Amino acid dipepetide frequency for Marinomonas aquimarina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.138AlaAla: 9.138 ± 0.134
0.96AlaCys: 0.96 ± 0.028
5.089AlaAsp: 5.089 ± 0.078
6.153AlaGlu: 6.153 ± 0.077
3.702AlaPhe: 3.702 ± 0.067
6.5AlaGly: 6.5 ± 0.102
1.928AlaHis: 1.928 ± 0.036
5.865AlaIle: 5.865 ± 0.078
4.619AlaLys: 4.619 ± 0.079
11.27AlaLeu: 11.27 ± 0.108
2.904AlaMet: 2.904 ± 0.06
3.522AlaAsn: 3.522 ± 0.061
3.546AlaPro: 3.546 ± 0.071
4.865AlaGln: 4.865 ± 0.09
4.215AlaArg: 4.215 ± 0.062
5.951AlaSer: 5.951 ± 0.082
4.713AlaThr: 4.713 ± 0.087
6.253AlaVal: 6.253 ± 0.084
1.174AlaTrp: 1.174 ± 0.038
2.554AlaTyr: 2.554 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.868CysAla: 0.868 ± 0.029
0.154CysCys: 0.154 ± 0.014
0.593CysAsp: 0.593 ± 0.022
0.595CysGlu: 0.595 ± 0.025
0.441CysPhe: 0.441 ± 0.024
0.795CysGly: 0.795 ± 0.027
0.338CysHis: 0.338 ± 0.019
0.524CysIle: 0.524 ± 0.021
0.332CysLys: 0.332 ± 0.018
1.065CysLeu: 1.065 ± 0.031
0.217CysMet: 0.217 ± 0.016
0.294CysAsn: 0.294 ± 0.016
0.411CysPro: 0.411 ± 0.019
0.505CysGln: 0.505 ± 0.026
0.496CysArg: 0.496 ± 0.022
0.622CysSer: 0.622 ± 0.023
0.461CysThr: 0.461 ± 0.023
0.676CysVal: 0.676 ± 0.025
0.123CysTrp: 0.123 ± 0.011
0.304CysTyr: 0.304 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.055AspAla: 5.055 ± 0.076
0.516AspCys: 0.516 ± 0.022
3.096AspAsp: 3.096 ± 0.064
4.023AspGlu: 4.023 ± 0.071
2.34AspPhe: 2.34 ± 0.045
3.842AspGly: 3.842 ± 0.08
1.321AspHis: 1.321 ± 0.044
3.821AspIle: 3.821 ± 0.063
2.448AspLys: 2.448 ± 0.046
5.709AspLeu: 5.709 ± 0.075
1.55AspMet: 1.55 ± 0.038
2.041AspAsn: 2.041 ± 0.055
2.265AspPro: 2.265 ± 0.051
2.583AspGln: 2.583 ± 0.046
2.619AspArg: 2.619 ± 0.045
3.292AspSer: 3.292 ± 0.062
2.798AspThr: 2.798 ± 0.061
4.115AspVal: 4.115 ± 0.07
0.935AspTrp: 0.935 ± 0.029
1.948AspTyr: 1.948 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
6.309GluAla: 6.309 ± 0.085
0.54GluCys: 0.54 ± 0.025
3.318GluAsp: 3.318 ± 0.066
4.071GluGlu: 4.071 ± 0.081
2.412GluPhe: 2.412 ± 0.047
3.882GluGly: 3.882 ± 0.06
1.742GluHis: 1.742 ± 0.044
3.439GluIle: 3.439 ± 0.053
3.013GluLys: 3.013 ± 0.059
7.033GluLeu: 7.033 ± 0.091
1.676GluMet: 1.676 ± 0.043
2.26GluAsn: 2.26 ± 0.05
2.218GluPro: 2.218 ± 0.059
4.558GluGln: 4.558 ± 0.075
3.978GluArg: 3.978 ± 0.059
3.699GluSer: 3.699 ± 0.066
3.069GluThr: 3.069 ± 0.047
4.548GluVal: 4.548 ± 0.075
0.81GluTrp: 0.81 ± 0.026
1.73GluTyr: 1.73 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.822PheAla: 3.822 ± 0.063
0.504PheCys: 0.504 ± 0.022
2.767PheAsp: 2.767 ± 0.052
2.565PheGlu: 2.565 ± 0.053
1.64PhePhe: 1.64 ± 0.044
3.097PheGly: 3.097 ± 0.059
0.844PheHis: 0.844 ± 0.028
2.51PheIle: 2.51 ± 0.049
1.722PheLys: 1.722 ± 0.039
3.442PheLeu: 3.442 ± 0.06
1.052PheMet: 1.052 ± 0.033
1.647PheAsn: 1.647 ± 0.043
1.478PhePro: 1.478 ± 0.037
1.4PheGln: 1.4 ± 0.036
1.589PheArg: 1.589 ± 0.04
3.017PheSer: 3.017 ± 0.053
2.102PheThr: 2.102 ± 0.054
2.833PheVal: 2.833 ± 0.049
0.548PheTrp: 0.548 ± 0.022
1.302PheTyr: 1.302 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
5.738GlyAla: 5.738 ± 0.1
0.807GlyCys: 0.807 ± 0.029
3.654GlyAsp: 3.654 ± 0.06
4.307GlyGlu: 4.307 ± 0.065
3.23GlyPhe: 3.23 ± 0.056
4.724GlyGly: 4.724 ± 0.092
1.712GlyHis: 1.712 ± 0.047
4.433GlyIle: 4.433 ± 0.072
3.443GlyLys: 3.443 ± 0.07
7.259GlyLeu: 7.259 ± 0.097
2.135GlyMet: 2.135 ± 0.054
2.328GlyAsn: 2.328 ± 0.052
1.753GlyPro: 1.753 ± 0.045
3.208GlyGln: 3.208 ± 0.056
3.45GlyArg: 3.45 ± 0.061
4.077GlySer: 4.077 ± 0.08
3.364GlyThr: 3.364 ± 0.075
5.529GlyVal: 5.529 ± 0.08
1.005GlyTrp: 1.005 ± 0.028
2.456GlyTyr: 2.456 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.891HisAla: 1.891 ± 0.044
0.294HisCys: 0.294 ± 0.019
1.308HisAsp: 1.308 ± 0.044
1.334HisGlu: 1.334 ± 0.039
1.129HisPhe: 1.129 ± 0.029
1.584HisGly: 1.584 ± 0.039
0.72HisHis: 0.72 ± 0.029
1.307HisIle: 1.307 ± 0.035
0.989HisLys: 0.989 ± 0.033
2.427HisLeu: 2.427 ± 0.054
0.578HisMet: 0.578 ± 0.021
0.855HisAsn: 0.855 ± 0.033
1.263HisPro: 1.263 ± 0.037
1.151HisGln: 1.151 ± 0.034
1.114HisArg: 1.114 ± 0.032
1.502HisSer: 1.502 ± 0.042
1.149HisThr: 1.149 ± 0.035
1.418HisVal: 1.418 ± 0.036
0.378HisTrp: 0.378 ± 0.022
0.887HisTyr: 0.887 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.205IleAla: 6.205 ± 0.079
0.623IleCys: 0.623 ± 0.022
3.813IleAsp: 3.813 ± 0.063
4.532IleGlu: 4.532 ± 0.071
1.929IlePhe: 1.929 ± 0.04
4.43IleGly: 4.43 ± 0.078
1.202IleHis: 1.202 ± 0.034
3.046IleIle: 3.046 ± 0.06
2.715IleLys: 2.715 ± 0.054
5.056IleLeu: 5.056 ± 0.086
1.314IleMet: 1.314 ± 0.036
2.397IleAsn: 2.397 ± 0.044
2.465IlePro: 2.465 ± 0.047
2.266IleGln: 2.266 ± 0.047
2.924IleArg: 2.924 ± 0.055
4.042IleSer: 4.042 ± 0.058
3.28IleThr: 3.28 ± 0.062
3.899IleVal: 3.899 ± 0.063
0.639IleTrp: 0.639 ± 0.026
1.448IleTyr: 1.448 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.619LysAla: 4.619 ± 0.075
0.26LysCys: 0.26 ± 0.016
2.561LysAsp: 2.561 ± 0.048
2.929LysGlu: 2.929 ± 0.054
1.26LysPhe: 1.26 ± 0.036
3.009LysGly: 3.009 ± 0.057
1.179LysHis: 1.179 ± 0.034
2.244LysIle: 2.244 ± 0.048
2.277LysLys: 2.277 ± 0.064
4.414LysLeu: 4.414 ± 0.07
1.184LysMet: 1.184 ± 0.028
1.503LysAsn: 1.503 ± 0.043
1.978LysPro: 1.978 ± 0.047
2.562LysGln: 2.562 ± 0.054
2.759LysArg: 2.759 ± 0.053
2.628LysSer: 2.628 ± 0.054
2.354LysThr: 2.354 ± 0.043
3.609LysVal: 3.609 ± 0.06
0.518LysTrp: 0.518 ± 0.022
0.99LysTyr: 0.99 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
11.02LeuAla: 11.02 ± 0.111
1.086LeuCys: 1.086 ± 0.031
6.101LeuAsp: 6.101 ± 0.091
6.808LeuGlu: 6.808 ± 0.078
4.099LeuPhe: 4.099 ± 0.076
7.342LeuGly: 7.342 ± 0.093
2.178LeuHis: 2.178 ± 0.049
5.981LeuIle: 5.981 ± 0.091
4.981LeuLys: 4.981 ± 0.073
11.276LeuLeu: 11.276 ± 0.138
2.848LeuMet: 2.848 ± 0.058
4.315LeuAsn: 4.315 ± 0.069
4.989LeuPro: 4.989 ± 0.071
4.417LeuGln: 4.417 ± 0.075
4.748LeuArg: 4.748 ± 0.076
8.176LeuSer: 8.176 ± 0.095
5.823LeuThr: 5.823 ± 0.085
7.341LeuVal: 7.341 ± 0.097
1.13LeuTrp: 1.13 ± 0.038
2.684LeuTyr: 2.684 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.827MetAla: 2.827 ± 0.057
0.206MetCys: 0.206 ± 0.014
1.358MetAsp: 1.358 ± 0.035
1.313MetGlu: 1.313 ± 0.036
0.856MetPhe: 0.856 ± 0.03
1.781MetGly: 1.781 ± 0.044
0.496MetHis: 0.496 ± 0.02
1.475MetIle: 1.475 ± 0.039
1.26MetLys: 1.26 ± 0.035
2.892MetLeu: 2.892 ± 0.058
0.789MetMet: 0.789 ± 0.029
1.046MetAsn: 1.046 ± 0.029
1.31MetPro: 1.31 ± 0.034
1.193MetGln: 1.193 ± 0.036
1.347MetArg: 1.347 ± 0.038
2.196MetSer: 2.196 ± 0.047
1.692MetThr: 1.692 ± 0.035
1.885MetVal: 1.885 ± 0.043
0.237MetTrp: 0.237 ± 0.016
0.532MetTyr: 0.532 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.421AsnAla: 3.421 ± 0.061
0.324AsnCys: 0.324 ± 0.02
2.189AsnAsp: 2.189 ± 0.039
2.243AsnGlu: 2.243 ± 0.046
1.388AsnPhe: 1.388 ± 0.038
2.718AsnGly: 2.718 ± 0.055
0.861AsnHis: 0.861 ± 0.027
2.297AsnIle: 2.297 ± 0.044
1.608AsnLys: 1.608 ± 0.037
3.704AsnLeu: 3.704 ± 0.063
0.941AsnMet: 0.941 ± 0.028
1.436AsnAsn: 1.436 ± 0.04
1.804AsnPro: 1.804 ± 0.044
1.822AsnGln: 1.822 ± 0.042
1.823AsnArg: 1.823 ± 0.041
2.183AsnSer: 2.183 ± 0.048
1.985AsnThr: 1.985 ± 0.045
2.461AsnVal: 2.461 ± 0.045
0.537AsnTrp: 0.537 ± 0.021
1.097AsnTyr: 1.097 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.522ProAla: 3.522 ± 0.058
0.323ProCys: 0.323 ± 0.018
2.416ProAsp: 2.416 ± 0.05
3.571ProGlu: 3.571 ± 0.068
1.779ProPhe: 1.779 ± 0.043
2.267ProGly: 2.267 ± 0.052
0.892ProHis: 0.892 ± 0.031
2.501ProIle: 2.501 ± 0.053
1.989ProLys: 1.989 ± 0.047
4.084ProLeu: 4.084 ± 0.06
1.159ProMet: 1.159 ± 0.035
1.748ProAsn: 1.748 ± 0.047
1.267ProPro: 1.267 ± 0.036
1.581ProGln: 1.581 ± 0.042
1.472ProArg: 1.472 ± 0.041
2.741ProSer: 2.741 ± 0.056
2.222ProThr: 2.222 ± 0.057
3.152ProVal: 3.152 ± 0.06
0.523ProTrp: 0.523 ± 0.024
1.272ProTyr: 1.272 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.525GlnAla: 5.525 ± 0.087
0.405GlnCys: 0.405 ± 0.02
2.436GlnAsp: 2.436 ± 0.047
2.767GlnGlu: 2.767 ± 0.055
1.686GlnPhe: 1.686 ± 0.043
3.426GlnGly: 3.426 ± 0.06
1.298GlnHis: 1.298 ± 0.035
2.49GlnIle: 2.49 ± 0.048
1.932GlnLys: 1.932 ± 0.049
5.254GlnLeu: 5.254 ± 0.086
1.144GlnMet: 1.144 ± 0.036
1.579GlnAsn: 1.579 ± 0.04
1.818GlnPro: 1.818 ± 0.041
3.41GlnGln: 3.41 ± 0.084
2.776GlnArg: 2.776 ± 0.06
3.024GlnSer: 3.024 ± 0.059
2.572GlnThr: 2.572 ± 0.051
3.552GlnVal: 3.552 ± 0.061
0.663GlnTrp: 0.663 ± 0.026
1.307GlnTyr: 1.307 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
4.076ArgAla: 4.076 ± 0.061
0.481ArgCys: 0.481 ± 0.021
2.649ArgAsp: 2.649 ± 0.056
3.09ArgGlu: 3.09 ± 0.057
2.342ArgPhe: 2.342 ± 0.046
2.816ArgGly: 2.816 ± 0.057
1.326ArgHis: 1.326 ± 0.038
3.204ArgIle: 3.204 ± 0.055
2.134ArgLys: 2.134 ± 0.044
5.593ArgLeu: 5.593 ± 0.081
1.346ArgMet: 1.346 ± 0.039
1.747ArgAsn: 1.747 ± 0.045
1.935ArgPro: 1.935 ± 0.047
2.548ArgGln: 2.548 ± 0.059
2.71ArgArg: 2.71 ± 0.061
2.946ArgSer: 2.946 ± 0.052
2.345ArgThr: 2.345 ± 0.05
3.376ArgVal: 3.376 ± 0.058
0.676ArgTrp: 0.676 ± 0.025
1.924ArgTyr: 1.924 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
6.004SerAla: 6.004 ± 0.081
0.572SerCys: 0.572 ± 0.025
3.767SerAsp: 3.767 ± 0.076
4.137SerGlu: 4.137 ± 0.068
2.795SerPhe: 2.795 ± 0.053
4.756SerGly: 4.756 ± 0.07
1.544SerHis: 1.544 ± 0.039
3.818SerIle: 3.818 ± 0.066
2.875SerLys: 2.875 ± 0.052
7.255SerLeu: 7.255 ± 0.087
1.753SerMet: 1.753 ± 0.042
2.47SerAsn: 2.47 ± 0.051
2.443SerPro: 2.443 ± 0.05
2.961SerGln: 2.961 ± 0.053
3.002SerArg: 3.002 ± 0.042
4.419SerSer: 4.419 ± 0.082
3.218SerThr: 3.218 ± 0.055
4.732SerVal: 4.732 ± 0.072
0.825SerTrp: 0.825 ± 0.03
1.95SerTyr: 1.95 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
4.46ThrAla: 4.46 ± 0.071
0.459ThrCys: 0.459 ± 0.021
2.785ThrAsp: 2.785 ± 0.059
3.065ThrGlu: 3.065 ± 0.059
2.059ThrPhe: 2.059 ± 0.042
3.968ThrGly: 3.968 ± 0.069
1.157ThrHis: 1.157 ± 0.031
2.903ThrIle: 2.903 ± 0.064
1.897ThrLys: 1.897 ± 0.04
6.735ThrLeu: 6.735 ± 0.103
1.129ThrMet: 1.129 ± 0.031
1.662ThrAsn: 1.662 ± 0.049
2.944ThrPro: 2.944 ± 0.054
2.471ThrGln: 2.471 ± 0.05
2.316ThrArg: 2.316 ± 0.048
3.203ThrSer: 3.203 ± 0.058
2.741ThrThr: 2.741 ± 0.065
3.76ThrVal: 3.76 ± 0.07
0.606ThrTrp: 0.606 ± 0.022
1.376ThrTyr: 1.376 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
7.2ValAla: 7.2 ± 0.094
0.778ValCys: 0.778 ± 0.026
4.123ValAsp: 4.123 ± 0.062
4.588ValGlu: 4.588 ± 0.071
2.811ValPhe: 2.811 ± 0.051
4.773ValGly: 4.773 ± 0.076
1.358ValHis: 1.358 ± 0.035
4.315ValIle: 4.315 ± 0.069
3.146ValLys: 3.146 ± 0.065
7.601ValLeu: 7.601 ± 0.102
2.014ValMet: 2.014 ± 0.049
2.654ValAsn: 2.654 ± 0.054
2.712ValPro: 2.712 ± 0.051
2.631ValGln: 2.631 ± 0.05
3.368ValArg: 3.368 ± 0.057
5.036ValSer: 5.036 ± 0.073
3.97ValThr: 3.97 ± 0.069
5.57ValVal: 5.57 ± 0.09
0.858ValTrp: 0.858 ± 0.031
1.885ValTyr: 1.885 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.863TrpAla: 0.863 ± 0.03
0.174TrpCys: 0.174 ± 0.014
0.554TrpAsp: 0.554 ± 0.02
0.542TrpGlu: 0.542 ± 0.02
0.625TrpPhe: 0.625 ± 0.026
0.819TrpGly: 0.819 ± 0.028
0.443TrpHis: 0.443 ± 0.021
0.647TrpIle: 0.647 ± 0.024
0.417TrpLys: 0.417 ± 0.021
1.988TrpLeu: 1.988 ± 0.048
0.316TrpMet: 0.316 ± 0.016
0.393TrpAsn: 0.393 ± 0.019
0.533TrpPro: 0.533 ± 0.02
1.068TrpGln: 1.068 ± 0.036
0.802TrpArg: 0.802 ± 0.029
0.765TrpSer: 0.765 ± 0.027
0.483TrpThr: 0.483 ± 0.021
0.895TrpVal: 0.895 ± 0.028
0.206TrpTrp: 0.206 ± 0.014
0.324TrpTyr: 0.324 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.359TyrAla: 2.359 ± 0.048
0.348TyrCys: 0.348 ± 0.018
1.738TyrAsp: 1.738 ± 0.045
1.676TyrGlu: 1.676 ± 0.046
1.357TyrPhe: 1.357 ± 0.037
2.081TyrGly: 2.081 ± 0.048
0.74TyrHis: 0.74 ± 0.03
1.408TyrIle: 1.408 ± 0.04
1.039TyrLys: 1.039 ± 0.034
3.285TyrLeu: 3.285 ± 0.05
0.64TyrMet: 0.64 ± 0.025
0.946TyrAsn: 0.946 ± 0.031
1.349TyrPro: 1.349 ± 0.037
1.862TyrGln: 1.862 ± 0.043
1.759TyrArg: 1.759 ± 0.046
1.777TyrSer: 1.777 ± 0.042
1.353TyrThr: 1.353 ± 0.038
1.785TyrVal: 1.785 ± 0.045
0.467TyrTrp: 0.467 ± 0.023
0.917TyrTyr: 0.917 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3360 proteins (1092500 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski