Amino acid dipepetide frequency for Vibrio sp. (strain N418)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.796AlaAla: 7.796 ± 0.109
0.924AlaCys: 0.924 ± 0.03
4.692AlaAsp: 4.692 ± 0.081
5.736AlaGlu: 5.736 ± 0.073
3.591AlaPhe: 3.591 ± 0.064
5.946AlaGly: 5.946 ± 0.086
1.711AlaHis: 1.711 ± 0.039
6.363AlaIle: 6.363 ± 0.075
4.905AlaLys: 4.905 ± 0.072
10.299AlaLeu: 10.299 ± 0.122
2.934AlaMet: 2.934 ± 0.052
3.645AlaAsn: 3.645 ± 0.054
2.873AlaPro: 2.873 ± 0.061
4.459AlaGln: 4.459 ± 0.07
3.64AlaArg: 3.64 ± 0.062
5.44AlaSer: 5.44 ± 0.078
4.655AlaThr: 4.655 ± 0.057
5.867AlaVal: 5.867 ± 0.075
0.998AlaTrp: 0.998 ± 0.03
2.42AlaTyr: 2.42 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.853CysAla: 0.853 ± 0.03
0.161CysCys: 0.161 ± 0.013
0.655CysAsp: 0.655 ± 0.025
0.618CysGlu: 0.618 ± 0.027
0.492CysPhe: 0.492 ± 0.021
0.936CysGly: 0.936 ± 0.028
0.344CysHis: 0.344 ± 0.019
0.584CysIle: 0.584 ± 0.023
0.424CysLys: 0.424 ± 0.02
1.022CysLeu: 1.022 ± 0.029
0.249CysMet: 0.249 ± 0.016
0.367CysAsn: 0.367 ± 0.017
0.413CysPro: 0.413 ± 0.019
0.541CysGln: 0.541 ± 0.023
0.497CysArg: 0.497 ± 0.019
0.726CysSer: 0.726 ± 0.025
0.478CysThr: 0.478 ± 0.018
0.685CysVal: 0.685 ± 0.026
0.142CysTrp: 0.142 ± 0.011
0.353CysTyr: 0.353 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.487AspAla: 4.487 ± 0.068
0.566AspCys: 0.566 ± 0.023
3.191AspAsp: 3.191 ± 0.102
3.856AspGlu: 3.856 ± 0.073
2.452AspPhe: 2.452 ± 0.043
3.727AspGly: 3.727 ± 0.091
1.193AspHis: 1.193 ± 0.036
3.919AspIle: 3.919 ± 0.078
3.045AspLys: 3.045 ± 0.049
5.236AspLeu: 5.236 ± 0.071
1.435AspMet: 1.435 ± 0.036
2.453AspAsn: 2.453 ± 0.057
1.988AspPro: 1.988 ± 0.048
2.186AspGln: 2.186 ± 0.046
2.216AspArg: 2.216 ± 0.049
3.268AspSer: 3.268 ± 0.059
2.587AspThr: 2.587 ± 0.068
3.978AspVal: 3.978 ± 0.064
0.85AspTrp: 0.85 ± 0.03
2.078AspTyr: 2.078 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
5.289GluAla: 5.289 ± 0.069
0.563GluCys: 0.563 ± 0.026
2.683GluAsp: 2.683 ± 0.059
3.796GluGlu: 3.796 ± 0.077
2.62GluPhe: 2.62 ± 0.043
3.514GluGly: 3.514 ± 0.067
1.645GluHis: 1.645 ± 0.039
3.842GluIle: 3.842 ± 0.057
3.707GluLys: 3.707 ± 0.057
7.092GluLeu: 7.092 ± 0.085
1.9GluMet: 1.9 ± 0.041
2.573GluAsn: 2.573 ± 0.044
2.021GluPro: 2.021 ± 0.042
4.531GluGln: 4.531 ± 0.069
3.519GluArg: 3.519 ± 0.061
3.625GluSer: 3.625 ± 0.061
2.996GluThr: 2.996 ± 0.048
4.35GluVal: 4.35 ± 0.06
0.777GluTrp: 0.777 ± 0.022
1.781GluTyr: 1.781 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.911PheAla: 3.911 ± 0.067
0.548PheCys: 0.548 ± 0.023
2.83PheAsp: 2.83 ± 0.057
2.617PheGlu: 2.617 ± 0.047
1.689PhePhe: 1.689 ± 0.041
3.283PheGly: 3.283 ± 0.059
0.83PheHis: 0.83 ± 0.027
2.841PheIle: 2.841 ± 0.058
1.901PheLys: 1.901 ± 0.041
3.401PheLeu: 3.401 ± 0.068
1.046PheMet: 1.046 ± 0.03
2.055PheAsn: 2.055 ± 0.049
1.365PhePro: 1.365 ± 0.035
1.278PheGln: 1.278 ± 0.025
1.463PheArg: 1.463 ± 0.031
3.393PheSer: 3.393 ± 0.054
2.393PheThr: 2.393 ± 0.051
3.0PheVal: 3.0 ± 0.052
0.547PheTrp: 0.547 ± 0.024
1.343PheTyr: 1.343 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
5.235GlyAla: 5.235 ± 0.08
0.926GlyCys: 0.926 ± 0.027
3.712GlyAsp: 3.712 ± 0.098
4.529GlyGlu: 4.529 ± 0.074
3.352GlyPhe: 3.352 ± 0.06
4.773GlyGly: 4.773 ± 0.091
1.56GlyHis: 1.56 ± 0.043
4.764GlyIle: 4.764 ± 0.063
3.729GlyLys: 3.729 ± 0.061
6.925GlyLeu: 6.925 ± 0.091
2.084GlyMet: 2.084 ± 0.044
2.586GlyAsn: 2.586 ± 0.079
1.526GlyPro: 1.526 ± 0.038
2.974GlyGln: 2.974 ± 0.056
3.029GlyArg: 3.029 ± 0.05
4.012GlySer: 4.012 ± 0.064
3.17GlyThr: 3.17 ± 0.056
5.182GlyVal: 5.182 ± 0.078
0.975GlyTrp: 0.975 ± 0.03
2.59GlyTyr: 2.59 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.773HisAla: 1.773 ± 0.037
0.348HisCys: 0.348 ± 0.016
1.17HisAsp: 1.17 ± 0.036
1.071HisGlu: 1.071 ± 0.028
1.09HisPhe: 1.09 ± 0.031
1.551HisGly: 1.551 ± 0.038
0.771HisHis: 0.771 ± 0.026
1.491HisIle: 1.491 ± 0.036
0.999HisLys: 0.999 ± 0.033
2.292HisLeu: 2.292 ± 0.05
0.526HisMet: 0.526 ± 0.019
0.966HisAsn: 0.966 ± 0.031
1.088HisPro: 1.088 ± 0.032
1.331HisGln: 1.331 ± 0.031
1.067HisArg: 1.067 ± 0.035
1.455HisSer: 1.455 ± 0.037
1.068HisThr: 1.068 ± 0.028
1.308HisVal: 1.308 ± 0.033
0.349HisTrp: 0.349 ± 0.018
0.919HisTyr: 0.919 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.728IleAla: 6.728 ± 0.084
0.783IleCys: 0.783 ± 0.025
4.407IleAsp: 4.407 ± 0.069
5.069IleGlu: 5.069 ± 0.067
2.315IlePhe: 2.315 ± 0.049
4.776IleGly: 4.776 ± 0.072
1.263IleHis: 1.263 ± 0.034
3.668IleIle: 3.668 ± 0.064
3.069IleLys: 3.069 ± 0.053
5.31IleLeu: 5.31 ± 0.075
1.379IleMet: 1.379 ± 0.036
2.953IleAsn: 2.953 ± 0.051
2.677IlePro: 2.677 ± 0.048
2.341IleGln: 2.341 ± 0.045
2.761IleArg: 2.761 ± 0.048
4.526IleSer: 4.526 ± 0.069
3.745IleThr: 3.745 ± 0.062
4.413IleVal: 4.413 ± 0.074
0.618IleTrp: 0.618 ± 0.022
1.74IleTyr: 1.74 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.687LysAla: 4.687 ± 0.072
0.33LysCys: 0.33 ± 0.016
2.364LysAsp: 2.364 ± 0.042
3.182LysGlu: 3.182 ± 0.056
1.526LysPhe: 1.526 ± 0.036
3.172LysGly: 3.172 ± 0.054
1.206LysHis: 1.206 ± 0.031
2.802LysIle: 2.802 ± 0.056
2.712LysLys: 2.712 ± 0.055
5.239LysLeu: 5.239 ± 0.071
1.429LysMet: 1.429 ± 0.035
1.949LysAsn: 1.949 ± 0.038
2.319LysPro: 2.319 ± 0.051
3.185LysGln: 3.185 ± 0.068
2.6LysArg: 2.6 ± 0.05
2.891LysSer: 2.891 ± 0.049
2.656LysThr: 2.656 ± 0.046
3.669LysVal: 3.669 ± 0.055
0.548LysTrp: 0.548 ± 0.021
1.362LysTyr: 1.362 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
10.472LeuAla: 10.472 ± 0.098
1.065LeuCys: 1.065 ± 0.031
5.832LeuAsp: 5.832 ± 0.072
6.366LeuGlu: 6.366 ± 0.084
4.438LeuPhe: 4.438 ± 0.072
7.004LeuGly: 7.004 ± 0.083
2.057LeuHis: 2.057 ± 0.041
6.369LeuIle: 6.369 ± 0.09
4.996LeuLys: 4.996 ± 0.071
10.689LeuLeu: 10.689 ± 0.148
2.839LeuMet: 2.839 ± 0.054
4.74LeuAsn: 4.74 ± 0.065
4.669LeuPro: 4.669 ± 0.066
3.755LeuGln: 3.755 ± 0.063
4.279LeuArg: 4.279 ± 0.068
7.837LeuSer: 7.837 ± 0.096
6.124LeuThr: 6.124 ± 0.079
7.295LeuVal: 7.295 ± 0.094
1.042LeuTrp: 1.042 ± 0.032
2.702LeuTyr: 2.702 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.752MetAla: 2.752 ± 0.052
0.227MetCys: 0.227 ± 0.013
1.294MetAsp: 1.294 ± 0.031
1.351MetGlu: 1.351 ± 0.034
1.021MetPhe: 1.021 ± 0.035
1.839MetGly: 1.839 ± 0.046
0.511MetHis: 0.511 ± 0.023
1.715MetIle: 1.715 ± 0.039
1.507MetLys: 1.507 ± 0.036
2.888MetLeu: 2.888 ± 0.048
0.894MetMet: 0.894 ± 0.027
1.141MetAsn: 1.141 ± 0.034
1.297MetPro: 1.297 ± 0.033
1.195MetGln: 1.195 ± 0.033
1.259MetArg: 1.259 ± 0.031
2.06MetSer: 2.06 ± 0.044
1.64MetThr: 1.64 ± 0.04
2.007MetVal: 2.007 ± 0.038
0.233MetTrp: 0.233 ± 0.014
0.576MetTyr: 0.576 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.447AsnAla: 3.447 ± 0.053
0.419AsnCys: 0.419 ± 0.018
2.389AsnAsp: 2.389 ± 0.072
2.354AsnGlu: 2.354 ± 0.05
1.57AsnPhe: 1.57 ± 0.037
3.037AsnGly: 3.037 ± 0.068
1.042AsnHis: 1.042 ± 0.028
2.713AsnIle: 2.713 ± 0.049
2.178AsnLys: 2.178 ± 0.047
3.929AsnLeu: 3.929 ± 0.058
1.072AsnMet: 1.072 ± 0.031
1.946AsnAsn: 1.946 ± 0.041
2.06AsnPro: 2.06 ± 0.042
2.438AsnGln: 2.438 ± 0.045
2.013AsnArg: 2.013 ± 0.045
2.488AsnSer: 2.488 ± 0.055
2.157AsnThr: 2.157 ± 0.046
2.777AsnVal: 2.777 ± 0.048
0.557AsnTrp: 0.557 ± 0.022
1.339AsnTyr: 1.339 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.101ProAla: 3.101 ± 0.054
0.36ProCys: 0.36 ± 0.017
2.074ProAsp: 2.074 ± 0.046
2.969ProGlu: 2.969 ± 0.059
1.68ProPhe: 1.68 ± 0.036
1.981ProGly: 1.981 ± 0.045
0.862ProHis: 0.862 ± 0.027
2.645ProIle: 2.645 ± 0.048
1.783ProLys: 1.783 ± 0.043
4.121ProLeu: 4.121 ± 0.06
1.076ProMet: 1.076 ± 0.032
1.748ProAsn: 1.748 ± 0.046
1.044ProPro: 1.044 ± 0.031
1.828ProGln: 1.828 ± 0.042
1.294ProArg: 1.294 ± 0.037
2.467ProSer: 2.467 ± 0.046
2.197ProThr: 2.197 ± 0.049
2.889ProVal: 2.889 ± 0.055
0.488ProTrp: 0.488 ± 0.023
1.223ProTyr: 1.223 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.952GlnAla: 4.952 ± 0.074
0.443GlnCys: 0.443 ± 0.02
2.229GlnAsp: 2.229 ± 0.045
2.605GlnGlu: 2.605 ± 0.052
1.929GlnPhe: 1.929 ± 0.037
3.392GlnGly: 3.392 ± 0.049
1.253GlnHis: 1.253 ± 0.036
2.729GlnIle: 2.729 ± 0.046
1.986GlnLys: 1.986 ± 0.042
5.687GlnLeu: 5.687 ± 0.08
1.21GlnMet: 1.21 ± 0.034
1.667GlnAsn: 1.667 ± 0.04
1.832GlnPro: 1.832 ± 0.039
3.57GlnGln: 3.57 ± 0.091
2.411GlnArg: 2.411 ± 0.051
3.003GlnSer: 3.003 ± 0.067
2.417GlnThr: 2.417 ± 0.042
3.451GlnVal: 3.451 ± 0.058
0.743GlnTrp: 0.743 ± 0.024
1.571GlnTyr: 1.571 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.387ArgAla: 3.387 ± 0.059
0.48ArgCys: 0.48 ± 0.019
2.549ArgAsp: 2.549 ± 0.049
3.006ArgGlu: 3.006 ± 0.053
2.266ArgPhe: 2.266 ± 0.043
2.501ArgGly: 2.501 ± 0.05
1.099ArgHis: 1.099 ± 0.031
3.037ArgIle: 3.037 ± 0.051
2.199ArgLys: 2.199 ± 0.044
4.871ArgLeu: 4.871 ± 0.076
1.219ArgMet: 1.219 ± 0.031
1.883ArgAsn: 1.883 ± 0.038
1.469ArgPro: 1.469 ± 0.032
2.19ArgGln: 2.19 ± 0.047
2.311ArgArg: 2.311 ± 0.059
2.695ArgSer: 2.695 ± 0.05
2.102ArgThr: 2.102 ± 0.041
3.095ArgVal: 3.095 ± 0.049
0.593ArgTrp: 0.593 ± 0.022
1.753ArgTyr: 1.753 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.627SerAla: 5.627 ± 0.075
0.601SerCys: 0.601 ± 0.024
3.649SerAsp: 3.649 ± 0.065
3.915SerGlu: 3.915 ± 0.068
2.791SerPhe: 2.791 ± 0.055
4.837SerGly: 4.837 ± 0.081
1.627SerHis: 1.627 ± 0.038
4.178SerIle: 4.178 ± 0.061
3.063SerLys: 3.063 ± 0.056
7.068SerLeu: 7.068 ± 0.077
1.756SerMet: 1.756 ± 0.041
2.655SerAsn: 2.655 ± 0.046
2.34SerPro: 2.34 ± 0.042
3.209SerGln: 3.209 ± 0.053
2.851SerArg: 2.851 ± 0.055
4.301SerSer: 4.301 ± 0.073
3.228SerThr: 3.228 ± 0.059
4.573SerVal: 4.573 ± 0.061
0.763SerTrp: 0.763 ± 0.024
2.024SerTyr: 2.024 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.511ThrAla: 4.511 ± 0.063
0.45ThrCys: 0.45 ± 0.021
2.636ThrAsp: 2.636 ± 0.052
2.985ThrGlu: 2.985 ± 0.05
2.079ThrPhe: 2.079 ± 0.048
3.786ThrGly: 3.786 ± 0.068
1.195ThrHis: 1.195 ± 0.03
3.614ThrIle: 3.614 ± 0.07
2.328ThrLys: 2.328 ± 0.046
6.346ThrLeu: 6.346 ± 0.071
1.257ThrMet: 1.257 ± 0.033
2.066ThrAsn: 2.066 ± 0.046
2.573ThrPro: 2.573 ± 0.05
2.581ThrGln: 2.581 ± 0.05
2.227ThrArg: 2.227 ± 0.043
3.277ThrSer: 3.277 ± 0.057
2.983ThrThr: 2.983 ± 0.065
3.754ThrVal: 3.754 ± 0.065
0.612ThrTrp: 0.612 ± 0.021
1.381ThrTyr: 1.381 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
6.634ValAla: 6.634 ± 0.087
0.802ValCys: 0.802 ± 0.023
4.126ValAsp: 4.126 ± 0.07
4.896ValGlu: 4.896 ± 0.069
2.76ValPhe: 2.76 ± 0.055
4.752ValGly: 4.752 ± 0.067
1.24ValHis: 1.24 ± 0.034
4.953ValIle: 4.953 ± 0.067
3.563ValLys: 3.563 ± 0.054
6.931ValLeu: 6.931 ± 0.091
2.121ValMet: 2.121 ± 0.048
2.94ValAsn: 2.94 ± 0.046
2.508ValPro: 2.508 ± 0.053
2.306ValGln: 2.306 ± 0.044
2.904ValArg: 2.904 ± 0.05
4.825ValSer: 4.825 ± 0.076
4.13ValThr: 4.13 ± 0.066
5.625ValVal: 5.625 ± 0.091
0.779ValTrp: 0.779 ± 0.025
1.855ValTyr: 1.855 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.913TrpAla: 0.913 ± 0.029
0.151TrpCys: 0.151 ± 0.012
0.583TrpAsp: 0.583 ± 0.018
0.48TrpGlu: 0.48 ± 0.022
0.622TrpPhe: 0.622 ± 0.022
0.759TrpGly: 0.759 ± 0.028
0.369TrpHis: 0.369 ± 0.019
0.661TrpIle: 0.661 ± 0.027
0.483TrpLys: 0.483 ± 0.02
1.81TrpLeu: 1.81 ± 0.047
0.34TrpMet: 0.34 ± 0.018
0.458TrpAsn: 0.458 ± 0.019
0.436TrpPro: 0.436 ± 0.022
1.024TrpGln: 1.024 ± 0.034
0.645TrpArg: 0.645 ± 0.024
0.712TrpSer: 0.712 ± 0.023
0.429TrpThr: 0.429 ± 0.02
0.856TrpVal: 0.856 ± 0.028
0.198TrpTrp: 0.198 ± 0.015
0.389TrpTyr: 0.389 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.338TyrAla: 2.338 ± 0.047
0.395TyrCys: 0.395 ± 0.018
1.646TyrAsp: 1.646 ± 0.036
1.421TyrGlu: 1.421 ± 0.029
1.448TyrPhe: 1.448 ± 0.032
2.072TyrGly: 2.072 ± 0.047
0.856TyrHis: 0.856 ± 0.026
1.653TyrIle: 1.653 ± 0.036
1.25TyrLys: 1.25 ± 0.035
3.416TyrLeu: 3.416 ± 0.054
0.644TyrMet: 0.644 ± 0.025
1.136TyrAsn: 1.136 ± 0.037
1.327TyrPro: 1.327 ± 0.034
2.159TyrGln: 2.159 ± 0.044
1.721TyrArg: 1.721 ± 0.041
2.052TyrSer: 2.052 ± 0.039
1.485TyrThr: 1.485 ± 0.037
1.874TyrVal: 1.874 ± 0.04
0.508TyrTrp: 0.508 ± 0.02
1.076TyrTyr: 1.076 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4028 proteins (1263308 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski