 0.016	4.166AspSer: 4.166 ± 0.023	2.523AspThr: 2.523 ± 0.015	3.034AspVal: 3.034 ± 0.021	0.62AspTrp: 0.62 ± 0.009	1.477AspTyr: 1.477 ± 0.012	0.003AspXaa: 0.003 ± 0.001
Glu	5.062GluAla: 5.062 ± 0.029	1.482GluCys: 1.482 ± 0.02	4.368GluAsp: 4.368 ± 0.021	7.697GluGlu: 7.697 ± 0.048	2.053GluPhe: 2.053 ± 0.013	4.044GluGly: 4.044 ± 0.021	1.482GluHis: 1.482 ± 0.011	3.147GluIle: 3.147 ± 0.018	5.232GluLys: 5.232 ± 0.036	6.408GluLeu: 6.408 ± 0.034	1.689GluMet: 1.689 ± 0.012	3.087GluAsn: 3.087 ± 0.02	3.156GluPro: 3.156 ± 0.02	3.124GluGln: 3.124 ± 0.022	3.906GluArg: 3.906 ± 0.026	4.326GluSer: 4.326 ± 0.024	3.406GluThr: 3.406 ± 0.017	4.129GluVal: 4.129 ± 0.023	0.676GluTrp: 0.676 ± 0.006	1.576GluTyr: 1.576 ± 0.012	0.005GluXaa: 0.005 ± 0.001
Phe	2.016PheAla: 2.016 ± 0.014	1.01PheCys: 1.01 ± 0.01	1.689PheAsp: 1.689 ± 0.013	1.994PheGlu: 1.994 ± 0.011	1.74PhePhe: 1.74 ± 0.013	2.266PheGly: 2.266 ± 0.017	1.039PheHis: 1.039 ± 0.009	2.01PheIle: 2.01 ± 0.015	1.777PheLys: 1.777 ± 0.013	4.251PheLeu: 4.251 ± 0.022	0.819PheMet: 0.819 ± 0.008	1.379PheAsn: 1.379 ± 0.011	1.994PhePro: 1.994 ± 0.015	1.801PheGln: 1.801 ± 0.012	1.951PheArg: 1.951 ± 0.014	3.477PheSer: 3.477 ± 0.018	2.071PheThr: 2.071 ± 0.015	2.204PheVal: 2.204 ± 0.016	0.483PheTrp: 0.483 ± 0.007	1.242PheTyr: 1.242 ± 0.011	0.004PheXaa: 0.004 ± 0.001
Gly	4.322GlyAla: 4.322 ± 0.025	1.27GlyCys: 1.27 ± 0.012	3.129GlyAsp: 3.129 ± 0.019	4.033GlyGlu: 4.033 ± 0.029	2.455GlyPhe: 2.455 ± 0.02	5.002GlyGly: 5.002 ± 0.037	1.639GlyHis: 1.639 ± 0.013	2.786GlyIle: 2.786 ± 0.017	3.747GlyLys: 3.747 ± 0.019	5.94GlyLeu: 5.94 ± 0.034	1.345GlyMet: 1.345 ± 0.011	2.45GlyAsn: 2.45 ± 0.015	4.173GlyPro: 4.173 ± 0.045	2.72GlyGln: 2.72 ± 0.017	3.621GlyArg: 3.621 ± 0.022	5.762GlySer: 5.762 ± 0.028	3.651GlyThr: 3.651 ± 0.024	3.536GlyVal: 3.536 ± 0.021	0.767GlyTrp: 0.767 ± 0.009	1.747GlyTyr: 1.747 ± 0.015	0.006GlyXaa: 0.006 ± 0.001
His	1.292HisAla: 1.292 ± 0.01	0.71HisCys: 0.71 ± 0.009	0.88HisAsp: 0.88 ± 0.008	1.305HisGlu: 1.305 ± 0.011	1.104HisPhe: 1.104 ± 0.009	1.504HisGly: 1.504 ± 0.012	0.913HisHis: 0.913 ± 0.012	1.293HisIle: 1.293 ± 0.01	1.266HisLys: 1.266 ± 0.01	2.966HisLeu: 2.966 ± 0.016	0.618HisMet: 0.618 ± 0.007	0.896HisAsn: 0.896 ± 0.009	1.64HisPro: 1.64 ± 0.012	1.346HisGln: 1.346 ± 0.014	1.577HisArg: 1.577 ± 0.01	2.384HisSer: 2.384 ± 0.017	1.51HisThr: 1.51 ± 0.014	1.486HisVal: 1.486 ± 0.012	0.352HisTrp: 0.352 ± 0.006	0.85HisTyr: 0.85 ± 0.008	0.003HisXaa: 0.003 ± 0.0
Ile	2.642IleAla: 2.642 ± 0.016	1.147IleCys: 1.147 ± 0.011	2.032IleAsp: 2.032 ± 0.014	2.596IleGlu: 2.596 ± 0.019	2.033IlePhe: 2.033 ± 0.015	2.26IleGly: 2.26 ± 0.014	1.385IleHis: 1.385 ± 0.012	2.571IleIle: 2.571 ± 0.019	2.666IleLys: 2.666 ± 0.02	4.8IleLeu: 4.8 ± 0.022	1.086IleMet: 1.086 ± 0.01	1.869IleAsn: 1.869 ± 0.014	2.68IlePro: 2.68 ± 0.016	2.31IleGln: 2.31 ± 0.014	2.388IleArg: 2.388 ± 0.015	3.806IleSer: 3.806 ± 0.02	2.656IleThr: 2.656 ± 0.019	2.608IleVal: 2.608 ± 0.015	0.511IleTrp: 0.511 ± 0.007	1.483IleTyr: 1.483 ± 0.013	0.003IleXaa: 0.003 ± 0.0
Lys	3.965LysAla: 3.965 ± 0.024	1.125LysCys: 1.125 ± 0.013	3.168LysAsp: 3.168 ± 0.02	5.037LysGlu: 5.037 ± 0.031	1.737LysPhe: 1.737 ± 0.014	3.267LysGly: 3.267 ± 0.027	1.404LysHis: 1.404 ± 0.011	2.783LysIle: 2.783 ± 0.017	4.67LysLys: 4.67 ± 0.035	5.154LysLeu: 5.154 ± 0.028	1.478LysMet: 1.478 ± 0.013	2.362LysAsn: 2.362 ± 0.016	3.029LysPro: 3.029 ± 0.02	2.586LysGln: 2.586 ± 0.019	3.267LysArg: 3.267 ± 0.02	3.894LysSer: 3.894 ± 0.029	3.148LysThr: 3.148 ± 0.019	3.495LysVal: 3.495 ± 0.027	0.602LysTrp: 0.602 ± 0.007	1.577LysTyr: 1.577 ± 0.012	0.006LysXaa: 0.006 ± 0.001
Leu	6.761LeuAla: 6.761 ± 0.029	2.139LeuCys: 2.139 ± 0.015	4.761LeuAsp: 4.761 ± 0.021	7.111LeuGlu: 7.111 ± 0.035	3.522LeuPhe: 3.522 ± 0.022	5.941LeuGly: 5.941 ± 0.029	2.769LeuHis: 2.769 ± 0.014	4.05LeuIle: 4.05 ± 0.023	5.836LeuLys: 5.836 ± 0.031	10.924LeuLeu: 10.924 ± 0.054	2.116LeuMet: 2.116 ± 0.014	3.612LeuAsn: 3.612 ± 0.021	5.904LeuPro: 5.904 ± 0.029	5.725LeuGln: 5.725 ± 0.031	5.926LeuArg: 5.926 ± 0.026	8.098LeuSer: 8.098 ± 0.028	5.278LeuThr: 5.278 ± 0.024	5.688LeuVal: 5.688 ± 0.027	1.133LeuTrp: 1.133 ± 0.011	2.579LeuTyr: 2.579 ± 0.014	0.011LeuXaa: 0.011 ± 0.001
Met	1.998MetAla: 1.998 ± 0.01	0.401MetCys: 0.401 ± 0.005	1.313MetAsp: 1.313 ± 0.01	1.875MetGlu: 1.875 ± 0.012	0.763MetPhe: 0.763 ± 0.007	1.325MetGly: 1.325 ± 0.012	0.479MetHis: 0.479 ± 0.006	0.896MetIle: 0.896 ± 0.009	1.475MetLys: 1.475 ± 0.011	2.079MetLeu: 2.079 ± 0.014	0.6MetMet: 0.6 ± 0.007	0.953MetAsn: 0.953 ± 0.01	1.12MetPro: 1.12 ± 0.013	0.95MetGln: 0.95 ± 0.009	1.05MetArg: 1.05 ± 0.009	1.65MetSer: 1.65 ± 0.013	1.174MetThr: 1.174 ± 0.01	1.457MetVal: 1.457 ± 0.01	0.24MetTrp: 0.24 ± 0.004	0.677MetTyr: 0.677 ± 0.008	0.001MetXaa: 0.001 ± 0.0
Asn	2.06AsnAla: 2.06 ± 0.014	0.85AsnCys: 0.85 ± 0.009	1.541AsnAsp: 1.541 ± 0.013	2.218AsnGlu: 2.218 ± 0.017	1.53AsnPhe: 1.53 ± 0.013	2.472AsnGly: 2.472 ± 0.018	0.992AsnHis: 0.992 ± 0.009	2.164AsnIle: 2.164 ± 0.014	2.258AsnLys: 2.258 ± 0.015	3.852AsnLeu: 3.852 ± 0.02	0.943AsnMet: 0.943 ± 0.009	1.565AsnAsn: 1.565 ± 0.013	2.295AsnPro: 2.295 ± 0.013	1.696AsnGln: 1.696 ± 0.012	1.848AsnArg: 1.848 ± 0.013	3.187AsnSer: 3.187 ± 0.022	2.01AsnThr: 2.01 ± 0.013	2.228AsnVal: 2.228 ± 0.013	0.448AsnTrp: 0.448 ± 0.006	1.145AsnTyr: 1.145 ± 0.01	0.003AsnXaa: 0.003 ± 0.001
Pro	4.491ProAla: 4.491 ± 0.027	1.083ProCys: 1.083 ± 0.013	2.715ProAsp: 2.715 ± 0.017	4.326ProGlu: 4.326 ± 0.025	1.948ProPhe: 1.948 ± 0.015	5.099ProGly: 5.099 ± 0.056	1.465ProHis: 1.465 ± 0.013	1.939ProIle: 1.939 ± 0.016	2.808ProLys: 2.808 ± 0.025	5.283ProLeu: 5.283 ± 0.025	1.18ProMet: 1.18 ± 0.01	1.903ProAsn: 1.903 ± 0.013	6.004ProPro: 6.004 ± 0.057	2.83ProGln: 2.83 ± 0.019	3.21ProArg: 3.21 ± 0.021	5.636ProSer: 5.636 ± 0.031	3.223ProThr: 3.223 ± 0.022	3.764ProVal: 3.764 ± 0.023	0.662ProTrp: 0.662 ± 0.008	1.586ProTyr: 1.586 ± 0.016	0.008ProXaa: 0.008 ± 0.001
Gln	3.436GlnAla: 3.436 ± 0.025	0.923GlnCys: 0.923 ± 0.012	2.328GlnAsp: 2.328 ± 0.015	3.774GlnGlu: 3.774 ± 0.023	1.377GlnPhe: 1.377 ± 0.01	2.811GlnGly: 2.811 ± 0.019	1.277GlnHis: 1.277 ± 0.01	2.021GlnIle: 2.021 ± 0.014	2.891GlnLys: 2.891 ± 0.019	4.798GlnLeu: 4.798 ± 0.024	1.167GlnMet: 1.167 ± 0.01	1.854GlnAsn: 1.854 ± 0.013	2.746GlnPro: 2.746 ± 0.022	3.113GlnGln: 3.113 ± 0.038	2.941GlnArg: 2.941 ± 0.022	3.145GlnSer: 3.145 ± 0.019	2.356GlnThr: 2.356 ± 0.014	2.854GlnVal: 2.854 ± 0.018	0.528GlnTrp: 0.528 ± 0.007	1.155GlnTyr: 1.155 ± 0.01	0.004GlnXaa: 0.004 ± 0.001
Arg	3.675ArgAla: 3.675 ± 0.02	1.144ArgCys: 1.144 ± 0.012	2.69ArgAsp: 2.69 ± 0.017	3.833ArgGlu: 3.833 ± 0.023	1.848ArgPhe: 1.848 ± 0.011	3.478ArgGly: 3.478 ± 0.027	1.516ArgHis: 1.516 ± 0.012	2.456ArgIle: 2.456 ± 0.015	3.642ArgLys: 3.642 ± 0.02	5.363ArgLeu: 5.363 ± 0.028	1.186ArgMet: 1.186 ± 0.01	2.152ArgAsn: 2.152 ± 0.012	3.175ArgPro: 3.175 ± 0.022	2.576ArgGln: 2.576 ± 0.017	4.261ArgArg: 4.261 ± 0.027	4.183ArgSer: 4.183 ± 0.029	2.86ArgThr: 2.86 ± 0.015	3.086ArgVal: 3.086 ± 0.016	0.661ArgTrp: 0.661 ± 0.008	1.484ArgTyr: 1.484 ± 0.01	0.007ArgXaa: 0.007 ± 0.001
Ser	5.22SerAla: 5.22 ± 0.023	1.86SerCys: 1.86 ± 0.017	3.852SerAsp: 3.852 ± 0.024	5.091SerGlu: 5.091 ± 0.026	3.055SerPhe: 3.055 ± 0.018	5.692SerGly: 5.692 ± 0.028	2.159SerHis: 2.159 ± 0.015	3.334SerIle: 3.334 ± 0.017	4.076SerLys: 4.076 ± 0.027	8.209SerLeu: 8.209 ± 0.032	1.67SerMet: 1.67 ± 0.014	2.803SerAsn: 2.803 ± 0.018	5.952SerPro: 5.952 ± 0.036	3.853SerGln: 3.853 ± 0.02	4.438SerArg: 4.438 ± 0.026	9.425SerSer: 9.425 ± 0.067	4.553SerThr: 4.553 ± 0.026	4.934SerVal: 4.934 ± 0.022	1.06SerTrp: 1.06 ± 0.009	2.167SerTyr: 2.167 ± 0.015	0.01SerXaa: 0.01 ± 0.001
Thr	3.722ThrAla: 3.722 ± 0.018	1.329ThrCys: 1.329 ± 0.016	2.489ThrAsp: 2.489 ± 0.016	3.587ThrGlu: 3.587 ± 0.02	2.17ThrPhe: 2.17 ± 0.013	3.573ThrGly: 3.573 ± 0.023	1.381ThrHis: 1.381 ± 0.015	2.547ThrIle: 2.547 ± 0.02	2.704ThrLys: 2.704 ± 0.018	5.454ThrLeu: 5.454 ± 0.023	1.177ThrMet: 1.177 ± 0.01	1.801ThrAsn: 1.801 ± 0.014	3.653ThrPro: 3.653 ± 0.024	2.353ThrGln: 2.353 ± 0.016	2.472ThrArg: 2.472 ± 0.014	4.683ThrSer: 4.683 ± 0.028	3.141ThrThr: 3.141 ± 0.027	3.991ThrVal: 3.991 ± 0.024	0.674ThrTrp: 0.674 ± 0.009	1.47ThrTyr: 1.47 ± 0.012	0.005ThrXaa: 0.005 ± 0.001
Val	4.224ValAla: 4.224 ± 0.022	1.477ValCys: 1.477 ± 0.014	2.962ValAsp: 2.962 ± 0.021	3.785ValGlu: 3.785 ± 0.021	2.462ValPhe: 2.462 ± 0.017	3.42ValGly: 3.42 ± 0.02	1.562ValHis: 1.562 ± 0.012	3.025ValIle: 3.025 ± 0.019	3.361ValLys: 3.361 ± 0.021	6.284ValLeu: 6.284 ± 0.029	1.37ValMet: 1.37 ± 0.009	2.307ValAsn: 2.307 ± 0.015	3.662ValPro: 3.662 ± 0.02	2.709ValGln: 2.709 ± 0.017	2.985ValArg: 2.985 ± 0.016	4.907ValSer: 4.907 ± 0.024	3.877ValThr: 3.877 ± 0.027	4.1ValVal: 4.1 ± 0.024	0.719ValTrp: 0.719 ± 0.008	1.664ValTyr: 1.664 ± 0.012	0.005ValXaa: 0.005 ± 0.001
Trp	0.773TrpAla: 0.773 ± 0.008	0.246TrpCys: 0.246 ± 0.004	0.64TrpAsp: 0.64 ± 0.008	0.783TrpGlu: 0.783 ± 0.009	0.455TrpPhe: 0.455 ± 0.006	0.698TrpGly: 0.698 ± 0.009	0.293TrpHis: 0.293 ± 0.005	0.55TrpIle: 0.55 ± 0.007	0.794TrpLys: 0.794 ± 0.008	1.193TrpLeu: 1.193 ± 0.011	0.315TrpMet: 0.315 ± 0.005	0.544TrpAsn: 0.544 ± 0.007	0.498TrpPro: 0.498 ± 0.007	0.508TrpGln: 0.508 ± 0.007	0.698TrpArg: 0.698 ± 0.009	0.846TrpSer: 0.846 ± 0.009	0.673TrpThr: 0.673 ± 0.008	0.686TrpVal: 0.686 ± 0.008	0.191TrpTrp: 0.191 ± 0.004	0.332TrpTyr: 0.332 ± 0.006	0.002TrpXaa: 0.002 ± 0.0
Tyr	1.408TyrAla: 1.408 ± 0.011	0.695TyrCys: 0.695 ± 0.007	1.332TyrAsp: 1.332 ± 0.011	1.72TyrGlu: 1.72 ± 0.015	1.312TyrPhe: 1.312 ± 0.011	1.732TyrGly: 1.732 ± 0.014	0.773TyrHis: 0.773 ± 0.009	1.447TyrIle: 1.447 ± 0.013	1.465TyrLys: 1.465 ± 0.013	2.721TyrLeu: 2.721 ± 0.014	0.636TyrMet: 0.636 ± 0.007	1.138TyrAsn: 1.138 ± 0.009	1.33TyrPro: 1.33 ± 0.014	1.268TyrGln: 1.268 ± 0.01	1.55TyrArg: 1.55 ± 0.011	2.282TyrSer: 2.282 ± 0.015	1.587TyrThr: 1.587 ± 0.014	1.64TyrVal: 1.64 ± 0.014	0.353TyrTrp: 0.353 ± 0.007	0.968TyrTyr: 0.968 ± 0.008	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.007XaaAla: 0.007 ± 0.001	0.003XaaCys: 0.003 ± 0.0	0.004XaaAsp: 0.004 ± 0.001	0.006XaaGlu: 0.006 ± 0.001	0.004XaaPhe: 0.004 ± 0.001	0.008XaaGly: 0.008 ± 0.001	0.003XaaHis: 0.003 ± 0.0	0.003XaaIle: 0.003 ± 0.0	0.007XaaLys: 0.007 ± 0.001	0.009XaaLeu: 0.009 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.004XaaAsn: 0.004 ± 0.001	0.006XaaPro: 0.006 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.006XaaArg: 0.006 ± 0.001	0.008XaaSer: 0.008 ± 0.001	0.005XaaThr: 0.005 ± 0.001	0.005XaaVal: 0.005 ± 0.001	0.002XaaTrp: 0.002 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.015XaaXaa: 0.015 ± 0.002

Statistics based on 24928 proteins (14419874 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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