Amino acid dipepetide frequency for Chimaeribacter arupi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.541AlaAla: 13.541 ± 0.153
1.236AlaCys: 1.236 ± 0.031
5.706AlaAsp: 5.706 ± 0.097
6.124AlaGlu: 6.124 ± 0.074
3.897AlaPhe: 3.897 ± 0.067
9.263AlaGly: 9.263 ± 0.123
2.201AlaHis: 2.201 ± 0.042
5.513AlaIle: 5.513 ± 0.072
3.24AlaLys: 3.24 ± 0.061
13.687AlaLeu: 13.687 ± 0.146
2.95AlaMet: 2.95 ± 0.057
2.92AlaAsn: 2.92 ± 0.043
4.554AlaPro: 4.554 ± 0.079
5.194AlaGln: 5.194 ± 0.086
6.369AlaArg: 6.369 ± 0.088
5.103AlaSer: 5.103 ± 0.074
5.17AlaThr: 5.17 ± 0.09
7.498AlaVal: 7.498 ± 0.095
1.572AlaTrp: 1.572 ± 0.038
2.486AlaTyr: 2.486 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.987CysAla: 0.987 ± 0.029
0.163CysCys: 0.163 ± 0.01
0.556CysAsp: 0.556 ± 0.02
0.502CysGlu: 0.502 ± 0.021
0.445CysPhe: 0.445 ± 0.018
1.047CysGly: 1.047 ± 0.03
0.317CysHis: 0.317 ± 0.013
0.501CysIle: 0.501 ± 0.019
0.247CysLys: 0.247 ± 0.013
1.064CysLeu: 1.064 ± 0.032
0.22CysMet: 0.22 ± 0.013
0.279CysAsn: 0.279 ± 0.015
0.496CysPro: 0.496 ± 0.02
0.339CysGln: 0.339 ± 0.016
0.787CysArg: 0.787 ± 0.026
0.567CysSer: 0.567 ± 0.021
0.473CysThr: 0.473 ± 0.02
0.691CysVal: 0.691 ± 0.026
0.166CysTrp: 0.166 ± 0.011
0.322CysTyr: 0.322 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.767AspAla: 5.767 ± 0.081
0.454AspCys: 0.454 ± 0.018
2.845AspAsp: 2.845 ± 0.06
3.296AspGlu: 3.296 ± 0.06
2.011AspPhe: 2.011 ± 0.036
3.953AspGly: 3.953 ± 0.11
1.122AspHis: 1.122 ± 0.026
2.949AspIle: 2.949 ± 0.051
1.925AspLys: 1.925 ± 0.04
4.861AspLeu: 4.861 ± 0.063
1.195AspMet: 1.195 ± 0.031
2.046AspAsn: 2.046 ± 0.055
2.483AspPro: 2.483 ± 0.045
1.971AspGln: 1.971 ± 0.043
2.924AspArg: 2.924 ± 0.049
2.588AspSer: 2.588 ± 0.053
2.76AspThr: 2.76 ± 0.075
3.787AspVal: 3.787 ± 0.062
0.805AspTrp: 0.805 ± 0.024
1.771AspTyr: 1.771 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.789GluAla: 5.789 ± 0.075
0.417GluCys: 0.417 ± 0.019
2.173GluAsp: 2.173 ± 0.045
3.22GluGlu: 3.22 ± 0.061
1.687GluPhe: 1.687 ± 0.038
3.679GluGly: 3.679 ± 0.057
1.374GluHis: 1.374 ± 0.033
3.04GluIle: 3.04 ± 0.054
2.754GluLys: 2.754 ± 0.058
5.307GluLeu: 5.307 ± 0.079
1.667GluMet: 1.667 ± 0.036
2.114GluAsn: 2.114 ± 0.044
2.192GluPro: 2.192 ± 0.051
3.418GluGln: 3.418 ± 0.056
3.46GluArg: 3.46 ± 0.061
2.644GluSer: 2.644 ± 0.052
2.804GluThr: 2.804 ± 0.047
3.695GluVal: 3.695 ± 0.05
0.674GluTrp: 0.674 ± 0.022
1.33GluTyr: 1.33 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.686PheAla: 3.686 ± 0.05
0.521PheCys: 0.521 ± 0.02
2.287PheAsp: 2.287 ± 0.049
1.637PheGlu: 1.637 ± 0.038
1.586PhePhe: 1.586 ± 0.04
3.202PheGly: 3.202 ± 0.052
0.829PheHis: 0.829 ± 0.028
2.361PheIle: 2.361 ± 0.048
1.041PheLys: 1.041 ± 0.03
3.335PheLeu: 3.335 ± 0.057
0.974PheMet: 0.974 ± 0.034
1.574PheAsn: 1.574 ± 0.032
1.569PhePro: 1.569 ± 0.033
1.082PheGln: 1.082 ± 0.027
1.998PheArg: 1.998 ± 0.04
3.064PheSer: 3.064 ± 0.053
2.564PheThr: 2.564 ± 0.058
2.328PheVal: 2.328 ± 0.044
0.568PheTrp: 0.568 ± 0.022
1.231PheTyr: 1.231 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
6.818GlyAla: 6.818 ± 0.08
0.978GlyCys: 0.978 ± 0.028
3.89GlyAsp: 3.89 ± 0.072
4.546GlyGlu: 4.546 ± 0.065
3.298GlyPhe: 3.298 ± 0.053
5.895GlyGly: 5.895 ± 0.088
1.825GlyHis: 1.825 ± 0.039
4.821GlyIle: 4.821 ± 0.07
3.566GlyLys: 3.566 ± 0.053
8.074GlyLeu: 8.074 ± 0.087
2.429GlyMet: 2.429 ± 0.052
2.893GlyAsn: 2.893 ± 0.08
2.329GlyPro: 2.329 ± 0.05
3.214GlyGln: 3.214 ± 0.059
4.285GlyArg: 4.285 ± 0.065
4.427GlySer: 4.427 ± 0.085
4.116GlyThr: 4.116 ± 0.083
5.985GlyVal: 5.985 ± 0.072
1.343GlyTrp: 1.343 ± 0.038
2.663GlyTyr: 2.663 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.244HisAla: 2.244 ± 0.039
0.334HisCys: 0.334 ± 0.015
1.224HisAsp: 1.224 ± 0.028
1.082HisGlu: 1.082 ± 0.031
1.067HisPhe: 1.067 ± 0.03
1.958HisGly: 1.958 ± 0.036
0.858HisHis: 0.858 ± 0.031
1.201HisIle: 1.201 ± 0.033
0.67HisLys: 0.67 ± 0.027
2.456HisLeu: 2.456 ± 0.05
0.512HisMet: 0.512 ± 0.018
0.779HisAsn: 0.779 ± 0.022
1.485HisPro: 1.485 ± 0.038
1.335HisGln: 1.335 ± 0.035
1.397HisArg: 1.397 ± 0.034
1.31HisSer: 1.31 ± 0.03
1.226HisThr: 1.226 ± 0.029
1.31HisVal: 1.31 ± 0.033
0.463HisTrp: 0.463 ± 0.018
0.971HisTyr: 0.971 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.977IleAla: 5.977 ± 0.071
0.554IleCys: 0.554 ± 0.02
3.268IleAsp: 3.268 ± 0.069
2.978IleGlu: 2.978 ± 0.051
1.762IlePhe: 1.762 ± 0.042
4.429IleGly: 4.429 ± 0.068
1.094IleHis: 1.094 ± 0.03
2.745IleIle: 2.745 ± 0.051
1.861IleLys: 1.861 ± 0.045
4.456IleLeu: 4.456 ± 0.07
1.19IleMet: 1.19 ± 0.035
2.342IleAsn: 2.342 ± 0.05
2.572IlePro: 2.572 ± 0.048
1.659IleGln: 1.659 ± 0.033
2.833IleArg: 2.833 ± 0.048
3.326IleSer: 3.326 ± 0.054
3.541IleThr: 3.541 ± 0.073
3.479IleVal: 3.479 ± 0.057
0.566IleTrp: 0.566 ± 0.024
1.429IleTyr: 1.429 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
3.77LysAla: 3.77 ± 0.071
0.202LysCys: 0.202 ± 0.013
1.558LysAsp: 1.558 ± 0.043
2.116LysGlu: 2.116 ± 0.045
0.949LysPhe: 0.949 ± 0.03
2.483LysGly: 2.483 ± 0.051
0.77LysHis: 0.77 ± 0.025
1.928LysIle: 1.928 ± 0.043
1.798LysLys: 1.798 ± 0.047
3.55LysLeu: 3.55 ± 0.065
1.035LysMet: 1.035 ± 0.029
1.362LysAsn: 1.362 ± 0.037
1.99LysPro: 1.99 ± 0.048
1.862LysGln: 1.862 ± 0.041
2.255LysArg: 2.255 ± 0.041
1.879LysSer: 1.879 ± 0.039
2.106LysThr: 2.106 ± 0.04
2.517LysVal: 2.517 ± 0.05
0.385LysTrp: 0.385 ± 0.015
0.891LysTyr: 0.891 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
12.988LeuAla: 12.988 ± 0.144
1.312LeuCys: 1.312 ± 0.031
5.424LeuAsp: 5.424 ± 0.072
5.296LeuGlu: 5.296 ± 0.077
4.371LeuPhe: 4.371 ± 0.07
7.857LeuGly: 7.857 ± 0.088
2.585LeuHis: 2.585 ± 0.045
5.495LeuIle: 5.495 ± 0.079
4.001LeuLys: 4.001 ± 0.065
12.635LeuLeu: 12.635 ± 0.175
3.039LeuMet: 3.039 ± 0.055
4.001LeuAsn: 4.001 ± 0.071
6.473LeuPro: 6.473 ± 0.079
4.146LeuGln: 4.146 ± 0.06
6.311LeuArg: 6.311 ± 0.096
7.371LeuSer: 7.371 ± 0.065
6.93LeuThr: 6.93 ± 0.114
7.382LeuVal: 7.382 ± 0.081
1.361LeuTrp: 1.361 ± 0.033
2.705LeuTyr: 2.705 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
3.092MetAla: 3.092 ± 0.065
0.177MetCys: 0.177 ± 0.012
1.123MetAsp: 1.123 ± 0.026
1.163MetGlu: 1.163 ± 0.032
0.845MetPhe: 0.845 ± 0.028
1.851MetGly: 1.851 ± 0.041
0.546MetHis: 0.546 ± 0.022
1.306MetIle: 1.306 ± 0.031
1.22MetLys: 1.22 ± 0.026
3.095MetLeu: 3.095 ± 0.054
0.883MetMet: 0.883 ± 0.025
0.939MetAsn: 0.939 ± 0.028
1.4MetPro: 1.4 ± 0.032
1.189MetGln: 1.189 ± 0.031
1.406MetArg: 1.406 ± 0.037
1.692MetSer: 1.692 ± 0.035
1.75MetThr: 1.75 ± 0.036
1.861MetVal: 1.861 ± 0.044
0.24MetTrp: 0.24 ± 0.014
0.476MetTyr: 0.476 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.525AsnAla: 3.525 ± 0.059
0.272AsnCys: 0.272 ± 0.014
1.806AsnAsp: 1.806 ± 0.04
1.58AsnGlu: 1.58 ± 0.035
1.139AsnPhe: 1.139 ± 0.029
2.916AsnGly: 2.916 ± 0.066
0.77AsnHis: 0.77 ± 0.024
1.961AsnIle: 1.961 ± 0.047
1.179AsnLys: 1.179 ± 0.034
3.363AsnLeu: 3.363 ± 0.047
0.749AsnMet: 0.749 ± 0.022
1.377AsnAsn: 1.377 ± 0.035
2.102AsnPro: 2.102 ± 0.043
1.544AsnGln: 1.544 ± 0.038
2.008AsnArg: 2.008 ± 0.035
1.868AsnSer: 1.868 ± 0.044
1.89AsnThr: 1.89 ± 0.059
2.408AsnVal: 2.408 ± 0.052
0.52AsnTrp: 0.52 ± 0.021
1.086AsnTyr: 1.086 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
6.177ProAla: 6.177 ± 0.101
0.384ProCys: 0.384 ± 0.017
3.201ProAsp: 3.201 ± 0.054
3.409ProGlu: 3.409 ± 0.054
1.923ProPhe: 1.923 ± 0.04
3.953ProGly: 3.953 ± 0.07
1.239ProHis: 1.239 ± 0.031
1.743ProIle: 1.743 ± 0.041
1.381ProLys: 1.381 ± 0.039
5.686ProLeu: 5.686 ± 0.063
1.153ProMet: 1.153 ± 0.029
1.176ProAsn: 1.176 ± 0.029
2.205ProPro: 2.205 ± 0.047
2.463ProGln: 2.463 ± 0.05
2.224ProArg: 2.224 ± 0.044
2.235ProSer: 2.235 ± 0.042
2.214ProThr: 2.214 ± 0.041
4.423ProVal: 4.423 ± 0.063
0.713ProTrp: 0.713 ± 0.026
1.339ProTyr: 1.339 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
5.691GlnAla: 5.691 ± 0.084
0.373GlnCys: 0.373 ± 0.018
1.915GlnAsp: 1.915 ± 0.04
2.208GlnGlu: 2.208 ± 0.045
1.425GlnPhe: 1.425 ± 0.031
3.47GlnGly: 3.47 ± 0.06
1.332GlnHis: 1.332 ± 0.032
2.14GlnIle: 2.14 ± 0.039
1.536GlnLys: 1.536 ± 0.039
4.927GlnLeu: 4.927 ± 0.067
1.135GlnMet: 1.135 ± 0.032
1.279GlnAsn: 1.279 ± 0.03
2.776GlnPro: 2.776 ± 0.055
3.674GlnGln: 3.674 ± 0.09
3.24GlnArg: 3.24 ± 0.06
2.038GlnSer: 2.038 ± 0.038
2.132GlnThr: 2.132 ± 0.065
3.387GlnVal: 3.387 ± 0.054
0.671GlnTrp: 0.671 ± 0.023
0.98GlnTyr: 0.98 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
5.402ArgAla: 5.402 ± 0.078
0.598ArgCys: 0.598 ± 0.02
3.123ArgAsp: 3.123 ± 0.053
3.566ArgGlu: 3.566 ± 0.062
2.562ArgPhe: 2.562 ± 0.047
3.668ArgGly: 3.668 ± 0.062
1.817ArgHis: 1.817 ± 0.04
3.254ArgIle: 3.254 ± 0.047
2.025ArgLys: 2.025 ± 0.045
7.028ArgLeu: 7.028 ± 0.094
1.566ArgMet: 1.566 ± 0.031
1.891ArgAsn: 1.891 ± 0.041
2.596ArgPro: 2.596 ± 0.058
3.185ArgGln: 3.185 ± 0.053
4.106ArgArg: 4.106 ± 0.073
2.682ArgSer: 2.682 ± 0.049
2.692ArgThr: 2.692 ± 0.05
4.049ArgVal: 4.049 ± 0.068
0.985ArgTrp: 0.985 ± 0.032
2.218ArgTyr: 2.218 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.869SerAla: 5.869 ± 0.078
0.476SerCys: 0.476 ± 0.02
2.98SerAsp: 2.98 ± 0.056
2.802SerGlu: 2.802 ± 0.047
2.072SerPhe: 2.072 ± 0.047
5.231SerGly: 5.231 ± 0.084
1.354SerHis: 1.354 ± 0.031
2.53SerIle: 2.53 ± 0.046
1.69SerLys: 1.69 ± 0.044
6.745SerLeu: 6.745 ± 0.076
1.354SerMet: 1.354 ± 0.033
1.631SerAsn: 1.631 ± 0.034
2.747SerPro: 2.747 ± 0.044
2.314SerGln: 2.314 ± 0.041
3.333SerArg: 3.333 ± 0.056
3.095SerSer: 3.095 ± 0.057
2.863SerThr: 2.863 ± 0.058
4.005SerVal: 4.005 ± 0.068
0.865SerTrp: 0.865 ± 0.03
1.617SerTyr: 1.617 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.67ThrAla: 5.67 ± 0.108
0.449ThrCys: 0.449 ± 0.019
2.749ThrAsp: 2.749 ± 0.074
2.49ThrGlu: 2.49 ± 0.045
2.096ThrPhe: 2.096 ± 0.042
4.712ThrGly: 4.712 ± 0.084
1.301ThrHis: 1.301 ± 0.034
2.426ThrIle: 2.426 ± 0.05
1.31ThrLys: 1.31 ± 0.036
8.35ThrLeu: 8.35 ± 0.141
1.033ThrMet: 1.033 ± 0.03
1.45ThrAsn: 1.45 ± 0.041
3.697ThrPro: 3.697 ± 0.061
2.272ThrGln: 2.272 ± 0.046
3.142ThrArg: 3.142 ± 0.048
2.721ThrSer: 2.721 ± 0.052
2.949ThrThr: 2.949 ± 0.096
4.177ThrVal: 4.177 ± 0.165
0.733ThrTrp: 0.733 ± 0.024
1.312ThrTyr: 1.312 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
7.466ValAla: 7.466 ± 0.089
0.751ValCys: 0.751 ± 0.026
3.563ValAsp: 3.563 ± 0.066
3.713ValGlu: 3.713 ± 0.06
2.524ValPhe: 2.524 ± 0.054
4.762ValGly: 4.762 ± 0.077
1.306ValHis: 1.306 ± 0.036
4.381ValIle: 4.381 ± 0.059
2.721ValLys: 2.721 ± 0.057
7.617ValLeu: 7.617 ± 0.082
2.222ValMet: 2.222 ± 0.049
2.69ValAsn: 2.69 ± 0.053
3.393ValPro: 3.393 ± 0.053
2.537ValGln: 2.537 ± 0.051
3.883ValArg: 3.883 ± 0.056
4.596ValSer: 4.596 ± 0.066
4.867ValThr: 4.867 ± 0.147
5.711ValVal: 5.711 ± 0.094
0.886ValTrp: 0.886 ± 0.027
1.706ValTyr: 1.706 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.145TrpAla: 1.145 ± 0.031
0.159TrpCys: 0.159 ± 0.009
0.646TrpAsp: 0.646 ± 0.024
0.565TrpGlu: 0.565 ± 0.022
0.596TrpPhe: 0.596 ± 0.021
0.908TrpGly: 0.908 ± 0.027
0.448TrpHis: 0.448 ± 0.019
0.544TrpIle: 0.544 ± 0.022
0.437TrpLys: 0.437 ± 0.019
2.213TrpLeu: 2.213 ± 0.056
0.37TrpMet: 0.37 ± 0.018
0.447TrpAsn: 0.447 ± 0.02
0.664TrpPro: 0.664 ± 0.022
1.184TrpGln: 1.184 ± 0.032
1.006TrpArg: 1.006 ± 0.028
0.74TrpSer: 0.74 ± 0.033
0.534TrpThr: 0.534 ± 0.022
0.971TrpVal: 0.971 ± 0.028
0.218TrpTrp: 0.218 ± 0.014
0.37TrpTyr: 0.37 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.621TyrAla: 2.621 ± 0.051
0.356TyrCys: 0.356 ± 0.017
1.473TyrAsp: 1.473 ± 0.044
1.145TyrGlu: 1.145 ± 0.031
1.181TyrPhe: 1.181 ± 0.033
2.158TyrGly: 2.158 ± 0.04
0.796TyrHis: 0.796 ± 0.025
1.221TyrIle: 1.221 ± 0.031
0.805TyrLys: 0.805 ± 0.03
3.237TyrLeu: 3.237 ± 0.052
0.58TyrMet: 0.58 ± 0.022
0.872TyrAsn: 0.872 ± 0.027
1.516TyrPro: 1.516 ± 0.036
1.745TyrGln: 1.745 ± 0.04
2.049TyrArg: 2.049 ± 0.043
1.628TyrSer: 1.628 ± 0.035
1.458TyrThr: 1.458 ± 0.039
1.63TyrVal: 1.63 ± 0.041
0.432TyrTrp: 0.432 ± 0.022
0.919TyrTyr: 0.919 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4159 proteins (1358501 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski