Amino acid dipepetide frequency for Hymenobacter sp. Fur1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.737AlaAla: 14.737 ± 0.134
0.813AlaCys: 0.813 ± 0.025
5.988AlaAsp: 5.988 ± 0.063
5.985AlaGlu: 5.985 ± 0.072
3.715AlaPhe: 3.715 ± 0.049
9.118AlaGly: 9.118 ± 0.115
2.184AlaHis: 2.184 ± 0.038
4.113AlaIle: 4.113 ± 0.057
3.82AlaLys: 3.82 ± 0.054
12.01AlaLeu: 12.01 ± 0.115
1.812AlaMet: 1.812 ± 0.034
3.624AlaAsn: 3.624 ± 0.064
6.059AlaPro: 6.059 ± 0.081
5.726AlaGln: 5.726 ± 0.066
5.944AlaArg: 5.944 ± 0.07
5.959AlaSer: 5.959 ± 0.077
7.649AlaThr: 7.649 ± 0.096
7.293AlaVal: 7.293 ± 0.073
1.329AlaTrp: 1.329 ± 0.032
3.436AlaTyr: 3.436 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.631CysAla: 0.631 ± 0.021
0.109CysCys: 0.109 ± 0.008
0.319CysAsp: 0.319 ± 0.014
0.3CysGlu: 0.3 ± 0.014
0.295CysPhe: 0.295 ± 0.012
0.609CysGly: 0.609 ± 0.019
0.201CysHis: 0.201 ± 0.012
0.299CysIle: 0.299 ± 0.013
0.197CysLys: 0.197 ± 0.011
0.821CysLeu: 0.821 ± 0.021
0.107CysMet: 0.107 ± 0.007
0.234CysAsn: 0.234 ± 0.013
0.407CysPro: 0.407 ± 0.019
0.347CysGln: 0.347 ± 0.015
0.422CysArg: 0.422 ± 0.018
0.386CysSer: 0.386 ± 0.016
0.405CysThr: 0.405 ± 0.017
0.458CysVal: 0.458 ± 0.017
0.107CysTrp: 0.107 ± 0.007
0.279CysTyr: 0.279 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.985AspAla: 4.985 ± 0.057
0.335AspCys: 0.335 ± 0.014
2.221AspAsp: 2.221 ± 0.042
2.951AspGlu: 2.951 ± 0.044
2.488AspPhe: 2.488 ± 0.041
3.788AspGly: 3.788 ± 0.061
0.892AspHis: 0.892 ± 0.022
2.343AspIle: 2.343 ± 0.037
2.172AspLys: 2.172 ± 0.045
5.253AspLeu: 5.253 ± 0.073
0.893AspMet: 0.893 ± 0.027
1.941AspAsn: 1.941 ± 0.034
2.404AspPro: 2.404 ± 0.035
1.959AspGln: 1.959 ± 0.031
2.391AspArg: 2.391 ± 0.038
2.48AspSer: 2.48 ± 0.043
2.546AspThr: 2.546 ± 0.038
3.386AspVal: 3.386 ± 0.05
0.766AspTrp: 0.766 ± 0.022
2.231AspTyr: 2.231 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
5.803GluAla: 5.803 ± 0.065
0.267GluCys: 0.267 ± 0.013
1.985GluAsp: 1.985 ± 0.039
2.758GluGlu: 2.758 ± 0.054
1.957GluPhe: 1.957 ± 0.037
3.167GluGly: 3.167 ± 0.047
1.128GluHis: 1.128 ± 0.028
2.345GluIle: 2.345 ± 0.041
2.436GluLys: 2.436 ± 0.044
6.151GluLeu: 6.151 ± 0.068
1.054GluMet: 1.054 ± 0.026
1.824GluAsn: 1.824 ± 0.036
2.268GluPro: 2.268 ± 0.042
2.743GluGln: 2.743 ± 0.039
3.135GluArg: 3.135 ± 0.043
2.111GluSer: 2.111 ± 0.037
2.532GluThr: 2.532 ± 0.036
3.963GluVal: 3.963 ± 0.051
0.625GluTrp: 0.625 ± 0.019
1.633GluTyr: 1.633 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.731PheAla: 3.731 ± 0.045
0.331PheCys: 0.331 ± 0.013
2.429PheAsp: 2.429 ± 0.046
2.058PheGlu: 2.058 ± 0.041
1.8PhePhe: 1.8 ± 0.041
3.288PheGly: 3.288 ± 0.051
0.691PheHis: 0.691 ± 0.023
1.721PheIle: 1.721 ± 0.04
1.474PheLys: 1.474 ± 0.032
3.629PheLeu: 3.629 ± 0.049
0.688PheMet: 0.688 ± 0.02
1.672PheAsn: 1.672 ± 0.03
1.643PhePro: 1.643 ± 0.031
1.486PheGln: 1.486 ± 0.031
2.298PheArg: 2.298 ± 0.034
2.68PheSer: 2.68 ± 0.04
2.776PheThr: 2.776 ± 0.038
2.751PheVal: 2.751 ± 0.046
0.574PheTrp: 0.574 ± 0.019
1.541PheTyr: 1.541 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
7.138GlyAla: 7.138 ± 0.078
0.633GlyCys: 0.633 ± 0.02
3.266GlyAsp: 3.266 ± 0.062
3.534GlyGlu: 3.534 ± 0.05
3.066GlyPhe: 3.066 ± 0.045
6.191GlyGly: 6.191 ± 0.096
1.757GlyHis: 1.757 ± 0.036
3.695GlyIle: 3.695 ± 0.057
3.391GlyLys: 3.391 ± 0.053
8.697GlyLeu: 8.697 ± 0.082
1.439GlyMet: 1.439 ± 0.033
2.708GlyAsn: 2.708 ± 0.053
3.331GlyPro: 3.331 ± 0.049
4.323GlyGln: 4.323 ± 0.05
4.765GlyArg: 4.765 ± 0.054
4.615GlySer: 4.615 ± 0.077
5.41GlyThr: 5.41 ± 0.103
5.184GlyVal: 5.184 ± 0.056
1.188GlyTrp: 1.188 ± 0.026
3.15GlyTyr: 3.15 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.93HisAla: 1.93 ± 0.035
0.196HisCys: 0.196 ± 0.01
1.079HisAsp: 1.079 ± 0.026
1.132HisGlu: 1.132 ± 0.025
1.012HisPhe: 1.012 ± 0.026
1.545HisGly: 1.545 ± 0.031
0.616HisHis: 0.616 ± 0.023
0.895HisIle: 0.895 ± 0.022
0.622HisLys: 0.622 ± 0.018
2.662HisLeu: 2.662 ± 0.041
0.327HisMet: 0.327 ± 0.013
0.691HisAsn: 0.691 ± 0.021
1.34HisPro: 1.34 ± 0.035
0.999HisGln: 0.999 ± 0.025
1.258HisArg: 1.258 ± 0.031
1.02HisSer: 1.02 ± 0.026
1.166HisThr: 1.166 ± 0.028
1.224HisVal: 1.224 ± 0.027
0.334HisTrp: 0.334 ± 0.013
0.955HisTyr: 0.955 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
4.21IleAla: 4.21 ± 0.053
0.364IleCys: 0.364 ± 0.014
2.388IleAsp: 2.388 ± 0.043
2.356IleGlu: 2.356 ± 0.043
1.648IlePhe: 1.648 ± 0.033
3.475IleGly: 3.475 ± 0.052
0.72IleHis: 0.72 ± 0.019
2.101IleIle: 2.101 ± 0.046
1.902IleLys: 1.902 ± 0.041
3.574IleLeu: 3.574 ± 0.049
0.702IleMet: 0.702 ± 0.021
1.777IleAsn: 1.777 ± 0.041
1.972IlePro: 1.972 ± 0.037
1.556IleGln: 1.556 ± 0.032
2.281IleArg: 2.281 ± 0.039
2.677IleSer: 2.677 ± 0.046
2.959IleThr: 2.959 ± 0.05
2.778IleVal: 2.778 ± 0.04
0.468IleTrp: 0.468 ± 0.016
1.375IleTyr: 1.375 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.941LysAla: 3.941 ± 0.058
0.162LysCys: 0.162 ± 0.011
1.873LysAsp: 1.873 ± 0.039
2.116LysGlu: 2.116 ± 0.042
1.382LysPhe: 1.382 ± 0.034
2.783LysGly: 2.783 ± 0.045
0.752LysHis: 0.752 ± 0.022
1.771LysIle: 1.771 ± 0.036
2.068LysLys: 2.068 ± 0.054
4.175LysLeu: 4.175 ± 0.058
0.993LysMet: 0.993 ± 0.028
1.597LysAsn: 1.597 ± 0.036
2.113LysPro: 2.113 ± 0.041
1.776LysGln: 1.776 ± 0.034
1.985LysArg: 1.985 ± 0.036
1.93LysSer: 1.93 ± 0.035
2.361LysThr: 2.361 ± 0.045
2.666LysVal: 2.666 ± 0.046
0.446LysTrp: 0.446 ± 0.017
1.4LysTyr: 1.4 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
13.589LeuAla: 13.589 ± 0.124
0.743LeuCys: 0.743 ± 0.02
5.545LeuAsp: 5.545 ± 0.057
4.679LeuGlu: 4.679 ± 0.057
3.902LeuPhe: 3.902 ± 0.062
9.402LeuGly: 9.402 ± 0.088
2.562LeuHis: 2.562 ± 0.04
3.797LeuIle: 3.797 ± 0.063
3.929LeuLys: 3.929 ± 0.06
14.019LeuLeu: 14.019 ± 0.158
1.729LeuMet: 1.729 ± 0.037
3.922LeuAsn: 3.922 ± 0.061
6.914LeuPro: 6.914 ± 0.078
4.18LeuGln: 4.18 ± 0.05
7.868LeuArg: 7.868 ± 0.072
6.359LeuSer: 6.359 ± 0.061
7.385LeuThr: 7.385 ± 0.073
7.902LeuVal: 7.902 ± 0.081
1.181LeuTrp: 1.181 ± 0.031
3.221LeuTyr: 3.221 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.816MetAla: 1.816 ± 0.042
0.095MetCys: 0.095 ± 0.008
0.684MetAsp: 0.684 ± 0.021
0.76MetGlu: 0.76 ± 0.024
0.519MetPhe: 0.519 ± 0.019
1.209MetGly: 1.209 ± 0.033
0.404MetHis: 0.404 ± 0.013
0.566MetIle: 0.566 ± 0.019
0.951MetLys: 0.951 ± 0.023
2.027MetLeu: 2.027 ± 0.04
0.372MetMet: 0.372 ± 0.016
0.673MetAsn: 0.673 ± 0.023
1.163MetPro: 1.163 ± 0.029
0.947MetGln: 0.947 ± 0.026
1.152MetArg: 1.152 ± 0.026
1.12MetSer: 1.12 ± 0.024
1.005MetThr: 1.005 ± 0.024
1.032MetVal: 1.032 ± 0.026
0.148MetTrp: 0.148 ± 0.01
0.429MetTyr: 0.429 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.338AsnAla: 3.338 ± 0.055
0.271AsnCys: 0.271 ± 0.015
1.731AsnAsp: 1.731 ± 0.035
1.684AsnGlu: 1.684 ± 0.031
1.632AsnPhe: 1.632 ± 0.033
3.006AsnGly: 3.006 ± 0.054
0.673AsnHis: 0.673 ± 0.019
1.728AsnIle: 1.728 ± 0.038
1.39AsnLys: 1.39 ± 0.031
3.775AsnLeu: 3.775 ± 0.056
0.634AsnMet: 0.634 ± 0.02
1.6AsnAsn: 1.6 ± 0.047
2.352AsnPro: 2.352 ± 0.041
1.751AsnGln: 1.751 ± 0.036
1.995AsnArg: 1.995 ± 0.039
2.043AsnSer: 2.043 ± 0.042
2.319AsnThr: 2.319 ± 0.049
2.44AsnVal: 2.44 ± 0.047
0.567AsnTrp: 0.567 ± 0.02
1.553AsnTyr: 1.553 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
