Amino acid dipepetide frequency for Klebsiella phage ST16-OXA48phi5.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.345AlaAla: 11.345 ± 1.036
1.141AlaCys: 1.141 ± 0.281
5.763AlaAsp: 5.763 ± 0.629
7.203AlaGlu: 7.203 ± 0.948
3.302AlaPhe: 3.302 ± 0.473
6.963AlaGly: 6.963 ± 0.677
1.561AlaHis: 1.561 ± 0.316
6.963AlaIle: 6.963 ± 0.796
3.962AlaLys: 3.962 ± 0.456
10.025AlaLeu: 10.025 ± 0.744
2.941AlaMet: 2.941 ± 0.415
3.782AlaAsn: 3.782 ± 0.458
3.782AlaPro: 3.782 ± 0.468
5.763AlaGln: 5.763 ± 0.835
5.402AlaArg: 5.402 ± 0.654
5.463AlaSer: 5.463 ± 0.571
5.042AlaThr: 5.042 ± 0.717
8.224AlaVal: 8.224 ± 0.626
1.741AlaTrp: 1.741 ± 0.363
2.461AlaTyr: 2.461 ± 0.384
0.0AlaXaa: 0.0 ± 0.0
Cys
0.84CysAla: 0.84 ± 0.203
0.36CysCys: 0.36 ± 0.146
0.9CysAsp: 0.9 ± 0.284
0.96CysGlu: 0.96 ± 0.285
0.3CysPhe: 0.3 ± 0.127
1.261CysGly: 1.261 ± 0.309
0.24CysHis: 0.24 ± 0.103
0.72CysIle: 0.72 ± 0.216
0.6CysLys: 0.6 ± 0.213
0.54CysLeu: 0.54 ± 0.175
0.24CysMet: 0.24 ± 0.128
0.6CysAsn: 0.6 ± 0.196
1.02CysPro: 1.02 ± 0.197
0.54CysGln: 0.54 ± 0.185
1.681CysArg: 1.681 ± 0.287
0.96CysSer: 0.96 ± 0.282
0.36CysThr: 0.36 ± 0.142
0.66CysVal: 0.66 ± 0.166
0.12CysTrp: 0.12 ± 0.079
0.54CysTyr: 0.54 ± 0.164
0.0CysXaa: 0.0 ± 0.0
Asp
6.063AspAla: 6.063 ± 0.675
0.6AspCys: 0.6 ± 0.198
4.022AspAsp: 4.022 ± 0.656
5.282AspGlu: 5.282 ± 0.622
2.281AspPhe: 2.281 ± 0.34
4.802AspGly: 4.802 ± 0.547
1.201AspHis: 1.201 ± 0.282
3.662AspIle: 3.662 ± 0.417
3.061AspLys: 3.061 ± 0.598
4.262AspLeu: 4.262 ± 0.536
1.921AspMet: 1.921 ± 0.36
1.981AspAsn: 1.981 ± 0.373
2.821AspPro: 2.821 ± 0.455
2.281AspGln: 2.281 ± 0.451
2.701AspArg: 2.701 ± 0.36
2.881AspSer: 2.881 ± 0.402
2.821AspThr: 2.821 ± 0.343
3.842AspVal: 3.842 ± 0.587
1.201AspTrp: 1.201 ± 0.293
2.521AspTyr: 2.521 ± 0.472
0.0AspXaa: 0.0 ± 0.0
Glu
6.723GluAla: 6.723 ± 0.722
0.84GluCys: 0.84 ± 0.291
2.821GluAsp: 2.821 ± 0.492
3.241GluGlu: 3.241 ± 0.514
1.741GluPhe: 1.741 ± 0.257
3.662GluGly: 3.662 ± 0.553
0.84GluHis: 0.84 ± 0.198
3.962GluIle: 3.962 ± 0.479
3.362GluLys: 3.362 ± 0.591
6.063GluLeu: 6.063 ± 0.62
1.921GluMet: 1.921 ± 0.311
2.521GluAsn: 2.521 ± 0.349
2.221GluPro: 2.221 ± 0.426
3.362GluGln: 3.362 ± 0.608
4.622GluArg: 4.622 ± 0.506
3.482GluSer: 3.482 ± 0.489
3.722GluThr: 3.722 ± 0.567
3.962GluVal: 3.962 ± 0.566
1.681GluTrp: 1.681 ± 0.316
2.041GluTyr: 2.041 ± 0.456
0.0GluXaa: 0.0 ± 0.0
Phe
3.602PheAla: 3.602 ± 0.416
0.48PheCys: 0.48 ± 0.148
2.881PheAsp: 2.881 ± 0.379
0.9PheGlu: 0.9 ± 0.278
1.141PhePhe: 1.141 ± 0.228
2.401PheGly: 2.401 ± 0.387
0.66PheHis: 0.66 ± 0.171
1.141PheIle: 1.141 ± 0.257
1.381PheLys: 1.381 ± 0.274
3.181PheLeu: 3.181 ± 0.464
0.72PheMet: 0.72 ± 0.2
1.681PheAsn: 1.681 ± 0.232
1.681PhePro: 1.681 ± 0.337
1.501PheGln: 1.501 ± 0.286
2.221PheArg: 2.221 ± 0.373
2.041PheSer: 2.041 ± 0.389
2.581PheThr: 2.581 ± 0.445
2.041PheVal: 2.041 ± 0.387
0.6PheTrp: 0.6 ± 0.177
0.96PheTyr: 0.96 ± 0.221
0.0PheXaa: 0.0 ± 0.0
Gly
6.483GlyAla: 6.483 ± 0.847
0.72GlyCys: 0.72 ± 0.197
3.902GlyAsp: 3.902 ± 0.52
4.922GlyGlu: 4.922 ± 0.606
3.302GlyPhe: 3.302 ± 0.569
5.042GlyGly: 5.042 ± 0.671
1.321GlyHis: 1.321 ± 0.356
3.722GlyIle: 3.722 ± 0.485
5.042GlyLys: 5.042 ± 0.486
6.003GlyLeu: 6.003 ± 0.745
1.981GlyMet: 1.981 ± 0.299
1.981GlyAsn: 1.981 ± 0.341
2.221GlyPro: 2.221 ± 0.386
2.281GlyGln: 2.281 ± 0.371
3.962GlyArg: 3.962 ± 0.431
4.142GlySer: 4.142 ± 0.647
3.602GlyThr: 3.602 ± 0.594
5.823GlyVal: 5.823 ± 0.55
1.561GlyTrp: 1.561 ± 0.286
2.281GlyTyr: 2.281 ± 0.37
0.0GlyXaa: 0.0 ± 0.0
His
1.381HisAla: 1.381 ± 0.222
0.3HisCys: 0.3 ± 0.129
1.261HisAsp: 1.261 ± 0.272
0.84HisGlu: 0.84 ± 0.182
1.08HisPhe: 1.08 ± 0.253
1.321HisGly: 1.321 ± 0.246
0.6HisHis: 0.6 ± 0.196
0.78HisIle: 0.78 ± 0.252
0.96HisLys: 0.96 ± 0.225
1.501HisLeu: 1.501 ± 0.35
0.3HisMet: 0.3 ± 0.116
0.6HisAsn: 0.6 ± 0.197
1.201HisPro: 1.201 ± 0.215
0.6HisGln: 0.6 ± 0.183
1.141HisArg: 1.141 ± 0.254
0.78HisSer: 0.78 ± 0.21
0.66HisThr: 0.66 ± 0.205
1.08HisVal: 1.08 ± 0.285
0.72HisTrp: 0.72 ± 0.225
0.9HisTyr: 0.9 ± 0.22
0.0HisXaa: 0.0 ± 0.0
Ile
6.123IleAla: 6.123 ± 0.613
1.321IleCys: 1.321 ± 0.299
4.322IleAsp: 4.322 ± 0.503
2.581IleGlu: 2.581 ± 0.378
1.141IlePhe: 1.141 ± 0.313
3.302IleGly: 3.302 ± 0.466
0.72IleHis: 0.72 ± 0.174
3.001IleIle: 3.001 ± 0.384
2.761IleLys: 2.761 ± 0.417
3.722IleLeu: 3.722 ± 0.538
0.9IleMet: 0.9 ± 0.219
2.101IleAsn: 2.101 ± 0.36
2.221IlePro: 2.221 ± 0.417
2.041IleGln: 2.041 ± 0.393
3.662IleArg: 3.662 ± 0.458
3.722IleSer: 3.722 ± 0.503
4.802IleThr: 4.802 ± 0.67
3.241IleVal: 3.241 ± 0.344
0.54IleTrp: 0.54 ± 0.164
1.621IleTyr: 1.621 ± 0.281
0.0IleXaa: 0.0 ± 0.0
Lys
5.342LysAla: 5.342 ± 0.855
0.96LysCys: 0.96 ± 0.261
2.161LysAsp: 2.161 ± 0.376
3.422LysGlu: 3.422 ± 0.511
1.441LysPhe: 1.441 ± 0.278
3.602LysGly: 3.602 ± 0.587
1.321LysHis: 1.321 ± 0.255
1.921LysIle: 1.921 ± 0.309
2.821LysLys: 2.821 ± 0.453
4.502LysLeu: 4.502 ± 0.492
1.441LysMet: 1.441 ± 0.331
1.381LysAsn: 1.381 ± 0.309
2.881LysPro: 2.881 ± 0.396
2.461LysGln: 2.461 ± 0.354
3.362LysArg: 3.362 ± 0.437
2.641LysSer: 2.641 ± 0.351
3.482LysThr: 3.482 ± 0.64
3.061LysVal: 3.061 ± 0.44
0.6LysTrp: 0.6 ± 0.173
1.501LysTyr: 1.501 ± 0.325
0.0LysXaa: 0.0 ± 0.0
Leu
9.544LeuAla: 9.544 ± 0.747
1.201LeuCys: 1.201 ± 0.283
5.523LeuAsp: 5.523 ± 0.532
6.123LeuGlu: 6.123 ± 0.688
3.181LeuPhe: 3.181 ± 0.508
6.603LeuGly: 6.603 ± 0.884
1.561LeuHis: 1.561 ± 0.297
4.862LeuIle: 4.862 ± 0.691
4.982LeuLys: 4.982 ± 0.768
8.824LeuLeu: 8.824 ± 0.962
1.441LeuMet: 1.441 ± 0.319
3.902LeuAsn: 3.902 ± 0.411
4.682LeuPro: 4.682 ± 0.626
3.722LeuGln: 3.722 ± 0.472
5.102LeuArg: 5.102 ± 0.545
6.123LeuSer: 6.123 ± 0.741
5.823LeuThr: 5.823 ± 0.664
4.982LeuVal: 4.982 ± 0.546
0.84LeuTrp: 0.84 ± 0.219
1.681LeuTyr: 1.681 ± 0.382
0.0LeuXaa: 0.0 ± 0.0
Met
2.761MetAla: 2.761 ± 0.373
0.18MetCys: 0.18 ± 0.132
0.96MetAsp: 0.96 ± 0.279
0.84MetGlu: 0.84 ± 0.236
0.9MetPhe: 0.9 ± 0.217
1.201MetGly: 1.201 ± 0.369
0.42MetHis: 0.42 ± 0.153
1.441MetIle: 1.441 ± 0.243
1.501MetLys: 1.501 ± 0.291
2.701MetLeu: 2.701 ± 0.463
0.9MetMet: 0.9 ± 0.209
0.9MetAsn: 0.9 ± 0.242
1.201MetPro: 1.201 ± 0.284
1.02MetGln: 1.02 ± 0.325
1.561MetArg: 1.561 ± 0.324
2.161MetSer: 2.161 ± 0.413
2.281MetThr: 2.281 ± 0.377
1.801MetVal: 1.801 ± 0.353
0.24MetTrp: 0.24 ± 0.133
0.6MetTyr: 0.6 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
3.782AsnAla: 3.782 ± 0.45
0.36AsnCys: 0.36 ± 0.142
2.701AsnAsp: 2.701 ± 0.39
2.401AsnGlu: 2.401 ± 0.381
0.6AsnPhe: 0.6 ± 0.206
3.241AsnGly: 3.241 ± 0.503
0.72AsnHis: 0.72 ± 0.201
1.921AsnIle: 1.921 ± 0.464
1.921AsnLys: 1.921 ± 0.342
2.821AsnLeu: 2.821 ± 0.385
0.72AsnMet: 0.72 ± 0.203
1.321AsnAsn: 1.321 ± 0.279
2.161AsnPro: 2.161 ± 0.425
1.561AsnGln: 1.561 ± 0.337
1.741AsnArg: 1.741 ± 0.402
1.981AsnSer: 1.981 ± 0.4
2.221AsnThr: 2.221 ± 0.371
2.101AsnVal: 2.101 ± 0.314
0.42AsnTrp: 0.42 ± 0.147
1.02AsnTyr: 1.02 ± 0.231
0.0AsnXaa: 0.0 ± 0.0
Pro
5.643ProAla: 5.643 ± 0.607
0.36ProCys: 0.36 ± 0.177
3.782ProAsp: 3.782 ± 0.474
3.362ProGlu: 3.362 ± 0.499
1.621ProPhe: 1.621 ± 0.356
3.302ProGly: 3.302 ± 0.632
1.201ProHis: 1.201 ± 0.246
1.321ProIle: 1.321 ± 0.236
1.981ProLys: 1.981 ± 0.364
3.722ProLeu: 3.722 ± 0.55
0.54ProMet: 0.54 ± 0.167
1.141ProAsn: 1.141 ± 0.263
1.561ProPro: 1.561 ± 0.298
1.141ProGln: 1.141 ± 0.359
2.341ProArg: 2.341 ± 0.397
1.981ProSer: 1.981 ± 0.317
2.341ProThr: 2.341 ± 0.4
3.902ProVal: 3.902 ± 0.556
0.78ProTrp: 0.78 ± 0.221
1.08ProTyr: 1.08 ± 0.29
0.0ProXaa: 0.0 ± 0.0
Gln
4.382GlnAla: 4.382 ± 0.537
0.3GlnCys: 0.3 ± 0.117
2.281GlnAsp: 2.281 ± 0.351
2.341GlnGlu: 2.341 ± 0.399
1.08GlnPhe: 1.08 ± 0.223
2.341GlnGly: 2.341 ± 0.311
0.6GlnHis: 0.6 ± 0.192
2.821GlnIle: 2.821 ± 0.483
2.521GlnLys: 2.521 ± 0.537
5.102GlnLeu: 5.102 ± 0.647
1.561GlnMet: 1.561 ± 0.268
1.201GlnAsn: 1.201 ± 0.259
1.621GlnPro: 1.621 ± 0.354
3.602GlnGln: 3.602 ± 0.887
3.482GlnArg: 3.482 ± 0.475
2.641GlnSer: 2.641 ± 0.445
2.761GlnThr: 2.761 ± 0.368
2.341GlnVal: 2.341 ± 0.457
0.72GlnTrp: 0.72 ± 0.185
1.201GlnTyr: 1.201 ± 0.267
0.0GlnXaa: 0.0 ± 0.0
Arg
6.543ArgAla: 6.543 ± 0.616
1.08ArgCys: 1.08 ± 0.214
3.422ArgAsp: 3.422 ± 0.544
3.722ArgGlu: 3.722 ± 0.498
2.221ArgPhe: 2.221 ± 0.407
3.722ArgGly: 3.722 ± 0.402
1.261ArgHis: 1.261 ± 0.26
3.241ArgIle: 3.241 ± 0.32
3.121ArgLys: 3.121 ± 0.436
6.363ArgLeu: 6.363 ± 0.702
2.401ArgMet: 2.401 ± 0.347
2.281ArgAsn: 2.281 ± 0.394
1.261ArgPro: 1.261 ± 0.292
3.181ArgGln: 3.181 ± 0.593
5.703ArgArg: 5.703 ± 0.796
3.121ArgSer: 3.121 ± 0.448
2.761ArgThr: 2.761 ± 0.361
3.662ArgVal: 3.662 ± 0.432
1.02ArgTrp: 1.02 ± 0.272
2.461ArgTyr: 2.461 ± 0.427
0.0ArgXaa: 0.0 ± 0.0
Ser
5.463SerAla: 5.463 ± 0.62
0.66SerCys: 0.66 ± 0.169
4.142SerAsp: 4.142 ± 0.367
3.542SerGlu: 3.542 ± 0.394
2.101SerPhe: 2.101 ± 0.475
5.042SerGly: 5.042 ± 0.719
0.84SerHis: 0.84 ± 0.19
2.941SerIle: 2.941 ± 0.4
3.061SerLys: 3.061 ± 0.548
4.982SerLeu: 4.982 ± 0.476
1.861SerMet: 1.861 ± 0.305
2.161SerAsn: 2.161 ± 0.332
2.761SerPro: 2.761 ± 0.409
2.161SerGln: 2.161 ± 0.364
3.842SerArg: 3.842 ± 0.505
4.322SerSer: 4.322 ± 0.67
4.742SerThr: 4.742 ± 0.684
3.542SerVal: 3.542 ± 0.53
1.321SerTrp: 1.321 ± 0.253
1.201SerTyr: 1.201 ± 0.274
0.0SerXaa: 0.0 ± 0.0
Thr
7.083ThrAla: 7.083 ± 0.822
0.48ThrCys: 0.48 ± 0.176
4.022ThrAsp: 4.022 ± 0.448
4.562ThrGlu: 4.562 ± 0.528
2.641ThrPhe: 2.641 ± 0.582
5.463ThrGly: 5.463 ± 0.713
1.02ThrHis: 1.02 ± 0.252
3.241ThrIle: 3.241 ± 0.568
1.621ThrLys: 1.621 ± 0.32
6.123ThrLeu: 6.123 ± 0.543
1.08ThrMet: 1.08 ± 0.192
1.321ThrAsn: 1.321 ± 0.224
3.001ThrPro: 3.001 ± 0.576
2.461ThrGln: 2.461 ± 0.396
2.881ThrArg: 2.881 ± 0.381
3.902ThrSer: 3.902 ± 0.596
3.061ThrThr: 3.061 ± 0.463
4.862ThrVal: 4.862 ± 0.631
1.08ThrTrp: 1.08 ± 0.248
1.141ThrTyr: 1.141 ± 0.23
0.0ThrXaa: 0.0 ± 0.0
Val
5.643ValAla: 5.643 ± 0.692
0.9ValCys: 0.9 ± 0.219
3.181ValAsp: 3.181 ± 0.522
4.322ValGlu: 4.322 ± 0.592
1.921ValPhe: 1.921 ± 0.345
4.682ValGly: 4.682 ± 0.593
0.9ValHis: 0.9 ± 0.215
3.482ValIle: 3.482 ± 0.428
3.782ValLys: 3.782 ± 0.56
6.363ValLeu: 6.363 ± 0.804
1.561ValMet: 1.561 ± 0.334
2.941ValAsn: 2.941 ± 0.459
2.581ValPro: 2.581 ± 0.455
2.221ValGln: 2.221 ± 0.454
3.482ValArg: 3.482 ± 0.422
5.583ValSer: 5.583 ± 0.585
5.463ValThr: 5.463 ± 0.604
3.602ValVal: 3.602 ± 0.504
0.9ValTrp: 0.9 ± 0.288
1.681ValTyr: 1.681 ± 0.357
0.0ValXaa: 0.0 ± 0.0
Trp
1.741TrpAla: 1.741 ± 0.319
0.48TrpCys: 0.48 ± 0.145
0.48TrpAsp: 0.48 ± 0.174
1.08TrpGlu: 1.08 ± 0.28
0.96TrpPhe: 0.96 ± 0.283
0.78TrpGly: 0.78 ± 0.272
0.24TrpHis: 0.24 ± 0.133
1.08TrpIle: 1.08 ± 0.28
0.6TrpLys: 0.6 ± 0.188
1.801TrpLeu: 1.801 ± 0.365
0.42TrpMet: 0.42 ± 0.178
1.08TrpAsn: 1.08 ± 0.278
0.66TrpPro: 0.66 ± 0.204
1.141TrpGln: 1.141 ± 0.271
1.381TrpArg: 1.381 ± 0.323
0.78TrpSer: 0.78 ± 0.189
0.78TrpThr: 0.78 ± 0.188
1.02TrpVal: 1.02 ± 0.227
0.24TrpTrp: 0.24 ± 0.116
0.36TrpTyr: 0.36 ± 0.14
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.341TyrAla: 2.341 ± 0.404
0.72TyrCys: 0.72 ± 0.212
1.741TyrAsp: 1.741 ± 0.347
1.141TyrGlu: 1.141 ± 0.218
0.84TyrPhe: 0.84 ± 0.238
1.561TyrGly: 1.561 ± 0.376
0.78TyrHis: 0.78 ± 0.31
1.621TyrIle: 1.621 ± 0.288
1.261TyrLys: 1.261 ± 0.331
2.101TyrLeu: 2.101 ± 0.342
0.66TyrMet: 0.66 ± 0.219
0.84TyrAsn: 0.84 ± 0.242
1.561TyrPro: 1.561 ± 0.468
1.861TyrGln: 1.861 ± 0.379
2.281TyrArg: 2.281 ± 0.401
1.981TyrSer: 1.981 ± 0.328
1.741TyrThr: 1.741 ± 0.304
1.441TyrVal: 1.441 ± 0.248
0.78TyrTrp: 0.78 ± 0.219
0.66TyrTyr: 0.66 ± 0.198
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (16660 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski