Amino acid dipepetide frequency for Sideroxydans lithotrophicus (strain ES-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.653AlaAla: 12.653 ± 0.173	1.141AlaCys: 1.141 ± 0.04	5.545AlaAsp: 5.545 ± 0.093	6.689AlaGlu: 6.689 ± 0.112	3.416AlaPhe: 3.416 ± 0.075	8.19AlaGly: 8.19 ± 0.126	2.369AlaHis: 2.369 ± 0.051	5.621AlaIle: 5.621 ± 0.076	4.792AlaLys: 4.792 ± 0.115	11.454AlaLeu: 11.454 ± 0.134	3.175AlaMet: 3.175 ± 0.066	3.362AlaAsn: 3.362 ± 0.061	3.877AlaPro: 3.877 ± 0.072	4.776AlaGln: 4.776 ± 0.071	6.035AlaArg: 6.035 ± 0.112	5.565AlaSer: 5.565 ± 0.087	5.336AlaThr: 5.336 ± 0.09	7.216AlaVal: 7.216 ± 0.105	1.298AlaTrp: 1.298 ± 0.042	2.523AlaTyr: 2.523 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.948CysAla: 0.948 ± 0.034	0.142CysCys: 0.142 ± 0.013	0.593CysAsp: 0.593 ± 0.025	0.534CysGlu: 0.534 ± 0.029	0.348CysPhe: 0.348 ± 0.02	1.018CysGly: 1.018 ± 0.038	0.45CysHis: 0.45 ± 0.052	0.519CysIle: 0.519 ± 0.027	0.389CysLys: 0.389 ± 0.025	0.812CysLeu: 0.812 ± 0.033	0.216CysMet: 0.216 ± 0.017	0.387CysAsn: 0.387 ± 0.022	0.544CysPro: 0.544 ± 0.028	0.285CysGln: 0.285 ± 0.017	0.6CysArg: 0.6 ± 0.026	0.599CysSer: 0.599 ± 0.03	0.566CysThr: 0.566 ± 0.031	0.729CysVal: 0.729 ± 0.027	0.123CysTrp: 0.123 ± 0.013	0.296CysTyr: 0.296 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.031AspAla: 6.031 ± 0.087	0.541AspCys: 0.541 ± 0.026	2.828AspAsp: 2.828 ± 0.066	3.605AspGlu: 3.605 ± 0.063	2.242AspPhe: 2.242 ± 0.051	4.069AspGly: 4.069 ± 0.093	1.126AspHis: 1.126 ± 0.042	3.333AspIle: 3.333 ± 0.066	2.707AspLys: 2.707 ± 0.064	5.028AspLeu: 5.028 ± 0.069	1.571AspMet: 1.571 ± 0.039	1.675AspAsn: 1.675 ± 0.045	2.386AspPro: 2.386 ± 0.055	1.643AspGln: 1.643 ± 0.046	2.684AspArg: 2.684 ± 0.058	2.689AspSer: 2.689 ± 0.055	2.641AspThr: 2.641 ± 0.072	3.906AspVal: 3.906 ± 0.068	0.848AspTrp: 0.848 ± 0.031	1.644AspTyr: 1.644 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.217GluAla: 6.217 ± 0.127	0.506GluCys: 0.506 ± 0.026	2.511GluAsp: 2.511 ± 0.058	3.383GluGlu: 3.383 ± 0.098	2.287GluPhe: 2.287 ± 0.051	3.614GluGly: 3.614 ± 0.073	1.566GluHis: 1.566 ± 0.052	3.658GluIle: 3.658 ± 0.07	3.215GluLys: 3.215 ± 0.069	6.523GluLeu: 6.523 ± 0.1	1.85GluMet: 1.85 ± 0.045	1.922GluAsn: 1.922 ± 0.045	1.983GluPro: 1.983 ± 0.055	3.197GluGln: 3.197 ± 0.081	3.991GluArg: 3.991 ± 0.079	3.04GluSer: 3.04 ± 0.058	2.892GluThr: 2.892 ± 0.065	4.29GluVal: 4.29 ± 0.082	0.771GluTrp: 0.771 ± 0.032	1.554GluTyr: 1.554 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.042PheAla: 4.042 ± 0.076	0.409PheCys: 0.409 ± 0.021	2.477PheAsp: 2.477 ± 0.056	2.145PheGlu: 2.145 ± 0.049	1.597PhePhe: 1.597 ± 0.049	3.352PheGly: 3.352 ± 0.052	0.829PheHis: 0.829 ± 0.031	2.129PheIle: 2.129 ± 0.056	1.542PheLys: 1.542 ± 0.045	3.32PheLeu: 3.32 ± 0.065	0.999PheMet: 0.999 ± 0.033	1.458PheAsn: 1.458 ± 0.043	1.571PhePro: 1.571 ± 0.04	1.165PheGln: 1.165 ± 0.033	1.943PheArg: 1.943 ± 0.051	2.535PheSer: 2.535 ± 0.059	1.956PheThr: 1.956 ± 0.044	2.781PheVal: 2.781 ± 0.056	0.504PheTrp: 0.504 ± 0.025	1.137PheTyr: 1.137 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.722GlyAla: 6.722 ± 0.102	0.913GlyCys: 0.913 ± 0.041	3.853GlyAsp: 3.853 ± 0.082	4.454GlyGlu: 4.454 ± 0.072	3.032GlyPhe: 3.032 ± 0.055	5.805GlyGly: 5.805 ± 0.121	1.846GlyHis: 1.846 ± 0.044	4.698GlyIle: 4.698 ± 0.079	4.753GlyLys: 4.753 ± 0.077	7.518GlyLeu: 7.518 ± 0.103	2.659GlyMet: 2.659 ± 0.057	2.765GlyAsn: 2.765 ± 0.091	1.668GlyPro: 1.668 ± 0.042	2.708GlyGln: 2.708 ± 0.057	4.153GlyArg: 4.153 ± 0.059	4.484GlySer: 4.484 ± 0.089	4.139GlyThr: 4.139 ± 0.098	5.805GlyVal: 5.805 ± 0.082	1.083GlyTrp: 1.083 ± 0.038	2.595GlyTyr: 2.595 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.511HisAla: 2.511 ± 0.059	0.297HisCys: 0.297 ± 0.02	1.421HisAsp: 1.421 ± 0.042	1.401HisGlu: 1.401 ± 0.042	1.069HisPhe: 1.069 ± 0.031	2.014HisGly: 2.014 ± 0.05	0.782HisHis: 0.782 ± 0.029	1.418HisIle: 1.418 ± 0.04	0.894HisLys: 0.894 ± 0.038	2.565HisLeu: 2.565 ± 0.056	0.553HisMet: 0.553 ± 0.028	0.762HisAsn: 0.762 ± 0.028	1.458HisPro: 1.458 ± 0.043	0.924HisGln: 0.924 ± 0.029	1.386HisArg: 1.386 ± 0.043	1.304HisSer: 1.304 ± 0.042	1.098HisThr: 1.098 ± 0.036	1.499HisVal: 1.499 ± 0.04	0.389HisTrp: 0.389 ± 0.022	0.809HisTyr: 0.809 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.545IleAla: 6.545 ± 0.082	0.537IleCys: 0.537 ± 0.025	3.171IleAsp: 3.171 ± 0.054	3.682IleGlu: 3.682 ± 0.072	1.853IlePhe: 1.853 ± 0.045	4.663IleGly: 4.663 ± 0.074	1.206IleHis: 1.206 ± 0.039	2.623IleIle: 2.623 ± 0.056	2.477IleLys: 2.477 ± 0.053	4.895IleLeu: 4.895 ± 0.076	1.143IleMet: 1.143 ± 0.037	2.0IleAsn: 2.0 ± 0.047	2.635IlePro: 2.635 ± 0.059	1.738IleGln: 1.738 ± 0.045	3.11IleArg: 3.11 ± 0.066	3.53IleSer: 3.53 ± 0.076	3.181IleThr: 3.181 ± 0.06	4.024IleVal: 4.024 ± 0.075	0.558IleTrp: 0.558 ± 0.022	1.413IleTyr: 1.413 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.382LysAla: 4.382 ± 0.094	0.324LysCys: 0.324 ± 0.027	2.347LysAsp: 2.347 ± 0.056	2.561LysGlu: 2.561 ± 0.057	1.445LysPhe: 1.445 ± 0.039	2.955LysGly: 2.955 ± 0.062	1.213LysHis: 1.213 ± 0.038	2.535LysIle: 2.535 ± 0.052	2.409LysLys: 2.409 ± 0.083	5.259LysLeu: 5.259 ± 0.09	1.411LysMet: 1.411 ± 0.043	1.714LysAsn: 1.714 ± 0.042	2.394LysPro: 2.394 ± 0.058	2.248LysGln: 2.248 ± 0.054	2.813LysArg: 2.813 ± 0.062	2.547LysSer: 2.547 ± 0.059	2.486LysThr: 2.486 ± 0.064	3.378LysVal: 3.378 ± 0.075	0.53LysTrp: 0.53 ± 0.024	1.136LysTyr: 1.136 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.697LeuAla: 11.697 ± 0.132	1.051LeuCys: 1.051 ± 0.032	5.828LeuAsp: 5.828 ± 0.083	5.761LeuGlu: 5.761 ± 0.106	4.053LeuPhe: 4.053 ± 0.082	7.713LeuGly: 7.713 ± 0.101	2.637LeuHis: 2.637 ± 0.059	5.178LeuIle: 5.178 ± 0.093	4.912LeuLys: 4.912 ± 0.085	12.035LeuLeu: 12.035 ± 0.171	2.675LeuMet: 2.675 ± 0.062	3.655LeuAsn: 3.655 ± 0.067	5.421LeuPro: 5.421 ± 0.078	4.401LeuGln: 4.401 ± 0.076	6.544LeuArg: 6.544 ± 0.097	6.64LeuSer: 6.64 ± 0.096	5.33LeuThr: 5.33 ± 0.089	6.987LeuVal: 6.987 ± 0.112	1.23LeuTrp: 1.23 ± 0.039	2.491LeuTyr: 2.491 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.761MetAla: 2.761 ± 0.055	0.201MetCys: 0.201 ± 0.015	1.354MetAsp: 1.354 ± 0.039	1.461MetGlu: 1.461 ± 0.039	0.927MetPhe: 0.927 ± 0.029	1.934MetGly: 1.934 ± 0.049	0.681MetHis: 0.681 ± 0.023	1.246MetIle: 1.246 ± 0.043	1.412MetLys: 1.412 ± 0.039	3.239MetLeu: 3.239 ± 0.071	0.74MetMet: 0.74 ± 0.03	1.13MetAsn: 1.13 ± 0.037	1.414MetPro: 1.414 ± 0.038	1.416MetGln: 1.416 ± 0.039	1.888MetArg: 1.888 ± 0.043	1.813MetSer: 1.813 ± 0.048	1.497MetThr: 1.497 ± 0.038	1.904MetVal: 1.904 ± 0.048	0.242MetTrp: 0.242 ± 0.014	0.518MetTyr: 0.518 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.52AsnAla: 3.52 ± 0.071	0.377AsnCys: 0.377 ± 0.02	1.956AsnAsp: 1.956 ± 0.075	1.945AsnGlu: 1.945 ± 0.048	1.305AsnPhe: 1.305 ± 0.037	2.862AsnGly: 2.862 ± 0.067	0.743AsnHis: 0.743 ± 0.028	2.023AsnIle: 2.023 ± 0.052	1.548AsnLys: 1.548 ± 0.044	3.595AsnLeu: 3.595 ± 0.066	0.854AsnMet: 0.854 ± 0.03	1.196AsnAsn: 1.196 ± 0.045	2.049AsnPro: 2.049 ± 0.051	1.246AsnGln: 1.246 ± 0.036	1.929AsnArg: 1.929 ± 0.048	1.95AsnSer: 1.95 ± 0.046	1.748AsnThr: 1.748 ± 0.053	2.374AsnVal: 2.374 ± 0.056	0.47AsnTrp: 0.47 ± 0.022	0.998AsnTyr: 0.998 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.789ProAla: 4.789 ± 0.087	0.401ProCys: 0.401 ± 0.022	2.715ProAsp: 2.715 ± 0.059	3.146ProGlu: 3.146 ± 0.058	1.681ProPhe: 1.681 ± 0.045	3.225ProGly: 3.225 ± 0.064	1.125ProHis: 1.125 ± 0.033	2.166ProIle: 2.166 ± 0.062	1.809ProLys: 1.809 ± 0.053	4.613ProLeu: 4.613 ± 0.073	1.087ProMet: 1.087 ± 0.037	1.523ProAsn: 1.523 ± 0.045	1.924ProPro: 1.924 ± 0.054	1.991ProGln: 1.991 ± 0.051	2.069ProArg: 2.069 ± 0.048	2.388ProSer: 2.388 ± 0.053	2.117ProThr: 2.117 ± 0.058	3.508ProVal: 3.508 ± 0.069	0.548ProTrp: 0.548 ± 0.023	1.26ProTyr: 1.26 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.562GlnAla: 4.562 ± 0.084	0.359GlnCys: 0.359 ± 0.02	1.968GlnAsp: 1.968 ± 0.055	2.211GlnGlu: 2.211 ± 0.061	1.377GlnPhe: 1.377 ± 0.037	2.922GlnGly: 2.922 ± 0.064	1.216GlnHis: 1.216 ± 0.043	2.15GlnIle: 2.15 ± 0.051	1.651GlnLys: 1.651 ± 0.045	4.376GlnLeu: 4.376 ± 0.074	1.199GlnMet: 1.199 ± 0.035	1.258GlnAsn: 1.258 ± 0.039	1.989GlnPro: 1.989 ± 0.051	2.53GlnGln: 2.53 ± 0.063	2.952GlnArg: 2.952 ± 0.068	2.236GlnSer: 2.236 ± 0.054	2.154GlnThr: 2.154 ± 0.055	2.948GlnVal: 2.948 ± 0.067	0.513GlnTrp: 0.513 ± 0.025	1.025GlnTyr: 1.025 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.164ArgAla: 5.164 ± 0.084	0.499ArgCys: 0.499 ± 0.025	3.297ArgAsp: 3.297 ± 0.064	3.999ArgGlu: 3.999 ± 0.071	2.583ArgPhe: 2.583 ± 0.056	3.563ArgGly: 3.563 ± 0.073	1.65ArgHis: 1.65 ± 0.047	3.957ArgIle: 3.957 ± 0.063	2.757ArgLys: 2.757 ± 0.059	6.234ArgLeu: 6.234 ± 0.097	1.754ArgMet: 1.754 ± 0.044	2.316ArgAsn: 2.316 ± 0.043	2.186ArgPro: 2.186 ± 0.05	2.492ArgGln: 2.492 ± 0.057	3.474ArgArg: 3.474 ± 0.066	3.073ArgSer: 3.073 ± 0.06	2.671ArgThr: 2.671 ± 0.059	3.932ArgVal: 3.932 ± 0.067	0.747ArgTrp: 0.747 ± 0.031	2.01ArgTyr: 2.01 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	5.881SerAla: 5.881 ± 0.084	0.65SerCys: 0.65 ± 0.035	2.947SerAsp: 2.947 ± 0.061	3.224SerGlu: 3.224 ± 0.059	2.288SerPhe: 2.288 ± 0.052	5.494SerGly: 5.494 ± 0.096	1.351SerHis: 1.351 ± 0.038	3.259SerIle: 3.259 ± 0.056	2.418SerLys: 2.418 ± 0.054	5.995SerLeu: 5.995 ± 0.095	1.574SerMet: 1.574 ± 0.043	2.102SerAsn: 2.102 ± 0.057	2.508SerPro: 2.508 ± 0.051	2.038SerGln: 2.038 ± 0.053	3.132SerArg: 3.132 ± 0.071	3.658SerSer: 3.658 ± 0.07	2.936SerThr: 2.936 ± 0.067	3.984SerVal: 3.984 ± 0.068	0.716SerTrp: 0.716 ± 0.028	1.651SerTyr: 1.651 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.181ThrAla: 5.181 ± 0.088	0.512ThrCys: 0.512 ± 0.03	2.518ThrAsp: 2.518 ± 0.06	2.68ThrGlu: 2.68 ± 0.066	1.941ThrPhe: 1.941 ± 0.059	4.447ThrGly: 4.447 ± 0.101	1.236ThrHis: 1.236 ± 0.037	2.696ThrIle: 2.696 ± 0.057	1.685ThrLys: 1.685 ± 0.048	6.18ThrLeu: 6.18 ± 0.09	1.249ThrMet: 1.249 ± 0.039	1.581ThrAsn: 1.581 ± 0.043	3.019ThrPro: 3.019 ± 0.061	2.106ThrGln: 2.106 ± 0.056	2.851ThrArg: 2.851 ± 0.058	2.955ThrSer: 2.955 ± 0.067	2.803ThrThr: 2.803 ± 0.086	3.976ThrVal: 3.976 ± 0.076	0.567ThrTrp: 0.567 ± 0.025	1.334ThrTyr: 1.334 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	7.841ValAla: 7.841 ± 0.096	0.749ValCys: 0.749 ± 0.03	3.762ValAsp: 3.762 ± 0.069	4.209ValGlu: 4.209 ± 0.072	2.719ValPhe: 2.719 ± 0.063	4.883ValGly: 4.883 ± 0.088	1.479ValHis: 1.479 ± 0.04	3.935ValIle: 3.935 ± 0.073	3.075ValLys: 3.075 ± 0.071	7.816ValLeu: 7.816 ± 0.1	2.064ValMet: 2.064 ± 0.047	2.509ValAsn: 2.509 ± 0.06	3.221ValPro: 3.221 ± 0.064	2.683ValGln: 2.683 ± 0.048	4.076ValArg: 4.076 ± 0.069	4.507ValSer: 4.507 ± 0.067	4.003ValThr: 4.003 ± 0.079	5.678ValVal: 5.678 ± 0.088	0.834ValTrp: 0.834 ± 0.033	1.654ValTyr: 1.654 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.902TrpAla: 0.902 ± 0.028	0.165TrpCys: 0.165 ± 0.014	0.629TrpAsp: 0.629 ± 0.024	0.608TrpGlu: 0.608 ± 0.026	0.543TrpPhe: 0.543 ± 0.025	0.806TrpGly: 0.806 ± 0.029	0.391TrpHis: 0.391 ± 0.021	0.627TrpIle: 0.627 ± 0.027	0.598TrpLys: 0.598 ± 0.029	1.805TrpLeu: 1.805 ± 0.056	0.436TrpMet: 0.436 ± 0.023	0.443TrpAsn: 0.443 ± 0.025	0.456TrpPro: 0.456 ± 0.025	0.783TrpGln: 0.783 ± 0.032	0.81TrpArg: 0.81 ± 0.031	0.655TrpSer: 0.655 ± 0.025	0.5TrpThr: 0.5 ± 0.024	0.939TrpVal: 0.939 ± 0.036	0.233TrpTrp: 0.233 ± 0.017	0.308TrpTyr: 0.308 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.683TyrAla: 2.683 ± 0.053	0.323TyrCys: 0.323 ± 0.018	1.477TyrAsp: 1.477 ± 0.043	1.273TyrGlu: 1.273 ± 0.034	1.185TyrPhe: 1.185 ± 0.038	2.122TyrGly: 2.122 ± 0.054	0.657TyrHis: 0.657 ± 0.026	1.215TyrIle: 1.215 ± 0.041	1.045TyrLys: 1.045 ± 0.035	2.978TyrLeu: 2.978 ± 0.059	0.569TyrMet: 0.569 ± 0.027	0.93TyrAsn: 0.93 ± 0.036	1.381TyrPro: 1.381 ± 0.043	1.225TyrGln: 1.225 ± 0.04	1.918TyrArg: 1.918 ± 0.044	1.638TyrSer: 1.638 ± 0.047	1.462TyrThr: 1.462 ± 0.041	1.84TyrVal: 1.84 ± 0.044	0.433TyrTrp: 0.433 ± 0.025	0.784TyrTyr: 0.784 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2977 proteins (913564 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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