Amino acid dipepetide frequency for Sphingobacterium sp. 2c-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.353AlaAla: 6.353 ± 0.086
0.645AlaCys: 0.645 ± 0.023
4.427AlaAsp: 4.427 ± 0.07
4.647AlaGlu: 4.647 ± 0.071
3.431AlaPhe: 3.431 ± 0.049
5.389AlaGly: 5.389 ± 0.072
1.476AlaHis: 1.476 ± 0.04
5.686AlaIle: 5.686 ± 0.079
4.571AlaLys: 4.571 ± 0.068
7.416AlaLeu: 7.416 ± 0.099
1.849AlaMet: 1.849 ± 0.041
3.918AlaAsn: 3.918 ± 0.063
2.253AlaPro: 2.253 ± 0.047
3.449AlaGln: 3.449 ± 0.056
2.941AlaArg: 2.941 ± 0.054
4.722AlaSer: 4.722 ± 0.069
4.298AlaThr: 4.298 ± 0.055
4.994AlaVal: 4.994 ± 0.07
0.893AlaTrp: 0.893 ± 0.029
2.978AlaTyr: 2.978 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.513CysAla: 0.513 ± 0.022
0.109CysCys: 0.109 ± 0.009
0.344CysAsp: 0.344 ± 0.017
0.364CysGlu: 0.364 ± 0.02
0.313CysPhe: 0.313 ± 0.015
0.564CysGly: 0.564 ± 0.022
0.178CysHis: 0.178 ± 0.013
0.512CysIle: 0.512 ± 0.021
0.347CysLys: 0.347 ± 0.018
0.637CysLeu: 0.637 ± 0.024
0.17CysMet: 0.17 ± 0.013
0.315CysAsn: 0.315 ± 0.017
0.293CysPro: 0.293 ± 0.016
0.249CysGln: 0.249 ± 0.015
0.299CysArg: 0.299 ± 0.018
0.462CysSer: 0.462 ± 0.021
0.419CysThr: 0.419 ± 0.018
0.463CysVal: 0.463 ± 0.022
0.075CysTrp: 0.075 ± 0.007
0.276CysTyr: 0.276 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.169AspAla: 4.169 ± 0.058
0.327AspCys: 0.327 ± 0.019
2.649AspAsp: 2.649 ± 0.052
3.545AspGlu: 3.545 ± 0.058
3.199AspPhe: 3.199 ± 0.05
4.023AspGly: 4.023 ± 0.067
1.211AspHis: 1.211 ± 0.035
4.11AspIle: 4.11 ± 0.061
3.418AspLys: 3.418 ± 0.059
5.639AspLeu: 5.639 ± 0.068
1.359AspMet: 1.359 ± 0.033
2.725AspAsn: 2.725 ± 0.048
2.145AspPro: 2.145 ± 0.049
2.391AspGln: 2.391 ± 0.042
2.821AspArg: 2.821 ± 0.042
3.022AspSer: 3.022 ± 0.053
2.667AspThr: 2.667 ± 0.051
3.786AspVal: 3.786 ± 0.056
0.822AspTrp: 0.822 ± 0.027
2.55AspTyr: 2.55 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.57GluAla: 4.57 ± 0.076
0.26GluCys: 0.26 ± 0.015
3.268GluAsp: 3.268 ± 0.059
4.407GluGlu: 4.407 ± 0.087
2.461GluPhe: 2.461 ± 0.047
3.485GluGly: 3.485 ± 0.065
1.238GluHis: 1.238 ± 0.036
4.478GluIle: 4.478 ± 0.073
4.404GluLys: 4.404 ± 0.067
5.947GluLeu: 5.947 ± 0.08
1.513GluMet: 1.513 ± 0.041
3.454GluAsn: 3.454 ± 0.052
1.602GluPro: 1.602 ± 0.042
2.888GluGln: 2.888 ± 0.052
3.076GluArg: 3.076 ± 0.054
3.398GluSer: 3.398 ± 0.052
2.94GluThr: 2.94 ± 0.048
4.238GluVal: 4.238 ± 0.069
0.696GluTrp: 0.696 ± 0.024
2.166GluTyr: 2.166 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.662PheAla: 3.662 ± 0.059
0.399PheCys: 0.399 ± 0.019
3.093PheAsp: 3.093 ± 0.048
2.95PheGlu: 2.95 ± 0.057
2.465PhePhe: 2.465 ± 0.059
3.579PheGly: 3.579 ± 0.06
0.926PheHis: 0.926 ± 0.028
3.135PheIle: 3.135 ± 0.06
2.527PheLys: 2.527 ± 0.046
4.266PheLeu: 4.266 ± 0.081
1.148PheMet: 1.148 ± 0.032
2.513PheAsn: 2.513 ± 0.058
1.689PhePro: 1.689 ± 0.035
1.749PheGln: 1.749 ± 0.041
2.11PheArg: 2.11 ± 0.041
3.526PheSer: 3.526 ± 0.064
2.81PheThr: 2.81 ± 0.054
3.255PheVal: 3.255 ± 0.054
0.594PheTrp: 0.594 ± 0.022
1.937PheTyr: 1.937 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.916GlyAla: 4.916 ± 0.077
0.494GlyCys: 0.494 ± 0.022
3.498GlyAsp: 3.498 ± 0.063
3.617GlyGlu: 3.617 ± 0.057
3.551GlyPhe: 3.551 ± 0.061
4.744GlyGly: 4.744 ± 0.076
1.26GlyHis: 1.26 ± 0.037
4.975GlyIle: 4.975 ± 0.074
4.525GlyLys: 4.525 ± 0.06
6.304GlyLeu: 6.304 ± 0.072
1.777GlyMet: 1.777 ± 0.038
3.451GlyAsn: 3.451 ± 0.058
1.365GlyPro: 1.365 ± 0.035
2.557GlyGln: 2.557 ± 0.049
2.91GlyArg: 2.91 ± 0.049
4.304GlySer: 4.304 ± 0.067
3.999GlyThr: 3.999 ± 0.059
4.693GlyVal: 4.693 ± 0.073
0.91GlyTrp: 0.91 ± 0.032
2.945GlyTyr: 2.945 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.397HisAla: 1.397 ± 0.035
0.17HisCys: 0.17 ± 0.012
1.066HisAsp: 1.066 ± 0.034
1.101HisGlu: 1.101 ± 0.034
1.166HisPhe: 1.166 ± 0.033
1.266HisGly: 1.266 ± 0.036
0.588HisHis: 0.588 ± 0.025
1.632HisIle: 1.632 ± 0.044
0.932HisLys: 0.932 ± 0.027
2.022HisLeu: 2.022 ± 0.046
0.422HisMet: 0.422 ± 0.018
0.949HisAsn: 0.949 ± 0.028
0.956HisPro: 0.956 ± 0.029
0.94HisGln: 0.94 ± 0.03
0.959HisArg: 0.959 ± 0.032
1.145HisSer: 1.145 ± 0.035
1.137HisThr: 1.137 ± 0.035
1.199HisVal: 1.199 ± 0.035
0.294HisTrp: 0.294 ± 0.017
0.909HisTyr: 0.909 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.001IleAla: 6.001 ± 0.075
0.616IleCys: 0.616 ± 0.024
4.402IleAsp: 4.402 ± 0.066
4.2IleGlu: 4.2 ± 0.066
3.103IlePhe: 3.103 ± 0.064
4.989IleGly: 4.989 ± 0.077
1.431IleHis: 1.431 ± 0.035
4.661IleIle: 4.661 ± 0.083
3.939IleLys: 3.939 ± 0.062
6.244IleLeu: 6.244 ± 0.083
1.377IleMet: 1.377 ± 0.038
3.715IleAsn: 3.715 ± 0.063
3.204IlePro: 3.204 ± 0.05
2.831IleGln: 2.831 ± 0.054
3.324IleArg: 3.324 ± 0.056
5.062IleSer: 5.062 ± 0.065
4.097IleThr: 4.097 ± 0.057
4.648IleVal: 4.648 ± 0.077
0.737IleTrp: 0.737 ± 0.029
2.56IleTyr: 2.56 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.454LysAla: 4.454 ± 0.073
0.249LysCys: 0.249 ± 0.015
3.688LysAsp: 3.688 ± 0.056
4.301LysGlu: 4.301 ± 0.074
2.185LysPhe: 2.185 ± 0.048
3.681LysGly: 3.681 ± 0.06
1.299LysHis: 1.299 ± 0.035
4.193LysIle: 4.193 ± 0.062
4.373LysLys: 4.373 ± 0.082
5.379LysLeu: 5.379 ± 0.071
1.613LysMet: 1.613 ± 0.041
3.318LysAsn: 3.318 ± 0.053
2.253LysPro: 2.253 ± 0.055
2.571LysGln: 2.571 ± 0.047
2.812LysArg: 2.812 ± 0.06
3.842LysSer: 3.842 ± 0.063
3.39LysThr: 3.39 ± 0.059
3.816LysVal: 3.816 ± 0.059
0.69LysTrp: 0.69 ± 0.024
2.363LysTyr: 2.363 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
7.226LeuAla: 7.226 ± 0.09
0.79LeuCys: 0.79 ± 0.03
5.339LeuAsp: 5.339 ± 0.078
5.423LeuGlu: 5.423 ± 0.077
4.66LeuPhe: 4.66 ± 0.082
6.159LeuGly: 6.159 ± 0.077
1.933LeuHis: 1.933 ± 0.044
6.35LeuIle: 6.35 ± 0.105
5.675LeuLys: 5.675 ± 0.083
9.611LeuLeu: 9.611 ± 0.122
2.226LeuMet: 2.226 ± 0.045
4.774LeuAsn: 4.774 ± 0.074
4.041LeuPro: 4.041 ± 0.058
4.233LeuGln: 4.233 ± 0.066
4.384LeuArg: 4.384 ± 0.067
7.08LeuSer: 7.08 ± 0.085
5.172LeuThr: 5.172 ± 0.07
5.744LeuVal: 5.744 ± 0.085
0.925LeuTrp: 0.925 ± 0.032
3.407LeuTyr: 3.407 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
1.842MetAla: 1.842 ± 0.043
0.134MetCys: 0.134 ± 0.011
1.295MetAsp: 1.295 ± 0.03
1.397MetGlu: 1.397 ± 0.037
0.851MetPhe: 0.851 ± 0.023
1.542MetGly: 1.542 ± 0.038
0.528MetHis: 0.528 ± 0.022
1.608MetIle: 1.608 ± 0.033
1.66MetLys: 1.66 ± 0.035
2.22MetLeu: 2.22 ± 0.047
0.667MetMet: 0.667 ± 0.025
1.303MetAsn: 1.303 ± 0.033
1.047MetPro: 1.047 ± 0.029
1.08MetGln: 1.08 ± 0.03
1.141MetArg: 1.141 ± 0.03
1.513MetSer: 1.513 ± 0.04
1.207MetThr: 1.207 ± 0.032
1.443MetVal: 1.443 ± 0.039
0.204MetTrp: 0.204 ± 0.013
0.74MetTyr: 0.74 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.824AsnAla: 3.824 ± 0.066
0.275AsnCys: 0.275 ± 0.017
2.696AsnAsp: 2.696 ± 0.047
2.853AsnGlu: 2.853 ± 0.06
2.549AsnPhe: 2.549 ± 0.054
3.457AsnGly: 3.457 ± 0.073
0.928AsnHis: 0.928 ± 0.031
3.845AsnIle: 3.845 ± 0.066
3.034AsnLys: 3.034 ± 0.059
4.884AsnLeu: 4.884 ± 0.071
1.245AsnMet: 1.245 ± 0.038
3.044AsnAsn: 3.044 ± 0.063
2.644AsnPro: 2.644 ± 0.054
2.072AsnGln: 2.072 ± 0.048
2.591AsnArg: 2.591 ± 0.055
3.21AsnSer: 3.21 ± 0.063
3.14AsnThr: 3.14 ± 0.056
3.225AsnVal: 3.225 ± 0.057
0.731AsnTrp: 0.731 ± 0.025
2.365AsnTyr: 2.365 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.809ProAla: 2.809 ± 0.056
0.215ProCys: 0.215 ± 0.013
2.33ProAsp: 2.33 ± 0.047
2.715ProGlu: 2.715 ± 0.052
1.866ProPhe: 1.866 ± 0.038
2.116ProGly: 2.116 ± 0.045
0.731ProHis: 0.731 ± 0.024
2.727ProIle: 2.727 ± 0.052
2.074ProLys: 2.074 ± 0.048
3.321ProLeu: 3.321 ± 0.06
0.731ProMet: 0.731 ± 0.028
2.012ProAsn: 2.012 ± 0.046
0.853ProPro: 0.853 ± 0.027
1.483ProGln: 1.483 ± 0.04
1.291ProArg: 1.291 ± 0.038
2.331ProSer: 2.331 ± 0.042
2.307ProThr: 2.307 ± 0.042
2.551ProVal: 2.551 ± 0.046
0.4ProTrp: 0.4 ± 0.02
1.496ProTyr: 1.496 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.235GlnAla: 3.235 ± 0.058
0.181GlnCys: 0.181 ± 0.013
2.206GlnAsp: 2.206 ± 0.044
2.729GlnGlu: 2.729 ± 0.053
1.858GlnPhe: 1.858 ± 0.041
2.363GlnGly: 2.363 ± 0.043
1.044GlnHis: 1.044 ± 0.033
2.981GlnIle: 2.981 ± 0.054
2.596GlnLys: 2.596 ± 0.047
4.106GlnLeu: 4.106 ± 0.063
0.952GlnMet: 0.952 ± 0.029
2.103GlnAsn: 2.103 ± 0.053
1.394GlnPro: 1.394 ± 0.034
2.458GlnGln: 2.458 ± 0.061
1.998GlnArg: 1.998 ± 0.047
2.543GlnSer: 2.543 ± 0.044
2.228GlnThr: 2.228 ± 0.041
2.732GlnVal: 2.732 ± 0.05
0.467GlnTrp: 0.467 ± 0.02
1.675GlnTyr: 1.675 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.117ArgAla: 3.117 ± 0.05
0.239ArgCys: 0.239 ± 0.015
2.447ArgAsp: 2.447 ± 0.052
2.712ArgGlu: 2.712 ± 0.06
2.418ArgPhe: 2.418 ± 0.05
2.594ArgGly: 2.594 ± 0.053
0.87ArgHis: 0.87 ± 0.025
3.485ArgIle: 3.485 ± 0.061
2.951ArgLys: 2.951 ± 0.049
4.303ArgLeu: 4.303 ± 0.056
1.175ArgMet: 1.175 ± 0.032
2.591ArgAsn: 2.591 ± 0.053
1.536ArgPro: 1.536 ± 0.035
1.809ArgGln: 1.809 ± 0.038
2.004ArgArg: 2.004 ± 0.046
2.723ArgSer: 2.723 ± 0.056
2.496ArgThr: 2.496 ± 0.046
2.933ArgVal: 2.933 ± 0.048
0.592ArgTrp: 0.592 ± 0.022
2.186ArgTyr: 2.186 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
4.982SerAla: 4.982 ± 0.072
0.577SerCys: 0.577 ± 0.022
3.534SerAsp: 3.534 ± 0.052
3.559SerGlu: 3.559 ± 0.059
3.567SerPhe: 3.567 ± 0.057
4.655SerGly: 4.655 ± 0.053
1.135SerHis: 1.135 ± 0.032
4.787SerIle: 4.787 ± 0.073
3.77SerLys: 3.77 ± 0.066
6.264SerLeu: 6.264 ± 0.081
1.474SerMet: 1.474 ± 0.035
3.271SerAsn: 3.271 ± 0.057
2.259SerPro: 2.259 ± 0.045
2.206SerGln: 2.206 ± 0.051
2.708SerArg: 2.708 ± 0.043
4.277SerSer: 4.277 ± 0.076
3.756SerThr: 3.756 ± 0.057
4.182SerVal: 4.182 ± 0.062
0.762SerTrp: 0.762 ± 0.029
2.8SerTyr: 2.8 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.412ThrAla: 4.412 ± 0.063
0.321ThrCys: 0.321 ± 0.018
3.218ThrAsp: 3.218 ± 0.046
3.133ThrGlu: 3.133 ± 0.056
2.809ThrPhe: 2.809 ± 0.048
4.129ThrGly: 4.129 ± 0.056
1.086ThrHis: 1.086 ± 0.033
4.215ThrIle: 4.215 ± 0.066
3.034ThrLys: 3.034 ± 0.045
5.232ThrLeu: 5.232 ± 0.075
1.086ThrMet: 1.086 ± 0.03
2.879ThrAsn: 2.879 ± 0.061
2.425ThrPro: 2.425 ± 0.043
2.004ThrGln: 2.004 ± 0.043
2.128ThrArg: 2.128 ± 0.043
3.572ThrSer: 3.572 ± 0.058
3.42ThrThr: 3.42 ± 0.062
3.863ThrVal: 3.863 ± 0.054
0.634ThrTrp: 0.634 ± 0.025
2.368ThrTyr: 2.368 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
5.051ValAla: 5.051 ± 0.074
0.508ValCys: 0.508 ± 0.021
4.088ValAsp: 4.088 ± 0.06
3.903ValGlu: 3.903 ± 0.059
3.142ValPhe: 3.142 ± 0.051
4.419ValGly: 4.419 ± 0.077
1.232ValHis: 1.232 ± 0.031
4.498ValIle: 4.498 ± 0.061
3.705ValLys: 3.705 ± 0.065
6.393ValLeu: 6.393 ± 0.091
1.468ValMet: 1.468 ± 0.033
3.369ValAsn: 3.369 ± 0.053
2.466ValPro: 2.466 ± 0.051
2.459ValGln: 2.459 ± 0.046
2.991ValArg: 2.991 ± 0.056
4.419ValSer: 4.419 ± 0.065
3.502ValThr: 3.502 ± 0.053
4.582ValVal: 4.582 ± 0.081
0.726ValTrp: 0.726 ± 0.025
2.466ValTyr: 2.466 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.743TrpAla: 0.743 ± 0.025
0.092TrpCys: 0.092 ± 0.009
0.636TrpAsp: 0.636 ± 0.024
0.734TrpGlu: 0.734 ± 0.026
0.546TrpPhe: 0.546 ± 0.024
0.808TrpGly: 0.808 ± 0.029
0.252TrpHis: 0.252 ± 0.014
0.79TrpIle: 0.79 ± 0.028
0.797TrpLys: 0.797 ± 0.024
1.116TrpLeu: 1.116 ± 0.031
0.364TrpMet: 0.364 ± 0.02
0.718TrpAsn: 0.718 ± 0.029
0.327TrpPro: 0.327 ± 0.018
0.583TrpGln: 0.583 ± 0.023
0.617TrpArg: 0.617 ± 0.024
0.765TrpSer: 0.765 ± 0.029
0.628TrpThr: 0.628 ± 0.026
0.665TrpVal: 0.665 ± 0.025
0.168TrpTrp: 0.168 ± 0.011
0.48TrpTyr: 0.48 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.059TyrAla: 3.059 ± 0.056
0.305TyrCys: 0.305 ± 0.016
2.354TyrAsp: 2.354 ± 0.044
2.2TyrGlu: 2.2 ± 0.043
2.191TyrPhe: 2.191 ± 0.049
2.833TyrGly: 2.833 ± 0.06
0.905TyrHis: 0.905 ± 0.03
2.47TyrIle: 2.47 ± 0.047
2.137TyrLys: 2.137 ± 0.049
3.847TyrLeu: 3.847 ± 0.059
0.806TyrMet: 0.806 ± 0.027
2.192TyrAsn: 2.192 ± 0.055
1.611TyrPro: 1.611 ± 0.043
1.836TyrGln: 1.836 ± 0.043
2.075TyrArg: 2.075 ± 0.047
2.61TyrSer: 2.61 ± 0.053
2.354TyrThr: 2.354 ± 0.051
2.376TyrVal: 2.376 ± 0.049
0.506TyrTrp: 0.506 ± 0.021
1.747TyrTyr: 1.747 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3348 proteins (1168914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski