Amino acid dipepetide frequency for Sphingopyxis sp. LC363

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.732AlaAla: 20.732 ± 0.178	0.986AlaCys: 0.986 ± 0.03	8.239AlaAsp: 8.239 ± 0.087	7.98AlaGlu: 7.98 ± 0.095	4.522AlaPhe: 4.522 ± 0.066	11.956AlaGly: 11.956 ± 0.121	2.318AlaHis: 2.318 ± 0.052	7.096AlaIle: 7.096 ± 0.081	4.717AlaLys: 4.717 ± 0.085	13.695AlaLeu: 13.695 ± 0.126	4.0AlaMet: 4.0 ± 0.061	3.382AlaAsn: 3.382 ± 0.062	6.806AlaPro: 6.806 ± 0.098	3.975AlaGln: 3.975 ± 0.059	9.469AlaArg: 9.469 ± 0.124	6.756AlaSer: 6.756 ± 0.074	6.602AlaThr: 6.602 ± 0.087	8.495AlaVal: 8.495 ± 0.079	1.695AlaTrp: 1.695 ± 0.041	2.588AlaTyr: 2.588 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.933CysAla: 0.933 ± 0.028	0.076CysCys: 0.076 ± 0.008	0.511CysAsp: 0.511 ± 0.02	0.4CysGlu: 0.4 ± 0.017	0.254CysPhe: 0.254 ± 0.014	0.783CysGly: 0.783 ± 0.026	0.213CysHis: 0.213 ± 0.015	0.328CysIle: 0.328 ± 0.018	0.162CysLys: 0.162 ± 0.012	0.65CysLeu: 0.65 ± 0.023	0.119CysMet: 0.119 ± 0.011	0.204CysAsn: 0.204 ± 0.013	0.433CysPro: 0.433 ± 0.029	0.19CysGln: 0.19 ± 0.012	0.554CysArg: 0.554 ± 0.024	0.449CysSer: 0.449 ± 0.02	0.371CysThr: 0.371 ± 0.018	0.494CysVal: 0.494 ± 0.018	0.126CysTrp: 0.126 ± 0.01	0.173CysTyr: 0.173 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.501AspAla: 8.501 ± 0.083	0.477AspCys: 0.477 ± 0.022	3.587AspAsp: 3.587 ± 0.07	3.581AspGlu: 3.581 ± 0.061	2.385AspPhe: 2.385 ± 0.046	5.896AspGly: 5.896 ± 0.113	1.286AspHis: 1.286 ± 0.035	3.214AspIle: 3.214 ± 0.051	1.891AspLys: 1.891 ± 0.038	5.651AspLeu: 5.651 ± 0.068	1.456AspMet: 1.456 ± 0.033	1.49AspAsn: 1.49 ± 0.043	3.889AspPro: 3.889 ± 0.059	1.671AspGln: 1.671 ± 0.039	5.084AspArg: 5.084 ± 0.084	2.473AspSer: 2.473 ± 0.054	2.672AspThr: 2.672 ± 0.058	4.119AspVal: 4.119 ± 0.064	1.149AspTrp: 1.149 ± 0.03	1.793AspTyr: 1.793 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.773GluAla: 7.773 ± 0.096	0.321GluCys: 0.321 ± 0.016	2.648GluAsp: 2.648 ± 0.053	2.917GluGlu: 2.917 ± 0.068	1.595GluPhe: 1.595 ± 0.036	4.674GluGly: 4.674 ± 0.064	1.046GluHis: 1.046 ± 0.024	3.089GluIle: 3.089 ± 0.05	2.071GluLys: 2.071 ± 0.045	5.224GluLeu: 5.224 ± 0.069	1.41GluMet: 1.41 ± 0.038	1.396GluAsn: 1.396 ± 0.031	2.488GluPro: 2.488 ± 0.042	1.894GluGln: 1.894 ± 0.04	4.942GluArg: 4.942 ± 0.077	2.239GluSer: 2.239 ± 0.041	3.089GluThr: 3.089 ± 0.043	3.559GluVal: 3.559 ± 0.057	0.817GluTrp: 0.817 ± 0.025	1.082GluTyr: 1.082 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	5.131PheAla: 5.131 ± 0.066	0.303PheCys: 0.303 ± 0.016	2.915PheAsp: 2.915 ± 0.049	2.091PheGlu: 2.091 ± 0.041	1.339PhePhe: 1.339 ± 0.039	3.813PheGly: 3.813 ± 0.064	0.647PheHis: 0.647 ± 0.022	1.479PheIle: 1.479 ± 0.035	0.869PheLys: 0.869 ± 0.028	3.146PheLeu: 3.146 ± 0.064	0.73PheMet: 0.73 ± 0.024	1.091PheAsn: 1.091 ± 0.031	1.577PhePro: 1.577 ± 0.038	0.909PheGln: 0.909 ± 0.025	2.299PheArg: 2.299 ± 0.047	1.98PheSer: 1.98 ± 0.043	1.993PheThr: 1.993 ± 0.051	2.637PheVal: 2.637 ± 0.038	0.521PheTrp: 0.521 ± 0.021	0.883PheTyr: 0.883 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.512GlyAla: 10.512 ± 0.108	0.748GlyCys: 0.748 ± 0.028	5.534GlyAsp: 5.534 ± 0.077	5.2GlyGlu: 5.2 ± 0.059	3.636GlyPhe: 3.636 ± 0.056	8.585GlyGly: 8.585 ± 0.142	1.816GlyHis: 1.816 ± 0.042	4.58GlyIle: 4.58 ± 0.056	3.497GlyLys: 3.497 ± 0.059	8.439GlyLeu: 8.439 ± 0.08	2.251GlyMet: 2.251 ± 0.045	2.399GlyAsn: 2.399 ± 0.054	3.622GlyPro: 3.622 ± 0.06	2.915GlyGln: 2.915 ± 0.05	6.425GlyArg: 6.425 ± 0.075	4.926GlySer: 4.926 ± 0.08	4.865GlyThr: 4.865 ± 0.096	6.273GlyVal: 6.273 ± 0.08	1.717GlyTrp: 1.717 ± 0.043	2.347GlyTyr: 2.347 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.259HisAla: 2.259 ± 0.048	0.24HisCys: 0.24 ± 0.015	1.174HisAsp: 1.174 ± 0.032	0.93HisGlu: 0.93 ± 0.028	0.827HisPhe: 0.827 ± 0.025	1.965HisGly: 1.965 ± 0.041	0.565HisHis: 0.565 ± 0.022	1.009HisIle: 1.009 ± 0.032	0.485HisLys: 0.485 ± 0.018	1.794HisLeu: 1.794 ± 0.041	0.465HisMet: 0.465 ± 0.02	0.463HisAsn: 0.463 ± 0.021	1.258HisPro: 1.258 ± 0.035	0.511HisGln: 0.511 ± 0.022	1.482HisArg: 1.482 ± 0.036	0.936HisSer: 0.936 ± 0.033	0.576HisThr: 0.576 ± 0.024	1.466HisVal: 1.466 ± 0.039	0.351HisTrp: 0.351 ± 0.016	0.561HisTyr: 0.561 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	8.003IleAla: 8.003 ± 0.084	0.405IleCys: 0.405 ± 0.019	4.183IleAsp: 4.183 ± 0.055	3.536IleGlu: 3.536 ± 0.053	1.777IlePhe: 1.777 ± 0.037	5.081IleGly: 5.081 ± 0.065	0.867IleHis: 0.867 ± 0.027	2.025IleIle: 2.025 ± 0.038	1.256IleLys: 1.256 ± 0.033	4.266IleLeu: 4.266 ± 0.065	0.854IleMet: 0.854 ± 0.026	1.313IleAsn: 1.313 ± 0.039	2.236IlePro: 2.236 ± 0.041	1.072IleGln: 1.072 ± 0.028	3.228IleArg: 3.228 ± 0.054	2.519IleSer: 2.519 ± 0.047	2.363IleThr: 2.363 ± 0.062	4.275IleVal: 4.275 ± 0.058	0.654IleTrp: 0.654 ± 0.028	1.011IleTyr: 1.011 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.291LysAla: 4.291 ± 0.083	0.157LysCys: 0.157 ± 0.012	1.709LysAsp: 1.709 ± 0.041	1.434LysGlu: 1.434 ± 0.039	0.93LysPhe: 0.93 ± 0.033	2.818LysGly: 2.818 ± 0.056	0.569LysHis: 0.569 ± 0.022	1.529LysIle: 1.529 ± 0.038	1.254LysLys: 1.254 ± 0.04	3.394LysLeu: 3.394 ± 0.057	0.781LysMet: 0.781 ± 0.025	0.768LysAsn: 0.768 ± 0.024	1.989LysPro: 1.989 ± 0.048	0.929LysGln: 0.929 ± 0.026	2.334LysArg: 2.334 ± 0.043	1.743LysSer: 1.743 ± 0.037	1.664LysThr: 1.664 ± 0.038	2.111LysVal: 2.111 ± 0.049	0.467LysTrp: 0.467 ± 0.02	0.658LysTyr: 0.658 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.403LeuAla: 14.403 ± 0.136	0.714LeuCys: 0.714 ± 0.025	6.077LeuAsp: 6.077 ± 0.081	4.333LeuGlu: 4.333 ± 0.062	3.793LeuPhe: 3.793 ± 0.075	8.24LeuGly: 8.24 ± 0.087	1.757LeuHis: 1.757 ± 0.036	4.843LeuIle: 4.843 ± 0.074	2.976LeuLys: 2.976 ± 0.054	9.305LeuLeu: 9.305 ± 0.117	2.089LeuMet: 2.089 ± 0.04	2.32LeuAsn: 2.32 ± 0.044	5.461LeuPro: 5.461 ± 0.081	2.307LeuGln: 2.307 ± 0.043	6.49LeuArg: 6.49 ± 0.086	5.716LeuSer: 5.716 ± 0.082	5.601LeuThr: 5.601 ± 0.077	7.113LeuVal: 7.113 ± 0.082	1.31LeuTrp: 1.31 ± 0.037	2.026LeuTyr: 2.026 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.235MetAla: 3.235 ± 0.051	0.14MetCys: 0.14 ± 0.01	1.088MetAsp: 1.088 ± 0.031	1.062MetGlu: 1.062 ± 0.03	0.72MetPhe: 0.72 ± 0.024	1.869MetGly: 1.869 ± 0.044	0.398MetHis: 0.398 ± 0.017	1.393MetIle: 1.393 ± 0.032	0.93MetLys: 0.93 ± 0.029	2.646MetLeu: 2.646 ± 0.05	0.634MetMet: 0.634 ± 0.022	0.658MetAsn: 0.658 ± 0.023	1.394MetPro: 1.394 ± 0.036	0.729MetGln: 0.729 ± 0.026	1.845MetArg: 1.845 ± 0.043	1.373MetSer: 1.373 ± 0.032	1.858MetThr: 1.858 ± 0.04	1.567MetVal: 1.567 ± 0.038	0.257MetTrp: 0.257 ± 0.015	0.246MetTyr: 0.246 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.138AsnAla: 3.138 ± 0.056	0.252AsnCys: 0.252 ± 0.015	1.512AsnAsp: 1.512 ± 0.037	1.176AsnGlu: 1.176 ± 0.032	1.07AsnPhe: 1.07 ± 0.032	2.425AsnGly: 2.425 ± 0.061	0.465AsnHis: 0.465 ± 0.018	1.473AsnIle: 1.473 ± 0.038	0.666AsnLys: 0.666 ± 0.024	2.49AsnLeu: 2.49 ± 0.053	0.59AsnMet: 0.59 ± 0.021	0.744AsnAsn: 0.744 ± 0.029	1.777AsnPro: 1.777 ± 0.042	0.734AsnGln: 0.734 ± 0.024	1.905AsnArg: 1.905 ± 0.038	1.329AsnSer: 1.329 ± 0.041	1.013AsnThr: 1.013 ± 0.035	1.781AsnVal: 1.781 ± 0.044	0.471AsnTrp: 0.471 ± 0.02	0.766AsnTyr: 0.766 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.546ProAla: 7.546 ± 0.106	0.316ProCys: 0.316 ± 0.016	3.884ProAsp: 3.884 ± 0.063	3.331ProGlu: 3.331 ± 0.05	1.875ProPhe: 1.875 ± 0.037	4.935ProGly: 4.935 ± 0.065	1.046ProHis: 1.046 ± 0.031	2.365ProIle: 2.365 ± 0.046	1.6ProLys: 1.6 ± 0.038	5.008ProLeu: 5.008 ± 0.077	1.199ProMet: 1.199 ± 0.03	1.272ProAsn: 1.272 ± 0.035	2.898ProPro: 2.898 ± 0.077	1.526ProGln: 1.526 ± 0.034	3.063ProArg: 3.063 ± 0.058	2.641ProSer: 2.641 ± 0.044	2.6ProThr: 2.6 ± 0.045	4.351ProVal: 4.351 ± 0.055	0.693ProTrp: 0.693 ± 0.026	1.085ProTyr: 1.085 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.779GlnAla: 3.779 ± 0.051	0.21GlnCys: 0.21 ± 0.015	1.4GlnAsp: 1.4 ± 0.037	1.149GlnGlu: 1.149 ± 0.027	1.046GlnPhe: 1.046 ± 0.033	2.261GlnGly: 2.261 ± 0.042	0.588GlnHis: 0.588 ± 0.024	1.638GlnIle: 1.638 ± 0.033	0.924GlnLys: 0.924 ± 0.027	3.035GlnLeu: 3.035 ± 0.059	0.779GlnMet: 0.779 ± 0.026	0.763GlnAsn: 0.763 ± 0.025	1.734GlnPro: 1.734 ± 0.037	1.074GlnGln: 1.074 ± 0.034	2.379GlnArg: 2.379 ± 0.051	1.695GlnSer: 1.695 ± 0.038	1.412GlnThr: 1.412 ± 0.04	1.951GlnVal: 1.951 ± 0.042	0.442GlnTrp: 0.442 ± 0.02	0.686GlnTyr: 0.686 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.887ArgAla: 8.887 ± 0.11	0.489ArgCys: 0.489 ± 0.021	4.386ArgAsp: 4.386 ± 0.061	4.018ArgGlu: 4.018 ± 0.061	3.119ArgPhe: 3.119 ± 0.055	5.309ArgGly: 5.309 ± 0.083	1.674ArgHis: 1.674 ± 0.044	4.149ArgIle: 4.149 ± 0.06	2.169ArgLys: 2.169 ± 0.042	7.812ArgLeu: 7.812 ± 0.104	1.906ArgMet: 1.906 ± 0.04	1.727ArgAsn: 1.727 ± 0.042	3.687ArgPro: 3.687 ± 0.057	2.381ArgGln: 2.381 ± 0.048	5.575ArgArg: 5.575 ± 0.097	3.625ArgSer: 3.625 ± 0.057	3.465ArgThr: 3.465 ± 0.057	4.703ArgVal: 4.703 ± 0.058	1.333ArgTrp: 1.333 ± 0.034	1.89ArgTyr: 1.89 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.371SerAla: 6.371 ± 0.079	0.4SerCys: 0.4 ± 0.023	3.319SerAsp: 3.319 ± 0.055	2.66SerGlu: 2.66 ± 0.044	2.29SerPhe: 2.29 ± 0.046	5.436SerGly: 5.436 ± 0.083	0.949SerHis: 0.949 ± 0.029	2.632SerIle: 2.632 ± 0.047	1.459SerLys: 1.459 ± 0.035	5.111SerLeu: 5.111 ± 0.067	1.141SerMet: 1.141 ± 0.028	1.429SerAsn: 1.429 ± 0.04	2.778SerPro: 2.778 ± 0.044	1.453SerGln: 1.453 ± 0.035	3.362SerArg: 3.362 ± 0.05	2.577SerSer: 2.577 ± 0.049	2.401SerThr: 2.401 ± 0.044	3.701SerVal: 3.701 ± 0.065	0.849SerTrp: 0.849 ± 0.026	1.352SerTyr: 1.352 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.496ThrAla: 6.496 ± 0.086	0.351ThrCys: 0.351 ± 0.026	3.057ThrAsp: 3.057 ± 0.066	2.274ThrGlu: 2.274 ± 0.041	1.667ThrPhe: 1.667 ± 0.042	5.312ThrGly: 5.312 ± 0.08	0.975ThrHis: 0.975 ± 0.027	2.974ThrIle: 2.974 ± 0.066	1.375ThrLys: 1.375 ± 0.032	5.634ThrLeu: 5.634 ± 0.081	1.211ThrMet: 1.211 ± 0.028	1.33ThrAsn: 1.33 ± 0.038	3.458ThrPro: 3.458 ± 0.057	1.355ThrGln: 1.355 ± 0.034	3.351ThrArg: 3.351 ± 0.055	2.661ThrSer: 2.661 ± 0.054	2.598ThrThr: 2.598 ± 0.059	3.76ThrVal: 3.76 ± 0.067	0.563ThrTrp: 0.563 ± 0.023	1.118ThrTyr: 1.118 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.809ValAla: 9.809 ± 0.09	0.49ValCys: 0.49 ± 0.02	4.548ValAsp: 4.548 ± 0.063	4.425ValGlu: 4.425 ± 0.058	2.013ValPhe: 2.013 ± 0.039	5.736ValGly: 5.736 ± 0.072	1.302ValHis: 1.302 ± 0.035	3.51ValIle: 3.51 ± 0.057	2.084ValLys: 2.084 ± 0.046	5.679ValLeu: 5.679 ± 0.07	1.627ValMet: 1.627 ± 0.038	1.941ValAsn: 1.941 ± 0.045	3.961ValPro: 3.961 ± 0.049	1.955ValGln: 1.955 ± 0.041	5.125ValArg: 5.125 ± 0.069	3.85ValSer: 3.85 ± 0.056	4.469ValThr: 4.469 ± 0.081	5.005ValVal: 5.005 ± 0.069	0.855ValTrp: 0.855 ± 0.027	1.346ValTyr: 1.346 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.464TrpAla: 1.464 ± 0.04	0.135TrpCys: 0.135 ± 0.01	0.806TrpAsp: 0.806 ± 0.025	0.626TrpGlu: 0.626 ± 0.021	0.605TrpPhe: 0.605 ± 0.023	0.979TrpGly: 0.979 ± 0.028	0.331TrpHis: 0.331 ± 0.018	0.734TrpIle: 0.734 ± 0.023	0.507TrpLys: 0.507 ± 0.021	1.871TrpLeu: 1.871 ± 0.042	0.363TrpMet: 0.363 ± 0.018	0.442TrpAsn: 0.442 ± 0.021	0.758TrpPro: 0.758 ± 0.028	0.649TrpGln: 0.649 ± 0.023	1.387TrpArg: 1.387 ± 0.035	0.902TrpSer: 0.902 ± 0.032	0.913TrpThr: 0.913 ± 0.028	0.866TrpVal: 0.866 ± 0.025	0.245TrpTrp: 0.245 ± 0.014	0.32TrpTyr: 0.32 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.746TyrAla: 2.746 ± 0.049	0.212TyrCys: 0.212 ± 0.017	1.69TyrAsp: 1.69 ± 0.041	1.15TyrGlu: 1.15 ± 0.036	0.889TyrPhe: 0.889 ± 0.029	2.215TyrGly: 2.215 ± 0.044	0.504TyrHis: 0.504 ± 0.023	0.862TyrIle: 0.862 ± 0.029	0.641TyrLys: 0.641 ± 0.021	2.026TyrLeu: 2.026 ± 0.037	0.435TyrMet: 0.435 ± 0.019	0.646TyrAsn: 0.646 ± 0.027	1.031TyrPro: 1.031 ± 0.031	0.714TyrGln: 0.714 ± 0.027	2.006TyrArg: 2.006 ± 0.044	1.278TyrSer: 1.278 ± 0.04	0.994TyrThr: 0.994 ± 0.032	1.505TyrVal: 1.505 ± 0.034	0.387TyrTrp: 0.387 ± 0.019	0.678TyrTyr: 0.678 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3880 proteins (1254710 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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