Amino acid dipepetide frequency for Brevilactibacter flavus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.488AlaAla: 19.488 ± 0.252	0.991AlaCys: 0.991 ± 0.033	8.267AlaAsp: 8.267 ± 0.111	7.659AlaGlu: 7.659 ± 0.134	3.836AlaPhe: 3.836 ± 0.071	11.569AlaGly: 11.569 ± 0.13	2.834AlaHis: 2.834 ± 0.058	5.265AlaIle: 5.265 ± 0.087	2.75AlaLys: 2.75 ± 0.074	14.808AlaLeu: 14.808 ± 0.181	2.974AlaMet: 2.974 ± 0.061	2.396AlaAsn: 2.396 ± 0.053	6.431AlaPro: 6.431 ± 0.116	4.491AlaGln: 4.491 ± 0.074	9.034AlaArg: 9.034 ± 0.128	8.223AlaSer: 8.223 ± 0.111	8.075AlaThr: 8.075 ± 0.115	10.904AlaVal: 10.904 ± 0.148	2.336AlaTrp: 2.336 ± 0.065	2.406AlaTyr: 2.406 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.85CysAla: 0.85 ± 0.032	0.087CysCys: 0.087 ± 0.01	0.351CysAsp: 0.351 ± 0.021	0.283CysGlu: 0.283 ± 0.02	0.2CysPhe: 0.2 ± 0.016	0.789CysGly: 0.789 ± 0.031	0.17CysHis: 0.17 ± 0.013	0.211CysIle: 0.211 ± 0.017	0.07CysLys: 0.07 ± 0.01	0.678CysLeu: 0.678 ± 0.033	0.11CysMet: 0.11 ± 0.011	0.113CysAsn: 0.113 ± 0.011	0.445CysPro: 0.445 ± 0.025	0.162CysGln: 0.162 ± 0.012	0.461CysArg: 0.461 ± 0.023	0.445CysSer: 0.445 ± 0.022	0.406CysThr: 0.406 ± 0.022	0.595CysVal: 0.595 ± 0.027	0.098CysTrp: 0.098 ± 0.011	0.138CysTyr: 0.138 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.529AspAla: 9.529 ± 0.127	0.292AspCys: 0.292 ± 0.019	3.555AspAsp: 3.555 ± 0.08	3.623AspGlu: 3.623 ± 0.078	1.57AspPhe: 1.57 ± 0.04	4.998AspGly: 4.998 ± 0.087	1.304AspHis: 1.304 ± 0.037	2.075AspIle: 2.075 ± 0.054	1.113AspLys: 1.113 ± 0.045	6.661AspLeu: 6.661 ± 0.095	0.9AspMet: 0.9 ± 0.032	0.959AspAsn: 0.959 ± 0.034	4.35AspPro: 4.35 ± 0.075	1.815AspGln: 1.815 ± 0.044	3.952AspArg: 3.952 ± 0.084	2.289AspSer: 2.289 ± 0.057	2.868AspThr: 2.868 ± 0.066	5.213AspVal: 5.213 ± 0.079	0.841AspTrp: 0.841 ± 0.031	1.25AspTyr: 1.25 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.453GluAla: 7.453 ± 0.102	0.283GluCys: 0.283 ± 0.018	2.592GluAsp: 2.592 ± 0.064	2.916GluGlu: 2.916 ± 0.073	1.587GluPhe: 1.587 ± 0.052	4.289GluGly: 4.289 ± 0.07	1.384GluHis: 1.384 ± 0.045	2.282GluIle: 2.282 ± 0.057	1.229GluLys: 1.229 ± 0.049	5.405GluLeu: 5.405 ± 0.089	1.034GluMet: 1.034 ± 0.041	1.053GluAsn: 1.053 ± 0.031	2.995GluPro: 2.995 ± 0.066	2.12GluGln: 2.12 ± 0.051	4.686GluArg: 4.686 ± 0.08	2.471GluSer: 2.471 ± 0.064	2.58GluThr: 2.58 ± 0.062	4.664GluVal: 4.664 ± 0.08	0.705GluTrp: 0.705 ± 0.028	0.966GluTyr: 0.966 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.069PheAla: 4.069 ± 0.063	0.235PheCys: 0.235 ± 0.018	2.186PheAsp: 2.186 ± 0.054	1.444PheGlu: 1.444 ± 0.044	1.056PhePhe: 1.056 ± 0.041	3.18PheGly: 3.18 ± 0.066	0.608PheHis: 0.608 ± 0.028	1.068PheIle: 1.068 ± 0.041	0.508PheLys: 0.508 ± 0.029	2.831PheLeu: 2.831 ± 0.065	0.482PheMet: 0.482 ± 0.025	0.701PheAsn: 0.701 ± 0.027	1.49PhePro: 1.49 ± 0.04	0.689PheGln: 0.689 ± 0.026	1.584PheArg: 1.584 ± 0.041	1.765PheSer: 1.765 ± 0.047	2.217PheThr: 2.217 ± 0.047	2.738PheVal: 2.738 ± 0.056	0.455PheTrp: 0.455 ± 0.026	0.594PheTyr: 0.594 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.345GlyAla: 10.345 ± 0.127	0.689GlyCys: 0.689 ± 0.031	4.697GlyAsp: 4.697 ± 0.081	4.732GlyGlu: 4.732 ± 0.075	3.188GlyPhe: 3.188 ± 0.065	7.351GlyGly: 7.351 ± 0.131	2.043GlyHis: 2.043 ± 0.05	4.136GlyIle: 4.136 ± 0.072	2.114GlyLys: 2.114 ± 0.063	9.518GlyLeu: 9.518 ± 0.112	2.08GlyMet: 2.08 ± 0.057	1.701GlyAsn: 1.701 ± 0.048	3.89GlyPro: 3.89 ± 0.07	2.752GlyGln: 2.752 ± 0.064	6.769GlyArg: 6.769 ± 0.098	5.047GlySer: 5.047 ± 0.085	5.295GlyThr: 5.295 ± 0.09	8.444GlyVal: 8.444 ± 0.112	1.759GlyTrp: 1.759 ± 0.053	2.208GlyTyr: 2.208 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.671HisAla: 2.671 ± 0.056	0.152HisCys: 0.152 ± 0.013	1.464HisAsp: 1.464 ± 0.041	1.146HisGlu: 1.146 ± 0.037	0.478HisPhe: 0.478 ± 0.025	2.103HisGly: 2.103 ± 0.052	0.614HisHis: 0.614 ± 0.027	0.667HisIle: 0.667 ± 0.03	0.335HisLys: 0.335 ± 0.019	2.388HisLeu: 2.388 ± 0.057	0.346HisMet: 0.346 ± 0.02	0.405HisAsn: 0.405 ± 0.023	1.731HisPro: 1.731 ± 0.049	0.665HisGln: 0.665 ± 0.027	1.718HisArg: 1.718 ± 0.049	0.92HisSer: 0.92 ± 0.036	1.184HisThr: 1.184 ± 0.035	1.817HisVal: 1.817 ± 0.052	0.323HisTrp: 0.323 ± 0.019	0.451HisTyr: 0.451 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.23IleAla: 6.23 ± 0.096	0.297IleCys: 0.297 ± 0.019	2.945IleAsp: 2.945 ± 0.06	2.457IleGlu: 2.457 ± 0.058	1.062IlePhe: 1.062 ± 0.044	4.111IleGly: 4.111 ± 0.089	0.709IleHis: 0.709 ± 0.034	1.823IleIle: 1.823 ± 0.053	0.92IleLys: 0.92 ± 0.034	3.552IleLeu: 3.552 ± 0.077	0.739IleMet: 0.739 ± 0.029	1.023IleAsn: 1.023 ± 0.038	2.307IlePro: 2.307 ± 0.049	0.975IleGln: 0.975 ± 0.036	2.23IleArg: 2.23 ± 0.05	2.107IleSer: 2.107 ± 0.052	2.884IleThr: 2.884 ± 0.067	4.013IleVal: 4.013 ± 0.078	0.47IleTrp: 0.47 ± 0.025	0.728IleTyr: 0.728 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.694LysAla: 2.694 ± 0.07	0.079LysCys: 0.079 ± 0.009	1.087LysAsp: 1.087 ± 0.043	1.037LysGlu: 1.037 ± 0.039	0.484LysPhe: 0.484 ± 0.021	1.596LysGly: 1.596 ± 0.056	0.409LysHis: 0.409 ± 0.021	0.892LysIle: 0.892 ± 0.04	0.808LysLys: 0.808 ± 0.038	1.936LysLeu: 1.936 ± 0.062	0.423LysMet: 0.423 ± 0.021	0.585LysAsn: 0.585 ± 0.028	1.132LysPro: 1.132 ± 0.041	0.792LysGln: 0.792 ± 0.036	1.456LysArg: 1.456 ± 0.047	1.051LysSer: 1.051 ± 0.04	1.276LysThr: 1.276 ± 0.046	1.985LysVal: 1.985 ± 0.062	0.2LysTrp: 0.2 ± 0.018	0.435LysTyr: 0.435 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.986LeuAla: 14.986 ± 0.17	0.654LeuCys: 0.654 ± 0.024	6.557LeuAsp: 6.557 ± 0.09	4.685LeuGlu: 4.685 ± 0.088	2.82LeuPhe: 2.82 ± 0.064	9.835LeuGly: 9.835 ± 0.128	2.086LeuHis: 2.086 ± 0.05	4.497LeuIle: 4.497 ± 0.088	1.876LeuLys: 1.876 ± 0.058	10.377LeuLeu: 10.377 ± 0.156	1.937LeuMet: 1.937 ± 0.051	2.062LeuAsn: 2.062 ± 0.048	6.017LeuPro: 6.017 ± 0.083	2.538LeuGln: 2.538 ± 0.051	7.452LeuArg: 7.452 ± 0.1	5.946LeuSer: 5.946 ± 0.089	7.08LeuThr: 7.08 ± 0.107	9.503LeuVal: 9.503 ± 0.135	1.268LeuTrp: 1.268 ± 0.043	1.62LeuTyr: 1.62 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.617MetAla: 2.617 ± 0.057	0.113MetCys: 0.113 ± 0.013	0.927MetAsp: 0.927 ± 0.041	0.825MetGlu: 0.825 ± 0.032	0.571MetPhe: 0.571 ± 0.026	1.622MetGly: 1.622 ± 0.04	0.334MetHis: 0.334 ± 0.021	0.919MetIle: 0.919 ± 0.029	0.474MetLys: 0.474 ± 0.025	2.04MetLeu: 2.04 ± 0.051	0.41MetMet: 0.41 ± 0.019	0.513MetAsn: 0.513 ± 0.023	1.133MetPro: 1.133 ± 0.036	0.567MetGln: 0.567 ± 0.023	1.463MetArg: 1.463 ± 0.044	1.5MetSer: 1.5 ± 0.043	1.629MetThr: 1.629 ± 0.041	1.684MetVal: 1.684 ± 0.043	0.249MetTrp: 0.249 ± 0.017	0.295MetTyr: 0.295 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.667AsnAla: 2.667 ± 0.06	0.123AsnCys: 0.123 ± 0.012	1.136AsnAsp: 1.136 ± 0.038	0.952AsnGlu: 0.952 ± 0.031	0.523AsnPhe: 0.523 ± 0.024	1.769AsnGly: 1.769 ± 0.052	0.451AsnHis: 0.451 ± 0.024	0.812AsnIle: 0.812 ± 0.032	0.479AsnLys: 0.479 ± 0.029	2.013AsnLeu: 2.013 ± 0.049	0.361AsnMet: 0.361 ± 0.019	0.512AsnAsn: 0.512 ± 0.027	1.674AsnPro: 1.674 ± 0.043	0.653AsnGln: 0.653 ± 0.028	1.323AsnArg: 1.323 ± 0.04	0.889AsnSer: 0.889 ± 0.032	1.229AsnThr: 1.229 ± 0.038	1.628AsnVal: 1.628 ± 0.034	0.322AsnTrp: 0.322 ± 0.019	0.497AsnTyr: 0.497 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.15ProAla: 7.15 ± 0.118	0.267ProCys: 0.267 ± 0.017	4.153ProAsp: 4.153 ± 0.072	3.665ProGlu: 3.665 ± 0.078	1.634ProPhe: 1.634 ± 0.05	5.561ProGly: 5.561 ± 0.097	1.394ProHis: 1.394 ± 0.046	2.001ProIle: 2.001 ± 0.05	1.0ProLys: 1.0 ± 0.036	5.385ProLeu: 5.385 ± 0.092	1.016ProMet: 1.016 ± 0.036	1.035ProAsn: 1.035 ± 0.032	2.675ProPro: 2.675 ± 0.073	2.012ProGln: 2.012 ± 0.05	3.699ProArg: 3.699 ± 0.073	3.316ProSer: 3.316 ± 0.076	3.731ProThr: 3.731 ± 0.075	4.734ProVal: 4.734 ± 0.075	1.002ProTrp: 1.002 ± 0.037	1.14ProTyr: 1.14 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.465GlnAla: 4.465 ± 0.072	0.167GlnCys: 0.167 ± 0.014	1.225GlnAsp: 1.225 ± 0.036	1.473GlnGlu: 1.473 ± 0.044	0.875GlnPhe: 0.875 ± 0.03	2.53GlnGly: 2.53 ± 0.053	0.734GlnHis: 0.734 ± 0.03	1.466GlnIle: 1.466 ± 0.044	0.602GlnLys: 0.602 ± 0.024	2.945GlnLeu: 2.945 ± 0.068	0.611GlnMet: 0.611 ± 0.029	0.57GlnAsn: 0.57 ± 0.029	1.725GlnPro: 1.725 ± 0.048	1.278GlnGln: 1.278 ± 0.04	2.931GlnArg: 2.931 ± 0.062	1.326GlnSer: 1.326 ± 0.037	1.527GlnThr: 1.527 ± 0.038	2.904GlnVal: 2.904 ± 0.049	0.52GlnTrp: 0.52 ± 0.025	0.582GlnTyr: 0.582 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.49ArgAla: 8.49 ± 0.115	0.488ArgCys: 0.488 ± 0.027	4.121ArgAsp: 4.121 ± 0.074	4.064ArgGlu: 4.064 ± 0.085	2.335ArgPhe: 2.335 ± 0.053	5.482ArgGly: 5.482 ± 0.093	1.723ArgHis: 1.723 ± 0.043	3.332ArgIle: 3.332 ± 0.058	1.344ArgLys: 1.344 ± 0.046	7.624ArgLeu: 7.624 ± 0.115	1.617ArgMet: 1.617 ± 0.046	1.388ArgAsn: 1.388 ± 0.036	4.161ArgPro: 4.161 ± 0.074	2.243ArgGln: 2.243 ± 0.045	6.737ArgArg: 6.737 ± 0.122	3.774ArgSer: 3.774 ± 0.076	4.145ArgThr: 4.145 ± 0.071	5.981ArgVal: 5.981 ± 0.09	1.327ArgTrp: 1.327 ± 0.039	1.529ArgTyr: 1.529 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	7.006SerAla: 7.006 ± 0.09	0.363SerCys: 0.363 ± 0.021	3.032SerAsp: 3.032 ± 0.064	2.609SerGlu: 2.609 ± 0.062	1.8SerPhe: 1.8 ± 0.045	5.726SerGly: 5.726 ± 0.077	1.057SerHis: 1.057 ± 0.039	2.261SerIle: 2.261 ± 0.055	1.075SerLys: 1.075 ± 0.036	5.732SerLeu: 5.732 ± 0.1	1.252SerMet: 1.252 ± 0.037	1.053SerAsn: 1.053 ± 0.037	3.235SerPro: 3.235 ± 0.073	1.505SerGln: 1.505 ± 0.039	3.759SerArg: 3.759 ± 0.065	3.382SerSer: 3.382 ± 0.075	3.514SerThr: 3.514 ± 0.072	4.723SerVal: 4.723 ± 0.089	0.974SerTrp: 0.974 ± 0.032	1.229SerTyr: 1.229 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	7.439ThrAla: 7.439 ± 0.095	0.46ThrCys: 0.46 ± 0.024	3.457ThrAsp: 3.457 ± 0.066	2.647ThrGlu: 2.647 ± 0.055	1.954ThrPhe: 1.954 ± 0.051	5.582ThrGly: 5.582 ± 0.087	1.349ThrHis: 1.349 ± 0.037	2.659ThrIle: 2.659 ± 0.06	1.234ThrLys: 1.234 ± 0.042	6.759ThrLeu: 6.759 ± 0.096	1.208ThrMet: 1.208 ± 0.035	1.301ThrAsn: 1.301 ± 0.04	4.5ThrPro: 4.5 ± 0.084	1.835ThrGln: 1.835 ± 0.046	3.894ThrArg: 3.894 ± 0.063	3.636ThrSer: 3.636 ± 0.072	4.072ThrThr: 4.072 ± 0.092	5.601ThrVal: 5.601 ± 0.101	1.095ThrTrp: 1.095 ± 0.034	1.264ThrTyr: 1.264 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	12.277ValAla: 12.277 ± 0.148	0.661ValCys: 0.661 ± 0.03	5.417ValAsp: 5.417 ± 0.085	4.786ValGlu: 4.786 ± 0.092	2.66ValPhe: 2.66 ± 0.061	7.519ValGly: 7.519 ± 0.104	1.664ValHis: 1.664 ± 0.048	4.001ValIle: 4.001 ± 0.072	1.779ValLys: 1.779 ± 0.057	8.915ValLeu: 8.915 ± 0.119	1.807ValMet: 1.807 ± 0.054	1.865ValAsn: 1.865 ± 0.057	4.798ValPro: 4.798 ± 0.081	2.214ValGln: 2.214 ± 0.054	5.835ValArg: 5.835 ± 0.077	5.149ValSer: 5.149 ± 0.083	6.191ValThr: 6.191 ± 0.097	9.011ValVal: 9.011 ± 0.114	1.284ValTrp: 1.284 ± 0.042	1.426ValTyr: 1.426 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.803TrpAla: 1.803 ± 0.052	0.119TrpCys: 0.119 ± 0.012	0.762TrpAsp: 0.762 ± 0.03	0.692TrpGlu: 0.692 ± 0.031	0.596TrpPhe: 0.596 ± 0.025	1.245TrpGly: 1.245 ± 0.038	0.335TrpHis: 0.335 ± 0.02	0.642TrpIle: 0.642 ± 0.028	0.306TrpLys: 0.306 ± 0.02	1.986TrpLeu: 1.986 ± 0.055	0.319TrpMet: 0.319 ± 0.02	0.376TrpAsn: 0.376 ± 0.022	0.798TrpPro: 0.798 ± 0.034	0.56TrpGln: 0.56 ± 0.025	1.36TrpArg: 1.36 ± 0.044	1.017TrpSer: 1.017 ± 0.043	0.901TrpThr: 0.901 ± 0.033	1.413TrpVal: 1.413 ± 0.043	0.427TrpTrp: 0.427 ± 0.024	0.294TrpTyr: 0.294 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.507TyrAla: 2.507 ± 0.057	0.143TyrCys: 0.143 ± 0.013	1.227TyrAsp: 1.227 ± 0.041	0.998TyrGlu: 0.998 ± 0.029	0.671TyrPhe: 0.671 ± 0.031	1.901TyrGly: 1.901 ± 0.046	0.378TyrHis: 0.378 ± 0.019	0.573TyrIle: 0.573 ± 0.027	0.339TyrLys: 0.339 ± 0.02	2.243TyrLeu: 2.243 ± 0.054	0.259TyrMet: 0.259 ± 0.019	0.402TyrAsn: 0.402 ± 0.024	1.085TyrPro: 1.085 ± 0.04	0.588TyrGln: 0.588 ± 0.026	1.559TyrArg: 1.559 ± 0.039	1.032TyrSer: 1.032 ± 0.035	1.144TyrThr: 1.144 ± 0.037	1.704TyrVal: 1.704 ± 0.044	0.297TyrTrp: 0.297 ± 0.018	0.452TyrTyr: 0.452 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2639 proteins (881072 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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