8.006ProAla: 8.006 ± 0.103
0.274ProCys: 0.274 ± 0.013
3.187ProAsp: 3.187 ± 0.048
3.187ProGlu: 3.187 ± 0.042
1.792ProPhe: 1.792 ± 0.038
4.387ProGly: 4.387 ± 0.054
1.027ProHis: 1.027 ± 0.026
1.982ProIle: 1.982 ± 0.037
1.748ProLys: 1.748 ± 0.041
5.513ProLeu: 5.513 ± 0.064
0.801ProMet: 0.801 ± 0.02
1.916ProAsn: 1.916 ± 0.036
2.386ProPro: 2.386 ± 0.045
2.086ProGln: 2.086 ± 0.036
2.636ProArg: 2.636 ± 0.045
2.818ProSer: 2.818 ± 0.05
4.087ProThr: 4.087 ± 0.059
4.218ProVal: 4.218 ± 0.044
0.632ProTrp: 0.632 ± 0.021
1.718ProTyr: 1.718 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
5.925GlnAla: 5.925 ± 0.077
0.227GlnCys: 0.227 ± 0.011
1.847GlnAsp: 1.847 ± 0.033
2.292GlnGlu: 2.292 ± 0.038
1.677GlnPhe: 1.677 ± 0.036
3.078GlnGly: 3.078 ± 0.041
1.286GlnHis: 1.286 ± 0.031
1.54GlnIle: 1.54 ± 0.033
1.665GlnLys: 1.665 ± 0.035
6.078GlnLeu: 6.078 ± 0.066
0.819GlnMet: 0.819 ± 0.023
1.521GlnAsn: 1.521 ± 0.035
3.242GlnPro: 3.242 ± 0.044
3.332GlnGln: 3.332 ± 0.06
3.335GlnArg: 3.335 ± 0.048
1.982GlnSer: 1.982 ± 0.036
2.431GlnThr: 2.431 ± 0.04
3.634GlnVal: 3.634 ± 0.046
0.585GlnTrp: 0.585 ± 0.018
1.607GlnTyr: 1.607 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.595ArgAla: 5.595 ± 0.062
0.349ArgCys: 0.349 ± 0.016
2.663ArgAsp: 2.663 ± 0.041
3.163ArgGlu: 3.163 ± 0.049
2.485ArgPhe: 2.485 ± 0.041
3.628ArgGly: 3.628 ± 0.049
1.443ArgHis: 1.443 ± 0.031
2.618ArgIle: 2.618 ± 0.038
1.94ArgLys: 1.94 ± 0.037
7.389ArgLeu: 7.389 ± 0.085
1.046ArgMet: 1.046 ± 0.025
2.031ArgAsn: 2.031 ± 0.04
3.465ArgPro: 3.465 ± 0.054
3.652ArgGln: 3.652 ± 0.056
4.33ArgArg: 4.33 ± 0.062
2.682ArgSer: 2.682 ± 0.038
3.51ArgThr: 3.51 ± 0.048
4.07ArgVal: 4.07 ± 0.049
0.921ArgTrp: 0.921 ± 0.025
2.532ArgTyr: 2.532 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.735SerAla: 5.735 ± 0.069
0.454SerCys: 0.454 ± 0.015
2.357SerAsp: 2.357 ± 0.035
2.324SerGlu: 2.324 ± 0.041
2.593SerPhe: 2.593 ± 0.04
4.572SerGly: 4.572 ± 0.072
1.061SerHis: 1.061 ± 0.026
2.497SerIle: 2.497 ± 0.041
1.973SerLys: 1.973 ± 0.036
6.137SerLeu: 6.137 ± 0.072
0.962SerMet: 0.962 ± 0.026
1.953SerAsn: 1.953 ± 0.048
3.035SerPro: 3.035 ± 0.041
2.371SerGln: 2.371 ± 0.037
2.918SerArg: 2.918 ± 0.038
3.394SerSer: 3.394 ± 0.064
3.658SerThr: 3.658 ± 0.065
3.719SerVal: 3.719 ± 0.055
0.759SerTrp: 0.759 ± 0.02
2.236SerTyr: 2.236 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
7.023ThrAla: 7.023 ± 0.096
0.372ThrCys: 0.372 ± 0.015
3.272ThrAsp: 3.272 ± 0.052
2.858ThrGlu: 2.858 ± 0.043
2.492ThrPhe: 2.492 ± 0.038
5.4ThrGly: 5.4 ± 0.083
1.166ThrHis: 1.166 ± 0.025
2.865ThrIle: 2.865 ± 0.049
2.3ThrLys: 2.3 ± 0.037
6.962ThrLeu: 6.962 ± 0.078
0.905ThrMet: 0.905 ± 0.023
2.324ThrAsn: 2.324 ± 0.05
3.992ThrPro: 3.992 ± 0.055
2.615ThrGln: 2.615 ± 0.037
3.005ThrArg: 3.005 ± 0.049
3.743ThrSer: 3.743 ± 0.063
4.59ThrThr: 4.59 ± 0.101
4.615ThrVal: 4.615 ± 0.07
0.837ThrTrp: 0.837 ± 0.024
2.44ThrTyr: 2.44 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
8.53ValAla: 8.53 ± 0.082
0.501ValCys: 0.501 ± 0.018
3.077ValAsp: 3.077 ± 0.04
3.4ValGlu: 3.4 ± 0.051
2.612ValPhe: 2.612 ± 0.038
5.226ValGly: 5.226 ± 0.058
1.235ValHis: 1.235 ± 0.028
2.829ValIle: 2.829 ± 0.043
2.569ValLys: 2.569 ± 0.052
8.093ValLeu: 8.093 ± 0.078
1.082ValMet: 1.082 ± 0.028
2.493ValAsn: 2.493 ± 0.042
3.984ValPro: 3.984 ± 0.053
3.242ValGln: 3.242 ± 0.046
4.542ValArg: 4.542 ± 0.054
4.048ValSer: 4.048 ± 0.052
4.05ValThr: 4.05 ± 0.067
5.778ValVal: 5.778 ± 0.077
0.78ValTrp: 0.78 ± 0.023
2.218ValTyr: 2.218 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.232TrpAla: 1.232 ± 0.028
0.109TrpCys: 0.109 ± 0.008
0.569TrpAsp: 0.569 ± 0.018
0.617TrpGlu: 0.617 ± 0.02
0.492TrpPhe: 0.492 ± 0.017
0.864TrpGly: 0.864 ± 0.028
0.377TrpHis: 0.377 ± 0.016
0.364TrpIle: 0.364 ± 0.016
0.457TrpLys: 0.457 ± 0.018
1.846TrpLeu: 1.846 ± 0.045
0.241TrpMet: 0.241 ± 0.013
0.459TrpAsn: 0.459 ± 0.016
0.606TrpPro: 0.606 ± 0.021
1.016TrpGln: 1.016 ± 0.026
0.878TrpArg: 0.878 ± 0.024
0.634TrpSer: 0.634 ± 0.018
0.702TrpThr: 0.702 ± 0.022
0.893TrpVal: 0.893 ± 0.024
0.229TrpTrp: 0.229 ± 0.013
0.418TrpTyr: 0.418 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.42TyrAla: 3.42 ± 0.048
0.329TyrCys: 0.329 ± 0.015
1.945TyrAsp: 1.945 ± 0.039
1.731TyrGlu: 1.731 ± 0.034
1.703TyrPhe: 1.703 ± 0.032
2.743TyrGly: 2.743 ± 0.05
0.826TyrHis: 0.826 ± 0.022
1.213TyrIle: 1.213 ± 0.026
1.29TyrLys: 1.29 ± 0.031
4.019TyrLeu: 4.019 ± 0.057
0.467TyrMet: 0.467 ± 0.017
1.52TyrAsn: 1.52 ± 0.033
1.723TyrPro: 1.723 ± 0.033
1.996TyrGln: 1.996 ± 0.04
2.375TyrArg: 2.375 ± 0.042
2.026TyrSer: 2.026 ± 0.04
2.235TyrThr: 2.235 ± 0.047
2.284TyrVal: 2.284 ± 0.041
0.528TyrTrp: 0.528 ± 0.017
1.58TyrTyr: 1.58 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4945 proteins (1754580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski