Amino acid dipepetide frequency for Pteropox virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.072AlaAla: 3.072 ± 0.287
1.22AlaCys: 1.22 ± 0.165
2.439AlaAsp: 2.439 ± 0.222
1.782AlaGlu: 1.782 ± 0.218
2.064AlaPhe: 2.064 ± 0.207
1.477AlaGly: 1.477 ± 0.157
0.657AlaHis: 0.657 ± 0.119
3.987AlaIle: 3.987 ± 0.284
3.682AlaLys: 3.682 ± 0.312
4.597AlaLeu: 4.597 ± 0.318
0.938AlaMet: 0.938 ± 0.143
2.65AlaAsn: 2.65 ± 0.216
1.876AlaPro: 1.876 ± 0.219
0.962AlaGln: 0.962 ± 0.151
1.712AlaArg: 1.712 ± 0.22
3.87AlaSer: 3.87 ± 0.296
2.533AlaThr: 2.533 ± 0.21
3.33AlaVal: 3.33 ± 0.334
0.305AlaTrp: 0.305 ± 0.076
1.759AlaTyr: 1.759 ± 0.182
0.0AlaXaa: 0.0 ± 0.0
Cys
1.102CysAla: 1.102 ± 0.197
0.727CysCys: 0.727 ± 0.16
1.149CysAsp: 1.149 ± 0.15
1.079CysGlu: 1.079 ± 0.146
1.196CysPhe: 1.196 ± 0.157
1.266CysGly: 1.266 ± 0.146
0.281CysHis: 0.281 ± 0.085
1.595CysIle: 1.595 ± 0.213
1.571CysLys: 1.571 ± 0.19
1.642CysLeu: 1.642 ± 0.202
0.516CysMet: 0.516 ± 0.103
1.36CysAsn: 1.36 ± 0.19
0.868CysPro: 0.868 ± 0.158
0.446CysGln: 0.446 ± 0.098
0.821CysArg: 0.821 ± 0.149
2.228CysSer: 2.228 ± 0.226
1.079CysThr: 1.079 ± 0.152
1.97CysVal: 1.97 ± 0.243
0.305CysTrp: 0.305 ± 0.087
1.102CysTyr: 1.102 ± 0.152
0.0CysXaa: 0.0 ± 0.0
Asp
2.322AspAla: 2.322 ± 0.249
1.079AspCys: 1.079 ± 0.173
3.588AspAsp: 3.588 ± 0.342
4.315AspGlu: 4.315 ± 0.336
2.791AspPhe: 2.791 ± 0.243
2.322AspGly: 2.322 ± 0.248
0.774AspHis: 0.774 ± 0.142
4.925AspIle: 4.925 ± 0.332
3.987AspLys: 3.987 ± 0.364
4.432AspLeu: 4.432 ± 0.309
1.571AspMet: 1.571 ± 0.142
3.823AspAsn: 3.823 ± 0.284
1.806AspPro: 1.806 ± 0.213
1.102AspGln: 1.102 ± 0.166
1.759AspArg: 1.759 ± 0.196
4.034AspSer: 4.034 ± 0.31
3.283AspThr: 3.283 ± 0.29
4.737AspVal: 4.737 ± 0.373
0.422AspTrp: 0.422 ± 0.095
2.627AspTyr: 2.627 ± 0.277
0.0AspXaa: 0.0 ± 0.0
Glu
2.228GluAla: 2.228 ± 0.268
1.032GluCys: 1.032 ± 0.154
3.541GluAsp: 3.541 ± 0.328
3.94GluGlu: 3.94 ± 0.443
2.72GluPhe: 2.72 ± 0.285
1.571GluGly: 1.571 ± 0.18
1.454GluHis: 1.454 ± 0.185
4.386GluIle: 4.386 ± 0.313
4.784GluLys: 4.784 ± 0.449
6.637GluLeu: 6.637 ± 0.703
1.313GluMet: 1.313 ± 0.162
4.01GluAsn: 4.01 ± 0.336
1.689GluPro: 1.689 ± 0.173
1.806GluGln: 1.806 ± 0.2
2.205GluArg: 2.205 ± 0.276
4.362GluSer: 4.362 ± 0.304
3.682GluThr: 3.682 ± 0.305
2.744GluVal: 2.744 ± 0.24
0.446GluTrp: 0.446 ± 0.1
2.955GluTyr: 2.955 ± 0.23
0.0GluXaa: 0.0 ± 0.0
Phe
2.017PheAla: 2.017 ± 0.215
1.102PheCys: 1.102 ± 0.164
2.744PheAsp: 2.744 ± 0.282
2.767PheGlu: 2.767 ± 0.285
2.228PhePhe: 2.228 ± 0.219
1.876PheGly: 1.876 ± 0.223
0.868PheHis: 0.868 ± 0.139
3.987PheIle: 3.987 ± 0.358
3.705PheLys: 3.705 ± 0.259
5.042PheLeu: 5.042 ± 0.344
1.29PheMet: 1.29 ± 0.157
3.87PheAsn: 3.87 ± 0.295
1.712PhePro: 1.712 ± 0.186
0.938PheGln: 0.938 ± 0.143
1.642PheArg: 1.642 ± 0.181
5.324PheSer: 5.324 ± 0.371
2.65PheThr: 2.65 ± 0.243
4.174PheVal: 4.174 ± 0.337
0.563PheTrp: 0.563 ± 0.115
2.275PheTyr: 2.275 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
1.477GlyAla: 1.477 ± 0.213
0.844GlyCys: 0.844 ± 0.126
2.205GlyAsp: 2.205 ± 0.227
1.806GlyGlu: 1.806 ± 0.229
1.642GlyPhe: 1.642 ± 0.18
1.759GlyGly: 1.759 ± 0.269
0.563GlyHis: 0.563 ± 0.084
3.189GlyIle: 3.189 ± 0.281
2.838GlyLys: 2.838 ± 0.273
2.744GlyLeu: 2.744 ± 0.236
0.75GlyMet: 0.75 ± 0.114
2.556GlyAsn: 2.556 ± 0.235
0.774GlyPro: 0.774 ± 0.141
0.563GlyGln: 0.563 ± 0.108
1.524GlyArg: 1.524 ± 0.225
2.697GlySer: 2.697 ± 0.315
1.947GlyThr: 1.947 ± 0.209
2.416GlyVal: 2.416 ± 0.231
0.164GlyTrp: 0.164 ± 0.071
1.97GlyTyr: 1.97 ± 0.19
0.0GlyXaa: 0.0 ± 0.0
His
0.868HisAla: 0.868 ± 0.138
0.516HisCys: 0.516 ± 0.107
0.774HisAsp: 0.774 ± 0.163
0.962HisGlu: 0.962 ± 0.14
0.868HisPhe: 0.868 ± 0.147
0.704HisGly: 0.704 ± 0.124
0.399HisHis: 0.399 ± 0.086
1.782HisIle: 1.782 ± 0.248
1.102HisLys: 1.102 ± 0.163
1.595HisLeu: 1.595 ± 0.196
0.516HisMet: 0.516 ± 0.128
1.126HisAsn: 1.126 ± 0.169
0.68HisPro: 0.68 ± 0.144
0.469HisGln: 0.469 ± 0.135
0.61HisArg: 0.61 ± 0.108
1.407HisSer: 1.407 ± 0.186
1.126HisThr: 1.126 ± 0.201
1.853HisVal: 1.853 ± 0.234
0.188HisTrp: 0.188 ± 0.057
0.797HisTyr: 0.797 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
3.307IleAla: 3.307 ± 0.223
1.501IleCys: 1.501 ± 0.219
5.019IleAsp: 5.019 ± 0.326
4.315IleGlu: 4.315 ± 0.293
3.799IlePhe: 3.799 ± 0.311
2.58IleGly: 2.58 ± 0.233
1.384IleHis: 1.384 ± 0.191
7.012IleIle: 7.012 ± 0.525
7.387IleLys: 7.387 ± 0.4
7.012IleLeu: 7.012 ± 0.384
1.782IleMet: 1.782 ± 0.221
6.496IleAsn: 6.496 ± 0.432
2.908IlePro: 2.908 ± 0.248
1.993IleGln: 1.993 ± 0.216
2.885IleArg: 2.885 ± 0.189
7.294IleSer: 7.294 ± 0.499
5.558IleThr: 5.558 ± 0.38
5.769IleVal: 5.769 ± 0.358
0.352IleTrp: 0.352 ± 0.088
3.424IleTyr: 3.424 ± 0.274
0.0IleXaa: 0.0 ± 0.0
Lys
2.791LysAla: 2.791 ± 0.256
1.618LysCys: 1.618 ± 0.161
4.479LysAsp: 4.479 ± 0.424
4.902LysGlu: 4.902 ± 0.456
4.104LysPhe: 4.104 ± 0.305
2.416LysGly: 2.416 ± 0.263
2.111LysHis: 2.111 ± 0.233
7.341LysIle: 7.341 ± 0.384
7.364LysLys: 7.364 ± 0.397
7.856LysLeu: 7.856 ± 0.405
1.876LysMet: 1.876 ± 0.207
5.675LysAsn: 5.675 ± 0.387
2.885LysPro: 2.885 ± 0.378
2.744LysGln: 2.744 ± 0.22
3.025LysArg: 3.025 ± 0.292
5.957LysSer: 5.957 ± 0.43
5.535LysThr: 5.535 ± 0.328
4.55LysVal: 4.55 ± 0.278
0.399LysTrp: 0.399 ± 0.095
3.799LysTyr: 3.799 ± 0.281
0.0LysXaa: 0.0 ± 0.0
Leu
4.737LeuAla: 4.737 ± 0.328
2.04LeuCys: 2.04 ± 0.247
4.761LeuAsp: 4.761 ± 0.281
6.402LeuGlu: 6.402 ± 0.595
5.019LeuPhe: 5.019 ± 0.345
2.814LeuGly: 2.814 ± 0.272
1.173LeuHis: 1.173 ± 0.177
6.473LeuIle: 6.473 ± 0.383
7.458LeuLys: 7.458 ± 0.42
9.076LeuLeu: 9.076 ± 0.424
2.392LeuMet: 2.392 ± 0.292
5.933LeuAsn: 5.933 ± 0.301
3.213LeuPro: 3.213 ± 0.281
2.205LeuGln: 2.205 ± 0.234
3.494LeuArg: 3.494 ± 0.305
7.927LeuSer: 7.927 ± 0.374
6.144LeuThr: 6.144 ± 0.34
6.473LeuVal: 6.473 ± 0.348
0.539LeuTrp: 0.539 ± 0.132
4.128LeuTyr: 4.128 ± 0.232
0.0LeuXaa: 0.0 ± 0.0
Met
1.665MetAla: 1.665 ± 0.219
0.563MetCys: 0.563 ± 0.118
1.477MetAsp: 1.477 ± 0.165
1.266MetGlu: 1.266 ± 0.176
1.782MetPhe: 1.782 ± 0.183
0.68MetGly: 0.68 ± 0.106
0.516MetHis: 0.516 ± 0.118
1.548MetIle: 1.548 ± 0.14
1.524MetLys: 1.524 ± 0.207
2.322MetLeu: 2.322 ± 0.244
0.422MetMet: 0.422 ± 0.105
1.196MetAsn: 1.196 ± 0.193
0.938MetPro: 0.938 ± 0.15
0.797MetGln: 0.797 ± 0.128
0.915MetArg: 0.915 ± 0.146
2.111MetSer: 2.111 ± 0.233
1.266MetThr: 1.266 ± 0.157
1.22MetVal: 1.22 ± 0.165
0.141MetTrp: 0.141 ± 0.054
1.524MetTyr: 1.524 ± 0.193
0.0MetXaa: 0.0 ± 0.0
Asn
2.861AsnAla: 2.861 ± 0.218
1.337AsnCys: 1.337 ± 0.175
3.518AsnAsp: 3.518 ± 0.282
4.104AsnGlu: 4.104 ± 0.337
3.189AsnPhe: 3.189 ± 0.274
2.697AsnGly: 2.697 ± 0.293
1.126AsnHis: 1.126 ± 0.16
6.825AsnIle: 6.825 ± 0.423
6.144AsnLys: 6.144 ± 0.445
5.066AsnLeu: 5.066 ± 0.267
1.923AsnMet: 1.923 ± 0.236
5.605AsnAsn: 5.605 ± 0.431
2.345AsnPro: 2.345 ± 0.272
1.759AsnGln: 1.759 ± 0.26
1.853AsnArg: 1.853 ± 0.18
4.878AsnSer: 4.878 ± 0.319
4.339AsnThr: 4.339 ± 0.299
5.066AsnVal: 5.066 ± 0.311
0.399AsnTrp: 0.399 ± 0.105
3.401AsnTyr: 3.401 ± 0.224
0.0AsnXaa: 0.0 ± 0.0
Pro
1.266ProAla: 1.266 ± 0.162
0.844ProCys: 0.844 ± 0.16
1.665ProAsp: 1.665 ± 0.171
2.251ProGlu: 2.251 ± 0.247
1.642ProPhe: 1.642 ± 0.202
1.196ProGly: 1.196 ± 0.2
0.915ProHis: 0.915 ± 0.17
2.838ProIle: 2.838 ± 0.25
2.674ProLys: 2.674 ± 0.265
3.189ProLeu: 3.189 ± 0.269
0.774ProMet: 0.774 ± 0.114
2.674ProAsn: 2.674 ± 0.249
2.181ProPro: 2.181 ± 0.405
1.126ProGln: 1.126 ± 0.235
1.173ProArg: 1.173 ± 0.154
3.002ProSer: 3.002 ± 0.293
2.65ProThr: 2.65 ± 0.294
2.861ProVal: 2.861 ± 0.301
0.211ProTrp: 0.211 ± 0.064
1.407ProTyr: 1.407 ± 0.196
0.0ProXaa: 0.0 ± 0.0
Gln
1.079GlnAla: 1.079 ± 0.154
0.539GlnCys: 0.539 ± 0.103
1.173GlnAsp: 1.173 ± 0.137
1.29GlnGlu: 1.29 ± 0.155
1.173GlnPhe: 1.173 ± 0.171
0.563GlnGly: 0.563 ± 0.114
0.61GlnHis: 0.61 ± 0.107
1.782GlnIle: 1.782 ± 0.185
1.947GlnLys: 1.947 ± 0.225
2.814GlnLeu: 2.814 ± 0.245
0.75GlnMet: 0.75 ± 0.119
1.595GlnAsn: 1.595 ± 0.189
1.102GlnPro: 1.102 ± 0.232
1.36GlnGln: 1.36 ± 0.283
1.173GlnArg: 1.173 ± 0.158
2.205GlnSer: 2.205 ± 0.229
1.689GlnThr: 1.689 ± 0.223
1.384GlnVal: 1.384 ± 0.178
0.235GlnTrp: 0.235 ± 0.077
1.384GlnTyr: 1.384 ± 0.217
0.0GlnXaa: 0.0 ± 0.0
Arg
1.782ArgAla: 1.782 ± 0.176
0.985ArgCys: 0.985 ± 0.166
1.735ArgAsp: 1.735 ± 0.204
2.04ArgGlu: 2.04 ± 0.283
1.665ArgPhe: 1.665 ± 0.189
1.407ArgGly: 1.407 ± 0.194
0.727ArgHis: 0.727 ± 0.128
2.744ArgIle: 2.744 ± 0.189
2.885ArgLys: 2.885 ± 0.281
3.143ArgLeu: 3.143 ± 0.246
0.938ArgMet: 0.938 ± 0.129
2.228ArgAsn: 2.228 ± 0.283
1.079ArgPro: 1.079 ± 0.2
1.337ArgGln: 1.337 ± 0.154
1.876ArgArg: 1.876 ± 0.217
2.814ArgSer: 2.814 ± 0.246
2.509ArgThr: 2.509 ± 0.276
2.556ArgVal: 2.556 ± 0.215
0.094ArgTrp: 0.094 ± 0.041
1.571ArgTyr: 1.571 ± 0.165
0.0ArgXaa: 0.0 ± 0.0
Ser
4.057SerAla: 4.057 ± 0.34
1.9SerCys: 1.9 ± 0.194
5.23SerAsp: 5.23 ± 0.285
4.292SerGlu: 4.292 ± 0.366
4.362SerPhe: 4.362 ± 0.38
2.58SerGly: 2.58 ± 0.237
1.29SerHis: 1.29 ± 0.167
6.52SerIle: 6.52 ± 0.361
7.387SerLys: 7.387 ± 0.433
7.81SerLeu: 7.81 ± 0.354
1.782SerMet: 1.782 ± 0.172
4.902SerAsn: 4.902 ± 0.325
3.025SerPro: 3.025 ± 0.274
2.158SerGln: 2.158 ± 0.227
3.049SerArg: 3.049 ± 0.329
6.895SerSer: 6.895 ± 0.576
5.019SerThr: 5.019 ± 0.33
6.098SerVal: 6.098 ± 0.421
0.492SerTrp: 0.492 ± 0.103
3.189SerTyr: 3.189 ± 0.3
0.0SerXaa: 0.0 ± 0.0
Thr
3.424ThrAla: 3.424 ± 0.306
1.431ThrCys: 1.431 ± 0.168
3.471ThrAsp: 3.471 ± 0.314
3.612ThrGlu: 3.612 ± 0.357
3.541ThrPhe: 3.541 ± 0.316
2.181ThrGly: 2.181 ± 0.237
1.243ThrHis: 1.243 ± 0.169
4.902ThrIle: 4.902 ± 0.32
5.441ThrLys: 5.441 ± 0.366
5.722ThrLeu: 5.722 ± 0.37
1.36ThrMet: 1.36 ± 0.19
3.659ThrAsn: 3.659 ± 0.305
2.674ThrPro: 2.674 ± 0.269
1.313ThrGln: 1.313 ± 0.164
1.947ThrArg: 1.947 ± 0.22
4.432ThrSer: 4.432 ± 0.297
4.339ThrThr: 4.339 ± 0.734
5.605ThrVal: 5.605 ± 0.407
0.492ThrTrp: 0.492 ± 0.098
2.72ThrTyr: 2.72 ± 0.242
0.0ThrXaa: 0.0 ± 0.0
Val
2.603ValAla: 2.603 ± 0.219
1.735ValCys: 1.735 ± 0.181
3.893ValAsp: 3.893 ± 0.276
3.588ValGlu: 3.588 ± 0.285
3.635ValPhe: 3.635 ± 0.344
2.205ValGly: 2.205 ± 0.223
1.266ValHis: 1.266 ± 0.184
5.23ValIle: 5.23 ± 0.295
5.277ValLys: 5.277 ± 0.387
6.989ValLeu: 6.989 ± 0.397
1.665ValMet: 1.665 ± 0.189
5.488ValAsn: 5.488 ± 0.35
3.002ValPro: 3.002 ± 0.283
1.759ValGln: 1.759 ± 0.225
3.096ValArg: 3.096 ± 0.331
6.356ValSer: 6.356 ± 0.376
5.113ValThr: 5.113 ± 0.379
4.057ValVal: 4.057 ± 0.263
0.352ValTrp: 0.352 ± 0.081
3.729ValTyr: 3.729 ± 0.416
0.0ValXaa: 0.0 ± 0.0
Trp
0.211TrpAla: 0.211 ± 0.071
0.141TrpCys: 0.141 ± 0.054
0.188TrpAsp: 0.188 ± 0.07
0.352TrpGlu: 0.352 ± 0.096
0.469TrpPhe: 0.469 ± 0.1
0.258TrpGly: 0.258 ± 0.062
0.07TrpHis: 0.07 ± 0.039
0.797TrpIle: 0.797 ± 0.14
0.492TrpLys: 0.492 ± 0.107
0.75TrpLeu: 0.75 ± 0.122
0.188TrpMet: 0.188 ± 0.067
0.328TrpAsn: 0.328 ± 0.095
0.235TrpPro: 0.235 ± 0.077
0.188TrpGln: 0.188 ± 0.066
0.305TrpArg: 0.305 ± 0.083
0.563TrpSer: 0.563 ± 0.109
0.446TrpThr: 0.446 ± 0.096
0.352TrpVal: 0.352 ± 0.079
0.0TrpTrp: 0.0 ± 0.0
0.235TrpTyr: 0.235 ± 0.069
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.04TyrAla: 2.04 ± 0.239
1.149TyrCys: 1.149 ± 0.155
2.65TyrAsp: 2.65 ± 0.236
2.439TyrGlu: 2.439 ± 0.229
2.885TyrPhe: 2.885 ± 0.266
1.876TyrGly: 1.876 ± 0.227
0.915TyrHis: 0.915 ± 0.165
3.917TyrIle: 3.917 ± 0.327
3.776TyrLys: 3.776 ± 0.274
3.987TyrLeu: 3.987 ± 0.335
1.102TyrMet: 1.102 ± 0.173
3.26TyrAsn: 3.26 ± 0.265
1.548TyrPro: 1.548 ± 0.186
0.821TyrGln: 0.821 ± 0.133
1.055TyrArg: 1.055 ± 0.166
3.682TyrSer: 3.682 ± 0.267
2.603TyrThr: 2.603 ± 0.216
3.823TyrVal: 3.823 ± 0.278
0.469TyrTrp: 0.469 ± 0.106
2.486TyrTyr: 2.486 ± 0.289
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 143 proteins (42641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski