Amino acid dipepetide frequency for Phytophthora kernoviae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.383AlaAla: 9.383 ± 0.07	1.191AlaCys: 1.191 ± 0.019	4.434AlaAsp: 4.434 ± 0.037	5.455AlaGlu: 5.455 ± 0.048	3.389AlaPhe: 3.389 ± 0.031	5.132AlaGly: 5.132 ± 0.039	1.747AlaHis: 1.747 ± 0.024	3.987AlaIle: 3.987 ± 0.038	4.763AlaLys: 4.763 ± 0.042	8.715AlaLeu: 8.715 ± 0.051	2.407AlaMet: 2.407 ± 0.023	3.181AlaAsn: 3.181 ± 0.03	3.822AlaPro: 3.822 ± 0.03	3.551AlaGln: 3.551 ± 0.032	4.444AlaArg: 4.444 ± 0.035	6.838AlaSer: 6.838 ± 0.048	5.44AlaThr: 5.44 ± 0.043	6.314AlaVal: 6.314 ± 0.046	0.85AlaTrp: 0.85 ± 0.014	2.104AlaTyr: 2.104 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.202CysAla: 1.202 ± 0.017	0.356CysCys: 0.356 ± 0.013	0.822CysAsp: 0.822 ± 0.014	0.869CysGlu: 0.869 ± 0.014	0.662CysPhe: 0.662 ± 0.013	1.176CysGly: 1.176 ± 0.017	0.373CysHis: 0.373 ± 0.011	0.808CysIle: 0.808 ± 0.016	0.678CysLys: 0.678 ± 0.015	1.338CysLeu: 1.338 ± 0.019	0.421CysMet: 0.421 ± 0.009	0.527CysAsn: 0.527 ± 0.011	0.695CysPro: 0.695 ± 0.014	0.515CysGln: 0.515 ± 0.013	0.815CysArg: 0.815 ± 0.014	1.253CysSer: 1.253 ± 0.019	0.893CysThr: 0.893 ± 0.016	1.196CysVal: 1.196 ± 0.017	0.201CysTrp: 0.201 ± 0.007	0.468CysTyr: 0.468 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.347AspAla: 5.347 ± 0.032	0.799AspCys: 0.799 ± 0.015	4.445AspAsp: 4.445 ± 0.044	4.998AspGlu: 4.998 ± 0.045	2.301AspPhe: 2.301 ± 0.023	4.1AspGly: 4.1 ± 0.038	1.121AspHis: 1.121 ± 0.019	2.77AspIle: 2.77 ± 0.024	2.721AspLys: 2.721 ± 0.029	5.013AspLeu: 5.013 ± 0.034	1.483AspMet: 1.483 ± 0.019	2.057AspAsn: 2.057 ± 0.022	2.591AspPro: 2.591 ± 0.027	1.93AspGln: 1.93 ± 0.021	2.648AspArg: 2.648 ± 0.025	3.992AspSer: 3.992 ± 0.035	2.98AspThr: 2.98 ± 0.026	4.524AspVal: 4.524 ± 0.035	0.652AspTrp: 0.652 ± 0.013	1.582AspTyr: 1.582 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.014GluAla: 6.014 ± 0.051	0.879GluCys: 0.879 ± 0.014	4.507GluAsp: 4.507 ± 0.04	6.558GluGlu: 6.558 ± 0.075	2.468GluPhe: 2.468 ± 0.03	3.559GluGly: 3.559 ± 0.028	1.464GluHis: 1.464 ± 0.02	3.144GluIle: 3.144 ± 0.031	4.28GluLys: 4.28 ± 0.041	6.949GluLeu: 6.949 ± 0.059	1.911GluMet: 1.911 ± 0.02	2.625GluAsn: 2.625 ± 0.023	2.163GluPro: 2.163 ± 0.029	3.2GluGln: 3.2 ± 0.035	4.021GluArg: 4.021 ± 0.039	4.185GluSer: 4.185 ± 0.032	3.732GluThr: 3.732 ± 0.033	4.463GluVal: 4.463 ± 0.039	0.751GluTrp: 0.751 ± 0.014	1.801GluTyr: 1.801 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.285PheAla: 3.285 ± 0.032	0.75PheCys: 0.75 ± 0.014	2.414PheAsp: 2.414 ± 0.023	2.414PheGlu: 2.414 ± 0.024	1.796PhePhe: 1.796 ± 0.024	2.962PheGly: 2.962 ± 0.032	1.007PheHis: 1.007 ± 0.016	1.711PheIle: 1.711 ± 0.023	1.62PheLys: 1.62 ± 0.019	3.748PheLeu: 3.748 ± 0.032	1.068PheMet: 1.068 ± 0.016	1.444PheAsn: 1.444 ± 0.02	1.686PhePro: 1.686 ± 0.021	1.608PheGln: 1.608 ± 0.02	2.082PheArg: 2.082 ± 0.023	2.997PheSer: 2.997 ± 0.026	2.192PheThr: 2.192 ± 0.021	3.145PheVal: 3.145 ± 0.028	0.484PheTrp: 0.484 ± 0.012	1.278PheTyr: 1.278 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.189GlyAla: 5.189 ± 0.04	1.03GlyCys: 1.03 ± 0.019	3.966GlyAsp: 3.966 ± 0.035	3.786GlyGlu: 3.786 ± 0.032	2.686GlyPhe: 2.686 ± 0.025	5.362GlyGly: 5.362 ± 0.059	1.463GlyHis: 1.463 ± 0.02	3.114GlyIle: 3.114 ± 0.027	3.472GlyLys: 3.472 ± 0.034	5.233GlyLeu: 5.233 ± 0.036	1.694GlyMet: 1.694 ± 0.022	2.515GlyAsn: 2.515 ± 0.025	2.052GlyPro: 2.052 ± 0.025	2.037GlyGln: 2.037 ± 0.02	3.198GlyArg: 3.198 ± 0.031	5.307GlySer: 5.307 ± 0.048	3.526GlyThr: 3.526 ± 0.037	4.936GlyVal: 4.936 ± 0.04	0.776GlyTrp: 0.776 ± 0.016	1.966GlyTyr: 1.966 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.823HisAla: 1.823 ± 0.019	0.392HisCys: 0.392 ± 0.01	1.268HisAsp: 1.268 ± 0.018	1.509HisGlu: 1.509 ± 0.021	1.031HisPhe: 1.031 ± 0.017	1.577HisGly: 1.577 ± 0.023	0.704HisHis: 0.704 ± 0.015	0.986HisIle: 0.986 ± 0.015	1.044HisLys: 1.044 ± 0.017	2.157HisLeu: 2.157 ± 0.023	0.557HisMet: 0.557 ± 0.01	0.768HisAsn: 0.768 ± 0.013	1.218HisPro: 1.218 ± 0.016	0.966HisGln: 0.966 ± 0.016	1.43HisArg: 1.43 ± 0.019	1.607HisSer: 1.607 ± 0.019	1.136HisThr: 1.136 ± 0.017	1.763HisVal: 1.763 ± 0.022	0.279HisTrp: 0.279 ± 0.008	0.689HisTyr: 0.689 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.996IleAla: 3.996 ± 0.035	0.834IleCys: 0.834 ± 0.013	2.651IleAsp: 2.651 ± 0.024	2.816IleGlu: 2.816 ± 0.031	1.851IlePhe: 1.851 ± 0.025	2.802IleGly: 2.802 ± 0.027	1.001IleHis: 1.001 ± 0.014	2.007IleIle: 2.007 ± 0.022	2.234IleLys: 2.234 ± 0.024	3.871IleLeu: 3.871 ± 0.031	1.147IleMet: 1.147 ± 0.017	1.697IleAsn: 1.697 ± 0.022	2.154IlePro: 2.154 ± 0.025	1.761IleGln: 1.761 ± 0.022	2.454IleArg: 2.454 ± 0.022	3.263IleSer: 3.263 ± 0.03	2.573IleThr: 2.573 ± 0.027	3.492IleVal: 3.492 ± 0.029	0.515IleTrp: 0.515 ± 0.012	1.28IleTyr: 1.28 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.302LysAla: 4.302 ± 0.04	0.718LysCys: 0.718 ± 0.014	2.789LysAsp: 2.789 ± 0.024	3.888LysGlu: 3.888 ± 0.039	1.839LysPhe: 1.839 ± 0.021	2.566LysGly: 2.566 ± 0.029	1.323LysHis: 1.323 ± 0.018	2.348LysIle: 2.348 ± 0.024	4.425LysLys: 4.425 ± 0.053	5.236LysLeu: 5.236 ± 0.038	1.485LysMet: 1.485 ± 0.017	2.097LysAsn: 2.097 ± 0.023	2.211LysPro: 2.211 ± 0.024	2.531LysGln: 2.531 ± 0.03	3.606LysArg: 3.606 ± 0.038	3.449LysSer: 3.449 ± 0.03	3.31LysThr: 3.31 ± 0.034	3.362LysVal: 3.362 ± 0.034	0.683LysTrp: 0.683 ± 0.015	1.618LysTyr: 1.618 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	8.172LeuAla: 8.172 ± 0.055	1.513LeuCys: 1.513 ± 0.021	5.298LeuAsp: 5.298 ± 0.038	6.685LeuGlu: 6.685 ± 0.055	3.66LeuPhe: 3.66 ± 0.036	5.444LeuGly: 5.444 ± 0.039	2.466LeuHis: 2.466 ± 0.025	3.48LeuIle: 3.48 ± 0.031	4.85LeuLys: 4.85 ± 0.034	9.805LeuLeu: 9.805 ± 0.067	2.349LeuMet: 2.349 ± 0.023	3.366LeuAsn: 3.366 ± 0.031	4.416LeuPro: 4.416 ± 0.036	4.723LeuGln: 4.723 ± 0.041	5.94LeuArg: 5.94 ± 0.042	7.099LeuSer: 7.099 ± 0.048	5.083LeuThr: 5.083 ± 0.032	6.724LeuVal: 6.724 ± 0.044	1.015LeuTrp: 1.015 ± 0.017	2.466LeuTyr: 2.466 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.417MetAla: 2.417 ± 0.027	0.376MetCys: 0.376 ± 0.011	1.587MetAsp: 1.587 ± 0.021	1.937MetGlu: 1.937 ± 0.024	0.914MetPhe: 0.914 ± 0.014	1.675MetGly: 1.675 ± 0.023	0.639MetHis: 0.639 ± 0.012	1.076MetIle: 1.076 ± 0.017	1.466MetLys: 1.466 ± 0.017	2.655MetLeu: 2.655 ± 0.024	0.791MetMet: 0.791 ± 0.016	1.025MetAsn: 1.025 ± 0.016	1.138MetPro: 1.138 ± 0.017	1.219MetGln: 1.219 ± 0.018	1.465MetArg: 1.465 ± 0.018	1.875MetSer: 1.875 ± 0.02	1.566MetThr: 1.566 ± 0.021	1.688MetVal: 1.688 ± 0.02	0.309MetTrp: 0.309 ± 0.009	0.728MetTyr: 0.728 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.42AsnAla: 3.42 ± 0.029	0.615AsnCys: 0.615 ± 0.012	2.206AsnAsp: 2.206 ± 0.022	2.444AsnGlu: 2.444 ± 0.024	1.495AsnPhe: 1.495 ± 0.018	2.887AsnGly: 2.887 ± 0.029	0.8AsnHis: 0.8 ± 0.013	1.754AsnIle: 1.754 ± 0.022	1.831AsnLys: 1.831 ± 0.022	3.109AsnLeu: 3.109 ± 0.033	1.01AsnMet: 1.01 ± 0.015	1.503AsnAsn: 1.503 ± 0.016	1.851AsnPro: 1.851 ± 0.02	1.354AsnGln: 1.354 ± 0.018	1.778AsnArg: 1.778 ± 0.019	2.807AsnSer: 2.807 ± 0.028	2.062AsnThr: 2.062 ± 0.024	2.836AsnVal: 2.836 ± 0.024	0.443AsnTrp: 0.443 ± 0.01	1.085AsnTyr: 1.085 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	3.552ProAla: 3.552 ± 0.034	0.49ProCys: 0.49 ± 0.013	2.327ProAsp: 2.327 ± 0.023	3.119ProGlu: 3.119 ± 0.03	1.723ProPhe: 1.723 ± 0.023	2.488ProGly: 2.488 ± 0.024	0.963ProHis: 0.963 ± 0.016	1.844ProIle: 1.844 ± 0.022	2.252ProLys: 2.252 ± 0.024	3.819ProLeu: 3.819 ± 0.035	1.123ProMet: 1.123 ± 0.016	1.656ProAsn: 1.656 ± 0.018	2.61ProPro: 2.61 ± 0.031	1.72ProGln: 1.72 ± 0.022	2.266ProArg: 2.266 ± 0.023	3.896ProSer: 3.896 ± 0.033	3.149ProThr: 3.149 ± 0.038	3.253ProVal: 3.253 ± 0.03	0.482ProTrp: 0.482 ± 0.012	1.087ProTyr: 1.087 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.247GlnAla: 3.247 ± 0.029	0.583GlnCys: 0.583 ± 0.012	2.081GlnAsp: 2.081 ± 0.022	3.026GlnGlu: 3.026 ± 0.033	1.553GlnPhe: 1.553 ± 0.02	1.951GlnGly: 1.951 ± 0.022	1.138GlnHis: 1.138 ± 0.016	1.854GlnIle: 1.854 ± 0.022	2.281GlnLys: 2.281 ± 0.024	4.549GlnLeu: 4.549 ± 0.04	1.156GlnMet: 1.156 ± 0.018	1.404GlnAsn: 1.404 ± 0.021	1.6GlnPro: 1.6 ± 0.021	2.94GlnGln: 2.94 ± 0.042	2.885GlnArg: 2.885 ± 0.029	2.695GlnSer: 2.695 ± 0.028	2.233GlnThr: 2.233 ± 0.023	2.817GlnVal: 2.817 ± 0.028	0.565GlnTrp: 0.565 ± 0.011	1.148GlnTyr: 1.148 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.495ArgAla: 4.495 ± 0.031	0.828ArgCys: 0.828 ± 0.014	2.959ArgAsp: 2.959 ± 0.031	3.926ArgGlu: 3.926 ± 0.035	2.313ArgPhe: 2.313 ± 0.023	3.319ArgGly: 3.319 ± 0.03	1.426ArgHis: 1.426 ± 0.017	2.446ArgIle: 2.446 ± 0.021	3.371ArgLys: 3.371 ± 0.032	5.299ArgLeu: 5.299 ± 0.037	1.457ArgMet: 1.457 ± 0.015	2.041ArgAsn: 2.041 ± 0.022	2.052ArgPro: 2.052 ± 0.023	2.533ArgGln: 2.533 ± 0.026	4.221ArgArg: 4.221 ± 0.036	4.077ArgSer: 4.077 ± 0.033	2.735ArgThr: 2.735 ± 0.027	4.17ArgVal: 4.17 ± 0.032	0.714ArgTrp: 0.714 ± 0.015	1.554ArgTyr: 1.554 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.391SerAla: 6.391 ± 0.041	1.106SerCys: 1.106 ± 0.017	4.366SerAsp: 4.366 ± 0.037	4.36SerGlu: 4.36 ± 0.033	2.998SerPhe: 2.998 ± 0.029	5.394SerGly: 5.394 ± 0.041	1.483SerHis: 1.483 ± 0.021	3.419SerIle: 3.419 ± 0.032	3.811SerLys: 3.811 ± 0.036	6.535SerLeu: 6.535 ± 0.041	1.949SerMet: 1.949 ± 0.023	2.945SerAsn: 2.945 ± 0.029	3.562SerPro: 3.562 ± 0.036	2.518SerGln: 2.518 ± 0.027	3.838SerArg: 3.838 ± 0.032	8.032SerSer: 8.032 ± 0.069	5.149SerThr: 5.149 ± 0.045	5.381SerVal: 5.381 ± 0.039	0.861SerTrp: 0.861 ± 0.015	2.024SerTyr: 2.024 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.176ThrAla: 5.176 ± 0.042	0.888ThrCys: 0.888 ± 0.015	3.003ThrAsp: 3.003 ± 0.03	3.517ThrGlu: 3.517 ± 0.038	2.244ThrPhe: 2.244 ± 0.026	3.799ThrGly: 3.799 ± 0.034	1.194ThrHis: 1.194 ± 0.016	2.73ThrIle: 2.73 ± 0.026	3.082ThrLys: 3.082 ± 0.03	5.501ThrLeu: 5.501 ± 0.037	1.464ThrMet: 1.464 ± 0.018	2.085ThrAsn: 2.085 ± 0.022	3.302ThrPro: 3.302 ± 0.041	2.245ThrGln: 2.245 ± 0.027	2.847ThrArg: 2.847 ± 0.023	4.87ThrSer: 4.87 ± 0.041	4.233ThrThr: 4.233 ± 0.065	4.013ThrVal: 4.013 ± 0.033	0.668ThrTrp: 0.668 ± 0.011	1.516ThrTyr: 1.516 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	6.712ValAla: 6.712 ± 0.043	1.216ValCys: 1.216 ± 0.019	4.5ValAsp: 4.5 ± 0.033	4.936ValGlu: 4.936 ± 0.04	2.972ValPhe: 2.972 ± 0.031	4.41ValGly: 4.41 ± 0.037	1.634ValHis: 1.634 ± 0.018	3.14ValIle: 3.14 ± 0.034	3.652ValLys: 3.652 ± 0.033	7.246ValLeu: 7.246 ± 0.044	1.91ValMet: 1.91 ± 0.024	2.71ValAsn: 2.71 ± 0.024	3.179ValPro: 3.179 ± 0.029	2.853ValGln: 2.853 ± 0.03	3.752ValArg: 3.752 ± 0.029	5.102ValSer: 5.102 ± 0.032	4.148ValThr: 4.148 ± 0.034	6.087ValVal: 6.087 ± 0.048	0.797ValTrp: 0.797 ± 0.013	2.049ValTyr: 2.049 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.761TrpAla: 0.761 ± 0.015	0.184TrpCys: 0.184 ± 0.007	0.71TrpAsp: 0.71 ± 0.013	0.687TrpGlu: 0.687 ± 0.012	0.496TrpPhe: 0.496 ± 0.011	0.73TrpGly: 0.73 ± 0.017	0.276TrpHis: 0.276 ± 0.007	0.577TrpIle: 0.577 ± 0.013	0.745TrpLys: 0.745 ± 0.015	1.141TrpLeu: 1.141 ± 0.018	0.385TrpMet: 0.385 ± 0.009	0.527TrpAsn: 0.527 ± 0.012	0.363TrpPro: 0.363 ± 0.011	0.455TrpGln: 0.455 ± 0.01	0.7TrpArg: 0.7 ± 0.012	0.849TrpSer: 0.849 ± 0.014	0.694TrpThr: 0.694 ± 0.014	0.775TrpVal: 0.775 ± 0.015	0.174TrpTrp: 0.174 ± 0.007	0.383TrpTyr: 0.383 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.263TyrAla: 2.263 ± 0.02	0.519TyrCys: 0.519 ± 0.01	1.723TyrAsp: 1.723 ± 0.018	1.746TyrGlu: 1.746 ± 0.02	1.302TyrPhe: 1.302 ± 0.018	1.972TyrGly: 1.972 ± 0.023	0.685TyrHis: 0.685 ± 0.013	1.202TyrIle: 1.202 ± 0.019	1.21TyrLys: 1.21 ± 0.02	2.635TyrLeu: 2.635 ± 0.026	0.776TyrMet: 0.776 ± 0.014	1.116TyrAsn: 1.116 ± 0.015	1.152TyrPro: 1.152 ± 0.018	1.043TyrGln: 1.043 ± 0.016	1.545TyrArg: 1.545 ± 0.021	1.931TyrSer: 1.931 ± 0.023	1.547TyrThr: 1.547 ± 0.02	2.065TyrVal: 2.065 ± 0.023	0.392TyrTrp: 0.392 ± 0.01	0.963TyrTyr: 0.963 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.009

Statistics based on 9833 proteins (4605710 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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