Amino acid dipepetide frequency for Bombyx mandarina (Wild silk moth) (Wild silkworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.0AlaAla: 8.0 ± 0.075	1.397AlaCys: 1.397 ± 0.026	3.651AlaAsp: 3.651 ± 0.026	4.636AlaGlu: 4.636 ± 0.03	2.206AlaPhe: 2.206 ± 0.019	4.46AlaGly: 4.46 ± 0.037	1.861AlaHis: 1.861 ± 0.017	3.231AlaIle: 3.231 ± 0.022	3.622AlaLys: 3.622 ± 0.028	7.224AlaLeu: 7.224 ± 0.043	1.504AlaMet: 1.504 ± 0.013	2.551AlaAsn: 2.551 ± 0.016	4.519AlaPro: 4.519 ± 0.041	2.686AlaGln: 2.686 ± 0.02	4.48AlaArg: 4.48 ± 0.032	5.289AlaSer: 5.289 ± 0.031	3.967AlaThr: 3.967 ± 0.026	4.811AlaVal: 4.811 ± 0.031	0.726AlaTrp: 0.726 ± 0.009	1.801AlaTyr: 1.801 ± 0.014	0.002AlaXaa: 0.002 ± 0.0
Cys	1.421CysAla: 1.421 ± 0.018	0.487CysCys: 0.487 ± 0.007	1.178CysAsp: 1.178 ± 0.017	1.247CysGlu: 1.247 ± 0.018	0.691CysPhe: 0.691 ± 0.01	1.553CysGly: 1.553 ± 0.034	0.456CysHis: 0.456 ± 0.009	0.987CysIle: 0.987 ± 0.024	1.07CysLys: 1.07 ± 0.017	1.727CysLeu: 1.727 ± 0.021	0.362CysMet: 0.362 ± 0.007	0.855CysAsn: 0.855 ± 0.015	1.054CysPro: 1.054 ± 0.026	0.678CysGln: 0.678 ± 0.013	1.171CysArg: 1.171 ± 0.022	1.553CysSer: 1.553 ± 0.025	1.086CysThr: 1.086 ± 0.019	1.386CysVal: 1.386 ± 0.023	0.228CysTrp: 0.228 ± 0.004	0.564CysTyr: 0.564 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.72AspAla: 3.72 ± 0.023	1.044AspCys: 1.044 ± 0.019	4.029AspAsp: 4.029 ± 0.03	4.471AspGlu: 4.471 ± 0.031	2.029AspPhe: 2.029 ± 0.015	3.249AspGly: 3.249 ± 0.029	1.194AspHis: 1.194 ± 0.013	3.217AspIle: 3.217 ± 0.022	3.492AspLys: 3.492 ± 0.028	4.858AspLeu: 4.858 ± 0.029	1.228AspMet: 1.228 ± 0.011	2.637AspAsn: 2.637 ± 0.02	2.671AspPro: 2.671 ± 0.027	1.646AspGln: 1.646 ± 0.017	2.827AspArg: 2.827 ± 0.022	4.439AspSer: 4.439 ± 0.029	3.021AspThr: 3.021 ± 0.019	3.721AspVal: 3.721 ± 0.022	0.617AspTrp: 0.617 ± 0.011	1.822AspTyr: 1.822 ± 0.016	0.002AspXaa: 0.002 ± 0.0
Glu	4.618GluAla: 4.618 ± 0.035	1.28GluCys: 1.28 ± 0.027	4.058GluAsp: 4.058 ± 0.025	5.982GluGlu: 5.982 ± 0.061	2.042GluPhe: 2.042 ± 0.018	3.345GluGly: 3.345 ± 0.027	1.567GluHis: 1.567 ± 0.017	3.813GluIle: 3.813 ± 0.031	5.135GluLys: 5.135 ± 0.057	6.12GluLeu: 6.12 ± 0.044	1.56GluMet: 1.56 ± 0.013	3.611GluAsn: 3.611 ± 0.03	3.193GluPro: 3.193 ± 0.034	2.771GluGln: 2.771 ± 0.029	4.282GluArg: 4.282 ± 0.031	4.544GluSer: 4.544 ± 0.029	3.934GluThr: 3.934 ± 0.036	3.944GluVal: 3.944 ± 0.025	0.711GluTrp: 0.711 ± 0.01	1.954GluTyr: 1.954 ± 0.015	0.001GluXaa: 0.001 ± 0.0
Phe	2.122PheAla: 2.122 ± 0.016	0.712PheCys: 0.712 ± 0.01	1.984PheAsp: 1.984 ± 0.015	2.044PheGlu: 2.044 ± 0.017	1.329PhePhe: 1.329 ± 0.016	2.182PheGly: 2.182 ± 0.021	0.833PheHis: 0.833 ± 0.009	1.976PheIle: 1.976 ± 0.017	1.992PheLys: 1.992 ± 0.016	3.086PheLeu: 3.086 ± 0.024	0.797PheMet: 0.797 ± 0.01	1.68PheAsn: 1.68 ± 0.015	1.486PhePro: 1.486 ± 0.015	1.218PheGln: 1.218 ± 0.014	1.812PheArg: 1.812 ± 0.018	2.599PheSer: 2.599 ± 0.021	2.026PheThr: 2.026 ± 0.018	2.356PheVal: 2.356 ± 0.02	0.387PheTrp: 0.387 ± 0.007	1.212PheTyr: 1.212 ± 0.012	0.001PheXaa: 0.001 ± 0.0
Gly	4.617GlyAla: 4.617 ± 0.041	1.094GlyCys: 1.094 ± 0.021	3.1GlyAsp: 3.1 ± 0.027	3.443GlyGlu: 3.443 ± 0.031	2.006GlyPhe: 2.006 ± 0.021	4.968GlyGly: 4.968 ± 0.056	1.416GlyHis: 1.416 ± 0.021	2.668GlyIle: 2.668 ± 0.024	3.128GlyLys: 3.128 ± 0.028	4.563GlyLeu: 4.563 ± 0.034	1.09GlyMet: 1.09 ± 0.014	2.354GlyAsn: 2.354 ± 0.02	2.73GlyPro: 2.73 ± 0.039	2.022GlyGln: 2.022 ± 0.026	3.339GlyArg: 3.339 ± 0.023	4.714GlySer: 4.714 ± 0.04	3.102GlyThr: 3.102 ± 0.026	3.683GlyVal: 3.683 ± 0.027	0.731GlyTrp: 0.731 ± 0.009	1.976GlyTyr: 1.976 ± 0.024	0.002GlyXaa: 0.002 ± 0.0
His	1.791HisAla: 1.791 ± 0.016	0.547HisCys: 0.547 ± 0.008	1.254HisAsp: 1.254 ± 0.013	1.467HisGlu: 1.467 ± 0.013	0.915HisPhe: 0.915 ± 0.01	1.383HisGly: 1.383 ± 0.024	1.076HisHis: 1.076 ± 0.02	1.253HisIle: 1.253 ± 0.011	1.43HisLys: 1.43 ± 0.015	2.302HisLeu: 2.302 ± 0.018	0.606HisMet: 0.606 ± 0.008	1.159HisAsn: 1.159 ± 0.011	1.387HisPro: 1.387 ± 0.014	1.056HisGln: 1.056 ± 0.011	1.515HisArg: 1.515 ± 0.014	2.012HisSer: 2.012 ± 0.017	1.446HisThr: 1.446 ± 0.013	1.578HisVal: 1.578 ± 0.014	0.286HisTrp: 0.286 ± 0.006	0.885HisTyr: 0.885 ± 0.008	0.001HisXaa: 0.001 ± 0.0
Ile	3.241IleAla: 3.241 ± 0.024	1.103IleCys: 1.103 ± 0.021	3.004IleAsp: 3.004 ± 0.022	3.689IleGlu: 3.689 ± 0.033	1.955IlePhe: 1.955 ± 0.02	2.584IleGly: 2.584 ± 0.022	1.228IleHis: 1.228 ± 0.011	3.062IleIle: 3.062 ± 0.028	3.474IleLys: 3.474 ± 0.032	4.505IleLeu: 4.505 ± 0.029	1.131IleMet: 1.131 ± 0.012	2.589IleAsn: 2.589 ± 0.018	2.618IlePro: 2.618 ± 0.018	2.072IleGln: 2.072 ± 0.018	2.542IleArg: 2.542 ± 0.016	3.957IleSer: 3.957 ± 0.027	3.123IleThr: 3.123 ± 0.025	3.352IleVal: 3.352 ± 0.022	0.477IleTrp: 0.477 ± 0.007	1.575IleTyr: 1.575 ± 0.017	0.001IleXaa: 0.001 ± 0.0
Lys	3.588LysAla: 3.588 ± 0.034	1.191LysCys: 1.191 ± 0.018	3.471LysAsp: 3.471 ± 0.029	4.638LysGlu: 4.638 ± 0.039	1.982LysPhe: 1.982 ± 0.016	2.616LysGly: 2.616 ± 0.023	1.537LysHis: 1.537 ± 0.017	3.629LysIle: 3.629 ± 0.027	5.291LysLys: 5.291 ± 0.05	5.523LysLeu: 5.523 ± 0.037	1.452LysMet: 1.452 ± 0.012	3.199LysAsn: 3.199 ± 0.023	3.364LysPro: 3.364 ± 0.046	2.569LysGln: 2.569 ± 0.018	3.751LysArg: 3.751 ± 0.027	4.571LysSer: 4.571 ± 0.034	3.659LysThr: 3.659 ± 0.028	3.435LysVal: 3.435 ± 0.024	0.647LysTrp: 0.647 ± 0.012	2.111LysTyr: 2.111 ± 0.018	0.002LysXaa: 0.002 ± 0.0
Leu	6.72LeuAla: 6.72 ± 0.036	1.849LeuCys: 1.849 ± 0.017	4.93LeuAsp: 4.93 ± 0.027	6.225LeuGlu: 6.225 ± 0.052	2.995LeuPhe: 2.995 ± 0.026	4.505LeuGly: 4.505 ± 0.03	2.423LeuHis: 2.423 ± 0.02	4.205LeuIle: 4.205 ± 0.029	5.921LeuLys: 5.921 ± 0.034	8.657LeuLeu: 8.657 ± 0.054	1.887LeuMet: 1.887 ± 0.015	4.154LeuAsn: 4.154 ± 0.025	4.738LeuPro: 4.738 ± 0.026	4.409LeuGln: 4.409 ± 0.037	5.692LeuArg: 5.692 ± 0.033	6.952LeuSer: 6.952 ± 0.032	5.009LeuThr: 5.009 ± 0.026	5.366LeuVal: 5.366 ± 0.031	0.917LeuTrp: 0.917 ± 0.009	2.561LeuTyr: 2.561 ± 0.02	0.002LeuXaa: 0.002 ± 0.0
Met	1.599MetAla: 1.599 ± 0.014	0.413MetCys: 0.413 ± 0.008	1.194MetAsp: 1.194 ± 0.012	1.515MetGlu: 1.515 ± 0.014	0.857MetPhe: 0.857 ± 0.011	1.112MetGly: 1.112 ± 0.017	0.511MetHis: 0.511 ± 0.007	1.005MetIle: 1.005 ± 0.011	1.412MetLys: 1.412 ± 0.013	1.956MetLeu: 1.956 ± 0.017	0.578MetMet: 0.578 ± 0.009	1.024MetAsn: 1.024 ± 0.012	1.071MetPro: 1.071 ± 0.012	0.912MetGln: 0.912 ± 0.011	1.192MetArg: 1.192 ± 0.012	1.82MetSer: 1.82 ± 0.017	1.174MetThr: 1.174 ± 0.011	1.195MetVal: 1.195 ± 0.011	0.244MetTrp: 0.244 ± 0.005	0.673MetTyr: 0.673 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.797AsnAla: 2.797 ± 0.02	0.862AsnCys: 0.862 ± 0.014	2.513AsnAsp: 2.513 ± 0.019	3.229AsnGlu: 3.229 ± 0.026	1.686AsnPhe: 1.686 ± 0.014	2.741AsnGly: 2.741 ± 0.027	1.028AsnHis: 1.028 ± 0.015	3.028AsnIle: 3.028 ± 0.021	3.199AsnLys: 3.199 ± 0.023	4.097AsnLeu: 4.097 ± 0.027	1.124AsnMet: 1.124 ± 0.013	2.763AsnAsn: 2.763 ± 0.024	2.083AsnPro: 2.083 ± 0.021	1.748AsnGln: 1.748 ± 0.018	2.19AsnArg: 2.19 ± 0.016	3.561AsnSer: 3.561 ± 0.03	2.716AsnThr: 2.716 ± 0.019	3.093AsnVal: 3.093 ± 0.02	0.459AsnTrp: 0.459 ± 0.007	1.575AsnTyr: 1.575 ± 0.014	0.001AsnXaa: 0.001 ± 0.0
Pro	4.683ProAla: 4.683 ± 0.035	0.822ProCys: 0.822 ± 0.033	2.964ProAsp: 2.964 ± 0.019	3.724ProGlu: 3.724 ± 0.027	1.6ProPhe: 1.6 ± 0.018	3.19ProGly: 3.19 ± 0.048	1.58ProHis: 1.58 ± 0.016	2.427ProIle: 2.427 ± 0.019	3.016ProLys: 3.016 ± 0.034	4.485ProLeu: 4.485 ± 0.026	0.992ProMet: 0.992 ± 0.014	2.212ProAsn: 2.212 ± 0.023	5.736ProPro: 5.736 ± 0.064	2.311ProGln: 2.311 ± 0.024	3.237ProArg: 3.237 ± 0.025	4.402ProSer: 4.402 ± 0.029	3.321ProThr: 3.321 ± 0.025	3.523ProVal: 3.523 ± 0.021	0.487ProTrp: 0.487 ± 0.007	1.596ProTyr: 1.596 ± 0.017	0.002ProXaa: 0.002 ± 0.0
Gln	2.64GlnAla: 2.64 ± 0.024	0.805GlnCys: 0.805 ± 0.015	1.852GlnAsp: 1.852 ± 0.016	2.686GlnGlu: 2.686 ± 0.025	1.279GlnPhe: 1.279 ± 0.013	1.824GlnGly: 1.824 ± 0.021	1.224GlnHis: 1.224 ± 0.013	2.082GlnIle: 2.082 ± 0.017	2.395GlnLys: 2.395 ± 0.023	3.94GlnLeu: 3.94 ± 0.033	0.948GlnMet: 0.948 ± 0.012	2.089GlnAsn: 2.089 ± 0.021	2.357GlnPro: 2.357 ± 0.03	2.634GlnGln: 2.634 ± 0.042	2.586GlnArg: 2.586 ± 0.022	2.838GlnSer: 2.838 ± 0.025	2.172GlnThr: 2.172 ± 0.018	2.189GlnVal: 2.189 ± 0.017	0.467GlnTrp: 0.467 ± 0.008	1.301GlnTyr: 1.301 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.626ArgAla: 4.626 ± 0.034	1.174ArgCys: 1.174 ± 0.017	3.346ArgAsp: 3.346 ± 0.029	3.775ArgGlu: 3.775 ± 0.03	1.808ArgPhe: 1.808 ± 0.016	3.248ArgGly: 3.248 ± 0.029	1.677ArgHis: 1.677 ± 0.014	2.665ArgIle: 2.665 ± 0.016	3.567ArgLys: 3.567 ± 0.026	5.31ArgLeu: 5.31 ± 0.034	1.147ArgMet: 1.147 ± 0.012	2.526ArgAsn: 2.526 ± 0.018	3.28ArgPro: 3.28 ± 0.026	2.338ArgGln: 2.338 ± 0.016	4.897ArgArg: 4.897 ± 0.035	4.538ArgSer: 4.538 ± 0.038	3.049ArgThr: 3.049 ± 0.019	3.378ArgVal: 3.378 ± 0.027	0.7ArgTrp: 0.7 ± 0.01	1.702ArgTyr: 1.702 ± 0.015	0.001ArgXaa: 0.001 ± 0.0
Ser	5.308SerAla: 5.308 ± 0.028	1.452SerCys: 1.452 ± 0.03	4.515SerAsp: 4.515 ± 0.03	5.078SerGlu: 5.078 ± 0.039	2.527SerPhe: 2.527 ± 0.019	4.805SerGly: 4.805 ± 0.032	1.775SerHis: 1.775 ± 0.018	3.641SerIle: 3.641 ± 0.023	4.411SerLys: 4.411 ± 0.033	6.836SerLeu: 6.836 ± 0.034	1.573SerMet: 1.573 ± 0.014	3.577SerAsn: 3.577 ± 0.036	5.038SerPro: 5.038 ± 0.039	2.983SerGln: 2.983 ± 0.023	4.385SerArg: 4.385 ± 0.033	7.953SerSer: 7.953 ± 0.081	4.907SerThr: 4.907 ± 0.043	4.794SerVal: 4.794 ± 0.024	0.83SerTrp: 0.83 ± 0.01	2.072SerTyr: 2.072 ± 0.018	0.002SerXaa: 0.002 ± 0.0
Thr	4.091ThrAla: 4.091 ± 0.024	1.126ThrCys: 1.126 ± 0.02	3.131ThrAsp: 3.131 ± 0.025	3.843ThrGlu: 3.843 ± 0.033	2.009ThrPhe: 2.009 ± 0.016	3.247ThrGly: 3.247 ± 0.033	1.381ThrHis: 1.381 ± 0.012	3.015ThrIle: 3.015 ± 0.02	3.478ThrLys: 3.478 ± 0.03	5.261ThrLeu: 5.261 ± 0.03	1.143ThrMet: 1.143 ± 0.011	2.609ThrAsn: 2.609 ± 0.018	3.791ThrPro: 3.791 ± 0.029	2.144ThrGln: 2.144 ± 0.015	2.793ThrArg: 2.793 ± 0.018	4.756ThrSer: 4.756 ± 0.028	3.954ThrThr: 3.954 ± 0.063	3.963ThrVal: 3.963 ± 0.026	0.6ThrTrp: 0.6 ± 0.008	1.665ThrTyr: 1.665 ± 0.016	0.001ThrXaa: 0.001 ± 0.0
Val	4.583ValAla: 4.583 ± 0.027	1.453ValCys: 1.453 ± 0.021	3.422ValAsp: 3.422 ± 0.023	4.109ValGlu: 4.109 ± 0.031	2.237ValPhe: 2.237 ± 0.018	3.196ValGly: 3.196 ± 0.025	1.513ValHis: 1.513 ± 0.014	3.239ValIle: 3.239 ± 0.022	3.737ValLys: 3.737 ± 0.025	5.819ValLeu: 5.819 ± 0.032	1.375ValMet: 1.375 ± 0.013	2.852ValAsn: 2.852 ± 0.021	3.381ValPro: 3.381 ± 0.026	2.481ValGln: 2.481 ± 0.019	3.513ValArg: 3.513 ± 0.022	4.81ValSer: 4.81 ± 0.023	3.988ValThr: 3.988 ± 0.029	4.293ValVal: 4.293 ± 0.025	0.717ValTrp: 0.717 ± 0.009	1.858ValTyr: 1.858 ± 0.016	0.001ValXaa: 0.001 ± 0.0
Trp	0.64TrpAla: 0.64 ± 0.009	0.241TrpCys: 0.241 ± 0.005	0.616TrpAsp: 0.616 ± 0.009	0.655TrpGlu: 0.655 ± 0.008	0.402TrpPhe: 0.402 ± 0.006	0.586TrpGly: 0.586 ± 0.009	0.243TrpHis: 0.243 ± 0.005	0.542TrpIle: 0.542 ± 0.008	0.631TrpLys: 0.631 ± 0.01	1.134TrpLeu: 1.134 ± 0.013	0.264TrpMet: 0.264 ± 0.005	0.521TrpAsn: 0.521 ± 0.007	0.449TrpPro: 0.449 ± 0.007	0.434TrpGln: 0.434 ± 0.007	0.818TrpArg: 0.818 ± 0.01	0.852TrpSer: 0.852 ± 0.011	0.602TrpThr: 0.602 ± 0.009	0.608TrpVal: 0.608 ± 0.011	0.212TrpTrp: 0.212 ± 0.005	0.359TrpTyr: 0.359 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.816TyrAla: 1.816 ± 0.018	0.702TyrCys: 0.702 ± 0.009	1.724TyrAsp: 1.724 ± 0.016	2.006TyrGlu: 2.006 ± 0.018	1.278TyrPhe: 1.278 ± 0.014	1.949TyrGly: 1.949 ± 0.022	0.826TyrHis: 0.826 ± 0.009	1.595TyrIle: 1.595 ± 0.014	1.822TyrLys: 1.822 ± 0.015	2.713TyrLeu: 2.713 ± 0.021	0.695TyrMet: 0.695 ± 0.008	1.531TyrAsn: 1.531 ± 0.015	1.36TyrPro: 1.36 ± 0.015	1.196TyrGln: 1.196 ± 0.012	1.73TyrArg: 1.73 ± 0.016	2.302TyrSer: 2.302 ± 0.017	1.745TyrThr: 1.745 ± 0.014	1.908TyrVal: 1.908 ± 0.016	0.366TyrTrp: 0.366 ± 0.008	1.214TyrTyr: 1.214 ± 0.013	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.002XaaThr: 0.002 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 17282 proteins (10885424 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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