Amino acid dipepetide frequency for Zamilon virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.015AlaAla: 1.015 ± 0.352
0.609AlaCys: 0.609 ± 0.373
1.421AlaAsp: 1.421 ± 0.346
2.841AlaGlu: 2.841 ± 1.079
2.436AlaPhe: 2.436 ± 0.87
4.262AlaGly: 4.262 ± 0.893
1.421AlaHis: 1.421 ± 0.428
1.827AlaIle: 1.827 ± 0.701
4.668AlaLys: 4.668 ± 1.291
3.653AlaLeu: 3.653 ± 0.569
1.421AlaMet: 1.421 ± 0.472
2.639AlaAsn: 2.639 ± 0.617
1.624AlaPro: 1.624 ± 0.657
2.233AlaGln: 2.233 ± 0.75
0.609AlaArg: 0.609 ± 0.412
3.856AlaSer: 3.856 ± 1.21
2.233AlaThr: 2.233 ± 0.882
3.044AlaVal: 3.044 ± 0.81
0.203AlaTrp: 0.203 ± 0.239
2.841AlaTyr: 2.841 ± 0.786
0.0AlaXaa: 0.0 ± 0.0
Cys
0.406CysAla: 0.406 ± 0.276
0.406CysCys: 0.406 ± 0.272
0.203CysAsp: 0.203 ± 0.188
0.609CysGlu: 0.609 ± 0.285
0.609CysPhe: 0.609 ± 0.415
1.218CysGly: 1.218 ± 0.557
0.0CysHis: 0.0 ± 0.0
0.812CysIle: 0.812 ± 0.386
1.421CysLys: 1.421 ± 0.51
1.015CysLeu: 1.015 ± 0.394
0.203CysMet: 0.203 ± 0.188
1.015CysAsn: 1.015 ± 0.429
0.812CysPro: 0.812 ± 0.453
0.609CysGln: 0.609 ± 0.311
0.203CysArg: 0.203 ± 0.212
0.609CysSer: 0.609 ± 0.335
0.609CysThr: 0.609 ± 0.345
0.609CysVal: 0.609 ± 0.346
0.0CysTrp: 0.0 ± 0.0
0.203CysTyr: 0.203 ± 0.188
0.0CysXaa: 0.0 ± 0.0
Asp
2.233AspAla: 2.233 ± 0.603
1.218AspCys: 1.218 ± 0.538
3.653AspAsp: 3.653 ± 1.648
5.48AspGlu: 5.48 ± 1.396
2.233AspPhe: 2.233 ± 0.609
2.233AspGly: 2.233 ± 0.599
0.609AspHis: 0.609 ± 0.365
7.51AspIle: 7.51 ± 1.623
6.089AspLys: 6.089 ± 1.595
4.668AspLeu: 4.668 ± 1.01
2.233AspMet: 2.233 ± 0.645
5.074AspAsn: 5.074 ± 1.989
2.03AspPro: 2.03 ± 0.656
1.827AspGln: 1.827 ± 0.607
0.812AspArg: 0.812 ± 0.466
1.624AspSer: 1.624 ± 0.635
1.218AspThr: 1.218 ± 0.488
3.653AspVal: 3.653 ± 0.868
0.0AspTrp: 0.0 ± 0.0
2.03AspTyr: 2.03 ± 0.631
0.0AspXaa: 0.0 ± 0.0
Glu
3.45GluAla: 3.45 ± 0.753
0.609GluCys: 0.609 ± 0.309
3.856GluAsp: 3.856 ± 1.336
6.698GluGlu: 6.698 ± 1.681
3.044GluPhe: 3.044 ± 0.928
1.827GluGly: 1.827 ± 0.889
1.218GluHis: 1.218 ± 0.545
4.262GluIle: 4.262 ± 0.946
5.886GluLys: 5.886 ± 2.12
5.886GluLeu: 5.886 ± 1.159
1.218GluMet: 1.218 ± 0.518
4.871GluAsn: 4.871 ± 1.615
1.421GluPro: 1.421 ± 0.488
2.233GluGln: 2.233 ± 0.883
0.609GluArg: 0.609 ± 0.311
4.262GluSer: 4.262 ± 2.258
3.044GluThr: 3.044 ± 0.932
4.465GluVal: 4.465 ± 1.124
0.203GluTrp: 0.203 ± 0.269
1.827GluTyr: 1.827 ± 0.713
0.0GluXaa: 0.0 ± 0.0
Phe
1.624PheAla: 1.624 ± 0.716
1.015PheCys: 1.015 ± 0.613
3.45PheAsp: 3.45 ± 1.43
1.421PheGlu: 1.421 ± 0.513
1.218PhePhe: 1.218 ± 0.54
1.827PheGly: 1.827 ± 0.452
0.406PheHis: 0.406 ± 0.253
3.653PheIle: 3.653 ± 0.826
4.465PheLys: 4.465 ± 1.861
2.436PheLeu: 2.436 ± 0.779
1.218PheMet: 1.218 ± 0.554
4.262PheAsn: 4.262 ± 0.742
2.233PhePro: 2.233 ± 0.62
1.015PheGln: 1.015 ± 0.474
2.03PheArg: 2.03 ± 0.535
3.653PheSer: 3.653 ± 0.922
2.639PheThr: 2.639 ± 0.821
3.044PheVal: 3.044 ± 0.857
0.203PheTrp: 0.203 ± 0.188
1.015PheTyr: 1.015 ± 0.419
0.0PheXaa: 0.0 ± 0.0
Gly
2.639GlyAla: 2.639 ± 0.534
0.609GlyCys: 0.609 ± 0.329
5.886GlyAsp: 5.886 ± 3.155
1.827GlyGlu: 1.827 ± 0.657
2.03GlyPhe: 2.03 ± 0.64
6.901GlyGly: 6.901 ± 1.837
0.609GlyHis: 0.609 ± 0.305
4.668GlyIle: 4.668 ± 0.887
4.059GlyLys: 4.059 ± 1.15
4.871GlyLeu: 4.871 ± 2.237
1.827GlyMet: 1.827 ± 0.737
3.653GlyAsn: 3.653 ± 1.217
1.421GlyPro: 1.421 ± 0.584
2.03GlyGln: 2.03 ± 0.652
3.247GlyArg: 3.247 ± 0.912
5.48GlySer: 5.48 ± 1.665
4.262GlyThr: 4.262 ± 1.778
4.059GlyVal: 4.059 ± 1.582
0.406GlyTrp: 0.406 ± 0.249
1.421GlyTyr: 1.421 ± 0.587
0.0GlyXaa: 0.0 ± 0.0
His
0.406HisAla: 0.406 ± 0.371
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.203HisGlu: 0.203 ± 0.185
0.203HisPhe: 0.203 ± 0.197
0.406HisGly: 0.406 ± 0.387
0.203HisHis: 0.203 ± 0.185
0.609HisIle: 0.609 ± 0.361
2.233HisLys: 2.233 ± 0.815
1.421HisLeu: 1.421 ± 0.455
0.0HisMet: 0.0 ± 0.0
0.812HisAsn: 0.812 ± 0.42
0.812HisPro: 0.812 ± 0.3
0.812HisGln: 0.812 ± 0.38
0.812HisArg: 0.812 ± 0.547
1.015HisSer: 1.015 ± 0.402
1.015HisThr: 1.015 ± 0.385
0.406HisVal: 0.406 ± 0.284
0.203HisTrp: 0.203 ± 0.197
0.812HisTyr: 0.812 ± 0.441
0.0HisXaa: 0.0 ± 0.0
Ile
1.827IleAla: 1.827 ± 0.764
1.015IleCys: 1.015 ± 0.416
4.465IleAsp: 4.465 ± 1.522
3.044IleGlu: 3.044 ± 1.072
2.436IlePhe: 2.436 ± 0.876
5.074IleGly: 5.074 ± 1.006
0.609IleHis: 0.609 ± 0.25
3.653IleIle: 3.653 ± 1.456
7.307IleLys: 7.307 ± 1.586
7.104IleLeu: 7.104 ± 1.379
2.03IleMet: 2.03 ± 0.615
6.495IleAsn: 6.495 ± 1.031
3.856IlePro: 3.856 ± 1.21
3.45IleGln: 3.45 ± 0.938
1.421IleArg: 1.421 ± 0.473
4.668IleSer: 4.668 ± 0.744
5.277IleThr: 5.277 ± 0.988
5.074IleVal: 5.074 ± 0.891
0.812IleTrp: 0.812 ± 0.47
3.653IleTyr: 3.653 ± 0.673
0.0IleXaa: 0.0 ± 0.0
Lys
5.48LysAla: 5.48 ± 1.673
0.609LysCys: 0.609 ± 0.416
4.059LysAsp: 4.059 ± 1.28
6.089LysGlu: 6.089 ± 1.613
3.856LysPhe: 3.856 ± 1.4
8.727LysGly: 8.727 ± 3.449
1.015LysHis: 1.015 ± 0.502
7.713LysIle: 7.713 ± 1.757
17.455LysLys: 17.455 ± 4.82
9.539LysLeu: 9.539 ± 2.273
2.436LysMet: 2.436 ± 0.804
6.495LysAsn: 6.495 ± 1.392
3.653LysPro: 3.653 ± 0.957
2.639LysGln: 2.639 ± 0.712
4.465LysArg: 4.465 ± 1.168
6.089LysSer: 6.089 ± 1.621
4.262LysThr: 4.262 ± 1.055
4.059LysVal: 4.059 ± 1.485
0.203LysTrp: 0.203 ± 0.188
4.262LysTyr: 4.262 ± 1.198
0.0LysXaa: 0.0 ± 0.0
Leu
4.465LeuAla: 4.465 ± 0.992
1.015LeuCys: 1.015 ± 0.56
5.074LeuAsp: 5.074 ± 0.811
5.683LeuGlu: 5.683 ± 1.135
3.247LeuPhe: 3.247 ± 0.933
4.059LeuGly: 4.059 ± 1.159
0.812LeuHis: 0.812 ± 0.464
4.871LeuIle: 4.871 ± 0.925
10.757LeuLys: 10.757 ± 2.279
6.495LeuLeu: 6.495 ± 1.447
1.624LeuMet: 1.624 ± 0.499
4.668LeuAsn: 4.668 ± 1.559
2.639LeuPro: 2.639 ± 0.776
3.45LeuGln: 3.45 ± 0.766
4.059LeuArg: 4.059 ± 0.889
7.713LeuSer: 7.713 ± 1.595
4.668LeuThr: 4.668 ± 1.009
4.059LeuVal: 4.059 ± 0.986
0.203LeuTrp: 0.203 ± 0.193
3.856LeuTyr: 3.856 ± 0.619
0.0LeuXaa: 0.0 ± 0.0
Met
1.624MetAla: 1.624 ± 0.598
0.406MetCys: 0.406 ± 0.265
1.421MetAsp: 1.421 ± 0.683
0.609MetGlu: 0.609 ± 0.343
1.421MetPhe: 1.421 ± 0.454
0.203MetGly: 0.203 ± 0.193
0.0MetHis: 0.0 ± 0.0
1.624MetIle: 1.624 ± 0.549
2.841MetLys: 2.841 ± 0.979
1.827MetLeu: 1.827 ± 0.551
1.421MetMet: 1.421 ± 0.496
2.639MetAsn: 2.639 ± 0.758
0.812MetPro: 0.812 ± 0.473
0.609MetGln: 0.609 ± 0.315
0.203MetArg: 0.203 ± 0.2
3.45MetSer: 3.45 ± 0.867
1.015MetThr: 1.015 ± 0.504
1.218MetVal: 1.218 ± 0.566
0.203MetTrp: 0.203 ± 0.185
2.436MetTyr: 2.436 ± 0.642
0.0MetXaa: 0.0 ± 0.0
Asn
3.044AsnAla: 3.044 ± 0.648
1.218AsnCys: 1.218 ± 0.605
5.48AsnAsp: 5.48 ± 1.326
6.901AsnGlu: 6.901 ± 1.98
3.856AsnPhe: 3.856 ± 0.945
5.277AsnGly: 5.277 ± 1.501
0.812AsnHis: 0.812 ± 0.417
6.089AsnIle: 6.089 ± 1.485
4.871AsnLys: 4.871 ± 1.124
6.292AsnLeu: 6.292 ± 1.253
1.015AsnMet: 1.015 ± 0.411
7.307AsnAsn: 7.307 ± 1.35
3.653AsnPro: 3.653 ± 0.923
2.841AsnGln: 2.841 ± 0.854
2.233AsnArg: 2.233 ± 0.754
4.465AsnSer: 4.465 ± 0.905
5.683AsnThr: 5.683 ± 1.089
3.044AsnVal: 3.044 ± 0.976
0.609AsnTrp: 0.609 ± 0.272
2.436AsnTyr: 2.436 ± 0.856
0.0AsnXaa: 0.0 ± 0.0
Pro
1.421ProAla: 1.421 ± 0.589
0.0ProCys: 0.0 ± 0.0
1.827ProAsp: 1.827 ± 0.707
2.436ProGlu: 2.436 ± 0.729
3.653ProPhe: 3.653 ± 1.083
2.03ProGly: 2.03 ± 0.623
0.812ProHis: 0.812 ± 0.353
3.044ProIle: 3.044 ± 1.031
3.653ProLys: 3.653 ± 1.255
3.044ProLeu: 3.044 ± 1.103
0.812ProMet: 0.812 ± 0.57
2.841ProAsn: 2.841 ± 0.62
3.247ProPro: 3.247 ± 1.267
0.0ProGln: 0.0 ± 0.0
2.639ProArg: 2.639 ± 0.97
1.624ProSer: 1.624 ± 0.735
3.856ProThr: 3.856 ± 0.839
2.233ProVal: 2.233 ± 0.563
0.609ProTrp: 0.609 ± 0.39
3.044ProTyr: 3.044 ± 0.863
0.0ProXaa: 0.0 ± 0.0
Gln
1.827GlnAla: 1.827 ± 0.583
0.203GlnCys: 0.203 ± 0.229
0.406GlnAsp: 0.406 ± 0.291
2.233GlnGlu: 2.233 ± 0.719
1.218GlnPhe: 1.218 ± 0.574
0.609GlnGly: 0.609 ± 0.277
0.406GlnHis: 0.406 ± 0.387
3.247GlnIle: 3.247 ± 1.123
2.841GlnLys: 2.841 ± 0.84
2.436GlnLeu: 2.436 ± 0.856
1.827GlnMet: 1.827 ± 0.606
2.233GlnAsn: 2.233 ± 0.763
2.436GlnPro: 2.436 ± 0.83
1.218GlnGln: 1.218 ± 0.903
1.421GlnArg: 1.421 ± 0.596
2.436GlnSer: 2.436 ± 0.657
1.624GlnThr: 1.624 ± 0.725
2.03GlnVal: 2.03 ± 0.97
0.203GlnTrp: 0.203 ± 0.239
3.044GlnTyr: 3.044 ± 0.592
0.0GlnXaa: 0.0 ± 0.0
Arg
1.015ArgAla: 1.015 ± 0.385
0.0ArgCys: 0.0 ± 0.0
2.436ArgAsp: 2.436 ± 0.705
3.044ArgGlu: 3.044 ± 0.902
1.218ArgPhe: 1.218 ± 0.517
1.218ArgGly: 1.218 ± 0.45
0.406ArgHis: 0.406 ± 0.272
3.45ArgIle: 3.45 ± 0.899
3.247ArgLys: 3.247 ± 0.914
2.841ArgLeu: 2.841 ± 0.909
1.015ArgMet: 1.015 ± 0.418
2.841ArgAsn: 2.841 ± 1.135
1.015ArgPro: 1.015 ± 0.557
0.812ArgGln: 0.812 ± 0.398
1.218ArgArg: 1.218 ± 0.45
1.218ArgSer: 1.218 ± 0.541
2.03ArgThr: 2.03 ± 0.741
1.421ArgVal: 1.421 ± 0.61
0.812ArgTrp: 0.812 ± 0.315
2.436ArgTyr: 2.436 ± 0.72
0.0ArgXaa: 0.0 ± 0.0
Ser
3.247SerAla: 3.247 ± 1.103
0.203SerCys: 0.203 ± 0.2
4.059SerAsp: 4.059 ± 1.442
3.45SerGlu: 3.45 ± 0.989
2.436SerPhe: 2.436 ± 0.822
7.307SerGly: 7.307 ± 1.949
1.827SerHis: 1.827 ± 0.342
4.668SerIle: 4.668 ± 1.134
5.48SerLys: 5.48 ± 1.412
6.292SerLeu: 6.292 ± 1.126
2.03SerMet: 2.03 ± 0.813
6.698SerAsn: 6.698 ± 1.714
2.03SerPro: 2.03 ± 1.004
1.218SerGln: 1.218 ± 0.687
3.044SerArg: 3.044 ± 0.715
3.044SerSer: 3.044 ± 0.721
3.45SerThr: 3.45 ± 1.005
3.856SerVal: 3.856 ± 0.97
0.0SerTrp: 0.0 ± 0.0
3.247SerTyr: 3.247 ± 0.832
0.0SerXaa: 0.0 ± 0.0
Thr
3.044ThrAla: 3.044 ± 0.78
0.812ThrCys: 0.812 ± 0.37
1.827ThrAsp: 1.827 ± 0.491
3.45ThrGlu: 3.45 ± 0.823
3.044ThrPhe: 3.044 ± 0.555
3.653ThrGly: 3.653 ± 1.325
0.203ThrHis: 0.203 ± 0.239
4.262ThrIle: 4.262 ± 1.131
4.668ThrLys: 4.668 ± 1.488
4.262ThrLeu: 4.262 ± 1.05
1.218ThrMet: 1.218 ± 0.577
4.668ThrAsn: 4.668 ± 1.248
3.45ThrPro: 3.45 ± 0.634
2.841ThrGln: 2.841 ± 0.623
1.421ThrArg: 1.421 ± 0.673
4.059ThrSer: 4.059 ± 0.918
3.45ThrThr: 3.45 ± 1.159
2.841ThrVal: 2.841 ± 0.601
0.609ThrTrp: 0.609 ± 0.556
2.841ThrTyr: 2.841 ± 0.931
0.0ThrXaa: 0.0 ± 0.0
Val
3.653ValAla: 3.653 ± 0.943
0.406ValCys: 0.406 ± 0.274
3.044ValAsp: 3.044 ± 0.765
1.624ValGlu: 1.624 ± 0.589
2.436ValPhe: 2.436 ± 0.749
2.639ValGly: 2.639 ± 0.597
0.406ValHis: 0.406 ± 0.22
3.45ValIle: 3.45 ± 0.554
5.886ValLys: 5.886 ± 1.341
5.886ValLeu: 5.886 ± 1.358
0.609ValMet: 0.609 ± 0.348
2.841ValAsn: 2.841 ± 0.875
3.247ValPro: 3.247 ± 0.907
2.233ValGln: 2.233 ± 0.68
1.218ValArg: 1.218 ± 0.694
5.074ValSer: 5.074 ± 0.87
4.059ValThr: 4.059 ± 0.938
3.45ValVal: 3.45 ± 0.816
0.203ValTrp: 0.203 ± 0.222
4.059ValTyr: 4.059 ± 0.88
0.0ValXaa: 0.0 ± 0.0
Trp
0.812TrpAla: 0.812 ± 0.35
0.406TrpCys: 0.406 ± 0.395
0.406TrpAsp: 0.406 ± 0.322
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.406TrpIle: 0.406 ± 0.274
0.203TrpLys: 0.203 ± 0.188
0.203TrpLeu: 0.203 ± 0.188
0.406TrpMet: 0.406 ± 0.255
0.406TrpAsn: 0.406 ± 0.272
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.203TrpArg: 0.203 ± 0.211
1.015TrpSer: 1.015 ± 0.389
0.812TrpThr: 0.812 ± 0.278
0.812TrpVal: 0.812 ± 0.459
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.624TyrAla: 1.624 ± 0.447
0.812TyrCys: 0.812 ± 0.452
3.45TyrAsp: 3.45 ± 0.893
3.247TyrGlu: 3.247 ± 0.797
2.233TyrPhe: 2.233 ± 0.522
2.436TyrGly: 2.436 ± 0.733
0.609TyrHis: 0.609 ± 0.434
3.45TyrIle: 3.45 ± 1.037
5.277TyrLys: 5.277 ± 1.034
3.247TyrLeu: 3.247 ± 1.052
1.218TyrMet: 1.218 ± 0.49
4.668TyrAsn: 4.668 ± 1.031
2.436TyrPro: 2.436 ± 0.953
1.827TyrGln: 1.827 ± 0.534
1.827TyrArg: 1.827 ± 0.549
2.233TyrSer: 2.233 ± 0.661
1.421TyrThr: 1.421 ± 0.436
3.044TyrVal: 3.044 ± 0.945
0.406TyrTrp: 0.406 ± 0.269
3.653TyrTyr: 3.653 ± 1.143
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (4928 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski