Amino acid dipepetide frequency for Nitrosomonas sp. AL212

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.739AlaAla: 8.739 ± 0.138
0.952AlaCys: 0.952 ± 0.033
4.562AlaAsp: 4.562 ± 0.078
5.299AlaGlu: 5.299 ± 0.082
3.285AlaPhe: 3.285 ± 0.068
6.466AlaGly: 6.466 ± 0.118
2.011AlaHis: 2.011 ± 0.055
6.53AlaIle: 6.53 ± 0.089
4.027AlaLys: 4.027 ± 0.083
9.507AlaLeu: 9.507 ± 0.11
2.351AlaMet: 2.351 ± 0.048
3.307AlaAsn: 3.307 ± 0.067
2.916AlaPro: 2.916 ± 0.07
3.853AlaGln: 3.853 ± 0.068
4.532AlaArg: 4.532 ± 0.071
5.001AlaSer: 5.001 ± 0.093
4.441AlaThr: 4.441 ± 0.105
5.785AlaVal: 5.785 ± 0.093
1.041AlaTrp: 1.041 ± 0.037
2.394AlaTyr: 2.394 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.879CysAla: 0.879 ± 0.036
0.153CysCys: 0.153 ± 0.015
0.534CysAsp: 0.534 ± 0.027
0.51CysGlu: 0.51 ± 0.025
0.425CysPhe: 0.425 ± 0.025
0.868CysGly: 0.868 ± 0.041
0.408CysHis: 0.408 ± 0.026
0.649CysIle: 0.649 ± 0.03
0.407CysLys: 0.407 ± 0.021
0.902CysLeu: 0.902 ± 0.032
0.197CysMet: 0.197 ± 0.015
0.412CysAsn: 0.412 ± 0.019
0.437CysPro: 0.437 ± 0.023
0.365CysGln: 0.365 ± 0.021
0.539CysArg: 0.539 ± 0.024
0.596CysSer: 0.596 ± 0.028
0.477CysThr: 0.477 ± 0.025
0.639CysVal: 0.639 ± 0.028
0.126CysTrp: 0.126 ± 0.012
0.316CysTyr: 0.316 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.402AspAla: 4.402 ± 0.079
0.465AspCys: 0.465 ± 0.021
2.918AspAsp: 2.918 ± 0.086
3.393AspGlu: 3.393 ± 0.078
2.492AspPhe: 2.492 ± 0.057
3.856AspGly: 3.856 ± 0.121
1.312AspHis: 1.312 ± 0.036
3.876AspIle: 3.876 ± 0.075
2.69AspLys: 2.69 ± 0.056
5.277AspLeu: 5.277 ± 0.077
1.285AspMet: 1.285 ± 0.038
2.147AspAsn: 2.147 ± 0.055
2.381AspPro: 2.381 ± 0.053
2.104AspGln: 2.104 ± 0.051
2.815AspArg: 2.815 ± 0.064
3.177AspSer: 3.177 ± 0.073
2.823AspThr: 2.823 ± 0.072
3.324AspVal: 3.324 ± 0.089
0.872AspTrp: 0.872 ± 0.037
1.828AspTyr: 1.828 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.021GluAla: 5.021 ± 0.085
0.443GluCys: 0.443 ± 0.023
2.465GluAsp: 2.465 ± 0.06
3.341GluGlu: 3.341 ± 0.069
2.338GluPhe: 2.338 ± 0.053
3.066GluGly: 3.066 ± 0.066
1.413GluHis: 1.413 ± 0.043
5.066GluIle: 5.066 ± 0.085
3.838GluLys: 3.838 ± 0.07
6.203GluLeu: 6.203 ± 0.089
1.61GluMet: 1.61 ± 0.047
2.877GluAsn: 2.877 ± 0.068
1.922GluPro: 1.922 ± 0.05
2.935GluGln: 2.935 ± 0.066
3.62GluArg: 3.62 ± 0.071
3.619GluSer: 3.619 ± 0.066
3.236GluThr: 3.236 ± 0.061
3.594GluVal: 3.594 ± 0.071
0.79GluTrp: 0.79 ± 0.03
1.585GluTyr: 1.585 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.364PheAla: 3.364 ± 0.06
0.514PheCys: 0.514 ± 0.028
2.691PheAsp: 2.691 ± 0.075
2.292PheGlu: 2.292 ± 0.052
1.91PhePhe: 1.91 ± 0.057
3.075PheGly: 3.075 ± 0.067
0.906PheHis: 0.906 ± 0.033
2.81PheIle: 2.81 ± 0.059
1.671PheLys: 1.671 ± 0.046
3.757PheLeu: 3.757 ± 0.073
1.014PheMet: 1.014 ± 0.033
1.911PheAsn: 1.911 ± 0.054
1.752PhePro: 1.752 ± 0.043
1.418PheGln: 1.418 ± 0.039
2.026PheArg: 2.026 ± 0.051
3.106PheSer: 3.106 ± 0.061
2.354PheThr: 2.354 ± 0.066
2.594PheVal: 2.594 ± 0.058
0.542PheTrp: 0.542 ± 0.023
1.3PheTyr: 1.3 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.443GlyAla: 5.443 ± 0.098
0.807GlyCys: 0.807 ± 0.029
3.669GlyAsp: 3.669 ± 0.123
3.748GlyGlu: 3.748 ± 0.067
3.483GlyPhe: 3.483 ± 0.1
5.16GlyGly: 5.16 ± 0.153
1.695GlyHis: 1.695 ± 0.05
5.413GlyIle: 5.413 ± 0.078
4.168GlyLys: 4.168 ± 0.077
6.785GlyLeu: 6.785 ± 0.107
1.96GlyMet: 1.96 ± 0.052
3.226GlyAsn: 3.226 ± 0.109
1.616GlyPro: 1.616 ± 0.043
2.478GlyGln: 2.478 ± 0.051
3.494GlyArg: 3.494 ± 0.072
4.198GlySer: 4.198 ± 0.105
3.842GlyThr: 3.842 ± 0.096
4.721GlyVal: 4.721 ± 0.079
0.988GlyTrp: 0.988 ± 0.031
2.407GlyTyr: 2.407 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.309HisAla: 2.309 ± 0.059
0.322HisCys: 0.322 ± 0.019
1.33HisAsp: 1.33 ± 0.037
1.386HisGlu: 1.386 ± 0.039
1.056HisPhe: 1.056 ± 0.037
1.78HisGly: 1.78 ± 0.047
0.813HisHis: 0.813 ± 0.038
1.565HisIle: 1.565 ± 0.048
0.976HisLys: 0.976 ± 0.036
2.496HisLeu: 2.496 ± 0.06
0.495HisMet: 0.495 ± 0.025
0.908HisAsn: 0.908 ± 0.035
1.341HisPro: 1.341 ± 0.039
1.153HisGln: 1.153 ± 0.041
1.289HisArg: 1.289 ± 0.04
1.484HisSer: 1.484 ± 0.041
1.231HisThr: 1.231 ± 0.042
1.476HisVal: 1.476 ± 0.042
0.368HisTrp: 0.368 ± 0.022
0.861HisTyr: 0.861 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
7.025IleAla: 7.025 ± 0.091
0.723IleCys: 0.723 ± 0.031
4.375IleAsp: 4.375 ± 0.075
4.836IleGlu: 4.836 ± 0.08
2.743IlePhe: 2.743 ± 0.069
5.014IleGly: 5.014 ± 0.076
1.686IleHis: 1.686 ± 0.045
4.742IleIle: 4.742 ± 0.088
3.789IleLys: 3.789 ± 0.078
6.67IleLeu: 6.67 ± 0.107
1.542IleMet: 1.542 ± 0.04
3.502IleAsn: 3.502 ± 0.069
3.357IlePro: 3.357 ± 0.064
2.784IleGln: 2.784 ± 0.058
3.814IleArg: 3.814 ± 0.062
4.844IleSer: 4.844 ± 0.091
4.208IleThr: 4.208 ± 0.085
4.553IleVal: 4.553 ± 0.078
0.744IleTrp: 0.744 ± 0.026
1.868IleTyr: 1.868 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
3.942LysAla: 3.942 ± 0.078
0.334LysCys: 0.334 ± 0.022
2.326LysAsp: 2.326 ± 0.05
3.01LysGlu: 3.01 ± 0.074
1.642LysPhe: 1.642 ± 0.044
2.639LysGly: 2.639 ± 0.061
1.182LysHis: 1.182 ± 0.039
4.014LysIle: 4.014 ± 0.075
2.965LysLys: 2.965 ± 0.072
5.261LysLeu: 5.261 ± 0.073
1.345LysMet: 1.345 ± 0.04
2.572LysAsn: 2.572 ± 0.059
2.292LysPro: 2.292 ± 0.057
2.656LysGln: 2.656 ± 0.064
2.752LysArg: 2.752 ± 0.059
2.998LysSer: 2.998 ± 0.055
2.844LysThr: 2.844 ± 0.063
2.845LysVal: 2.845 ± 0.06
0.507LysTrp: 0.507 ± 0.025
1.284LysTyr: 1.284 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
9.349LeuAla: 9.349 ± 0.116
1.029LeuCys: 1.029 ± 0.039
5.551LeuAsp: 5.551 ± 0.094
5.936LeuGlu: 5.936 ± 0.092
3.998LeuPhe: 3.998 ± 0.076
6.697LeuGly: 6.697 ± 0.093
2.441LeuHis: 2.441 ± 0.053
7.526LeuIle: 7.526 ± 0.111
5.029LeuLys: 5.029 ± 0.081
11.114LeuLeu: 11.114 ± 0.156
2.518LeuMet: 2.518 ± 0.055
4.575LeuAsn: 4.575 ± 0.087
5.023LeuPro: 5.023 ± 0.088
4.443LeuGln: 4.443 ± 0.077
5.613LeuArg: 5.613 ± 0.097
7.351LeuSer: 7.351 ± 0.096
5.977LeuThr: 5.977 ± 0.087
6.1LeuVal: 6.1 ± 0.086
1.164LeuTrp: 1.164 ± 0.044
2.501LeuTyr: 2.501 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.112MetAla: 2.112 ± 0.048
0.173MetCys: 0.173 ± 0.014
1.205MetAsp: 1.205 ± 0.035
1.328MetGlu: 1.328 ± 0.036
0.759MetPhe: 0.759 ± 0.03
1.607MetGly: 1.607 ± 0.054
0.63MetHis: 0.63 ± 0.028
1.742MetIle: 1.742 ± 0.044
1.374MetLys: 1.374 ± 0.042
2.752MetLeu: 2.752 ± 0.06
0.66MetMet: 0.66 ± 0.028
1.227MetAsn: 1.227 ± 0.04
1.238MetPro: 1.238 ± 0.036
1.294MetGln: 1.294 ± 0.046
1.514MetArg: 1.514 ± 0.04
1.502MetSer: 1.502 ± 0.043
1.466MetThr: 1.466 ± 0.044
1.55MetVal: 1.55 ± 0.05
0.191MetTrp: 0.191 ± 0.016
0.457MetTyr: 0.457 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.519AsnAla: 3.519 ± 0.071
0.427AsnCys: 0.427 ± 0.023
2.42AsnAsp: 2.42 ± 0.068
2.444AsnGlu: 2.444 ± 0.052
1.783AsnPhe: 1.783 ± 0.055
3.22AsnGly: 3.22 ± 0.11
1.042AsnHis: 1.042 ± 0.035
3.117AsnIle: 3.117 ± 0.068
2.192AsnLys: 2.192 ± 0.052
4.564AsnLeu: 4.564 ± 0.084
0.926AsnMet: 0.926 ± 0.033
2.1AsnAsn: 2.1 ± 0.061
2.517AsnPro: 2.517 ± 0.062
2.042AsnGln: 2.042 ± 0.051
2.306AsnArg: 2.306 ± 0.052
2.65AsnSer: 2.65 ± 0.064
2.381AsnThr: 2.381 ± 0.064
2.558AsnVal: 2.558 ± 0.065
0.617AsnTrp: 0.617 ± 0.028
1.344AsnTyr: 1.344 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
3.511ProAla: 3.511 ± 0.069
0.361ProCys: 0.361 ± 0.02
2.812ProAsp: 2.812 ± 0.06
3.143ProGlu: 3.143 ± 0.066
1.786ProPhe: 1.786 ± 0.051
3.166ProGly: 3.166 ± 0.071
1.012ProHis: 1.012 ± 0.035
2.677ProIle: 2.677 ± 0.063
1.741ProLys: 1.741 ± 0.045
4.084ProLeu: 4.084 ± 0.073
1.006ProMet: 1.006 ± 0.032
1.682ProAsn: 1.682 ± 0.046
1.654ProPro: 1.654 ± 0.049
1.731ProGln: 1.731 ± 0.047
1.724ProArg: 1.724 ± 0.047
2.36ProSer: 2.36 ± 0.05
2.042ProThr: 2.042 ± 0.049
3.36ProVal: 3.36 ± 0.06
0.546ProTrp: 0.546 ± 0.026
1.252ProTyr: 1.252 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.065GlnAla: 4.065 ± 0.077
0.327GlnCys: 0.327 ± 0.019
1.885GlnAsp: 1.885 ± 0.045
2.436GlnGlu: 2.436 ± 0.052
1.719GlnPhe: 1.719 ± 0.04
2.664GlnGly: 2.664 ± 0.05
1.226GlnHis: 1.226 ± 0.042
3.071GlnIle: 3.071 ± 0.067
2.249GlnLys: 2.249 ± 0.063
4.824GlnLeu: 4.824 ± 0.079
1.047GlnMet: 1.047 ± 0.03
1.768GlnAsn: 1.768 ± 0.046
1.735GlnPro: 1.735 ± 0.041
2.502GlnGln: 2.502 ± 0.057
2.548GlnArg: 2.548 ± 0.067
2.699GlnSer: 2.699 ± 0.063
2.225GlnThr: 2.225 ± 0.059
2.727GlnVal: 2.727 ± 0.069
0.578GlnTrp: 0.578 ± 0.026
1.231GlnTyr: 1.231 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
4.102ArgAla: 4.102 ± 0.08
0.468ArgCys: 0.468 ± 0.024
2.763ArgAsp: 2.763 ± 0.056
3.448ArgGlu: 3.448 ± 0.061
2.354ArgPhe: 2.354 ± 0.049
3.024ArgGly: 3.024 ± 0.067
1.398ArgHis: 1.398 ± 0.043
4.407ArgIle: 4.407 ± 0.075
2.727ArgLys: 2.727 ± 0.066
5.858ArgLeu: 5.858 ± 0.099
1.501ArgMet: 1.501 ± 0.045
2.629ArgAsn: 2.629 ± 0.054
1.838ArgPro: 1.838 ± 0.047
2.394ArgGln: 2.394 ± 0.056
3.037ArgArg: 3.037 ± 0.08
2.97ArgSer: 2.97 ± 0.055
2.494ArgThr: 2.494 ± 0.059
3.187ArgVal: 3.187 ± 0.064
0.788ArgTrp: 0.788 ± 0.033
1.98ArgTyr: 1.98 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.322SerAla: 5.322 ± 0.084
0.693SerCys: 0.693 ± 0.031
3.432SerAsp: 3.432 ± 0.065
3.532SerGlu: 3.532 ± 0.073
2.601SerPhe: 2.601 ± 0.054
5.586SerGly: 5.586 ± 0.134
1.519SerHis: 1.519 ± 0.044
4.379SerIle: 4.379 ± 0.07
2.703SerLys: 2.703 ± 0.06
6.283SerLeu: 6.283 ± 0.089
1.566SerMet: 1.566 ± 0.043
2.794SerAsn: 2.794 ± 0.067
2.489SerPro: 2.489 ± 0.054
2.459SerGln: 2.459 ± 0.059
3.199SerArg: 3.199 ± 0.062
4.218SerSer: 4.218 ± 0.101
3.3SerThr: 3.3 ± 0.074
4.106SerVal: 4.106 ± 0.071
0.696SerTrp: 0.696 ± 0.029
1.784SerTyr: 1.784 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.819ThrAla: 4.819 ± 0.088
0.505ThrCys: 0.505 ± 0.028
2.936ThrAsp: 2.936 ± 0.068
3.032ThrGlu: 3.032 ± 0.056
2.025ThrPhe: 2.025 ± 0.051
4.519ThrGly: 4.519 ± 0.114
1.43ThrHis: 1.43 ± 0.043
3.7ThrIle: 3.7 ± 0.07
2.064ThrLys: 2.064 ± 0.055
6.2ThrLeu: 6.2 ± 0.088
1.105ThrMet: 1.105 ± 0.038
2.034ThrAsn: 2.034 ± 0.054
2.722ThrPro: 2.722 ± 0.051
2.421ThrGln: 2.421 ± 0.056
2.651ThrArg: 2.651 ± 0.063
3.099ThrSer: 3.099 ± 0.07
2.898ThrThr: 2.898 ± 0.071
3.773ThrVal: 3.773 ± 0.081
0.672ThrTrp: 0.672 ± 0.031
1.5ThrTyr: 1.5 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.799ValAla: 5.799 ± 0.085
0.66ValCys: 0.66 ± 0.029
3.472ValAsp: 3.472 ± 0.061
3.705ValGlu: 3.705 ± 0.075
2.676ValPhe: 2.676 ± 0.063
4.09ValGly: 4.09 ± 0.07
1.356ValHis: 1.356 ± 0.041
4.969ValIle: 4.969 ± 0.081
3.068ValLys: 3.068 ± 0.066
6.548ValLeu: 6.548 ± 0.094
1.812ValMet: 1.812 ± 0.043
2.896ValAsn: 2.896 ± 0.066
2.576ValPro: 2.576 ± 0.059
2.176ValGln: 2.176 ± 0.053
3.202ValArg: 3.202 ± 0.067
4.225ValSer: 4.225 ± 0.072
3.877ValThr: 3.877 ± 0.073
4.395ValVal: 4.395 ± 0.088
0.68ValTrp: 0.68 ± 0.026
1.705ValTyr: 1.705 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.785TrpAla: 0.785 ± 0.03
0.152TrpCys: 0.152 ± 0.014
0.546TrpAsp: 0.546 ± 0.025
0.636TrpGlu: 0.636 ± 0.028
0.564TrpPhe: 0.564 ± 0.029
0.729TrpGly: 0.729 ± 0.034
0.363TrpHis: 0.363 ± 0.022
0.937TrpIle: 0.937 ± 0.036
0.603TrpLys: 0.603 ± 0.025
1.719TrpLeu: 1.719 ± 0.049
0.344TrpMet: 0.344 ± 0.021
0.555TrpAsn: 0.555 ± 0.024
0.459TrpPro: 0.459 ± 0.025
0.751TrpGln: 0.751 ± 0.027
0.854TrpArg: 0.854 ± 0.034
0.722TrpSer: 0.722 ± 0.031
0.502TrpThr: 0.502 ± 0.026
0.796TrpVal: 0.796 ± 0.029
0.184TrpTrp: 0.184 ± 0.017
0.347TrpTyr: 0.347 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.494TyrAla: 2.494 ± 0.06
0.334TyrCys: 0.334 ± 0.022
1.545TyrAsp: 1.545 ± 0.045
1.528TyrGlu: 1.528 ± 0.04
1.371TyrPhe: 1.371 ± 0.044
2.073TyrGly: 2.073 ± 0.056
0.797TyrHis: 0.797 ± 0.03
1.627TyrIle: 1.627 ± 0.042
1.126TyrLys: 1.126 ± 0.039
3.128TyrLeu: 3.128 ± 0.057
0.496TyrMet: 0.496 ± 0.025
1.046TyrAsn: 1.046 ± 0.041
1.383TyrPro: 1.383 ± 0.045
1.569TyrGln: 1.569 ± 0.047
1.839TyrArg: 1.839 ± 0.047
1.842TyrSer: 1.842 ± 0.05
1.486TyrThr: 1.486 ± 0.049
1.803TyrVal: 1.803 ± 0.05
0.454TyrTrp: 0.454 ± 0.024
0.999TyrTyr: 0.999 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2841 proteins (886936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski