Amino acid dipepetide frequency for Crenobacter luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.75AlaAla: 19.75 ± 0.269	1.306AlaCys: 1.306 ± 0.035	7.462AlaAsp: 7.462 ± 0.108	8.849AlaGlu: 8.849 ± 0.131	4.543AlaPhe: 4.543 ± 0.081	11.88AlaGly: 11.88 ± 0.14	2.577AlaHis: 2.577 ± 0.062	5.589AlaIle: 5.589 ± 0.081	3.851AlaLys: 3.851 ± 0.084	16.654AlaLeu: 16.654 ± 0.216	3.409AlaMet: 3.409 ± 0.073	3.055AlaAsn: 3.055 ± 0.064	6.387AlaPro: 6.387 ± 0.133	4.204AlaGln: 4.204 ± 0.084	11.202AlaArg: 11.202 ± 0.144	6.136AlaSer: 6.136 ± 0.106	5.614AlaThr: 5.614 ± 0.089	9.376AlaVal: 9.376 ± 0.132	1.919AlaTrp: 1.919 ± 0.055	2.65AlaTyr: 2.65 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.109CysAla: 1.109 ± 0.044	0.116CysCys: 0.116 ± 0.013	0.5CysAsp: 0.5 ± 0.025	0.486CysGlu: 0.486 ± 0.026	0.264CysPhe: 0.264 ± 0.018	0.932CysGly: 0.932 ± 0.039	0.279CysHis: 0.279 ± 0.02	0.299CysIle: 0.299 ± 0.019	0.255CysLys: 0.255 ± 0.019	0.875CysLeu: 0.875 ± 0.029	0.128CysMet: 0.128 ± 0.011	0.202CysAsn: 0.202 ± 0.016	0.507CysPro: 0.507 ± 0.027	0.261CysGln: 0.261 ± 0.016	0.676CysArg: 0.676 ± 0.032	0.384CysSer: 0.384 ± 0.021	0.395CysThr: 0.395 ± 0.025	0.701CysVal: 0.701 ± 0.028	0.116CysTrp: 0.116 ± 0.012	0.254CysTyr: 0.254 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	8.999AspAla: 8.999 ± 0.126	0.535AspCys: 0.535 ± 0.03	3.327AspAsp: 3.327 ± 0.07	3.877AspGlu: 3.877 ± 0.056	2.264AspPhe: 2.264 ± 0.055	5.292AspGly: 5.292 ± 0.087	1.042AspHis: 1.042 ± 0.037	2.485AspIle: 2.485 ± 0.052	2.243AspLys: 2.243 ± 0.053	5.01AspLeu: 5.01 ± 0.079	1.121AspMet: 1.121 ± 0.044	1.175AspAsn: 1.175 ± 0.042	2.655AspPro: 2.655 ± 0.057	1.173AspGln: 1.173 ± 0.037	3.005AspArg: 3.005 ± 0.057	2.214AspSer: 2.214 ± 0.052	2.676AspThr: 2.676 ± 0.055	4.152AspVal: 4.152 ± 0.072	1.083AspTrp: 1.083 ± 0.035	1.717AspTyr: 1.717 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.434GluAla: 8.434 ± 0.118	0.373GluCys: 0.373 ± 0.022	2.278GluAsp: 2.278 ± 0.048	2.78GluGlu: 2.78 ± 0.082	1.804GluPhe: 1.804 ± 0.05	3.849GluGly: 3.849 ± 0.068	1.48GluHis: 1.48 ± 0.042	2.845GluIle: 2.845 ± 0.079	2.094GluLys: 2.094 ± 0.062	7.286GluLeu: 7.286 ± 0.102	1.334GluMet: 1.334 ± 0.038	1.401GluAsn: 1.401 ± 0.044	2.656GluPro: 2.656 ± 0.061	2.322GluGln: 2.322 ± 0.062	5.277GluArg: 5.277 ± 0.085	2.424GluSer: 2.424 ± 0.062	2.874GluThr: 2.874 ± 0.059	4.42GluVal: 4.42 ± 0.08	0.776GluTrp: 0.776 ± 0.033	1.107GluTyr: 1.107 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	5.061PheAla: 5.061 ± 0.09	0.406PheCys: 0.406 ± 0.025	2.65PheAsp: 2.65 ± 0.057	2.11PheGlu: 2.11 ± 0.053	1.395PhePhe: 1.395 ± 0.059	3.418PheGly: 3.418 ± 0.066	0.792PheHis: 0.792 ± 0.034	1.35PheIle: 1.35 ± 0.053	1.178PheLys: 1.178 ± 0.036	3.185PheLeu: 3.185 ± 0.073	0.795PheMet: 0.795 ± 0.028	1.093PheAsn: 1.093 ± 0.034	1.469PhePro: 1.469 ± 0.041	0.91PheGln: 0.91 ± 0.036	1.983PheArg: 1.983 ± 0.05	1.994PheSer: 1.994 ± 0.048	1.817PheThr: 1.817 ± 0.052	3.146PheVal: 3.146 ± 0.06	0.528PheTrp: 0.528 ± 0.031	0.972PheTyr: 0.972 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.327GlyAla: 9.327 ± 0.123	0.851GlyCys: 0.851 ± 0.039	4.44GlyAsp: 4.44 ± 0.072	5.182GlyGlu: 5.182 ± 0.089	3.467GlyPhe: 3.467 ± 0.06	6.925GlyGly: 6.925 ± 0.108	1.915GlyHis: 1.915 ± 0.051	3.369GlyIle: 3.369 ± 0.075	3.338GlyLys: 3.338 ± 0.072	9.107GlyLeu: 9.107 ± 0.114	2.108GlyMet: 2.108 ± 0.059	2.02GlyAsn: 2.02 ± 0.053	2.555GlyPro: 2.555 ± 0.064	3.102GlyGln: 3.102 ± 0.068	6.62GlyArg: 6.62 ± 0.088	3.926GlySer: 3.926 ± 0.076	3.427GlyThr: 3.427 ± 0.075	7.41GlyVal: 7.41 ± 0.112	1.375GlyTrp: 1.375 ± 0.047	2.275GlyTyr: 2.275 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.718HisAla: 2.718 ± 0.051	0.247HisCys: 0.247 ± 0.018	1.215HisAsp: 1.215 ± 0.041	1.182HisGlu: 1.182 ± 0.039	0.951HisPhe: 0.951 ± 0.034	2.062HisGly: 2.062 ± 0.053	0.589HisHis: 0.589 ± 0.03	0.888HisIle: 0.888 ± 0.034	0.619HisLys: 0.619 ± 0.028	2.195HisLeu: 2.195 ± 0.056	0.415HisMet: 0.415 ± 0.024	0.498HisAsn: 0.498 ± 0.021	1.539HisPro: 1.539 ± 0.049	0.572HisGln: 0.572 ± 0.028	1.407HisArg: 1.407 ± 0.041	0.949HisSer: 0.949 ± 0.034	0.914HisThr: 0.914 ± 0.035	1.337HisVal: 1.337 ± 0.046	0.341HisTrp: 0.341 ± 0.021	0.723HisTyr: 0.723 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.172IleAla: 6.172 ± 0.088	0.36IleCys: 0.36 ± 0.019	3.152IleAsp: 3.152 ± 0.074	3.046IleGlu: 3.046 ± 0.07	1.065IlePhe: 1.065 ± 0.044	4.097IleGly: 4.097 ± 0.075	0.867IleHis: 0.867 ± 0.031	1.302IleIle: 1.302 ± 0.05	1.515IleLys: 1.515 ± 0.047	3.452IleLeu: 3.452 ± 0.073	0.68IleMet: 0.68 ± 0.033	1.191IleAsn: 1.191 ± 0.039	1.867IlePro: 1.867 ± 0.053	1.13IleGln: 1.13 ± 0.039	2.784IleArg: 2.784 ± 0.053	1.849IleSer: 1.849 ± 0.052	1.886IleThr: 1.886 ± 0.048	3.74IleVal: 3.74 ± 0.059	0.355IleTrp: 0.355 ± 0.023	0.875IleTyr: 0.875 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.014LysAla: 4.014 ± 0.073	0.154LysCys: 0.154 ± 0.016	1.534LysAsp: 1.534 ± 0.05	1.682LysGlu: 1.682 ± 0.055	0.837LysPhe: 0.837 ± 0.038	2.512LysGly: 2.512 ± 0.069	0.661LysHis: 0.661 ± 0.033	1.556LysIle: 1.556 ± 0.05	1.696LysLys: 1.696 ± 0.051	4.105LysLeu: 4.105 ± 0.081	0.777LysMet: 0.777 ± 0.031	1.053LysAsn: 1.053 ± 0.041	2.033LysPro: 2.033 ± 0.05	1.29LysGln: 1.29 ± 0.039	2.301LysArg: 2.301 ± 0.059	1.799LysSer: 1.799 ± 0.05	1.984LysThr: 1.984 ± 0.05	2.744LysVal: 2.744 ± 0.068	0.335LysTrp: 0.335 ± 0.021	0.706LysTyr: 0.706 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	18.668LeuAla: 18.668 ± 0.262	0.919LeuCys: 0.919 ± 0.035	6.569LeuAsp: 6.569 ± 0.094	5.784LeuGlu: 5.784 ± 0.088	4.244LeuPhe: 4.244 ± 0.089	8.415LeuGly: 8.415 ± 0.125	1.896LeuHis: 1.896 ± 0.048	4.879LeuIle: 4.879 ± 0.088	4.421LeuLys: 4.421 ± 0.073	11.543LeuLeu: 11.543 ± 0.194	2.558LeuMet: 2.558 ± 0.063	2.874LeuAsn: 2.874 ± 0.057	6.744LeuPro: 6.744 ± 0.104	2.743LeuGln: 2.743 ± 0.058	6.367LeuArg: 6.367 ± 0.107	6.975LeuSer: 6.975 ± 0.113	6.063LeuThr: 6.063 ± 0.099	8.378LeuVal: 8.378 ± 0.119	1.281LeuTrp: 1.281 ± 0.04	2.413LeuTyr: 2.413 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.73MetAla: 2.73 ± 0.06	0.15MetCys: 0.15 ± 0.014	1.022MetAsp: 1.022 ± 0.033	1.01MetGlu: 1.01 ± 0.043	0.638MetPhe: 0.638 ± 0.031	1.604MetGly: 1.604 ± 0.052	0.442MetHis: 0.442 ± 0.024	0.984MetIle: 0.984 ± 0.037	1.121MetLys: 1.121 ± 0.036	2.585MetLeu: 2.585 ± 0.06	0.594MetMet: 0.594 ± 0.03	0.779MetAsn: 0.779 ± 0.032	1.167MetPro: 1.167 ± 0.037	0.896MetGln: 0.896 ± 0.032	1.567MetArg: 1.567 ± 0.047	1.533MetSer: 1.533 ± 0.045	1.297MetThr: 1.297 ± 0.036	1.587MetVal: 1.587 ± 0.045	0.19MetTrp: 0.19 ± 0.014	0.347MetTyr: 0.347 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.048AsnAla: 3.048 ± 0.068	0.213AsnCys: 0.213 ± 0.017	1.32AsnAsp: 1.32 ± 0.041	1.204AsnGlu: 1.204 ± 0.041	0.808AsnPhe: 0.808 ± 0.031	2.231AsnGly: 2.231 ± 0.054	0.512AsnHis: 0.512 ± 0.023	1.088AsnIle: 1.088 ± 0.044	0.798AsnLys: 0.798 ± 0.034	2.726AsnLeu: 2.726 ± 0.057	0.504AsnMet: 0.504 ± 0.025	0.712AsnAsn: 0.712 ± 0.033	1.847AsnPro: 1.847 ± 0.05	0.839AsnGln: 0.839 ± 0.034	1.867AsnArg: 1.867 ± 0.044	0.991AsnSer: 0.991 ± 0.039	1.227AsnThr: 1.227 ± 0.042	1.976AsnVal: 1.976 ± 0.058	0.385AsnTrp: 0.385 ± 0.022	0.639AsnTyr: 0.639 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.202ProAla: 7.202 ± 0.127	0.402ProCys: 0.402 ± 0.021	3.423ProAsp: 3.423 ± 0.069	3.387ProGlu: 3.387 ± 0.075	1.974ProPhe: 1.974 ± 0.049	4.129ProGly: 4.129 ± 0.071	1.054ProHis: 1.054 ± 0.034	1.752ProIle: 1.752 ± 0.049	1.4ProLys: 1.4 ± 0.043	5.711ProLeu: 5.711 ± 0.115	1.027ProMet: 1.027 ± 0.034	1.236ProAsn: 1.236 ± 0.04	2.403ProPro: 2.403 ± 0.064	1.721ProGln: 1.721 ± 0.047	2.929ProArg: 2.929 ± 0.074	2.263ProSer: 2.263 ± 0.045	2.111ProThr: 2.111 ± 0.058	4.324ProVal: 4.324 ± 0.082	0.697ProTrp: 0.697 ± 0.028	1.196ProTyr: 1.196 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.058GlnAla: 4.058 ± 0.076	0.214GlnCys: 0.214 ± 0.015	1.4GlnAsp: 1.4 ± 0.046	1.333GlnGlu: 1.333 ± 0.041	1.07GlnPhe: 1.07 ± 0.038	2.591GlnGly: 2.591 ± 0.056	0.821GlnHis: 0.821 ± 0.03	1.575GlnIle: 1.575 ± 0.045	1.175GlnLys: 1.175 ± 0.041	3.922GlnLeu: 3.922 ± 0.073	0.858GlnMet: 0.858 ± 0.031	0.77GlnAsn: 0.77 ± 0.03	1.757GlnPro: 1.757 ± 0.054	1.423GlnGln: 1.423 ± 0.053	2.542GlnArg: 2.542 ± 0.06	1.612GlnSer: 1.612 ± 0.042	1.704GlnThr: 1.704 ± 0.039	2.291GlnVal: 2.291 ± 0.054	0.461GlnTrp: 0.461 ± 0.022	0.72GlnTyr: 0.72 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	8.818ArgAla: 8.818 ± 0.135	0.578ArgCys: 0.578 ± 0.026	4.42ArgAsp: 4.42 ± 0.073	4.696ArgGlu: 4.696 ± 0.078	3.253ArgPhe: 3.253 ± 0.071	4.528ArgGly: 4.528 ± 0.07	2.02ArgHis: 2.02 ± 0.05	3.012ArgIle: 3.012 ± 0.058	1.841ArgLys: 1.841 ± 0.049	9.387ArgLeu: 9.387 ± 0.156	1.625ArgMet: 1.625 ± 0.043	1.551ArgAsn: 1.551 ± 0.04	3.392ArgPro: 3.392 ± 0.069	2.847ArgGln: 2.847 ± 0.061	6.046ArgArg: 6.046 ± 0.118	2.561ArgSer: 2.561 ± 0.064	2.607ArgThr: 2.607 ± 0.055	5.848ArgVal: 5.848 ± 0.085	1.102ArgTrp: 1.102 ± 0.04	2.211ArgTyr: 2.211 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.066SerAla: 6.066 ± 0.1	0.42SerCys: 0.42 ± 0.021	2.396SerAsp: 2.396 ± 0.057	2.374SerGlu: 2.374 ± 0.059	1.796SerPhe: 1.796 ± 0.047	4.84SerGly: 4.84 ± 0.068	1.06SerHis: 1.06 ± 0.035	1.849SerIle: 1.849 ± 0.048	1.295SerLys: 1.295 ± 0.041	5.692SerLeu: 5.692 ± 0.092	0.997SerMet: 0.997 ± 0.037	1.236SerAsn: 1.236 ± 0.042	2.523SerPro: 2.523 ± 0.057	1.623SerGln: 1.623 ± 0.042	3.657SerArg: 3.657 ± 0.074	2.245SerSer: 2.245 ± 0.061	2.208SerThr: 2.208 ± 0.049	3.483SerVal: 3.483 ± 0.073	0.598SerTrp: 0.598 ± 0.03	1.215SerTyr: 1.215 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.249ThrAla: 5.249 ± 0.097	0.343ThrCys: 0.343 ± 0.024	2.165ThrAsp: 2.165 ± 0.053	2.177ThrGlu: 2.177 ± 0.059	1.617ThrPhe: 1.617 ± 0.049	4.22ThrGly: 4.22 ± 0.081	1.027ThrHis: 1.027 ± 0.036	1.889ThrIle: 1.889 ± 0.051	0.944ThrLys: 0.944 ± 0.036	7.013ThrLeu: 7.013 ± 0.118	0.934ThrMet: 0.934 ± 0.035	0.935ThrAsn: 0.935 ± 0.036	3.127ThrPro: 3.127 ± 0.069	1.469ThrGln: 1.469 ± 0.043	3.498ThrArg: 3.498 ± 0.076	1.939ThrSer: 1.939 ± 0.045	2.121ThrThr: 2.121 ± 0.064	4.484ThrVal: 4.484 ± 0.076	0.469ThrTrp: 0.469 ± 0.022	0.878ThrTyr: 0.878 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	11.083ValAla: 11.083 ± 0.13	0.76ValCys: 0.76 ± 0.031	4.879ValAsp: 4.879 ± 0.08	4.999ValGlu: 4.999 ± 0.091	2.78ValPhe: 2.78 ± 0.061	6.253ValGly: 6.253 ± 0.106	1.398ValHis: 1.398 ± 0.046	3.355ValIle: 3.355 ± 0.08	2.893ValLys: 2.893 ± 0.074	8.012ValLeu: 8.012 ± 0.103	1.691ValMet: 1.691 ± 0.044	2.234ValAsn: 2.234 ± 0.058	3.669ValPro: 3.669 ± 0.071	1.939ValGln: 1.939 ± 0.048	5.114ValArg: 5.114 ± 0.083	4.127ValSer: 4.127 ± 0.078	3.861ValThr: 3.861 ± 0.076	6.527ValVal: 6.527 ± 0.108	0.991ValTrp: 0.991 ± 0.036	1.768ValTyr: 1.768 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.229TrpAla: 1.229 ± 0.039	0.159TrpCys: 0.159 ± 0.014	0.534TrpAsp: 0.534 ± 0.026	0.528TrpGlu: 0.528 ± 0.03	0.523TrpPhe: 0.523 ± 0.027	0.895TrpGly: 0.895 ± 0.036	0.377TrpHis: 0.377 ± 0.021	0.529TrpIle: 0.529 ± 0.024	0.403TrpLys: 0.403 ± 0.023	2.385TrpLeu: 2.385 ± 0.07	0.326TrpMet: 0.326 ± 0.02	0.323TrpAsn: 0.323 ± 0.021	0.7TrpPro: 0.7 ± 0.032	0.823TrpGln: 0.823 ± 0.033	1.393TrpArg: 1.393 ± 0.049	0.6TrpSer: 0.6 ± 0.026	0.523TrpThr: 0.523 ± 0.027	0.839TrpVal: 0.839 ± 0.03	0.247TrpTrp: 0.247 ± 0.017	0.276TrpTyr: 0.276 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.677TyrAla: 2.677 ± 0.063	0.235TyrCys: 0.235 ± 0.016	1.358TyrAsp: 1.358 ± 0.046	1.126TyrGlu: 1.126 ± 0.04	0.957TyrPhe: 0.957 ± 0.041	2.065TyrGly: 2.065 ± 0.051	0.553TyrHis: 0.553 ± 0.027	0.79TyrIle: 0.79 ± 0.03	0.693TyrLys: 0.693 ± 0.03	2.889TyrLeu: 2.889 ± 0.056	0.363TyrMet: 0.363 ± 0.022	0.596TyrAsn: 0.596 ± 0.027	1.344TyrPro: 1.344 ± 0.039	1.011TyrGln: 1.011 ± 0.034	2.106TyrArg: 2.106 ± 0.049	1.054TyrSer: 1.054 ± 0.035	1.19TyrThr: 1.19 ± 0.04	1.57TyrVal: 1.57 ± 0.048	0.364TyrTrp: 0.364 ± 0.022	0.616TyrTyr: 0.616 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2660 proteins (835546 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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