Amino acid dipepetide frequency for Celeribacter neptunius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.863AlaAla: 14.863 ± 0.145	1.066AlaCys: 1.066 ± 0.034	6.258AlaAsp: 6.258 ± 0.089	8.55AlaGlu: 8.55 ± 0.092	4.366AlaPhe: 4.366 ± 0.059	9.96AlaGly: 9.96 ± 0.086	2.315AlaHis: 2.315 ± 0.04	5.711AlaIle: 5.711 ± 0.071	4.326AlaLys: 4.326 ± 0.07	13.8AlaLeu: 13.8 ± 0.139	3.869AlaMet: 3.869 ± 0.062	2.546AlaAsn: 2.546 ± 0.047	5.672AlaPro: 5.672 ± 0.076	4.277AlaGln: 4.277 ± 0.06	8.045AlaArg: 8.045 ± 0.086	5.663AlaSer: 5.663 ± 0.071	5.976AlaThr: 5.976 ± 0.07	7.744AlaVal: 7.744 ± 0.08	1.3AlaTrp: 1.3 ± 0.032	2.621AlaTyr: 2.621 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.029	0.097CysCys: 0.097 ± 0.009	0.627CysAsp: 0.627 ± 0.024	0.462CysGlu: 0.462 ± 0.019	0.319CysPhe: 0.319 ± 0.014	0.925CysGly: 0.925 ± 0.029	0.308CysHis: 0.308 ± 0.016	0.381CysIle: 0.381 ± 0.018	0.237CysLys: 0.237 ± 0.013	0.852CysLeu: 0.852 ± 0.026	0.172CysMet: 0.172 ± 0.01	0.203CysAsn: 0.203 ± 0.011	0.492CysPro: 0.492 ± 0.02	0.237CysGln: 0.237 ± 0.014	0.507CysArg: 0.507 ± 0.021	0.471CysSer: 0.471 ± 0.023	0.405CysThr: 0.405 ± 0.019	0.605CysVal: 0.605 ± 0.022	0.098CysTrp: 0.098 ± 0.009	0.206CysTyr: 0.206 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.547AspAla: 6.547 ± 0.086	0.513AspCys: 0.513 ± 0.021	3.115AspAsp: 3.115 ± 0.066	3.704AspGlu: 3.704 ± 0.063	2.331AspPhe: 2.331 ± 0.043	5.402AspGly: 5.402 ± 0.077	1.415AspHis: 1.415 ± 0.036	3.045AspIle: 3.045 ± 0.047	1.906AspLys: 1.906 ± 0.038	6.54AspLeu: 6.54 ± 0.077	1.78AspMet: 1.78 ± 0.034	1.243AspAsn: 1.243 ± 0.032	3.527AspPro: 3.527 ± 0.058	1.93AspGln: 1.93 ± 0.041	3.874AspArg: 3.874 ± 0.066	2.147AspSer: 2.147 ± 0.035	2.975AspThr: 2.975 ± 0.062	4.062AspVal: 4.062 ± 0.061	1.14AspTrp: 1.14 ± 0.028	1.626AspTyr: 1.626 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.802GluAla: 8.802 ± 0.092	0.356GluCys: 0.356 ± 0.018	3.681GluAsp: 3.681 ± 0.06	4.282GluGlu: 4.282 ± 0.071	2.041GluPhe: 2.041 ± 0.039	5.126GluGly: 5.126 ± 0.067	1.288GluHis: 1.288 ± 0.034	4.288GluIle: 4.288 ± 0.059	2.588GluLys: 2.588 ± 0.053	5.763GluLeu: 5.763 ± 0.072	2.106GluMet: 2.106 ± 0.039	1.898GluAsn: 1.898 ± 0.032	2.499GluPro: 2.499 ± 0.051	1.996GluGln: 1.996 ± 0.043	4.245GluArg: 4.245 ± 0.061	2.464GluSer: 2.464 ± 0.045	4.194GluThr: 4.194 ± 0.055	4.521GluVal: 4.521 ± 0.061	0.659GluTrp: 0.659 ± 0.023	1.091GluTyr: 1.091 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.55PheAla: 4.55 ± 0.067	0.408PheCys: 0.408 ± 0.015	2.907PheAsp: 2.907 ± 0.046	2.515PheGlu: 2.515 ± 0.052	1.53PhePhe: 1.53 ± 0.045	3.886PheGly: 3.886 ± 0.06	0.772PheHis: 0.772 ± 0.023	1.708PheIle: 1.708 ± 0.038	1.128PheLys: 1.128 ± 0.028	3.531PheLeu: 3.531 ± 0.059	0.95PheMet: 0.95 ± 0.026	1.092PheAsn: 1.092 ± 0.029	1.59PhePro: 1.59 ± 0.034	1.008PheGln: 1.008 ± 0.027	1.994PheArg: 1.994 ± 0.032	2.392PheSer: 2.392 ± 0.041	2.21PheThr: 2.21 ± 0.044	2.676PheVal: 2.676 ± 0.05	0.588PheTrp: 0.588 ± 0.026	0.976PheTyr: 0.976 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.759GlyAla: 9.759 ± 0.089	0.843GlyCys: 0.843 ± 0.029	4.619GlyAsp: 4.619 ± 0.075	5.14GlyGlu: 5.14 ± 0.064	3.83GlyPhe: 3.83 ± 0.061	7.038GlyGly: 7.038 ± 0.094	1.935GlyHis: 1.935 ± 0.046	4.562GlyIle: 4.562 ± 0.066	3.493GlyLys: 3.493 ± 0.063	9.235GlyLeu: 9.235 ± 0.091	2.638GlyMet: 2.638 ± 0.049	2.166GlyAsn: 2.166 ± 0.051	3.47GlyPro: 3.47 ± 0.056	3.12GlyGln: 3.12 ± 0.052	5.14GlyArg: 5.14 ± 0.062	4.167GlySer: 4.167 ± 0.061	4.668GlyThr: 4.668 ± 0.064	6.292GlyVal: 6.292 ± 0.074	1.35GlyTrp: 1.35 ± 0.033	2.375GlyTyr: 2.375 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.231HisAla: 2.231 ± 0.043	0.246HisCys: 0.246 ± 0.013	1.308HisAsp: 1.308 ± 0.033	1.218HisGlu: 1.218 ± 0.03	0.87HisPhe: 0.87 ± 0.026	1.957HisGly: 1.957 ± 0.041	0.576HisHis: 0.576 ± 0.023	1.015HisIle: 1.015 ± 0.028	0.614HisLys: 0.614 ± 0.024	2.157HisLeu: 2.157 ± 0.044	0.615HisMet: 0.615 ± 0.019	0.466HisAsn: 0.466 ± 0.017	1.353HisPro: 1.353 ± 0.035	0.576HisGln: 0.576 ± 0.021	1.315HisArg: 1.315 ± 0.036	0.951HisSer: 0.951 ± 0.03	0.835HisThr: 0.835 ± 0.024	1.54HisVal: 1.54 ± 0.038	0.356HisTrp: 0.356 ± 0.016	0.531HisTyr: 0.531 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.0IleAla: 7.0 ± 0.08	0.59IleCys: 0.59 ± 0.022	3.466IleAsp: 3.466 ± 0.055	3.746IleGlu: 3.746 ± 0.055	1.907IlePhe: 1.907 ± 0.039	4.951IleGly: 4.951 ± 0.078	0.99IleHis: 0.99 ± 0.029	2.198IleIle: 2.198 ± 0.046	1.631IleLys: 1.631 ± 0.038	4.926IleLeu: 4.926 ± 0.068	1.151IleMet: 1.151 ± 0.029	1.348IleAsn: 1.348 ± 0.033	2.484IlePro: 2.484 ± 0.048	1.206IleGln: 1.206 ± 0.034	3.104IleArg: 3.104 ± 0.044	3.348IleSer: 3.348 ± 0.058	3.106IleThr: 3.106 ± 0.052	3.727IleVal: 3.727 ± 0.048	0.794IleTrp: 0.794 ± 0.027	1.24IleTyr: 1.24 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.413LysAla: 4.413 ± 0.062	0.216LysCys: 0.216 ± 0.013	2.058LysAsp: 2.058 ± 0.044	1.938LysGlu: 1.938 ± 0.045	1.132LysPhe: 1.132 ± 0.029	3.056LysGly: 3.056 ± 0.053	0.652LysHis: 0.652 ± 0.026	1.966LysIle: 1.966 ± 0.039	1.411LysLys: 1.411 ± 0.038	3.395LysLeu: 3.395 ± 0.058	0.981LysMet: 0.981 ± 0.029	0.882LysAsn: 0.882 ± 0.027	2.018LysPro: 2.018 ± 0.041	0.948LysGln: 0.948 ± 0.026	2.497LysArg: 2.497 ± 0.042	2.151LysSer: 2.151 ± 0.045	2.215LysThr: 2.215 ± 0.037	2.417LysVal: 2.417 ± 0.054	0.452LysTrp: 0.452 ± 0.021	0.735LysTyr: 0.735 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.49LeuAla: 12.49 ± 0.123	0.921LeuCys: 0.921 ± 0.027	5.986LeuAsp: 5.986 ± 0.064	5.698LeuGlu: 5.698 ± 0.073	3.793LeuPhe: 3.793 ± 0.058	8.64LeuGly: 8.64 ± 0.084	1.892LeuHis: 1.892 ± 0.039	5.673LeuIle: 5.673 ± 0.08	3.852LeuLys: 3.852 ± 0.061	9.013LeuLeu: 9.013 ± 0.107	2.857LeuMet: 2.857 ± 0.048	2.612LeuAsn: 2.612 ± 0.053	5.551LeuPro: 5.551 ± 0.071	2.589LeuGln: 2.589 ± 0.044	6.474LeuArg: 6.474 ± 0.088	7.529LeuSer: 7.529 ± 0.101	6.1LeuThr: 6.1 ± 0.084	6.535LeuVal: 6.535 ± 0.08	1.346LeuTrp: 1.346 ± 0.039	2.154LeuTyr: 2.154 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.508MetAla: 3.508 ± 0.052	0.209MetCys: 0.209 ± 0.014	1.432MetAsp: 1.432 ± 0.037	1.477MetGlu: 1.477 ± 0.035	0.893MetPhe: 0.893 ± 0.028	2.308MetGly: 2.308 ± 0.045	0.509MetHis: 0.509 ± 0.021	1.748MetIle: 1.748 ± 0.041	1.183MetLys: 1.183 ± 0.029	2.663MetLeu: 2.663 ± 0.048	0.854MetMet: 0.854 ± 0.026	0.913MetAsn: 0.913 ± 0.027	1.511MetPro: 1.511 ± 0.032	0.951MetGln: 0.951 ± 0.025	1.919MetArg: 1.919 ± 0.039	2.094MetSer: 2.094 ± 0.039	2.178MetThr: 2.178 ± 0.038	1.953MetVal: 1.953 ± 0.038	0.238MetTrp: 0.238 ± 0.013	0.363MetTyr: 0.363 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.164AsnAla: 3.164 ± 0.058	0.24AsnCys: 0.24 ± 0.013	1.409AsnAsp: 1.409 ± 0.041	1.231AsnGlu: 1.231 ± 0.027	1.02AsnPhe: 1.02 ± 0.029	2.424AsnGly: 2.424 ± 0.048	0.511AsnHis: 0.511 ± 0.019	1.407AsnIle: 1.407 ± 0.034	0.74AsnLys: 0.74 ± 0.026	2.528AsnLeu: 2.528 ± 0.045	0.729AsnMet: 0.729 ± 0.025	0.627AsnAsn: 0.627 ± 0.024	1.766AsnPro: 1.766 ± 0.041	0.631AsnGln: 0.631 ± 0.024	1.6AsnArg: 1.6 ± 0.036	1.222AsnSer: 1.222 ± 0.032	1.389AsnThr: 1.389 ± 0.031	1.838AsnVal: 1.838 ± 0.041	0.447AsnTrp: 0.447 ± 0.021	0.65AsnTyr: 0.65 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.344ProAla: 5.344 ± 0.078	0.335ProCys: 0.335 ± 0.016	3.517ProAsp: 3.517 ± 0.054	4.713ProGlu: 4.713 ± 0.059	1.963ProPhe: 1.963 ± 0.045	4.217ProGly: 4.217 ± 0.06	1.023ProHis: 1.023 ± 0.025	2.266ProIle: 2.266 ± 0.045	1.919ProLys: 1.919 ± 0.04	4.711ProLeu: 4.711 ± 0.071	1.389ProMet: 1.389 ± 0.035	1.332ProAsn: 1.332 ± 0.031	2.061ProPro: 2.061 ± 0.049	1.623ProGln: 1.623 ± 0.043	2.678ProArg: 2.678 ± 0.058	2.577ProSer: 2.577 ± 0.043	2.357ProThr: 2.357 ± 0.047	4.167ProVal: 4.167 ± 0.061	0.629ProTrp: 0.629 ± 0.022	1.192ProTyr: 1.192 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.762GlnAla: 3.762 ± 0.057	0.21GlnCys: 0.21 ± 0.013	1.688GlnAsp: 1.688 ± 0.033	1.697GlnGlu: 1.697 ± 0.034	1.058GlnPhe: 1.058 ± 0.028	2.562GlnGly: 2.562 ± 0.051	0.57GlnHis: 0.57 ± 0.022	2.062GlnIle: 2.062 ± 0.038	1.181GlnLys: 1.181 ± 0.031	2.792GlnLeu: 2.792 ± 0.047	1.059GlnMet: 1.059 ± 0.031	0.919GlnAsn: 0.919 ± 0.027	1.494GlnPro: 1.494 ± 0.029	1.003GlnGln: 1.003 ± 0.034	2.033GlnArg: 2.033 ± 0.047	1.853GlnSer: 1.853 ± 0.041	1.687GlnThr: 1.687 ± 0.038	2.239GlnVal: 2.239 ± 0.039	0.391GlnTrp: 0.391 ± 0.018	0.624GlnTyr: 0.624 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.252ArgAla: 7.252 ± 0.085	0.457ArgCys: 0.457 ± 0.019	4.104ArgAsp: 4.104 ± 0.062	3.91ArgGlu: 3.91 ± 0.062	2.618ArgPhe: 2.618 ± 0.048	4.252ArgGly: 4.252 ± 0.064	1.516ArgHis: 1.516 ± 0.036	3.638ArgIle: 3.638 ± 0.055	2.382ArgLys: 2.382 ± 0.047	6.997ArgLeu: 6.997 ± 0.094	1.823ArgMet: 1.823 ± 0.041	1.707ArgAsn: 1.707 ± 0.034	3.052ArgPro: 3.052 ± 0.051	2.177ArgGln: 2.177 ± 0.042	4.333ArgArg: 4.333 ± 0.065	3.098ArgSer: 3.098 ± 0.055	2.723ArgThr: 2.723 ± 0.054	4.344ArgVal: 4.344 ± 0.065	0.821ArgTrp: 0.821 ± 0.026	1.583ArgTyr: 1.583 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.865SerAla: 5.865 ± 0.072	0.505SerCys: 0.505 ± 0.022	3.334SerAsp: 3.334 ± 0.055	3.5SerGlu: 3.5 ± 0.057	2.381SerPhe: 2.381 ± 0.049	5.507SerGly: 5.507 ± 0.076	1.241SerHis: 1.241 ± 0.034	2.419SerIle: 2.419 ± 0.047	1.741SerLys: 1.741 ± 0.038	5.423SerLeu: 5.423 ± 0.084	1.463SerMet: 1.463 ± 0.031	1.448SerAsn: 1.448 ± 0.039	2.662SerPro: 2.662 ± 0.049	1.705SerGln: 1.705 ± 0.039	3.235SerArg: 3.235 ± 0.049	2.857SerSer: 2.857 ± 0.056	2.651SerThr: 2.651 ± 0.044	3.813SerVal: 3.813 ± 0.053	0.733SerTrp: 0.733 ± 0.023	1.511SerTyr: 1.511 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.034ThrAla: 6.034 ± 0.076	0.498ThrCys: 0.498 ± 0.021	3.068ThrAsp: 3.068 ± 0.05	3.332ThrGlu: 3.332 ± 0.06	2.058ThrPhe: 2.058 ± 0.049	5.392ThrGly: 5.392 ± 0.059	1.129ThrHis: 1.129 ± 0.027	2.712ThrIle: 2.712 ± 0.05	1.545ThrLys: 1.545 ± 0.036	6.247ThrLeu: 6.247 ± 0.081	1.374ThrMet: 1.374 ± 0.033	1.256ThrAsn: 1.256 ± 0.03	3.58ThrPro: 3.58 ± 0.051	1.644ThrGln: 1.644 ± 0.034	3.514ThrArg: 3.514 ± 0.054	2.74ThrSer: 2.74 ± 0.053	2.872ThrThr: 2.872 ± 0.053	4.279ThrVal: 4.279 ± 0.066	0.652ThrTrp: 0.652 ± 0.024	1.291ThrTyr: 1.291 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.343ValAla: 8.343 ± 0.074	0.561ValCys: 0.561 ± 0.021	3.868ValAsp: 3.868 ± 0.058	4.752ValGlu: 4.752 ± 0.078	2.775ValPhe: 2.775 ± 0.056	5.003ValGly: 5.003 ± 0.071	1.232ValHis: 1.232 ± 0.037	4.417ValIle: 4.417 ± 0.067	2.491ValLys: 2.491 ± 0.048	7.244ValLeu: 7.244 ± 0.093	2.165ValMet: 2.165 ± 0.043	1.867ValAsn: 1.867 ± 0.04	3.477ValPro: 3.477 ± 0.056	1.963ValGln: 1.963 ± 0.039	3.786ValArg: 3.786 ± 0.059	4.318ValSer: 4.318 ± 0.059	4.74ValThr: 4.74 ± 0.054	5.33ValVal: 5.33 ± 0.076	0.905ValTrp: 0.905 ± 0.026	1.423ValTyr: 1.423 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.327TrpAla: 1.327 ± 0.034	0.124TrpCys: 0.124 ± 0.009	0.743TrpAsp: 0.743 ± 0.028	0.632TrpGlu: 0.632 ± 0.024	0.556TrpPhe: 0.556 ± 0.022	1.025TrpGly: 1.025 ± 0.031	0.349TrpHis: 0.349 ± 0.018	0.692TrpIle: 0.692 ± 0.026	0.466TrpLys: 0.466 ± 0.019	1.577TrpLeu: 1.577 ± 0.037	0.39TrpMet: 0.39 ± 0.017	0.42TrpAsn: 0.42 ± 0.018	0.661TrpPro: 0.661 ± 0.028	0.601TrpGln: 0.601 ± 0.025	0.968TrpArg: 0.968 ± 0.026	0.757TrpSer: 0.757 ± 0.027	0.723TrpThr: 0.723 ± 0.027	0.926TrpVal: 0.926 ± 0.031	0.175TrpTrp: 0.175 ± 0.012	0.313TrpTyr: 0.313 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.634TyrAla: 2.634 ± 0.045	0.253TyrCys: 0.253 ± 0.013	1.635TyrAsp: 1.635 ± 0.038	1.389TyrGlu: 1.389 ± 0.034	0.972TyrPhe: 0.972 ± 0.029	2.208TyrGly: 2.208 ± 0.047	0.508TyrHis: 0.508 ± 0.02	1.007TyrIle: 1.007 ± 0.024	0.699TyrLys: 0.699 ± 0.022	2.311TyrLeu: 2.311 ± 0.043	0.539TyrMet: 0.539 ± 0.022	0.629TyrAsn: 0.629 ± 0.026	1.096TyrPro: 1.096 ± 0.028	0.695TyrGln: 0.695 ± 0.024	1.526TyrArg: 1.526 ± 0.038	1.192TyrSer: 1.192 ± 0.036	1.216TyrThr: 1.216 ± 0.033	1.648TyrVal: 1.648 ± 0.039	0.35TyrTrp: 0.35 ± 0.017	0.615TyrTyr: 0.615 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4197 proteins (1294092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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