Amino acid dipepetide frequency for Azomonas agilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.812AlaAla: 10.812 ± 0.135
1.182AlaCys: 1.182 ± 0.031
5.02AlaAsp: 5.02 ± 0.075
6.78AlaGlu: 6.78 ± 0.091
3.442AlaPhe: 3.442 ± 0.065
7.283AlaGly: 7.283 ± 0.093
2.211AlaHis: 2.211 ± 0.05
5.013AlaIle: 5.013 ± 0.078
3.833AlaLys: 3.833 ± 0.076
13.308AlaLeu: 13.308 ± 0.143
2.181AlaMet: 2.181 ± 0.046
2.903AlaAsn: 2.903 ± 0.061
4.034AlaPro: 4.034 ± 0.085
5.999AlaGln: 5.999 ± 0.102
6.271AlaArg: 6.271 ± 0.1
5.361AlaSer: 5.361 ± 0.082
4.582AlaThr: 4.582 ± 0.074
6.594AlaVal: 6.594 ± 0.097
1.327AlaTrp: 1.327 ± 0.04
2.506AlaTyr: 2.506 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.97CysAla: 0.97 ± 0.034
0.175CysCys: 0.175 ± 0.013
0.517CysAsp: 0.517 ± 0.021
0.518CysGlu: 0.518 ± 0.025
0.392CysPhe: 0.392 ± 0.024
0.905CysGly: 0.905 ± 0.028
0.331CysHis: 0.331 ± 0.018
0.586CysIle: 0.586 ± 0.023
0.304CysLys: 0.304 ± 0.018
1.221CysLeu: 1.221 ± 0.033
0.212CysMet: 0.212 ± 0.013
0.288CysAsn: 0.288 ± 0.015
0.588CysPro: 0.588 ± 0.027
0.518CysGln: 0.518 ± 0.023
0.612CysArg: 0.612 ± 0.023
0.746CysSer: 0.746 ± 0.029
0.544CysThr: 0.544 ± 0.024
0.667CysVal: 0.667 ± 0.03
0.169CysTrp: 0.169 ± 0.012
0.296CysTyr: 0.296 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.487AspAla: 4.487 ± 0.082
0.578AspCys: 0.578 ± 0.025
2.193AspAsp: 2.193 ± 0.055
3.256AspGlu: 3.256 ± 0.06
2.229AspPhe: 2.229 ± 0.053
3.41AspGly: 3.41 ± 0.071
1.083AspHis: 1.083 ± 0.033
2.8AspIle: 2.8 ± 0.051
1.868AspLys: 1.868 ± 0.048
6.036AspLeu: 6.036 ± 0.077
1.106AspMet: 1.106 ± 0.034
1.522AspAsn: 1.522 ± 0.042
2.766AspPro: 2.766 ± 0.049
2.501AspGln: 2.501 ± 0.05
2.932AspArg: 2.932 ± 0.058
3.014AspSer: 3.014 ± 0.065
2.529AspThr: 2.529 ± 0.06
2.988AspVal: 2.988 ± 0.06
1.038AspTrp: 1.038 ± 0.033
1.719AspTyr: 1.719 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.972GluAla: 6.972 ± 0.119
0.456GluCys: 0.456 ± 0.02
2.793GluAsp: 2.793 ± 0.057
3.321GluGlu: 3.321 ± 0.078
1.837GluPhe: 1.837 ± 0.046
4.127GluGly: 4.127 ± 0.07
1.877GluHis: 1.877 ± 0.052
2.996GluIle: 2.996 ± 0.061
2.11GluLys: 2.11 ± 0.051
7.123GluLeu: 7.123 ± 0.105
1.142GluMet: 1.142 ± 0.035
1.505GluAsn: 1.505 ± 0.04
2.639GluPro: 2.639 ± 0.061
4.451GluGln: 4.451 ± 0.077
4.847GluArg: 4.847 ± 0.074
2.803GluSer: 2.803 ± 0.059
2.665GluThr: 2.665 ± 0.048
4.475GluVal: 4.475 ± 0.086
0.702GluTrp: 0.702 ± 0.025
1.511GluTyr: 1.511 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.394PheAla: 3.394 ± 0.067
0.472PheCys: 0.472 ± 0.021
2.312PheAsp: 2.312 ± 0.054
2.201PheGlu: 2.201 ± 0.051
1.495PhePhe: 1.495 ± 0.043
2.953PheGly: 2.953 ± 0.066
0.702PheHis: 0.702 ± 0.027
2.005PheIle: 2.005 ± 0.05
1.343PheLys: 1.343 ± 0.04
3.229PheLeu: 3.229 ± 0.072
0.801PheMet: 0.801 ± 0.029
1.394PheAsn: 1.394 ± 0.038
1.467PhePro: 1.467 ± 0.038
1.399PheGln: 1.399 ± 0.038
1.822PheArg: 1.822 ± 0.042
2.67PheSer: 2.67 ± 0.053
1.741PheThr: 1.741 ± 0.043
2.347PheVal: 2.347 ± 0.048
0.636PheTrp: 0.636 ± 0.027
1.129PheTyr: 1.129 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
6.132GlyAla: 6.132 ± 0.09
1.064GlyCys: 1.064 ± 0.033
3.399GlyAsp: 3.399 ± 0.064
3.86GlyGlu: 3.86 ± 0.068
3.141GlyPhe: 3.141 ± 0.068
5.386GlyGly: 5.386 ± 0.124
1.832GlyHis: 1.832 ± 0.044
4.405GlyIle: 4.405 ± 0.063
3.096GlyLys: 3.096 ± 0.068
8.95GlyLeu: 8.95 ± 0.096
1.857GlyMet: 1.857 ± 0.047
2.304GlyAsn: 2.304 ± 0.093
2.397GlyPro: 2.397 ± 0.06
3.844GlyGln: 3.844 ± 0.068
4.527GlyArg: 4.527 ± 0.075
4.439GlySer: 4.439 ± 0.08
3.647GlyThr: 3.647 ± 0.068
5.324GlyVal: 5.324 ± 0.094
1.267GlyTrp: 1.267 ± 0.038
2.339GlyTyr: 2.339 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.005HisAla: 2.005 ± 0.053
0.354HisCys: 0.354 ± 0.019
1.011HisAsp: 1.011 ± 0.029
1.277HisGlu: 1.277 ± 0.037
0.999HisPhe: 0.999 ± 0.031
1.524HisGly: 1.524 ± 0.044
0.746HisHis: 0.746 ± 0.032
1.255HisIle: 1.255 ± 0.041
0.821HisLys: 0.821 ± 0.028
3.051HisLeu: 3.051 ± 0.063
0.548HisMet: 0.548 ± 0.023
0.764HisAsn: 0.764 ± 0.031
1.548HisPro: 1.548 ± 0.049
1.489HisGln: 1.489 ± 0.046
1.404HisArg: 1.404 ± 0.036
1.416HisSer: 1.416 ± 0.042
1.186HisThr: 1.186 ± 0.039
1.206HisVal: 1.206 ± 0.042
0.556HisTrp: 0.556 ± 0.024
0.853HisTyr: 0.853 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.61IleAla: 5.61 ± 0.086
0.537IleCys: 0.537 ± 0.023
2.912IleAsp: 2.912 ± 0.058
3.572IleGlu: 3.572 ± 0.065
1.565IlePhe: 1.565 ± 0.048
4.162IleGly: 4.162 ± 0.077
1.174IleHis: 1.174 ± 0.037
2.354IleIle: 2.354 ± 0.056
2.063IleLys: 2.063 ± 0.05
5.148IleLeu: 5.148 ± 0.084
0.91IleMet: 0.91 ± 0.032
2.03IleAsn: 2.03 ± 0.051
2.88IlePro: 2.88 ± 0.055
2.527IleGln: 2.527 ± 0.056
3.376IleArg: 3.376 ± 0.061
3.454IleSer: 3.454 ± 0.07
2.854IleThr: 2.854 ± 0.054
3.164IleVal: 3.164 ± 0.061
0.562IleTrp: 0.562 ± 0.027
1.254IleTyr: 1.254 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.393LysAla: 4.393 ± 0.09
0.216LysCys: 0.216 ± 0.017
1.985LysAsp: 1.985 ± 0.047
2.114LysGlu: 2.114 ± 0.059
0.895LysPhe: 0.895 ± 0.036
2.693LysGly: 2.693 ± 0.053
0.825LysHis: 0.825 ± 0.032
1.902LysIle: 1.902 ± 0.051
1.581LysLys: 1.581 ± 0.063
3.832LysLeu: 3.832 ± 0.07
0.756LysMet: 0.756 ± 0.03
1.292LysAsn: 1.292 ± 0.045
2.157LysPro: 2.157 ± 0.051
1.781LysGln: 1.781 ± 0.047
2.384LysArg: 2.384 ± 0.058
2.103LysSer: 2.103 ± 0.056
2.262LysThr: 2.262 ± 0.053
2.636LysVal: 2.636 ± 0.058
0.314LysTrp: 0.314 ± 0.018
0.77LysTyr: 0.77 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
13.024LeuAla: 13.024 ± 0.157
1.301LeuCys: 1.301 ± 0.04
6.581LeuAsp: 6.581 ± 0.09
7.728LeuGlu: 7.728 ± 0.107
4.04LeuPhe: 4.04 ± 0.074
9.093LeuGly: 9.093 ± 0.109
2.593LeuHis: 2.593 ± 0.054
6.302LeuIle: 6.302 ± 0.096
4.919LeuLys: 4.919 ± 0.086
13.668LeuLeu: 13.668 ± 0.163
2.667LeuMet: 2.667 ± 0.055
4.338LeuAsn: 4.338 ± 0.065
6.229LeuPro: 6.229 ± 0.102
4.856LeuGln: 4.856 ± 0.085
6.852LeuArg: 6.852 ± 0.095
8.298LeuSer: 8.298 ± 0.099
5.82LeuThr: 5.82 ± 0.077
7.875LeuVal: 7.875 ± 0.11
1.519LeuTrp: 1.519 ± 0.045
2.874LeuTyr: 2.874 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.35MetAla: 2.35 ± 0.053
0.136MetCys: 0.136 ± 0.012
1.078MetAsp: 1.078 ± 0.036
1.028MetGlu: 1.028 ± 0.033
0.559MetPhe: 0.559 ± 0.024
1.587MetGly: 1.587 ± 0.045
0.491MetHis: 0.491 ± 0.024
0.981MetIle: 0.981 ± 0.029
0.767MetLys: 0.767 ± 0.025
2.543MetLeu: 2.543 ± 0.052
0.482MetMet: 0.482 ± 0.019
0.738MetAsn: 0.738 ± 0.028
1.233MetPro: 1.233 ± 0.034
1.146MetGln: 1.146 ± 0.032
1.34MetArg: 1.34 ± 0.038
1.66MetSer: 1.66 ± 0.04
1.354MetThr: 1.354 ± 0.037
1.394MetVal: 1.394 ± 0.041
0.152MetTrp: 0.152 ± 0.012
0.363MetTyr: 0.363 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.117AsnAla: 3.117 ± 0.058
0.311AsnCys: 0.311 ± 0.019
1.487AsnAsp: 1.487 ± 0.054
1.522AsnGlu: 1.522 ± 0.04
1.127AsnPhe: 1.127 ± 0.034
2.24AsnGly: 2.24 ± 0.053
0.692AsnHis: 0.692 ± 0.03
1.747AsnIle: 1.747 ± 0.047
1.113AsnLys: 1.113 ± 0.043
3.857AsnLeu: 3.857 ± 0.073
0.638AsnMet: 0.638 ± 0.025
1.085AsnAsn: 1.085 ± 0.056
2.329AsnPro: 2.329 ± 0.055
1.71AsnGln: 1.71 ± 0.046
1.947AsnArg: 1.947 ± 0.05
1.859AsnSer: 1.859 ± 0.058
1.967AsnThr: 1.967 ± 0.051
1.7AsnVal: 1.7 ± 0.042
0.461AsnTrp: 0.461 ± 0.019
0.939AsnTyr: 0.939 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
4.599ProAla: 4.599 ± 0.076
0.427ProCys: 0.427 ± 0.02
2.781ProAsp: 2.781 ± 0.052
4.269ProGlu: 4.269 ± 0.077
1.681ProPhe: 1.681 ± 0.04
2.988ProGly: 2.988 ± 0.06
1.144ProHis: 1.144 ± 0.039
2.555ProIle: 2.555 ± 0.055
2.15ProLys: 2.15 ± 0.057
5.705ProLeu: 5.705 ± 0.104
1.171ProMet: 1.171 ± 0.036
1.674ProAsn: 1.674 ± 0.04
2.035ProPro: 2.035 ± 0.059
2.45ProGln: 2.45 ± 0.056
2.288ProArg: 2.288 ± 0.052
2.991ProSer: 2.991 ± 0.06
2.417ProThr: 2.417 ± 0.055
3.768ProVal: 3.768 ± 0.063
0.77ProTrp: 0.77 ± 0.03
1.259ProTyr: 1.259 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
6.604GlnAla: 6.604 ± 0.125
0.416GlnCys: 0.416 ± 0.021
2.217GlnAsp: 2.217 ± 0.047
2.828GlnGlu: 2.828 ± 0.053
1.396GlnPhe: 1.396 ± 0.035
4.125GlnGly: 4.125 ± 0.075
1.553GlnHis: 1.553 ± 0.047
2.663GlnIle: 2.663 ± 0.055
1.623GlnLys: 1.623 ± 0.047
6.227GlnLeu: 6.227 ± 0.11
0.978GlnMet: 0.978 ± 0.027
1.443GlnAsn: 1.443 ± 0.044
2.738GlnPro: 2.738 ± 0.056
3.977GlnGln: 3.977 ± 0.108
3.917GlnArg: 3.917 ± 0.079
2.787GlnSer: 2.787 ± 0.063
2.401GlnThr: 2.401 ± 0.05
3.811GlnVal: 3.811 ± 0.075
0.744GlnTrp: 0.744 ± 0.03
1.303GlnTyr: 1.303 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
5.355ArgAla: 5.355 ± 0.084
0.653ArgCys: 0.653 ± 0.024
3.013ArgAsp: 3.013 ± 0.058
3.676ArgGlu: 3.676 ± 0.07
2.699ArgPhe: 2.699 ± 0.06
3.499ArgGly: 3.499 ± 0.068
1.733ArgHis: 1.733 ± 0.041
3.631ArgIle: 3.631 ± 0.059
2.03ArgLys: 2.03 ± 0.052
8.429ArgLeu: 8.429 ± 0.117
1.403ArgMet: 1.403 ± 0.041
1.875ArgAsn: 1.875 ± 0.045
2.782ArgPro: 2.782 ± 0.063
3.618ArgGln: 3.618 ± 0.066
3.806ArgArg: 3.806 ± 0.076
3.253ArgSer: 3.253 ± 0.06
2.869ArgThr: 2.869 ± 0.052
4.123ArgVal: 4.123 ± 0.068
1.118ArgTrp: 1.118 ± 0.037
2.221ArgTyr: 2.221 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.643SerAla: 5.643 ± 0.092
0.624SerCys: 0.624 ± 0.026
2.733SerAsp: 2.733 ± 0.061
3.304SerGlu: 3.304 ± 0.064
2.361SerPhe: 2.361 ± 0.052
5.165SerGly: 5.165 ± 0.089
1.409SerHis: 1.409 ± 0.033
3.355SerIle: 3.355 ± 0.071
2.024SerLys: 2.024 ± 0.049
7.745SerLeu: 7.745 ± 0.109
1.414SerMet: 1.414 ± 0.041
1.827SerAsn: 1.827 ± 0.05
2.734SerPro: 2.734 ± 0.058
2.616SerGln: 2.616 ± 0.053
3.403SerArg: 3.403 ± 0.066
4.122SerSer: 4.122 ± 0.082
3.152SerThr: 3.152 ± 0.062
4.141SerVal: 4.141 ± 0.071
0.824SerTrp: 0.824 ± 0.032
1.652SerTyr: 1.652 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.888ThrAla: 4.888 ± 0.075
0.494ThrCys: 0.494 ± 0.025
2.572ThrAsp: 2.572 ± 0.064
3.07ThrGlu: 3.07 ± 0.056
1.551ThrPhe: 1.551 ± 0.045
4.423ThrGly: 4.423 ± 0.077
1.28ThrHis: 1.28 ± 0.041
1.914ThrIle: 1.914 ± 0.048
1.498ThrLys: 1.498 ± 0.043
6.918ThrLeu: 6.918 ± 0.088
0.701ThrMet: 0.701 ± 0.027
1.446ThrAsn: 1.446 ± 0.044
3.423ThrPro: 3.423 ± 0.06
2.929ThrGln: 2.929 ± 0.062
2.891ThrArg: 2.891 ± 0.054
2.738ThrSer: 2.738 ± 0.05
2.622ThrThr: 2.622 ± 0.057
2.806ThrVal: 2.806 ± 0.066
0.629ThrTrp: 0.629 ± 0.031
1.266ThrTyr: 1.266 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
6.585ValAla: 6.585 ± 0.1
0.681ValCys: 0.681 ± 0.026
3.538ValAsp: 3.538 ± 0.06
4.098ValGlu: 4.098 ± 0.07
2.485ValPhe: 2.485 ± 0.054
4.733ValGly: 4.733 ± 0.084
1.346ValHis: 1.346 ± 0.048
3.744ValIle: 3.744 ± 0.068
2.447ValLys: 2.447 ± 0.062
8.034ValLeu: 8.034 ± 0.107
1.584ValMet: 1.584 ± 0.043
2.134ValAsn: 2.134 ± 0.055
2.978ValPro: 2.978 ± 0.053
3.203ValGln: 3.203 ± 0.058
4.18ValArg: 4.18 ± 0.065
3.991ValSer: 3.991 ± 0.061
3.464ValThr: 3.464 ± 0.073
4.982ValVal: 4.982 ± 0.088
0.828ValTrp: 0.828 ± 0.03
1.559ValTyr: 1.559 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.17TrpAla: 1.17 ± 0.039
0.171TrpCys: 0.171 ± 0.011
0.62TrpAsp: 0.62 ± 0.027
0.596TrpGlu: 0.596 ± 0.022
0.527TrpPhe: 0.527 ± 0.025
0.921TrpGly: 0.921 ± 0.041
0.367TrpHis: 0.367 ± 0.018
0.754TrpIle: 0.754 ± 0.031
0.434TrpLys: 0.434 ± 0.021
2.147TrpLeu: 2.147 ± 0.055
0.366TrpMet: 0.366 ± 0.019
0.447TrpAsn: 0.447 ± 0.023
0.713TrpPro: 0.713 ± 0.027
0.988TrpGln: 0.988 ± 0.037
1.014TrpArg: 1.014 ± 0.037
0.814TrpSer: 0.814 ± 0.029
0.646TrpThr: 0.646 ± 0.028
1.029TrpVal: 1.029 ± 0.03
0.199TrpTrp: 0.199 ± 0.013
0.389TrpTyr: 0.389 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.532TyrAla: 2.532 ± 0.06
0.309TyrCys: 0.309 ± 0.016
1.295TyrAsp: 1.295 ± 0.039
1.334TyrGlu: 1.334 ± 0.039
1.091TyrPhe: 1.091 ± 0.036
1.995TyrGly: 1.995 ± 0.045
0.627TyrHis: 0.627 ± 0.023
1.147TyrIle: 1.147 ± 0.036
0.868TyrLys: 0.868 ± 0.032
3.406TyrLeu: 3.406 ± 0.063
0.465TyrMet: 0.465 ± 0.023
0.842TyrAsn: 0.842 ± 0.03
1.451TyrPro: 1.451 ± 0.041
1.747TyrGln: 1.747 ± 0.053
1.969TyrArg: 1.969 ± 0.046
1.73TyrSer: 1.73 ± 0.042
1.334TyrThr: 1.334 ± 0.043
1.563TyrVal: 1.563 ± 0.038
0.499TyrTrp: 0.499 ± 0.023
0.788TyrTyr: 0.788 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3016 proteins (982890 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski