Amino acid dipepetide frequency for Hubei tombus-like virus 19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.98AlaAla: 1.98 ± 0.698
1.98AlaCys: 1.98 ± 1.136
3.3AlaAsp: 3.3 ± 2.223
1.32AlaGlu: 1.32 ± 0.537
3.3AlaPhe: 3.3 ± 1.487
5.281AlaGly: 5.281 ± 1.234
1.98AlaHis: 1.98 ± 0.698
3.3AlaIle: 3.3 ± 0.598
5.281AlaLys: 5.281 ± 1.115
6.601AlaLeu: 6.601 ± 1.195
2.64AlaMet: 2.64 ± 0.682
2.64AlaAsn: 2.64 ± 0.38
3.3AlaPro: 3.3 ± 1.531
5.941AlaGln: 5.941 ± 1.944
5.281AlaArg: 5.281 ± 2.08
3.96AlaSer: 3.96 ± 1.183
3.96AlaThr: 3.96 ± 1.697
1.98AlaVal: 1.98 ± 0.439
1.98AlaTrp: 1.98 ± 0.94
1.32AlaTyr: 1.32 ± 1.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.32CysAla: 1.32 ± 0.848
0.0CysCys: 0.0 ± 0.0
1.32CysAsp: 1.32 ± 0.843
1.98CysGlu: 1.98 ± 1.042
0.0CysPhe: 0.0 ± 0.0
2.64CysGly: 2.64 ± 1.997
0.66CysHis: 0.66 ± 0.805
0.66CysIle: 0.66 ± 0.499
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.66CysGln: 0.66 ± 0.527
1.32CysArg: 1.32 ± 0.999
1.32CysSer: 1.32 ± 1.11
1.32CysThr: 1.32 ± 0.647
1.32CysVal: 1.32 ± 0.537
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.62AspAla: 4.62 ± 2.289
0.0AspCys: 0.0 ± 0.0
1.32AspAsp: 1.32 ± 0.647
1.98AspGlu: 1.98 ± 0.698
1.32AspPhe: 1.32 ± 0.537
2.64AspGly: 2.64 ± 0.933
0.66AspHis: 0.66 ± 0.499
1.98AspIle: 1.98 ± 1.664
2.64AspLys: 2.64 ± 1.405
4.62AspLeu: 4.62 ± 1.355
2.64AspMet: 2.64 ± 1.519
1.32AspAsn: 1.32 ± 0.566
1.98AspPro: 1.98 ± 0.698
1.98AspGln: 1.98 ± 0.439
1.32AspArg: 1.32 ± 1.611
6.601AspSer: 6.601 ± 1.633
2.64AspThr: 2.64 ± 1.519
0.66AspVal: 0.66 ± 0.527
0.66AspTrp: 0.66 ± 0.527
3.3AspTyr: 3.3 ± 1.503
0.0AspXaa: 0.0 ± 0.0
Glu
2.64GluAla: 2.64 ± 1.074
0.66GluCys: 0.66 ± 0.499
3.96GluAsp: 3.96 ± 1.308
2.64GluGlu: 2.64 ± 1.357
1.98GluPhe: 1.98 ± 1.153
2.64GluGly: 2.64 ± 1.519
1.98GluHis: 1.98 ± 1.153
3.3GluIle: 3.3 ± 1.417
1.98GluLys: 1.98 ± 1.498
3.96GluLeu: 3.96 ± 0.461
1.32GluMet: 1.32 ± 0.537
1.32GluAsn: 1.32 ± 0.566
1.98GluPro: 1.98 ± 0.912
1.32GluGln: 1.32 ± 0.537
4.62GluArg: 4.62 ± 2.301
7.261GluSer: 7.261 ± 2.165
3.96GluThr: 3.96 ± 1.611
3.96GluVal: 3.96 ± 1.727
0.66GluTrp: 0.66 ± 0.527
1.98GluTyr: 1.98 ± 1.128
0.0GluXaa: 0.0 ± 0.0
Phe
2.64PheAla: 2.64 ± 1.295
1.32PheCys: 1.32 ± 1.054
2.64PheAsp: 2.64 ± 1.0
2.64PheGlu: 2.64 ± 1.686
1.98PhePhe: 1.98 ± 1.562
3.96PheGly: 3.96 ± 2.529
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
1.98PheLys: 1.98 ± 1.581
3.96PheLeu: 3.96 ± 1.897
0.0PheMet: 0.0 ± 0.0
2.64PheAsn: 2.64 ± 0.682
1.32PhePro: 1.32 ± 0.843
0.66PheGln: 0.66 ± 0.527
3.3PheArg: 3.3 ± 1.306
3.3PheSer: 3.3 ± 0.488
1.32PheThr: 1.32 ± 0.566
3.3PheVal: 3.3 ± 1.458
0.0PheTrp: 0.0 ± 0.0
1.32PheTyr: 1.32 ± 0.647
0.0PheXaa: 0.0 ± 0.0
Gly
1.98GlyAla: 1.98 ± 0.912
0.66GlyCys: 0.66 ± 0.499
2.64GlyAsp: 2.64 ± 0.788
3.96GlyGlu: 3.96 ± 1.144
1.98GlyPhe: 1.98 ± 1.042
2.64GlyGly: 2.64 ± 1.519
0.66GlyHis: 0.66 ± 0.527
2.64GlyIle: 2.64 ± 0.844
3.96GlyLys: 3.96 ± 2.212
5.281GlyLeu: 5.281 ± 1.655
0.66GlyMet: 0.66 ± 0.527
1.98GlyAsn: 1.98 ± 1.042
4.62GlyPro: 4.62 ± 0.758
2.64GlyGln: 2.64 ± 1.447
2.64GlyArg: 2.64 ± 0.788
3.96GlySer: 3.96 ± 1.143
2.64GlyThr: 2.64 ± 1.0
7.921GlyVal: 7.921 ± 1.972
0.66GlyTrp: 0.66 ± 0.527
1.98GlyTyr: 1.98 ± 0.912
0.0GlyXaa: 0.0 ± 0.0
His
0.66HisAla: 0.66 ± 0.499
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
2.64HisGlu: 2.64 ± 0.96
0.66HisPhe: 0.66 ± 0.805
1.98HisGly: 1.98 ± 1.664
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.66HisLys: 0.66 ± 0.499
2.64HisLeu: 2.64 ± 1.426
0.66HisMet: 0.66 ± 0.499
1.32HisAsn: 1.32 ± 0.808
1.98HisPro: 1.98 ± 0.912
0.0HisGln: 0.0 ± 0.0
1.32HisArg: 1.32 ± 0.647
0.66HisSer: 0.66 ± 0.555
0.66HisThr: 0.66 ± 0.527
1.32HisVal: 1.32 ± 0.843
0.0HisTrp: 0.0 ± 0.0
1.32HisTyr: 1.32 ± 0.848
0.0HisXaa: 0.0 ± 0.0
Ile
1.98IleAla: 1.98 ± 0.439
0.0IleCys: 0.0 ± 0.0
1.32IleAsp: 1.32 ± 0.999
3.96IleGlu: 3.96 ± 1.308
0.0IlePhe: 0.0 ± 0.0
0.66IleGly: 0.66 ± 0.499
1.98IleHis: 1.98 ± 1.153
1.98IleIle: 1.98 ± 0.737
1.32IleLys: 1.32 ± 0.843
4.62IleLeu: 4.62 ± 1.162
1.98IleMet: 1.98 ± 0.439
1.98IleAsn: 1.98 ± 0.893
3.3IlePro: 3.3 ± 0.987
3.3IleGln: 3.3 ± 1.439
5.281IleArg: 5.281 ± 1.423
5.941IleSer: 5.941 ± 0.871
1.32IleThr: 1.32 ± 0.566
3.3IleVal: 3.3 ± 1.285
0.66IleTrp: 0.66 ± 0.527
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
3.96LysAla: 3.96 ± 1.179
1.32LysCys: 1.32 ± 1.054
2.64LysAsp: 2.64 ± 1.0
3.96LysGlu: 3.96 ± 0.467
4.62LysPhe: 4.62 ± 2.322
1.98LysGly: 1.98 ± 1.581
0.66LysHis: 0.66 ± 0.805
3.3LysIle: 3.3 ± 0.983
3.96LysLys: 3.96 ± 1.339
7.921LysLeu: 7.921 ± 1.687
0.66LysMet: 0.66 ± 0.555
1.32LysAsn: 1.32 ± 0.537
5.281LysPro: 5.281 ± 1.234
0.66LysGln: 0.66 ± 0.555
1.32LysArg: 1.32 ± 0.566
5.281LysSer: 5.281 ± 1.175
4.62LysThr: 4.62 ± 1.394
1.98LysVal: 1.98 ± 0.893
1.98LysTrp: 1.98 ± 1.042
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
7.921LeuAla: 7.921 ± 1.805
0.0LeuCys: 0.0 ± 0.0
4.62LeuAsp: 4.62 ± 2.443
5.281LeuGlu: 5.281 ± 1.186
2.64LeuPhe: 2.64 ± 1.131
5.281LeuGly: 5.281 ± 0.379
1.32LeuHis: 1.32 ± 0.566
3.3LeuIle: 3.3 ± 1.82
3.96LeuLys: 3.96 ± 1.829
6.601LeuLeu: 6.601 ± 2.087
1.32LeuMet: 1.32 ± 1.054
1.98LeuAsn: 1.98 ± 1.003
5.281LeuPro: 5.281 ± 0.675
3.96LeuGln: 3.96 ± 0.878
5.281LeuArg: 5.281 ± 1.186
10.561LeuSer: 10.561 ± 3.367
7.921LeuThr: 7.921 ± 1.786
9.241LeuVal: 9.241 ± 1.869
1.32LeuTrp: 1.32 ± 0.843
0.66LeuTyr: 0.66 ± 0.805
0.0LeuXaa: 0.0 ± 0.0
Met
3.3MetAla: 3.3 ± 2.021
0.0MetCys: 0.0 ± 0.0
1.32MetAsp: 1.32 ± 1.054
1.98MetGlu: 1.98 ± 0.893
0.66MetPhe: 0.66 ± 0.527
0.66MetGly: 0.66 ± 0.555
0.0MetHis: 0.0 ± 0.0
0.66MetIle: 0.66 ± 0.527
1.32MetLys: 1.32 ± 0.537
2.64MetLeu: 2.64 ± 0.844
0.0MetMet: 0.0 ± 0.0
1.98MetAsn: 1.98 ± 0.698
1.32MetPro: 1.32 ± 1.11
0.66MetGln: 0.66 ± 0.555
1.98MetArg: 1.98 ± 0.893
1.32MetSer: 1.32 ± 0.647
1.32MetThr: 1.32 ± 0.647
1.32MetVal: 1.32 ± 0.566
0.66MetTrp: 0.66 ± 0.527
1.32MetTyr: 1.32 ± 0.537
0.0MetXaa: 0.0 ± 0.0
Asn
1.98AsnAla: 1.98 ± 0.439
1.32AsnCys: 1.32 ± 1.11
0.66AsnAsp: 0.66 ± 0.499
2.64AsnGlu: 2.64 ± 1.997
1.32AsnPhe: 1.32 ± 0.566
1.98AsnGly: 1.98 ± 0.893
0.0AsnHis: 0.0 ± 0.0
1.98AsnIle: 1.98 ± 1.003
0.66AsnLys: 0.66 ± 0.527
2.64AsnLeu: 2.64 ± 0.682
2.64AsnMet: 2.64 ± 0.869
1.32AsnAsn: 1.32 ± 0.999
3.3AsnPro: 3.3 ± 0.987
1.98AsnGln: 1.98 ± 1.664
3.96AsnArg: 3.96 ± 1.267
5.941AsnSer: 5.941 ± 2.532
1.98AsnThr: 1.98 ± 1.136
3.96AsnVal: 3.96 ± 0.878
0.66AsnTrp: 0.66 ± 0.555
1.32AsnTyr: 1.32 ± 0.808
0.0AsnXaa: 0.0 ± 0.0
Pro
5.281ProAla: 5.281 ± 2.334
0.0ProCys: 0.0 ± 0.0
5.281ProAsp: 5.281 ± 1.726
2.64ProGlu: 2.64 ± 0.844
3.96ProPhe: 3.96 ± 1.143
3.96ProGly: 3.96 ± 1.703
1.98ProHis: 1.98 ± 0.94
1.98ProIle: 1.98 ± 1.581
4.62ProLys: 4.62 ± 1.394
3.3ProLeu: 3.3 ± 0.987
0.66ProMet: 0.66 ± 0.555
4.62ProAsn: 4.62 ± 2.39
5.941ProPro: 5.941 ± 2.166
3.96ProGln: 3.96 ± 1.823
3.96ProArg: 3.96 ± 1.314
3.96ProSer: 3.96 ± 1.823
5.941ProThr: 5.941 ± 0.871
6.601ProVal: 6.601 ± 1.325
0.66ProTrp: 0.66 ± 0.805
1.32ProTyr: 1.32 ± 0.537
0.0ProXaa: 0.0 ± 0.0
Gln
1.98GlnAla: 1.98 ± 0.439
1.32GlnCys: 1.32 ± 0.647
1.98GlnAsp: 1.98 ± 0.741
3.96GlnGlu: 3.96 ± 1.283
1.32GlnPhe: 1.32 ± 0.843
2.64GlnGly: 2.64 ± 0.682
1.32GlnHis: 1.32 ± 1.11
3.96GlnIle: 3.96 ± 1.144
0.0GlnLys: 0.0 ± 0.0
4.62GlnLeu: 4.62 ± 0.758
1.98GlnMet: 1.98 ± 1.085
1.32GlnAsn: 1.32 ± 0.537
5.281GlnPro: 5.281 ± 1.715
2.64GlnGln: 2.64 ± 1.405
3.3GlnArg: 3.3 ± 1.425
3.3GlnSer: 3.3 ± 0.488
1.98GlnThr: 1.98 ± 0.912
1.98GlnVal: 1.98 ± 1.664
0.0GlnTrp: 0.0 ± 0.0
0.66GlnTyr: 0.66 ± 0.527
0.0GlnXaa: 0.0 ± 0.0
Arg
3.96ArgAla: 3.96 ± 1.88
0.0ArgCys: 0.0 ± 0.0
1.32ArgAsp: 1.32 ± 0.843
1.32ArgGlu: 1.32 ± 0.999
4.62ArgPhe: 4.62 ± 2.098
3.3ArgGly: 3.3 ± 1.439
0.66ArgHis: 0.66 ± 0.499
3.3ArgIle: 3.3 ± 1.007
5.281ArgLys: 5.281 ± 1.228
6.601ArgLeu: 6.601 ± 2.829
3.3ArgMet: 3.3 ± 1.653
4.62ArgAsn: 4.62 ± 1.877
4.62ArgPro: 4.62 ± 1.521
5.281ArgGln: 5.281 ± 1.078
4.62ArgArg: 4.62 ± 1.313
4.62ArgSer: 4.62 ± 2.804
5.281ArgThr: 5.281 ± 1.175
5.281ArgVal: 5.281 ± 3.691
1.98ArgTrp: 1.98 ± 0.698
1.98ArgTyr: 1.98 ± 0.439
0.0ArgXaa: 0.0 ± 0.0
Ser
5.281SerAla: 5.281 ± 2.094
1.98SerCys: 1.98 ± 1.498
3.96SerAsp: 3.96 ± 0.467
3.96SerGlu: 3.96 ± 2.545
2.64SerPhe: 2.64 ± 0.844
3.96SerGly: 3.96 ± 1.611
1.98SerHis: 1.98 ± 0.439
4.62SerIle: 4.62 ± 1.226
5.941SerLys: 5.941 ± 1.76
7.921SerLeu: 7.921 ± 2.629
1.32SerMet: 1.32 ± 0.537
2.64SerAsn: 2.64 ± 1.536
5.941SerPro: 5.941 ± 2.799
1.98SerGln: 1.98 ± 1.136
7.921SerArg: 7.921 ± 1.036
9.241SerSer: 9.241 ± 3.364
3.3SerThr: 3.3 ± 1.433
5.281SerVal: 5.281 ± 0.675
1.98SerTrp: 1.98 ± 1.515
1.98SerTyr: 1.98 ± 0.737
0.0SerXaa: 0.0 ± 0.0
Thr
6.601ThrAla: 6.601 ± 3.544
1.32ThrCys: 1.32 ± 0.647
3.96ThrAsp: 3.96 ± 0.878
1.98ThrGlu: 1.98 ± 0.893
0.0ThrPhe: 0.0 ± 0.0
2.64ThrGly: 2.64 ± 1.582
0.66ThrHis: 0.66 ± 0.499
3.96ThrIle: 3.96 ± 0.467
3.96ThrLys: 3.96 ± 0.912
5.281ThrLeu: 5.281 ± 1.576
1.98ThrMet: 1.98 ± 1.254
3.96ThrAsn: 3.96 ± 1.823
3.96ThrPro: 3.96 ± 1.897
1.98ThrGln: 1.98 ± 0.912
5.281ThrArg: 5.281 ± 0.675
1.98ThrSer: 1.98 ± 0.94
0.66ThrThr: 0.66 ± 0.499
5.941ThrVal: 5.941 ± 1.224
1.98ThrTrp: 1.98 ± 0.439
1.98ThrTyr: 1.98 ± 1.581
0.0ThrXaa: 0.0 ± 0.0
Val
7.261ValAla: 7.261 ± 1.371
1.32ValCys: 1.32 ± 0.848
2.64ValAsp: 2.64 ± 1.131
3.3ValGlu: 3.3 ± 1.934
3.96ValPhe: 3.96 ± 1.339
3.96ValGly: 3.96 ± 0.638
1.32ValHis: 1.32 ± 1.11
1.98ValIle: 1.98 ± 0.893
5.941ValLys: 5.941 ± 1.311
5.281ValLeu: 5.281 ± 1.423
0.0ValMet: 0.0 ± 0.0
4.62ValAsn: 4.62 ± 0.753
9.241ValPro: 9.241 ± 1.237
3.3ValGln: 3.3 ± 2.088
4.62ValArg: 4.62 ± 1.394
3.3ValSer: 3.3 ± 1.306
5.281ValThr: 5.281 ± 0.966
5.941ValVal: 5.941 ± 1.456
1.32ValTrp: 1.32 ± 0.848
0.66ValTyr: 0.66 ± 0.805
0.0ValXaa: 0.0 ± 0.0
Trp
0.66TrpAla: 0.66 ± 0.805
0.66TrpCys: 0.66 ± 0.499
0.0TrpAsp: 0.0 ± 0.0
0.66TrpGlu: 0.66 ± 0.555
0.66TrpPhe: 0.66 ± 0.527
1.98TrpGly: 1.98 ± 1.153
0.0TrpHis: 0.0 ± 0.0
0.66TrpIle: 0.66 ± 0.527
1.98TrpLys: 1.98 ± 1.042
1.32TrpLeu: 1.32 ± 0.843
0.0TrpMet: 0.0 ± 0.0
0.66TrpAsn: 0.66 ± 0.805
0.66TrpPro: 0.66 ± 0.527
1.98TrpGln: 1.98 ± 1.153
1.98TrpArg: 1.98 ± 0.698
0.66TrpSer: 0.66 ± 0.555
1.32TrpThr: 1.32 ± 0.647
1.32TrpVal: 1.32 ± 0.999
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.32TyrAla: 1.32 ± 0.537
0.66TyrCys: 0.66 ± 0.805
0.0TyrAsp: 0.0 ± 0.0
1.32TyrGlu: 1.32 ± 0.843
0.66TyrPhe: 0.66 ± 0.499
1.32TyrGly: 1.32 ± 0.843
0.66TyrHis: 0.66 ± 0.499
1.32TyrIle: 1.32 ± 0.999
1.98TyrLys: 1.98 ± 0.94
2.64TyrLeu: 2.64 ± 1.616
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
1.32TyrPro: 1.32 ± 0.566
0.66TyrGln: 0.66 ± 0.805
2.64TyrArg: 2.64 ± 1.001
0.66TyrSer: 0.66 ± 0.527
3.3TyrThr: 3.3 ± 2.057
2.64TyrVal: 2.64 ± 0.788
0.0TyrTrp: 0.0 ± 0.0
1.32TyrTyr: 1.32 ± 0.566
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1516 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski