Amino acid dipepetide frequency for Tomato necrotic streak virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.969AlaAla: 4.969 ± 1.73
0.382AlaCys: 0.382 ± 0.432
3.823AlaAsp: 3.823 ± 1.037
3.44AlaGlu: 3.44 ± 0.414
1.529AlaPhe: 1.529 ± 0.389
3.44AlaGly: 3.44 ± 1.007
0.765AlaHis: 0.765 ± 0.432
3.058AlaIle: 3.058 ± 0.561
3.058AlaLys: 3.058 ± 0.698
4.587AlaLeu: 4.587 ± 1.491
1.529AlaMet: 1.529 ± 0.649
3.058AlaAsn: 3.058 ± 1.041
4.969AlaPro: 4.969 ± 2.403
1.529AlaGln: 1.529 ± 0.531
4.205AlaArg: 4.205 ± 1.641
5.352AlaSer: 5.352 ± 1.612
7.263AlaThr: 7.263 ± 1.231
6.116AlaVal: 6.116 ± 1.604
0.765AlaTrp: 0.765 ± 0.538
3.058AlaTyr: 3.058 ± 1.014
0.0AlaXaa: 0.0 ± 0.0
Cys
2.676CysAla: 2.676 ± 0.545
0.382CysCys: 0.382 ± 0.269
2.294CysAsp: 2.294 ± 0.482
1.147CysGlu: 1.147 ± 0.424
1.911CysPhe: 1.911 ± 0.397
0.382CysGly: 0.382 ± 0.269
0.0CysHis: 0.0 ± 0.0
1.147CysIle: 1.147 ± 0.807
1.147CysLys: 1.147 ± 0.643
1.529CysLeu: 1.529 ± 0.767
0.0CysMet: 0.0 ± 0.0
0.382CysAsn: 0.382 ± 0.269
1.911CysPro: 1.911 ± 1.345
0.382CysGln: 0.382 ± 0.305
0.765CysArg: 0.765 ± 0.24
1.529CysSer: 1.529 ± 0.767
1.147CysThr: 1.147 ± 0.479
0.382CysVal: 0.382 ± 0.269
0.765CysTrp: 0.765 ± 0.61
0.382CysTyr: 0.382 ± 0.305
0.0CysXaa: 0.0 ± 0.0
Asp
8.792AspAla: 8.792 ± 0.833
1.529AspCys: 1.529 ± 0.649
4.587AspAsp: 4.587 ± 0.789
4.969AspGlu: 4.969 ± 0.979
2.294AspPhe: 2.294 ± 0.417
2.676AspGly: 2.676 ± 0.6
0.765AspHis: 0.765 ± 0.432
3.823AspIle: 3.823 ± 0.57
1.911AspLys: 1.911 ± 0.727
6.498AspLeu: 6.498 ± 1.096
1.529AspMet: 1.529 ± 0.86
1.911AspAsn: 1.911 ± 0.577
2.676AspPro: 2.676 ± 0.605
0.765AspGln: 0.765 ± 0.24
1.529AspArg: 1.529 ± 0.649
3.44AspSer: 3.44 ± 0.799
3.058AspThr: 3.058 ± 0.687
6.116AspVal: 6.116 ± 0.517
0.382AspTrp: 0.382 ± 0.547
2.676AspTyr: 2.676 ± 0.655
0.0AspXaa: 0.0 ± 0.0
Glu
3.44GluAla: 3.44 ± 0.966
1.529GluCys: 1.529 ± 0.481
3.058GluAsp: 3.058 ± 1.207
4.969GluGlu: 4.969 ± 1.345
3.058GluPhe: 3.058 ± 1.553
1.529GluGly: 1.529 ± 0.389
1.529GluHis: 1.529 ± 0.481
4.587GluIle: 4.587 ± 1.212
4.587GluLys: 4.587 ± 1.19
5.352GluLeu: 5.352 ± 1.231
2.294GluMet: 2.294 ± 1.152
0.765GluAsn: 0.765 ± 0.432
2.294GluPro: 2.294 ± 0.413
1.529GluGln: 1.529 ± 0.531
3.058GluArg: 3.058 ± 0.654
3.058GluSer: 3.058 ± 0.902
4.205GluThr: 4.205 ± 1.389
6.498GluVal: 6.498 ± 1.049
0.0GluTrp: 0.0 ± 0.0
1.529GluTyr: 1.529 ± 0.767
0.0GluXaa: 0.0 ± 0.0
Phe
1.529PheAla: 1.529 ± 0.389
0.765PheCys: 0.765 ± 0.24
3.823PheAsp: 3.823 ± 1.136
2.294PheGlu: 2.294 ± 0.417
0.765PhePhe: 0.765 ± 0.583
2.294PheGly: 2.294 ± 0.592
1.529PheHis: 1.529 ± 0.767
2.676PheIle: 2.676 ± 0.42
3.058PheLys: 3.058 ± 1.92
3.058PheLeu: 3.058 ± 0.778
0.765PheMet: 0.765 ± 0.471
1.147PheAsn: 1.147 ± 0.409
3.823PhePro: 3.823 ± 0.912
2.294PheGln: 2.294 ± 0.739
2.676PheArg: 2.676 ± 0.581
3.058PheSer: 3.058 ± 0.956
3.44PheThr: 3.44 ± 1.41
1.911PheVal: 1.911 ± 0.633
0.0PheTrp: 0.0 ± 0.0
1.529PheTyr: 1.529 ± 0.467
0.0PheXaa: 0.0 ± 0.0
Gly
1.911GlyAla: 1.911 ± 0.397
1.911GlyCys: 1.911 ± 0.694
3.823GlyAsp: 3.823 ± 0.15
1.911GlyGlu: 1.911 ± 1.041
3.44GlyPhe: 3.44 ± 1.272
1.911GlyGly: 1.911 ± 0.46
0.382GlyHis: 0.382 ± 0.305
2.294GlyIle: 2.294 ± 0.496
4.587GlyLys: 4.587 ± 1.785
3.823GlyLeu: 3.823 ± 1.467
0.765GlyMet: 0.765 ± 0.538
1.529GlyAsn: 1.529 ± 0.536
1.529GlyPro: 1.529 ± 0.531
1.529GlyGln: 1.529 ± 0.737
3.44GlyArg: 3.44 ± 0.627
3.058GlySer: 3.058 ± 1.25
1.911GlyThr: 1.911 ± 0.97
4.205GlyVal: 4.205 ± 0.823
1.911GlyTrp: 1.911 ± 0.465
1.147GlyTyr: 1.147 ± 0.709
0.0GlyXaa: 0.0 ± 0.0
His
1.147HisAla: 1.147 ± 0.409
0.765HisCys: 0.765 ± 0.538
0.765HisAsp: 0.765 ± 0.535
2.294HisGlu: 2.294 ± 0.417
0.382HisPhe: 0.382 ± 0.269
0.382HisGly: 0.382 ± 0.305
0.765HisHis: 0.765 ± 0.24
2.294HisIle: 2.294 ± 0.774
1.147HisLys: 1.147 ± 0.479
1.529HisLeu: 1.529 ± 0.536
0.382HisMet: 0.382 ± 0.305
1.147HisAsn: 1.147 ± 0.409
1.147HisPro: 1.147 ± 0.576
1.911HisGln: 1.911 ± 0.789
1.147HisArg: 1.147 ± 0.409
1.911HisSer: 1.911 ± 1.011
1.911HisThr: 1.911 ± 0.793
1.147HisVal: 1.147 ± 0.479
0.382HisTrp: 0.382 ± 0.305
0.382HisTyr: 0.382 ± 0.269
0.0HisXaa: 0.0 ± 0.0
Ile
4.205IleAla: 4.205 ± 1.048
1.147IleCys: 1.147 ± 0.704
2.294IleAsp: 2.294 ± 1.003
2.676IleGlu: 2.676 ± 0.712
1.529IlePhe: 1.529 ± 0.478
1.911IleGly: 1.911 ± 0.543
1.147IleHis: 1.147 ± 0.479
3.823IleIle: 3.823 ± 0.997
2.676IleLys: 2.676 ± 1.007
2.294IleLeu: 2.294 ± 1.278
1.147IleMet: 1.147 ± 0.409
2.676IleAsn: 2.676 ± 1.063
8.028IlePro: 8.028 ± 1.526
1.529IleGln: 1.529 ± 0.536
2.676IleArg: 2.676 ± 0.946
4.587IleSer: 4.587 ± 2.285
4.205IleThr: 4.205 ± 1.022
4.205IleVal: 4.205 ± 0.568
0.382IleTrp: 0.382 ± 0.432
1.529IleTyr: 1.529 ± 0.444
0.0IleXaa: 0.0 ± 0.0
Lys
3.44LysAla: 3.44 ± 1.163
0.765LysCys: 0.765 ± 0.24
3.44LysAsp: 3.44 ± 0.481
2.676LysGlu: 2.676 ± 0.369
4.205LysPhe: 4.205 ± 1.097
3.44LysGly: 3.44 ± 0.611
1.529LysHis: 1.529 ± 0.649
2.676LysIle: 2.676 ± 0.484
3.44LysLys: 3.44 ± 0.989
3.058LysLeu: 3.058 ± 1.168
3.058LysMet: 3.058 ± 1.698
2.294LysAsn: 2.294 ± 0.676
3.823LysPro: 3.823 ± 0.784
2.676LysGln: 2.676 ± 1.193
2.676LysArg: 2.676 ± 0.921
6.116LysSer: 6.116 ± 1.553
4.587LysThr: 4.587 ± 1.943
6.116LysVal: 6.116 ± 0.442
1.911LysTrp: 1.911 ± 0.543
2.676LysTyr: 2.676 ± 0.484
0.0LysXaa: 0.0 ± 0.0
Leu
4.205LeuAla: 4.205 ± 0.742
2.294LeuCys: 2.294 ± 1.008
4.969LeuAsp: 4.969 ± 1.86
4.587LeuGlu: 4.587 ± 1.927
3.44LeuPhe: 3.44 ± 1.569
3.058LeuGly: 3.058 ± 0.358
1.529LeuHis: 1.529 ± 0.521
5.352LeuIle: 5.352 ± 0.86
8.41LeuLys: 8.41 ± 1.066
8.028LeuLeu: 8.028 ± 2.415
0.765LeuMet: 0.765 ± 0.538
2.294LeuAsn: 2.294 ± 1.278
4.205LeuPro: 4.205 ± 1.178
1.529LeuGln: 1.529 ± 0.923
5.734LeuArg: 5.734 ± 1.806
9.174LeuSer: 9.174 ± 1.483
5.734LeuThr: 5.734 ± 1.188
6.116LeuVal: 6.116 ± 1.011
0.382LeuTrp: 0.382 ± 0.305
2.676LeuTyr: 2.676 ± 0.671
0.0LeuXaa: 0.0 ± 0.0
Met
1.911MetAla: 1.911 ± 1.338
0.0MetCys: 0.0 ± 0.0
2.676MetAsp: 2.676 ± 1.021
1.147MetGlu: 1.147 ± 0.409
0.765MetPhe: 0.765 ± 0.864
1.529MetGly: 1.529 ± 0.767
0.765MetHis: 0.765 ± 0.24
0.765MetIle: 0.765 ± 0.24
1.529MetLys: 1.529 ± 0.536
3.058MetLeu: 3.058 ± 1.579
1.529MetMet: 1.529 ± 0.494
0.765MetAsn: 0.765 ± 0.535
1.529MetPro: 1.529 ± 0.605
1.911MetGln: 1.911 ± 0.614
1.911MetArg: 1.911 ± 0.858
2.294MetSer: 2.294 ± 0.591
1.911MetThr: 1.911 ± 0.577
1.529MetVal: 1.529 ± 1.5
1.147MetTrp: 1.147 ± 0.666
0.765MetTyr: 0.765 ± 0.535
0.0MetXaa: 0.0 ± 0.0
Asn
3.823AsnAla: 3.823 ± 2.611
0.382AsnCys: 0.382 ± 0.432
1.147AsnAsp: 1.147 ± 0.479
0.765AsnGlu: 0.765 ± 0.864
1.911AsnPhe: 1.911 ± 0.927
2.294AsnGly: 2.294 ± 0.417
0.382AsnHis: 0.382 ± 0.269
0.765AsnIle: 0.765 ± 0.24
0.765AsnLys: 0.765 ± 0.24
3.058AsnLeu: 3.058 ± 0.496
0.765AsnMet: 0.765 ± 0.535
1.529AsnAsn: 1.529 ± 0.521
2.294AsnPro: 2.294 ± 0.413
0.765AsnGln: 0.765 ± 0.24
2.676AsnArg: 2.676 ± 0.89
3.44AsnSer: 3.44 ± 0.837
3.058AsnThr: 3.058 ± 1.12
4.969AsnVal: 4.969 ± 1.911
0.382AsnTrp: 0.382 ± 0.513
1.147AsnTyr: 1.147 ± 0.807
0.0AsnXaa: 0.0 ± 0.0
Pro
3.44ProAla: 3.44 ± 0.908
0.0ProCys: 0.0 ± 0.0
1.911ProAsp: 1.911 ± 0.585
5.352ProGlu: 5.352 ± 1.802
1.529ProPhe: 1.529 ± 0.481
3.058ProGly: 3.058 ± 1.636
1.529ProHis: 1.529 ± 0.478
4.205ProIle: 4.205 ± 1.791
3.058ProLys: 3.058 ± 1.124
7.263ProLeu: 7.263 ± 0.649
2.294ProMet: 2.294 ± 0.734
3.058ProAsn: 3.058 ± 1.992
3.44ProPro: 3.44 ± 1.773
1.911ProGln: 1.911 ± 0.614
3.823ProArg: 3.823 ± 0.926
3.823ProSer: 3.823 ± 1.318
2.294ProThr: 2.294 ± 1.402
1.911ProVal: 1.911 ± 0.789
0.382ProTrp: 0.382 ± 0.269
0.382ProTyr: 0.382 ± 0.269
0.0ProXaa: 0.0 ± 0.0
Gln
1.911GlnAla: 1.911 ± 0.591
0.382GlnCys: 0.382 ± 0.269
1.529GlnAsp: 1.529 ± 1.221
1.147GlnGlu: 1.147 ± 0.479
1.147GlnPhe: 1.147 ± 0.424
1.529GlnGly: 1.529 ± 0.478
0.0GlnHis: 0.0 ± 0.0
0.765GlnIle: 0.765 ± 0.432
1.911GlnLys: 1.911 ± 0.905
1.529GlnLeu: 1.529 ± 0.536
1.529GlnMet: 1.529 ± 0.531
0.765GlnAsn: 0.765 ± 0.432
1.529GlnPro: 1.529 ± 0.91
1.529GlnGln: 1.529 ± 0.91
1.911GlnArg: 1.911 ± 1.214
3.44GlnSer: 3.44 ± 1.456
2.676GlnThr: 2.676 ± 0.563
1.529GlnVal: 1.529 ± 0.649
0.765GlnTrp: 0.765 ± 0.535
0.765GlnTyr: 0.765 ± 0.538
0.0GlnXaa: 0.0 ± 0.0
Arg
1.529ArgAla: 1.529 ± 0.767
1.147ArgCys: 1.147 ± 0.409
4.587ArgAsp: 4.587 ± 1.017
4.205ArgGlu: 4.205 ± 1.041
1.529ArgPhe: 1.529 ± 0.481
2.676ArgGly: 2.676 ± 0.42
0.765ArgHis: 0.765 ± 0.538
3.058ArgIle: 3.058 ± 1.399
4.205ArgLys: 4.205 ± 0.826
7.263ArgLeu: 7.263 ± 1.134
1.147ArgMet: 1.147 ± 0.71
3.058ArgAsn: 3.058 ± 0.787
2.294ArgPro: 2.294 ± 0.958
1.529ArgGln: 1.529 ± 0.467
5.352ArgArg: 5.352 ± 0.919
3.823ArgSer: 3.823 ± 1.569
2.294ArgThr: 2.294 ± 0.626
6.116ArgVal: 6.116 ± 0.944
1.911ArgTrp: 1.911 ± 1.011
1.911ArgTyr: 1.911 ± 0.465
0.0ArgXaa: 0.0 ± 0.0
Ser
3.823SerAla: 3.823 ± 0.997
1.911SerCys: 1.911 ± 0.614
3.44SerAsp: 3.44 ± 1.481
3.44SerGlu: 3.44 ± 0.966
5.352SerPhe: 5.352 ± 0.693
7.263SerGly: 7.263 ± 0.682
2.676SerHis: 2.676 ± 0.369
5.352SerIle: 5.352 ± 1.829
5.352SerLys: 5.352 ± 1.519
6.498SerLeu: 6.498 ± 1.814
2.676SerMet: 2.676 ± 1.013
4.205SerAsn: 4.205 ± 1.745
2.294SerPro: 2.294 ± 0.696
0.765SerGln: 0.765 ± 0.535
5.734SerArg: 5.734 ± 1.225
5.734SerSer: 5.734 ± 1.225
4.587SerThr: 4.587 ± 0.789
4.969SerVal: 4.969 ± 0.584
1.529SerTrp: 1.529 ± 0.605
3.058SerTyr: 3.058 ± 0.705
0.0SerXaa: 0.0 ± 0.0
Thr
4.969ThrAla: 4.969 ± 2.71
1.529ThrCys: 1.529 ± 0.389
4.205ThrAsp: 4.205 ± 1.016
3.44ThrGlu: 3.44 ± 0.627
3.058ThrPhe: 3.058 ± 0.767
2.676ThrGly: 2.676 ± 0.946
2.294ThrHis: 2.294 ± 0.496
1.911ThrIle: 1.911 ± 0.457
3.44ThrLys: 3.44 ± 0.408
7.645ThrLeu: 7.645 ± 1.932
2.294ThrMet: 2.294 ± 0.825
1.529ThrAsn: 1.529 ± 0.444
2.676ThrPro: 2.676 ± 1.007
1.529ThrGln: 1.529 ± 0.481
4.205ThrArg: 4.205 ± 0.94
5.734ThrSer: 5.734 ± 1.439
4.205ThrThr: 4.205 ± 1.943
2.294ThrVal: 2.294 ± 0.626
1.529ThrTrp: 1.529 ± 0.467
1.911ThrTyr: 1.911 ± 1.064
0.0ThrXaa: 0.0 ± 0.0
Val
3.823ValAla: 3.823 ± 1.405
1.911ValCys: 1.911 ± 0.755
6.498ValAsp: 6.498 ± 1.321
5.352ValGlu: 5.352 ± 1.307
1.911ValPhe: 1.911 ± 0.46
2.294ValGly: 2.294 ± 0.793
3.058ValHis: 3.058 ± 0.887
4.205ValIle: 4.205 ± 0.916
7.263ValLys: 7.263 ± 2.116
3.823ValLeu: 3.823 ± 0.948
3.058ValMet: 3.058 ± 0.438
2.294ValAsn: 2.294 ± 0.696
3.823ValPro: 3.823 ± 0.887
1.529ValGln: 1.529 ± 0.767
3.44ValArg: 3.44 ± 1.173
7.263ValSer: 7.263 ± 1.261
3.058ValThr: 3.058 ± 0.887
5.734ValVal: 5.734 ± 1.621
1.529ValTrp: 1.529 ± 0.467
2.294ValTyr: 2.294 ± 0.696
0.0ValXaa: 0.0 ± 0.0
Trp
1.911TrpAla: 1.911 ± 0.849
0.382TrpCys: 0.382 ± 0.269
1.147TrpAsp: 1.147 ± 0.338
1.147TrpGlu: 1.147 ± 0.576
1.529TrpPhe: 1.529 ± 0.481
1.529TrpGly: 1.529 ± 0.605
0.765TrpHis: 0.765 ± 0.535
0.382TrpIle: 0.382 ± 0.305
1.147TrpLys: 1.147 ± 0.64
1.911TrpLeu: 1.911 ± 0.694
0.765TrpMet: 0.765 ± 0.512
0.382TrpAsn: 0.382 ± 0.305
0.0TrpPro: 0.0 ± 0.0
0.382TrpGln: 0.382 ± 0.513
0.382TrpArg: 0.382 ± 0.269
1.147TrpSer: 1.147 ± 0.443
0.0TrpThr: 0.0 ± 0.0
0.765TrpVal: 0.765 ± 0.471
0.0TrpTrp: 0.0 ± 0.0
1.147TrpTyr: 1.147 ± 0.762
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.44TyrAla: 3.44 ± 0.769
1.147TyrCys: 1.147 ± 0.64
1.911TyrAsp: 1.911 ± 0.614
1.911TyrGlu: 1.911 ± 0.591
1.147TyrPhe: 1.147 ± 0.479
1.147TyrGly: 1.147 ± 1.247
0.765TyrHis: 0.765 ± 0.512
1.529TyrIle: 1.529 ± 0.481
1.911TyrLys: 1.911 ± 0.577
2.676TyrLeu: 2.676 ± 0.558
1.147TyrMet: 1.147 ± 0.338
1.529TyrAsn: 1.529 ± 0.531
0.382TyrPro: 0.382 ± 0.305
0.765TyrGln: 0.765 ± 0.61
3.058TyrArg: 3.058 ± 0.887
2.676TyrSer: 2.676 ± 1.265
1.529TyrThr: 1.529 ± 0.669
1.529TyrVal: 1.529 ± 0.531
0.765TyrTrp: 0.765 ± 0.24
1.147TyrTyr: 1.147 ± 0.409
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2617 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski