Amino acid dipepetide frequency for Pseudidiomarina indica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.454AlaAla: 11.454 ± 0.182
0.91AlaCys: 0.91 ± 0.037
5.497AlaAsp: 5.497 ± 0.083
7.146AlaGlu: 7.146 ± 0.115
3.399AlaPhe: 3.399 ± 0.083
7.124AlaGly: 7.124 ± 0.109
2.205AlaHis: 2.205 ± 0.055
6.128AlaIle: 6.128 ± 0.107
3.892AlaLys: 3.892 ± 0.087
10.92AlaLeu: 10.92 ± 0.154
2.782AlaMet: 2.782 ± 0.064
3.206AlaAsn: 3.206 ± 0.07
3.874AlaPro: 3.874 ± 0.089
5.697AlaGln: 5.697 ± 0.091
5.04AlaArg: 5.04 ± 0.088
4.965AlaSer: 4.965 ± 0.095
5.572AlaThr: 5.572 ± 0.099
7.211AlaVal: 7.211 ± 0.117
1.248AlaTrp: 1.248 ± 0.044
2.585AlaTyr: 2.585 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.82CysAla: 0.82 ± 0.035
0.122CysCys: 0.122 ± 0.016
0.516CysAsp: 0.516 ± 0.029
0.516CysGlu: 0.516 ± 0.027
0.363CysPhe: 0.363 ± 0.023
0.757CysGly: 0.757 ± 0.037
0.298CysHis: 0.298 ± 0.025
0.432CysIle: 0.432 ± 0.029
0.241CysLys: 0.241 ± 0.02
0.766CysLeu: 0.766 ± 0.037
0.173CysMet: 0.173 ± 0.016
0.213CysAsn: 0.213 ± 0.018
0.428CysPro: 0.428 ± 0.025
0.437CysGln: 0.437 ± 0.026
0.488CysArg: 0.488 ± 0.026
0.501CysSer: 0.501 ± 0.029
0.412CysThr: 0.412 ± 0.023
0.594CysVal: 0.594 ± 0.031
0.126CysTrp: 0.126 ± 0.014
0.323CysTyr: 0.323 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
5.1AspAla: 5.1 ± 0.108
0.448AspCys: 0.448 ± 0.025
3.104AspAsp: 3.104 ± 0.075
3.753AspGlu: 3.753 ± 0.081
2.242AspPhe: 2.242 ± 0.057
3.753AspGly: 3.753 ± 0.088
1.342AspHis: 1.342 ± 0.047
3.414AspIle: 3.414 ± 0.075
1.957AspLys: 1.957 ± 0.068
4.888AspLeu: 4.888 ± 0.101
1.364AspMet: 1.364 ± 0.048
1.738AspAsn: 1.738 ± 0.052
2.349AspPro: 2.349 ± 0.066
2.145AspGln: 2.145 ± 0.047
2.533AspArg: 2.533 ± 0.065
2.557AspSer: 2.557 ± 0.062
2.496AspThr: 2.496 ± 0.064
3.946AspVal: 3.946 ± 0.067
0.904AspTrp: 0.904 ± 0.038
2.113AspTyr: 2.113 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.735GluAla: 5.735 ± 0.111
0.418GluCys: 0.418 ± 0.029
2.305GluAsp: 2.305 ± 0.059
3.393GluGlu: 3.393 ± 0.083
2.539GluPhe: 2.539 ± 0.064
3.339GluGly: 3.339 ± 0.081
1.817GluHis: 1.817 ± 0.052
3.406GluIle: 3.406 ± 0.08
2.339GluLys: 2.339 ± 0.064
7.927GluLeu: 7.927 ± 0.112
1.498GluMet: 1.498 ± 0.047
2.036GluAsn: 2.036 ± 0.06
2.49GluPro: 2.49 ± 0.066
5.1GluGln: 5.1 ± 0.099
4.646GluArg: 4.646 ± 0.096
2.762GluSer: 2.762 ± 0.065
2.92GluThr: 2.92 ± 0.074
4.431GluVal: 4.431 ± 0.092
0.754GluTrp: 0.754 ± 0.037
1.527GluTyr: 1.527 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.883PheAla: 3.883 ± 0.09
0.345PheCys: 0.345 ± 0.02
2.402PheAsp: 2.402 ± 0.057
2.299PheGlu: 2.299 ± 0.062
1.467PhePhe: 1.467 ± 0.059
3.095PheGly: 3.095 ± 0.071
0.878PheHis: 0.878 ± 0.034
2.501PheIle: 2.501 ± 0.068
1.444PheLys: 1.444 ± 0.054
3.112PheLeu: 3.112 ± 0.079
0.981PheMet: 0.981 ± 0.033
1.579PheAsn: 1.579 ± 0.052
1.414PhePro: 1.414 ± 0.045
1.401PheGln: 1.401 ± 0.046
1.798PheArg: 1.798 ± 0.054
2.545PheSer: 2.545 ± 0.07
2.327PheThr: 2.327 ± 0.065
2.69PheVal: 2.69 ± 0.069
0.557PheTrp: 0.557 ± 0.034
1.304PheTyr: 1.304 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
6.138GlyAla: 6.138 ± 0.126
0.767GlyCys: 0.767 ± 0.032
3.778GlyAsp: 3.778 ± 0.085
4.234GlyGlu: 4.234 ± 0.066
2.959GlyPhe: 2.959 ± 0.067
5.043GlyGly: 5.043 ± 0.101
1.802GlyHis: 1.802 ± 0.048
4.347GlyIle: 4.347 ± 0.088
3.015GlyLys: 3.015 ± 0.079
7.235GlyLeu: 7.235 ± 0.109
2.076GlyMet: 2.076 ± 0.055
2.177GlyAsn: 2.177 ± 0.079
2.054GlyPro: 2.054 ± 0.058
3.345GlyGln: 3.345 ± 0.068
3.822GlyArg: 3.822 ± 0.082
3.724GlySer: 3.724 ± 0.078
3.684GlyThr: 3.684 ± 0.085
5.779GlyVal: 5.779 ± 0.102
1.044GlyTrp: 1.044 ± 0.039
2.535GlyTyr: 2.535 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
2.308HisAla: 2.308 ± 0.063
0.338HisCys: 0.338 ± 0.023
1.37HisAsp: 1.37 ± 0.05
1.601HisGlu: 1.601 ± 0.049
1.028HisPhe: 1.028 ± 0.038
1.967HisGly: 1.967 ± 0.059
0.891HisHis: 0.891 ± 0.049
1.276HisIle: 1.276 ± 0.039
0.778HisLys: 0.778 ± 0.036
2.582HisLeu: 2.582 ± 0.067
0.456HisMet: 0.456 ± 0.028
0.728HisAsn: 0.728 ± 0.034
1.492HisPro: 1.492 ± 0.051
1.645HisGln: 1.645 ± 0.053
1.451HisArg: 1.451 ± 0.048
1.247HisSer: 1.247 ± 0.048
1.154HisThr: 1.154 ± 0.042
1.597HisVal: 1.597 ± 0.056
0.522HisTrp: 0.522 ± 0.03
1.034HisTyr: 1.034 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.597IleAla: 6.597 ± 0.093
0.523IleCys: 0.523 ± 0.03
3.674IleAsp: 3.674 ± 0.084
4.137IleGlu: 4.137 ± 0.085
1.899IlePhe: 1.899 ± 0.06
4.528IleGly: 4.528 ± 0.105
1.389IleHis: 1.389 ± 0.046
3.177IleIle: 3.177 ± 0.084
2.061IleLys: 2.061 ± 0.064
5.004IleLeu: 5.004 ± 0.104
1.247IleMet: 1.247 ± 0.044
2.114IleAsn: 2.114 ± 0.064
2.737IlePro: 2.737 ± 0.069
2.577IleGln: 2.577 ± 0.067
3.199IleArg: 3.199 ± 0.068
3.237IleSer: 3.237 ± 0.084
3.324IleThr: 3.324 ± 0.07
4.011IleVal: 4.011 ± 0.087
0.575IleTrp: 0.575 ± 0.035
1.586IleTyr: 1.586 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
3.599LysAla: 3.599 ± 0.104
0.2LysCys: 0.2 ± 0.016
1.677LysAsp: 1.677 ± 0.059
2.163LysGlu: 2.163 ± 0.07
1.288LysPhe: 1.288 ± 0.045
2.232LysGly: 2.232 ± 0.065
0.92LysHis: 0.92 ± 0.037
1.98LysIle: 1.98 ± 0.061
1.766LysLys: 1.766 ± 0.058
3.905LysLeu: 3.905 ± 0.087
0.898LysMet: 0.898 ± 0.035
1.301LysAsn: 1.301 ± 0.054
1.883LysPro: 1.883 ± 0.052
2.196LysGln: 2.196 ± 0.062
2.41LysArg: 2.41 ± 0.069
1.944LysSer: 1.944 ± 0.051
1.967LysThr: 1.967 ± 0.055
2.889LysVal: 2.889 ± 0.083
0.394LysTrp: 0.394 ± 0.023
0.986LysTyr: 0.986 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
12.144LeuAla: 12.144 ± 0.153
0.844LeuCys: 0.844 ± 0.034
5.393LeuAsp: 5.393 ± 0.086
6.029LeuGlu: 6.029 ± 0.093
3.915LeuPhe: 3.915 ± 0.092
7.273LeuGly: 7.273 ± 0.125
2.442LeuHis: 2.442 ± 0.058
5.888LeuIle: 5.888 ± 0.114
4.105LeuLys: 4.105 ± 0.091
11.519LeuLeu: 11.519 ± 0.206
2.549LeuMet: 2.549 ± 0.069
3.89LeuAsn: 3.89 ± 0.075
5.269LeuPro: 5.269 ± 0.096
5.698LeuGln: 5.698 ± 0.12
6.053LeuArg: 6.053 ± 0.105
6.311LeuSer: 6.311 ± 0.098
6.779LeuThr: 6.779 ± 0.093
7.443LeuVal: 7.443 ± 0.118
1.25LeuTrp: 1.25 ± 0.048
2.59LeuTyr: 2.59 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.746MetAla: 2.746 ± 0.088
0.141MetCys: 0.141 ± 0.016
1.059MetAsp: 1.059 ± 0.042
1.135MetGlu: 1.135 ± 0.05
0.764MetPhe: 0.764 ± 0.035
1.647MetGly: 1.647 ± 0.051
0.515MetHis: 0.515 ± 0.028
1.366MetIle: 1.366 ± 0.049
1.138MetLys: 1.138 ± 0.047
2.671MetLeu: 2.671 ± 0.06
0.709MetMet: 0.709 ± 0.033
1.044MetAsn: 1.044 ± 0.038
1.269MetPro: 1.269 ± 0.045
1.294MetGln: 1.294 ± 0.042
1.473MetArg: 1.473 ± 0.044
1.63MetSer: 1.63 ± 0.054
1.654MetThr: 1.654 ± 0.05
1.807MetVal: 1.807 ± 0.054
0.228MetTrp: 0.228 ± 0.019
0.544MetTyr: 0.544 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.049AsnAla: 3.049 ± 0.085
0.284AsnCys: 0.284 ± 0.024
1.899AsnAsp: 1.899 ± 0.056
2.054AsnGlu: 2.054 ± 0.064
1.306AsnPhe: 1.306 ± 0.051
2.467AsnGly: 2.467 ± 0.061
0.895AsnHis: 0.895 ± 0.037
1.923AsnIle: 1.923 ± 0.057
1.297AsnLys: 1.297 ± 0.046
3.234AsnLeu: 3.234 ± 0.079
0.832AsnMet: 0.832 ± 0.033
1.276AsnAsn: 1.276 ± 0.05
1.98AsnPro: 1.98 ± 0.055
1.923AsnGln: 1.923 ± 0.056
1.921AsnArg: 1.921 ± 0.059
1.736AsnSer: 1.736 ± 0.064
1.797AsnThr: 1.797 ± 0.05
2.202AsnVal: 2.202 ± 0.063
0.494AsnTrp: 0.494 ± 0.024
1.203AsnTyr: 1.203 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
4.499ProAla: 4.499 ± 0.094
0.276ProCys: 0.276 ± 0.02
2.454ProAsp: 2.454 ± 0.063
3.362ProGlu: 3.362 ± 0.076
1.708ProPhe: 1.708 ± 0.049
2.834ProGly: 2.834 ± 0.069
1.151ProHis: 1.151 ± 0.042
2.595ProIle: 2.595 ± 0.06
1.527ProLys: 1.527 ± 0.056
4.844ProLeu: 4.844 ± 0.086
1.11ProMet: 1.11 ± 0.04
1.714ProAsn: 1.714 ± 0.05
1.72ProPro: 1.72 ± 0.06
2.402ProGln: 2.402 ± 0.063
1.994ProArg: 1.994 ± 0.054
2.496ProSer: 2.496 ± 0.056
2.63ProThr: 2.63 ± 0.07
3.437ProVal: 3.437 ± 0.079
0.665ProTrp: 0.665 ± 0.032
1.378ProTyr: 1.378 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
5.909GlnAla: 5.909 ± 0.095
0.435GlnCys: 0.435 ± 0.028
1.895GlnAsp: 1.895 ± 0.056
2.821GlnGlu: 2.821 ± 0.076
2.004GlnPhe: 2.004 ± 0.056
3.602GlnGly: 3.602 ± 0.08
1.813GlnHis: 1.813 ± 0.061
2.486GlnIle: 2.486 ± 0.06
1.492GlnLys: 1.492 ± 0.054
7.646GlnLeu: 7.646 ± 0.145
1.11GlnMet: 1.11 ± 0.036
1.295GlnAsn: 1.295 ± 0.041
2.796GlnPro: 2.796 ± 0.068
5.823GlnGln: 5.823 ± 0.128
4.253GlnArg: 4.253 ± 0.095
2.465GlnSer: 2.465 ± 0.063
2.374GlnThr: 2.374 ± 0.062
4.25GlnVal: 4.25 ± 0.09
0.998GlnTrp: 0.998 ± 0.043
1.379GlnTyr: 1.379 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
4.904ArgAla: 4.904 ± 0.076
0.438ArgCys: 0.438 ± 0.026
3.211ArgAsp: 3.211 ± 0.077
3.774ArgGlu: 3.774 ± 0.077
2.432ArgPhe: 2.432 ± 0.058
3.418ArgGly: 3.418 ± 0.072
1.586ArgHis: 1.586 ± 0.047
3.509ArgIle: 3.509 ± 0.075
1.996ArgLys: 1.996 ± 0.063
6.247ArgLeu: 6.247 ± 0.113
1.479ArgMet: 1.479 ± 0.045
1.916ArgAsn: 1.916 ± 0.061
2.245ArgPro: 2.245 ± 0.065
3.49ArgGln: 3.49 ± 0.078
3.547ArgArg: 3.547 ± 0.099
2.979ArgSer: 2.979 ± 0.069
2.552ArgThr: 2.552 ± 0.058
4.115ArgVal: 4.115 ± 0.087
1.035ArgTrp: 1.035 ± 0.049
2.213ArgTyr: 2.213 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.121SerAla: 5.121 ± 0.088
0.548SerCys: 0.548 ± 0.032
2.752SerAsp: 2.752 ± 0.073
3.046SerGlu: 3.046 ± 0.078
2.182SerPhe: 2.182 ± 0.062
4.202SerGly: 4.202 ± 0.082
1.342SerHis: 1.342 ± 0.047
3.006SerIle: 3.006 ± 0.08
1.958SerLys: 1.958 ± 0.064
5.763SerLeu: 5.763 ± 0.103
1.527SerMet: 1.527 ± 0.047
1.848SerAsn: 1.848 ± 0.062
2.396SerPro: 2.396 ± 0.062
2.632SerGln: 2.632 ± 0.066
2.827SerArg: 2.827 ± 0.061
3.343SerSer: 3.343 ± 0.089
2.739SerThr: 2.739 ± 0.066
3.897SerVal: 3.897 ± 0.088
0.81SerTrp: 0.81 ± 0.034
1.801SerTyr: 1.801 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
5.57ThrAla: 5.57 ± 0.095
0.398ThrCys: 0.398 ± 0.027
3.02ThrAsp: 3.02 ± 0.066
3.205ThrGlu: 3.205 ± 0.069
1.923ThrPhe: 1.923 ± 0.055
4.118ThrGly: 4.118 ± 0.088
1.355ThrHis: 1.355 ± 0.048
3.234ThrIle: 3.234 ± 0.064
1.683ThrLys: 1.683 ± 0.058
6.086ThrLeu: 6.086 ± 0.093
1.156ThrMet: 1.156 ± 0.043
1.652ThrAsn: 1.652 ± 0.054
3.205ThrPro: 3.205 ± 0.084
2.576ThrGln: 2.576 ± 0.061
2.689ThrArg: 2.689 ± 0.067
2.877ThrSer: 2.877 ± 0.069
3.165ThrThr: 3.165 ± 0.076
4.153ThrVal: 4.153 ± 0.079
0.644ThrTrp: 0.644 ± 0.032
1.527ThrTyr: 1.527 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
7.751ValAla: 7.751 ± 0.115
0.592ValCys: 0.592 ± 0.028
3.899ValAsp: 3.899 ± 0.086
4.491ValGlu: 4.491 ± 0.091
2.683ValPhe: 2.683 ± 0.062
5.065ValGly: 5.065 ± 0.096
1.495ValHis: 1.495 ± 0.044
4.925ValIle: 4.925 ± 0.099
2.789ValLys: 2.789 ± 0.08
7.445ValLeu: 7.445 ± 0.122
1.955ValMet: 1.955 ± 0.063
2.633ValAsn: 2.633 ± 0.057
3.165ValPro: 3.165 ± 0.074
3.152ValGln: 3.152 ± 0.066
3.927ValArg: 3.927 ± 0.085
4.106ValSer: 4.106 ± 0.085
4.734ValThr: 4.734 ± 0.088
6.019ValVal: 6.019 ± 0.114
0.838ValTrp: 0.838 ± 0.038
1.822ValTyr: 1.822 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.897TrpAla: 0.897 ± 0.041
0.154TrpCys: 0.154 ± 0.016
0.609TrpAsp: 0.609 ± 0.026
0.594TrpGlu: 0.594 ± 0.028
0.645TrpPhe: 0.645 ± 0.036
0.825TrpGly: 0.825 ± 0.036
0.441TrpHis: 0.441 ± 0.028
0.606TrpIle: 0.606 ± 0.029
0.275TrpLys: 0.275 ± 0.021
2.224TrpLeu: 2.224 ± 0.076
0.337TrpMet: 0.337 ± 0.022
0.395TrpAsn: 0.395 ± 0.024
0.6TrpPro: 0.6 ± 0.029
1.269TrpGln: 1.269 ± 0.056
0.985TrpArg: 0.985 ± 0.04
0.669TrpSer: 0.669 ± 0.032
0.482TrpThr: 0.482 ± 0.027
1.044TrpVal: 1.044 ± 0.044
0.257TrpTrp: 0.257 ± 0.024
0.475TrpTyr: 0.475 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.632TyrAla: 2.632 ± 0.066
0.344TyrCys: 0.344 ± 0.022
1.633TyrAsp: 1.633 ± 0.057
1.629TyrGlu: 1.629 ± 0.052
1.276TyrPhe: 1.276 ± 0.044
2.273TyrGly: 2.273 ± 0.06
0.884TyrHis: 0.884 ± 0.038
1.398TyrIle: 1.398 ± 0.051
0.845TyrLys: 0.845 ± 0.037
3.364TyrLeu: 3.364 ± 0.067
0.592TyrMet: 0.592 ± 0.029
1.016TyrAsn: 1.016 ± 0.037
1.429TyrPro: 1.429 ± 0.05
2.046TyrGln: 2.046 ± 0.056
2.03TyrArg: 2.03 ± 0.061
1.647TyrSer: 1.647 ± 0.058
1.476TyrThr: 1.476 ± 0.051
1.97TyrVal: 1.97 ± 0.052
0.44TyrTrp: 0.44 ± 0.025
0.953TyrTyr: 0.953 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2066 proteins (680199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski