Amino acid dipepetide frequency for Rubrivirga sp. SAORIC476

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.998AlaAla: 17.998 ± 0.181
0.825AlaCys: 0.825 ± 0.023
10.075AlaAsp: 10.075 ± 0.111
9.104AlaGlu: 9.104 ± 0.105
5.11AlaPhe: 5.11 ± 0.068
11.038AlaGly: 11.038 ± 0.107
2.313AlaHis: 2.313 ± 0.045
4.252AlaIle: 4.252 ± 0.064
1.73AlaLys: 1.73 ± 0.038
15.677AlaLeu: 15.677 ± 0.155
2.384AlaMet: 2.384 ± 0.047
2.091AlaAsn: 2.091 ± 0.04
7.39AlaPro: 7.39 ± 0.095
3.795AlaGln: 3.795 ± 0.063
9.985AlaArg: 9.985 ± 0.124
7.467AlaSer: 7.467 ± 0.085
7.697AlaThr: 7.697 ± 0.08
11.506AlaVal: 11.506 ± 0.116
1.766AlaTrp: 1.766 ± 0.044
3.026AlaTyr: 3.026 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.662CysAla: 0.662 ± 0.023
0.056CysCys: 0.056 ± 0.006
0.446CysAsp: 0.446 ± 0.02
0.284CysGlu: 0.284 ± 0.013
0.161CysPhe: 0.161 ± 0.011
0.593CysGly: 0.593 ± 0.025
0.149CysHis: 0.149 ± 0.014
0.164CysIle: 0.164 ± 0.01
0.063CysLys: 0.063 ± 0.008
0.52CysLeu: 0.52 ± 0.021
0.068CysMet: 0.068 ± 0.007
0.128CysAsn: 0.128 ± 0.01
0.324CysPro: 0.324 ± 0.019
0.157CysGln: 0.157 ± 0.011
0.338CysArg: 0.338 ± 0.016
0.32CysSer: 0.32 ± 0.018
0.33CysThr: 0.33 ± 0.018
0.451CysVal: 0.451 ± 0.018
0.059CysTrp: 0.059 ± 0.006
0.125CysTyr: 0.125 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
10.813AspAla: 10.813 ± 0.111
0.302AspCys: 0.302 ± 0.018
4.454AspAsp: 4.454 ± 0.063
3.823AspGlu: 3.823 ± 0.065
1.967AspPhe: 1.967 ± 0.045
8.097AspGly: 8.097 ± 0.114
1.235AspHis: 1.235 ± 0.036
1.868AspIle: 1.868 ± 0.036
0.791AspLys: 0.791 ± 0.032
7.765AspLeu: 7.765 ± 0.088
0.765AspMet: 0.765 ± 0.024
1.056AspAsn: 1.056 ± 0.033
4.599AspPro: 4.599 ± 0.069
1.582AspGln: 1.582 ± 0.038
5.651AspArg: 5.651 ± 0.07
2.442AspSer: 2.442 ± 0.046
3.218AspThr: 3.218 ± 0.054
5.617AspVal: 5.617 ± 0.065
0.98AspTrp: 0.98 ± 0.03
1.434AspTyr: 1.434 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
10.63GluAla: 10.63 ± 0.118
0.204GluCys: 0.204 ± 0.013
3.09GluAsp: 3.09 ± 0.058
2.879GluGlu: 2.879 ± 0.055
1.283GluPhe: 1.283 ± 0.031
5.237GluGly: 5.237 ± 0.06
1.112GluHis: 1.112 ± 0.028
2.438GluIle: 2.438 ± 0.047
0.957GluLys: 0.957 ± 0.035
3.851GluLeu: 3.851 ± 0.057
1.174GluMet: 1.174 ± 0.031
1.06GluAsn: 1.06 ± 0.032
3.002GluPro: 3.002 ± 0.053
1.639GluGln: 1.639 ± 0.042
5.304GluArg: 5.304 ± 0.075
2.479GluSer: 2.479 ± 0.045
4.015GluThr: 4.015 ± 0.056
5.529GluVal: 5.529 ± 0.057
0.698GluTrp: 0.698 ± 0.024
0.994GluTyr: 0.994 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.133PheAla: 4.133 ± 0.064
0.22PheCys: 0.22 ± 0.013
2.852PheAsp: 2.852 ± 0.044
2.424PheGlu: 2.424 ± 0.043
1.231PhePhe: 1.231 ± 0.035
3.545PheGly: 3.545 ± 0.056
0.57PheHis: 0.57 ± 0.02
0.893PheIle: 0.893 ± 0.028
0.473PheLys: 0.473 ± 0.02
2.996PheLeu: 2.996 ± 0.054
0.452PheMet: 0.452 ± 0.019
0.734PheAsn: 0.734 ± 0.025
1.494PhePro: 1.494 ± 0.033
0.954PheGln: 0.954 ± 0.027
2.375PheArg: 2.375 ± 0.044
2.093PheSer: 2.093 ± 0.044
1.87PheThr: 1.87 ± 0.042
3.134PheVal: 3.134 ± 0.053
0.494PheTrp: 0.494 ± 0.02
0.92PheTyr: 0.92 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
11.35GlyAla: 11.35 ± 0.12
0.698GlyCys: 0.698 ± 0.024
5.985GlyAsp: 5.985 ± 0.067
5.016GlyGlu: 5.016 ± 0.067
3.151GlyPhe: 3.151 ± 0.048
8.79GlyGly: 8.79 ± 0.128
1.709GlyHis: 1.709 ± 0.041
3.408GlyIle: 3.408 ± 0.058
1.482GlyLys: 1.482 ± 0.04
9.856GlyLeu: 9.856 ± 0.101
1.884GlyMet: 1.884 ± 0.041
1.691GlyAsn: 1.691 ± 0.058
4.644GlyPro: 4.644 ± 0.06
2.761GlyGln: 2.761 ± 0.053
7.117GlyArg: 7.117 ± 0.088
4.823GlySer: 4.823 ± 0.074
6.571GlyThr: 6.571 ± 0.097
8.031GlyVal: 8.031 ± 0.098
1.47GlyTrp: 1.47 ± 0.034
2.394GlyTyr: 2.394 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.325HisAla: 2.325 ± 0.041
0.117HisCys: 0.117 ± 0.01
1.124HisAsp: 1.124 ± 0.03
0.971HisGlu: 0.971 ± 0.031
0.572HisPhe: 0.572 ± 0.023
1.665HisGly: 1.665 ± 0.044
0.457HisHis: 0.457 ± 0.022
0.527HisIle: 0.527 ± 0.02
0.256HisLys: 0.256 ± 0.015
2.054HisLeu: 2.054 ± 0.046
0.215HisMet: 0.215 ± 0.013
0.355HisAsn: 0.355 ± 0.02
1.337HisPro: 1.337 ± 0.034
0.449HisGln: 0.449 ± 0.02
1.43HisArg: 1.43 ± 0.038
0.68HisSer: 0.68 ± 0.024
0.99HisThr: 0.99 ± 0.029
1.76HisVal: 1.76 ± 0.036
0.227HisTrp: 0.227 ± 0.014
0.476HisTyr: 0.476 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
4.283IleAla: 4.283 ± 0.073
0.174IleCys: 0.174 ± 0.011
2.648IleAsp: 2.648 ± 0.057
2.658IleGlu: 2.658 ± 0.046
0.724IlePhe: 0.724 ± 0.028
3.455IleGly: 3.455 ± 0.058
0.639IleHis: 0.639 ± 0.022
0.802IleIle: 0.802 ± 0.033
0.556IleLys: 0.556 ± 0.023
2.94IleLeu: 2.94 ± 0.053
0.367IleMet: 0.367 ± 0.02
0.674IleAsn: 0.674 ± 0.025
1.986IlePro: 1.986 ± 0.04
1.091IleGln: 1.091 ± 0.028
2.625IleArg: 2.625 ± 0.051
1.537IleSer: 1.537 ± 0.039
1.867IleThr: 1.867 ± 0.037
2.93IleVal: 2.93 ± 0.05
0.368IleTrp: 0.368 ± 0.017
0.791IleTyr: 0.791 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
1.995LysAla: 1.995 ± 0.05
0.062LysCys: 0.062 ± 0.007
0.784LysAsp: 0.784 ± 0.028
0.814LysGlu: 0.814 ± 0.03
0.32LysPhe: 0.32 ± 0.016
1.281LysGly: 1.281 ± 0.038
0.284LysHis: 0.284 ± 0.018
0.549LysIle: 0.549 ± 0.025
0.599LysLys: 0.599 ± 0.028
1.409LysLeu: 1.409 ± 0.039
0.342LysMet: 0.342 ± 0.018
0.401LysAsn: 0.401 ± 0.019
0.834LysPro: 0.834 ± 0.027
0.444LysGln: 0.444 ± 0.021
1.21LysArg: 1.21 ± 0.036
0.77LysSer: 0.77 ± 0.028
1.097LysThr: 1.097 ± 0.034
1.175LysVal: 1.175 ± 0.036
0.173LysTrp: 0.173 ± 0.011
0.323LysTyr: 0.323 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
15.295LeuAla: 15.295 ± 0.164
0.526LeuCys: 0.526 ± 0.021
8.169LeuAsp: 8.169 ± 0.088
4.256LeuGlu: 4.256 ± 0.059
3.473LeuPhe: 3.473 ± 0.057
9.84LeuGly: 9.84 ± 0.102
1.766LeuHis: 1.766 ± 0.046
2.968LeuIle: 2.968 ± 0.056
1.542LeuLys: 1.542 ± 0.042
10.256LeuLeu: 10.256 ± 0.122
1.491LeuMet: 1.491 ± 0.036
1.811LeuAsn: 1.811 ± 0.044
5.763LeuPro: 5.763 ± 0.069
2.657LeuGln: 2.657 ± 0.051
8.151LeuArg: 8.151 ± 0.098
5.803LeuSer: 5.803 ± 0.063
6.319LeuThr: 6.319 ± 0.088
9.116LeuVal: 9.116 ± 0.1
1.231LeuTrp: 1.231 ± 0.038
2.361LeuTyr: 2.361 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.118MetAla: 2.118 ± 0.041
0.068MetCys: 0.068 ± 0.007
1.032MetAsp: 1.032 ± 0.031
0.878MetGlu: 0.878 ± 0.027
0.368MetPhe: 0.368 ± 0.018
1.408MetGly: 1.408 ± 0.035
0.29MetHis: 0.29 ± 0.015
0.605MetIle: 0.605 ± 0.022
0.357MetLys: 0.357 ± 0.019
1.644MetLeu: 1.644 ± 0.033
0.357MetMet: 0.357 ± 0.018
0.413MetAsn: 0.413 ± 0.021
1.259MetPro: 1.259 ± 0.032
0.512MetGln: 0.512 ± 0.019
1.478MetArg: 1.478 ± 0.033
1.037MetSer: 1.037 ± 0.033
1.325MetThr: 1.325 ± 0.027
1.181MetVal: 1.181 ± 0.034
0.164MetTrp: 0.164 ± 0.011
0.235MetTyr: 0.235 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.469AsnAla: 2.469 ± 0.043
0.116AsnCys: 0.116 ± 0.009
1.116AsnAsp: 1.116 ± 0.027
0.98AsnGlu: 0.98 ± 0.028
0.515AsnPhe: 0.515 ± 0.022
1.98AsnGly: 1.98 ± 0.047
0.326AsnHis: 0.326 ± 0.014
0.582AsnIle: 0.582 ± 0.027
0.277AsnLys: 0.277 ± 0.015
1.793AsnLeu: 1.793 ± 0.043
0.278AsnMet: 0.278 ± 0.016
0.504AsnAsn: 0.504 ± 0.03
1.56AsnPro: 1.56 ± 0.036
0.57AsnGln: 0.57 ± 0.023
1.338AsnArg: 1.338 ± 0.035
0.794AsnSer: 0.794 ± 0.03
1.109AsnThr: 1.109 ± 0.035
1.775AsnVal: 1.775 ± 0.041
0.259AsnTrp: 0.259 ± 0.015
0.472AsnTyr: 0.472 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.497ProAla: 7.497 ± 0.09
0.22ProCys: 0.22 ± 0.014
5.022ProAsp: 5.022 ± 0.067
4.108ProGlu: 4.108 ± 0.058
2.282ProPhe: 2.282 ± 0.045
5.313ProGly: 5.313 ± 0.073
0.972ProHis: 0.972 ± 0.029
1.839ProIle: 1.839 ± 0.04
0.729ProLys: 0.729 ± 0.029
5.246ProLeu: 5.246 ± 0.071
0.979ProMet: 0.979 ± 0.027
1.184ProAsn: 1.184 ± 0.029
3.51ProPro: 3.51 ± 0.089
1.276ProGln: 1.276 ± 0.033
3.154ProArg: 3.154 ± 0.052
3.604ProSer: 3.604 ± 0.055
3.94ProThr: 3.94 ± 0.055
5.118ProVal: 5.118 ± 0.057
0.647ProTrp: 0.647 ± 0.023
1.328ProTyr: 1.328 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.889GlnAla: 3.889 ± 0.059
0.106GlnCys: 0.106 ± 0.009
1.37GlnAsp: 1.37 ± 0.037
1.299GlnGlu: 1.299 ± 0.04
1.027GlnPhe: 1.027 ± 0.03
2.162GlnGly: 2.162 ± 0.039
0.44GlnHis: 0.44 ± 0.018
1.332GlnIle: 1.332 ± 0.035
0.57GlnLys: 0.57 ± 0.024
2.264GlnLeu: 2.264 ± 0.052
0.602GlnMet: 0.602 ± 0.022
0.665GlnAsn: 0.665 ± 0.023
1.68GlnPro: 1.68 ± 0.039
0.948GlnGln: 0.948 ± 0.033
2.315GlnArg: 2.315 ± 0.039
1.586GlnSer: 1.586 ± 0.039
2.089GlnThr: 2.089 ± 0.045
2.215GlnVal: 2.215 ± 0.047
0.312GlnTrp: 0.312 ± 0.018
0.638GlnTyr: 0.638 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
9.513ArgAla: 9.513 ± 0.114
0.32ArgCys: 0.32 ± 0.015
4.681ArgAsp: 4.681 ± 0.064
4.413ArgGlu: 4.413 ± 0.062
3.179ArgPhe: 3.179 ± 0.05
5.426ArgGly: 5.426 ± 0.074
1.51ArgHis: 1.51 ± 0.039
3.116ArgIle: 3.116 ± 0.048
1.113ArgLys: 1.113 ± 0.033
9.321ArgLeu: 9.321 ± 0.096
1.676ArgMet: 1.676 ± 0.031
1.283ArgAsn: 1.283 ± 0.032
4.366ArgPro: 4.366 ± 0.053
2.454ArgGln: 2.454 ± 0.037
6.359ArgArg: 6.359 ± 0.106
3.786ArgSer: 3.786 ± 0.062
4.574ArgThr: 4.574 ± 0.062
6.688ArgVal: 6.688 ± 0.084
1.245ArgTrp: 1.245 ± 0.033
2.195ArgTyr: 2.195 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.465SerAla: 6.465 ± 0.08
0.278SerCys: 0.278 ± 0.017
3.374SerAsp: 3.374 ± 0.057
2.642SerGlu: 2.642 ± 0.048
1.94SerPhe: 1.94 ± 0.046
5.718SerGly: 5.718 ± 0.081
0.839SerHis: 0.839 ± 0.024
1.765SerIle: 1.765 ± 0.044
0.773SerLys: 0.773 ± 0.029
5.286SerLeu: 5.286 ± 0.069
0.933SerMet: 0.933 ± 0.029
1.155SerAsn: 1.155 ± 0.035
3.191SerPro: 3.191 ± 0.054
1.3SerGln: 1.3 ± 0.033
3.53SerArg: 3.53 ± 0.051
2.706SerSer: 2.706 ± 0.054
3.185SerThr: 3.185 ± 0.055
4.671SerVal: 4.671 ± 0.068
0.637SerTrp: 0.637 ± 0.022
1.248SerTyr: 1.248 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
7.684ThrAla: 7.684 ± 0.088
0.352ThrCys: 0.352 ± 0.018
3.97ThrAsp: 3.97 ± 0.065
3.329ThrGlu: 3.329 ± 0.052
2.458ThrPhe: 2.458 ± 0.055
5.938ThrGly: 5.938 ± 0.072
1.015ThrHis: 1.015 ± 0.026
2.17ThrIle: 2.17 ± 0.049
0.836ThrLys: 0.836 ± 0.031
7.026ThrLeu: 7.026 ± 0.081
0.889ThrMet: 0.889 ± 0.026
1.186ThrAsn: 1.186 ± 0.033
4.394ThrPro: 4.394 ± 0.065
1.421ThrGln: 1.421 ± 0.037
3.909ThrArg: 3.909 ± 0.06
3.122ThrSer: 3.122 ± 0.056
3.75ThrThr: 3.75 ± 0.071
6.277ThrVal: 6.277 ± 0.074
0.88ThrTrp: 0.88 ± 0.031
1.607ThrTyr: 1.607 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
11.35ValAla: 11.35 ± 0.104
0.523ValCys: 0.523 ± 0.021
5.58ValAsp: 5.58 ± 0.063
5.754ValGlu: 5.754 ± 0.068
2.906ValPhe: 2.906 ± 0.048
8.008ValGly: 8.008 ± 0.088
1.577ValHis: 1.577 ± 0.033
2.7ValIle: 2.7 ± 0.052
1.22ValLys: 1.22 ± 0.034
9.274ValLeu: 9.274 ± 0.105
1.274ValMet: 1.274 ± 0.032
1.579ValAsn: 1.579 ± 0.041
4.841ValPro: 4.841 ± 0.065
2.398ValGln: 2.398 ± 0.05
7.596ValArg: 7.596 ± 0.083
4.725ValSer: 4.725 ± 0.07
5.675ValThr: 5.675 ± 0.081
8.551ValVal: 8.551 ± 0.113
1.185ValTrp: 1.185 ± 0.033
2.134ValTyr: 2.134 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.69TrpAla: 1.69 ± 0.039
0.087TrpCys: 0.087 ± 0.008
0.766TrpAsp: 0.766 ± 0.026
0.63TrpGlu: 0.63 ± 0.021
0.425TrpPhe: 0.425 ± 0.018
1.059TrpGly: 1.059 ± 0.032
0.294TrpHis: 0.294 ± 0.014
0.537TrpIle: 0.537 ± 0.02
0.219TrpLys: 0.219 ± 0.013
1.381TrpLeu: 1.381 ± 0.036
0.331TrpMet: 0.331 ± 0.016
0.312TrpAsn: 0.312 ± 0.018
0.638TrpPro: 0.638 ± 0.024
0.413TrpGln: 0.413 ± 0.017
1.155TrpArg: 1.155 ± 0.031
0.782TrpSer: 0.782 ± 0.025
1.071TrpThr: 1.071 ± 0.029
1.037TrpVal: 1.037 ± 0.031
0.25TrpTrp: 0.25 ± 0.015
0.294TrpTyr: 0.294 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.066TyrAla: 3.066 ± 0.051
0.143TyrCys: 0.143 ± 0.011
1.921TyrAsp: 1.921 ± 0.04
1.31TyrGlu: 1.31 ± 0.037
0.766TyrPhe: 0.766 ± 0.025
2.279TyrGly: 2.279 ± 0.043
0.488TyrHis: 0.488 ± 0.019
0.6TyrIle: 0.6 ± 0.022
0.324TyrLys: 0.324 ± 0.016
2.234TyrLeu: 2.234 ± 0.048
0.271TyrMet: 0.271 ± 0.013
0.533TyrAsn: 0.533 ± 0.022
1.157TyrPro: 1.157 ± 0.033
0.687TyrGln: 0.687 ± 0.023
2.196TyrArg: 2.196 ± 0.041
1.081TyrSer: 1.081 ± 0.032
1.523TyrThr: 1.523 ± 0.041
2.087TyrVal: 2.087 ± 0.041
0.328TyrTrp: 0.328 ± 0.016
0.6TyrTyr: 0.6 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3744 proteins (1333258 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski