Amino acid dipepetide frequency for Streptococcus phage Javan118

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.588AlaAla: 4.588 ± 0.89
0.275AlaCys: 0.275 ± 0.154
4.772AlaAsp: 4.772 ± 0.519
5.873AlaGlu: 5.873 ± 0.742
2.019AlaPhe: 2.019 ± 0.369
4.038AlaGly: 4.038 ± 1.007
0.734AlaHis: 0.734 ± 0.323
6.791AlaIle: 6.791 ± 1.106
6.791AlaLys: 6.791 ± 0.888
4.497AlaLeu: 4.497 ± 0.633
1.835AlaMet: 1.835 ± 0.392
3.579AlaAsn: 3.579 ± 0.775
1.468AlaPro: 1.468 ± 0.322
3.212AlaGln: 3.212 ± 0.486
2.478AlaArg: 2.478 ± 0.45
5.323AlaSer: 5.323 ± 0.766
4.864AlaThr: 4.864 ± 0.83
4.864AlaVal: 4.864 ± 0.58
0.459AlaTrp: 0.459 ± 0.209
2.294AlaTyr: 2.294 ± 0.35
0.0AlaXaa: 0.0 ± 0.0
Cys
0.092CysAla: 0.092 ± 0.094
0.184CysCys: 0.184 ± 0.117
0.642CysAsp: 0.642 ± 0.272
0.734CysGlu: 0.734 ± 0.287
0.367CysPhe: 0.367 ± 0.178
0.275CysGly: 0.275 ± 0.169
0.184CysHis: 0.184 ± 0.137
0.275CysIle: 0.275 ± 0.149
0.275CysLys: 0.275 ± 0.136
0.734CysLeu: 0.734 ± 0.245
0.184CysMet: 0.184 ± 0.131
0.092CysAsn: 0.092 ± 0.085
0.0CysPro: 0.0 ± 0.0
0.184CysGln: 0.184 ± 0.116
0.275CysArg: 0.275 ± 0.157
0.367CysSer: 0.367 ± 0.148
0.0CysThr: 0.0 ± 0.0
0.367CysVal: 0.367 ± 0.219
0.0CysTrp: 0.0 ± 0.0
0.459CysTyr: 0.459 ± 0.289
0.0CysXaa: 0.0 ± 0.0
Asp
4.038AspAla: 4.038 ± 0.662
0.734AspCys: 0.734 ± 0.283
4.313AspAsp: 4.313 ± 0.563
5.047AspGlu: 5.047 ± 0.717
2.202AspPhe: 2.202 ± 0.473
5.781AspGly: 5.781 ± 0.691
0.642AspHis: 0.642 ± 0.219
4.772AspIle: 4.772 ± 0.583
5.506AspLys: 5.506 ± 0.905
6.607AspLeu: 6.607 ± 0.66
1.193AspMet: 1.193 ± 0.271
4.955AspAsn: 4.955 ± 0.489
1.285AspPro: 1.285 ± 0.398
1.009AspGln: 1.009 ± 0.271
2.845AspArg: 2.845 ± 0.479
3.946AspSer: 3.946 ± 0.679
3.946AspThr: 3.946 ± 0.634
4.588AspVal: 4.588 ± 0.705
1.009AspTrp: 1.009 ± 0.275
2.478AspTyr: 2.478 ± 0.533
0.0AspXaa: 0.0 ± 0.0
Glu
6.974GluAla: 6.974 ± 0.773
0.275GluCys: 0.275 ± 0.162
3.671GluAsp: 3.671 ± 0.653
6.332GluGlu: 6.332 ± 0.985
3.579GluPhe: 3.579 ± 0.441
3.12GluGly: 3.12 ± 0.479
1.193GluHis: 1.193 ± 0.387
6.424GluIle: 6.424 ± 0.881
5.598GluLys: 5.598 ± 0.742
8.167GluLeu: 8.167 ± 0.971
2.294GluMet: 2.294 ± 0.5
3.763GluAsn: 3.763 ± 0.685
2.294GluPro: 2.294 ± 0.467
2.386GluGln: 2.386 ± 0.534
3.304GluArg: 3.304 ± 0.573
3.12GluSer: 3.12 ± 0.557
4.405GluThr: 4.405 ± 0.7
4.405GluVal: 4.405 ± 0.938
0.551GluTrp: 0.551 ± 0.264
2.202GluTyr: 2.202 ± 0.454
0.0GluXaa: 0.0 ± 0.0
Phe
3.212PheAla: 3.212 ± 0.581
0.0PheCys: 0.0 ± 0.0
3.304PheAsp: 3.304 ± 0.52
3.854PheGlu: 3.854 ± 0.718
1.468PhePhe: 1.468 ± 0.287
2.845PheGly: 2.845 ± 0.453
0.459PheHis: 0.459 ± 0.207
1.652PheIle: 1.652 ± 0.408
3.671PheLys: 3.671 ± 0.502
2.386PheLeu: 2.386 ± 0.547
1.009PheMet: 1.009 ± 0.315
2.661PheAsn: 2.661 ± 0.521
0.734PhePro: 0.734 ± 0.341
0.642PheGln: 0.642 ± 0.203
1.927PheArg: 1.927 ± 0.38
2.845PheSer: 2.845 ± 0.593
2.57PheThr: 2.57 ± 0.527
2.57PheVal: 2.57 ± 0.453
0.275PheTrp: 0.275 ± 0.16
1.193PheTyr: 1.193 ± 0.301
0.0PheXaa: 0.0 ± 0.0
Gly
3.395GlyAla: 3.395 ± 0.728
0.275GlyCys: 0.275 ± 0.161
4.497GlyAsp: 4.497 ± 0.88
4.038GlyGlu: 4.038 ± 0.6
3.395GlyPhe: 3.395 ± 0.764
3.671GlyGly: 3.671 ± 0.728
1.101GlyHis: 1.101 ± 0.311
4.864GlyIle: 4.864 ± 0.839
5.873GlyLys: 5.873 ± 0.804
5.781GlyLeu: 5.781 ± 0.675
1.927GlyMet: 1.927 ± 0.407
3.763GlyAsn: 3.763 ± 0.54
0.642GlyPro: 0.642 ± 0.214
2.661GlyGln: 2.661 ± 0.525
2.111GlyArg: 2.111 ± 0.397
3.395GlySer: 3.395 ± 0.617
4.221GlyThr: 4.221 ± 0.507
3.395GlyVal: 3.395 ± 0.554
1.009GlyTrp: 1.009 ± 0.445
4.405GlyTyr: 4.405 ± 0.587
0.0GlyXaa: 0.0 ± 0.0
His
0.918HisAla: 0.918 ± 0.263
0.184HisCys: 0.184 ± 0.133
0.551HisAsp: 0.551 ± 0.219
1.193HisGlu: 1.193 ± 0.316
0.734HisPhe: 0.734 ± 0.26
1.377HisGly: 1.377 ± 0.334
0.184HisHis: 0.184 ± 0.115
1.009HisIle: 1.009 ± 0.29
0.826HisLys: 0.826 ± 0.25
1.193HisLeu: 1.193 ± 0.343
0.184HisMet: 0.184 ± 0.127
0.551HisAsn: 0.551 ± 0.203
0.551HisPro: 0.551 ± 0.213
1.009HisGln: 1.009 ± 0.251
0.551HisArg: 0.551 ± 0.212
1.193HisSer: 1.193 ± 0.281
0.642HisThr: 0.642 ± 0.251
0.734HisVal: 0.734 ± 0.315
0.184HisTrp: 0.184 ± 0.126
0.367HisTyr: 0.367 ± 0.164
0.0HisXaa: 0.0 ± 0.0
Ile
4.772IleAla: 4.772 ± 0.677
0.275IleCys: 0.275 ± 0.219
6.24IleAsp: 6.24 ± 0.754
4.588IleGlu: 4.588 ± 0.647
2.386IlePhe: 2.386 ± 0.435
3.946IleGly: 3.946 ± 0.625
1.193IleHis: 1.193 ± 0.32
4.221IleIle: 4.221 ± 0.609
7.8IleLys: 7.8 ± 0.884
4.864IleLeu: 4.864 ± 0.641
2.019IleMet: 2.019 ± 0.522
4.038IleAsn: 4.038 ± 0.677
2.57IlePro: 2.57 ± 0.561
2.57IleGln: 2.57 ± 0.513
3.12IleArg: 3.12 ± 0.605
6.424IleSer: 6.424 ± 0.95
4.13IleThr: 4.13 ± 0.549
3.487IleVal: 3.487 ± 0.52
0.459IleTrp: 0.459 ± 0.244
1.835IleTyr: 1.835 ± 0.402
0.0IleXaa: 0.0 ± 0.0
Lys
5.873LysAla: 5.873 ± 0.739
0.642LysCys: 0.642 ± 0.296
6.057LysAsp: 6.057 ± 0.768
6.516LysGlu: 6.516 ± 0.792
2.294LysPhe: 2.294 ± 0.453
5.414LysGly: 5.414 ± 0.817
1.468LysHis: 1.468 ± 0.351
5.965LysIle: 5.965 ± 0.754
10.095LysLys: 10.095 ± 1.508
6.791LysLeu: 6.791 ± 0.744
2.937LysMet: 2.937 ± 0.426
4.221LysAsn: 4.221 ± 0.499
2.57LysPro: 2.57 ± 0.522
3.671LysGln: 3.671 ± 0.681
3.854LysArg: 3.854 ± 0.741
5.69LysSer: 5.69 ± 0.687
6.974LysThr: 6.974 ± 0.741
6.24LysVal: 6.24 ± 0.797
1.193LysTrp: 1.193 ± 0.386
3.212LysTyr: 3.212 ± 0.485
0.0LysXaa: 0.0 ± 0.0
Leu
6.607LeuAla: 6.607 ± 0.578
0.184LeuCys: 0.184 ± 0.114
6.607LeuAsp: 6.607 ± 0.695
6.057LeuGlu: 6.057 ± 0.847
3.028LeuPhe: 3.028 ± 0.42
5.139LeuGly: 5.139 ± 0.854
0.918LeuHis: 0.918 ± 0.351
5.506LeuIle: 5.506 ± 0.665
10.095LeuLys: 10.095 ± 1.108
7.066LeuLeu: 7.066 ± 0.838
1.101LeuMet: 1.101 ± 0.316
3.946LeuAsn: 3.946 ± 0.427
2.478LeuPro: 2.478 ± 0.439
3.12LeuGln: 3.12 ± 0.598
3.212LeuArg: 3.212 ± 0.65
6.699LeuSer: 6.699 ± 0.89
4.497LeuThr: 4.497 ± 0.667
4.772LeuVal: 4.772 ± 0.719
0.734LeuTrp: 0.734 ± 0.282
2.019LeuTyr: 2.019 ± 0.335
0.0LeuXaa: 0.0 ± 0.0
Met
2.111MetAla: 2.111 ± 0.449
0.092MetCys: 0.092 ± 0.097
1.652MetAsp: 1.652 ± 0.427
1.652MetGlu: 1.652 ± 0.456
0.275MetPhe: 0.275 ± 0.167
1.468MetGly: 1.468 ± 0.362
0.184MetHis: 0.184 ± 0.122
2.019MetIle: 2.019 ± 0.353
1.468MetLys: 1.468 ± 0.37
1.835MetLeu: 1.835 ± 0.365
0.092MetMet: 0.092 ± 0.097
1.377MetAsn: 1.377 ± 0.395
0.826MetPro: 0.826 ± 0.236
1.377MetGln: 1.377 ± 0.338
0.367MetArg: 0.367 ± 0.192
1.744MetSer: 1.744 ± 0.313
2.294MetThr: 2.294 ± 0.387
1.652MetVal: 1.652 ± 0.363
0.184MetTrp: 0.184 ± 0.12
1.193MetTyr: 1.193 ± 0.317
0.0MetXaa: 0.0 ± 0.0
Asn
3.304AsnAla: 3.304 ± 0.599
0.642AsnCys: 0.642 ± 0.236
2.202AsnAsp: 2.202 ± 0.383
3.487AsnGlu: 3.487 ± 0.483
2.294AsnPhe: 2.294 ± 0.476
4.038AsnGly: 4.038 ± 0.538
0.642AsnHis: 0.642 ± 0.29
2.937AsnIle: 2.937 ± 0.521
4.772AsnLys: 4.772 ± 0.663
5.965AsnLeu: 5.965 ± 0.78
1.652AsnMet: 1.652 ± 0.35
2.294AsnAsn: 2.294 ± 0.343
2.386AsnPro: 2.386 ± 0.514
2.019AsnGln: 2.019 ± 0.414
2.57AsnArg: 2.57 ± 0.544
2.478AsnSer: 2.478 ± 0.392
2.294AsnThr: 2.294 ± 0.411
2.937AsnVal: 2.937 ± 0.525
0.459AsnTrp: 0.459 ± 0.201
2.386AsnTyr: 2.386 ± 0.474
0.0AsnXaa: 0.0 ± 0.0
Pro
1.56ProAla: 1.56 ± 0.499
0.275ProCys: 0.275 ± 0.157
1.744ProAsp: 1.744 ± 0.464
1.56ProGlu: 1.56 ± 0.42
0.918ProPhe: 0.918 ± 0.311
0.918ProGly: 0.918 ± 0.313
0.184ProHis: 0.184 ± 0.13
2.019ProIle: 2.019 ± 0.393
2.937ProLys: 2.937 ± 0.447
1.927ProLeu: 1.927 ± 0.442
0.734ProMet: 0.734 ± 0.215
1.468ProAsn: 1.468 ± 0.368
0.734ProPro: 0.734 ± 0.26
1.009ProGln: 1.009 ± 0.291
0.826ProArg: 0.826 ± 0.251
2.019ProSer: 2.019 ± 0.392
2.57ProThr: 2.57 ± 0.443
1.468ProVal: 1.468 ± 0.364
0.275ProTrp: 0.275 ± 0.158
0.918ProTyr: 0.918 ± 0.222
0.0ProXaa: 0.0 ± 0.0
Gln
2.937GlnAla: 2.937 ± 0.512
0.367GlnCys: 0.367 ± 0.175
2.111GlnAsp: 2.111 ± 0.449
2.845GlnGlu: 2.845 ± 0.71
1.835GlnPhe: 1.835 ± 0.348
2.937GlnGly: 2.937 ± 0.637
0.826GlnHis: 0.826 ± 0.258
2.845GlnIle: 2.845 ± 0.497
3.395GlnLys: 3.395 ± 0.626
2.845GlnLeu: 2.845 ± 0.539
0.551GlnMet: 0.551 ± 0.278
2.019GlnAsn: 2.019 ± 0.45
0.642GlnPro: 0.642 ± 0.247
1.285GlnGln: 1.285 ± 0.323
1.468GlnArg: 1.468 ± 0.405
3.028GlnSer: 3.028 ± 0.614
1.927GlnThr: 1.927 ± 0.416
2.202GlnVal: 2.202 ± 0.449
0.826GlnTrp: 0.826 ± 0.305
1.101GlnTyr: 1.101 ± 0.329
0.0GlnXaa: 0.0 ± 0.0
Arg
2.845ArgAla: 2.845 ± 0.555
0.275ArgCys: 0.275 ± 0.158
2.661ArgAsp: 2.661 ± 0.459
3.671ArgGlu: 3.671 ± 0.621
1.009ArgPhe: 1.009 ± 0.314
1.744ArgGly: 1.744 ± 0.388
0.642ArgHis: 0.642 ± 0.269
3.028ArgIle: 3.028 ± 0.469
3.395ArgLys: 3.395 ± 0.546
3.395ArgLeu: 3.395 ± 0.512
1.009ArgMet: 1.009 ± 0.319
2.294ArgAsn: 2.294 ± 0.442
1.56ArgPro: 1.56 ± 0.308
1.56ArgGln: 1.56 ± 0.358
1.652ArgArg: 1.652 ± 0.453
2.294ArgSer: 2.294 ± 0.55
2.111ArgThr: 2.111 ± 0.409
2.937ArgVal: 2.937 ± 0.535
0.734ArgTrp: 0.734 ± 0.249
1.744ArgTyr: 1.744 ± 0.367
0.0ArgXaa: 0.0 ± 0.0
Ser
4.313SerAla: 4.313 ± 1.22
0.275SerCys: 0.275 ± 0.207
4.13SerAsp: 4.13 ± 0.593
4.038SerGlu: 4.038 ± 0.621
3.763SerPhe: 3.763 ± 0.851
5.873SerGly: 5.873 ± 0.904
1.101SerHis: 1.101 ± 0.332
4.405SerIle: 4.405 ± 0.792
4.772SerLys: 4.772 ± 0.745
5.506SerLeu: 5.506 ± 0.936
1.377SerMet: 1.377 ± 0.379
3.12SerAsn: 3.12 ± 0.643
1.101SerPro: 1.101 ± 0.361
2.937SerGln: 2.937 ± 0.575
2.753SerArg: 2.753 ± 0.638
4.13SerSer: 4.13 ± 0.741
3.671SerThr: 3.671 ± 0.552
4.313SerVal: 4.313 ± 0.497
0.826SerTrp: 0.826 ± 0.349
3.946SerTyr: 3.946 ± 0.725
0.0SerXaa: 0.0 ± 0.0
Thr
6.148ThrAla: 6.148 ± 0.678
0.184ThrCys: 0.184 ± 0.131
4.313ThrAsp: 4.313 ± 0.544
3.395ThrGlu: 3.395 ± 0.543
2.753ThrPhe: 2.753 ± 0.412
5.139ThrGly: 5.139 ± 0.766
0.734ThrHis: 0.734 ± 0.239
4.955ThrIle: 4.955 ± 0.764
5.231ThrLys: 5.231 ± 0.737
5.323ThrLeu: 5.323 ± 0.852
1.56ThrMet: 1.56 ± 0.364
2.019ThrAsn: 2.019 ± 0.348
1.744ThrPro: 1.744 ± 0.411
2.294ThrGln: 2.294 ± 0.46
2.019ThrArg: 2.019 ± 0.453
4.588ThrSer: 4.588 ± 0.595
4.038ThrThr: 4.038 ± 0.763
3.395ThrVal: 3.395 ± 0.455
0.551ThrTrp: 0.551 ± 0.212
1.652ThrTyr: 1.652 ± 0.333
0.0ThrXaa: 0.0 ± 0.0
Val
3.671ValAla: 3.671 ± 0.506
0.184ValCys: 0.184 ± 0.117
4.313ValAsp: 4.313 ± 0.687
5.69ValGlu: 5.69 ± 0.672
2.937ValPhe: 2.937 ± 0.495
3.854ValGly: 3.854 ± 0.683
0.826ValHis: 0.826 ± 0.279
4.038ValIle: 4.038 ± 0.72
4.405ValLys: 4.405 ± 0.577
4.955ValLeu: 4.955 ± 0.738
1.468ValMet: 1.468 ± 0.344
3.028ValAsn: 3.028 ± 0.528
1.193ValPro: 1.193 ± 0.352
2.57ValGln: 2.57 ± 0.477
2.57ValArg: 2.57 ± 0.412
4.313ValSer: 4.313 ± 0.443
4.864ValThr: 4.864 ± 0.646
4.772ValVal: 4.772 ± 0.804
0.459ValTrp: 0.459 ± 0.188
1.652ValTyr: 1.652 ± 0.385
0.0ValXaa: 0.0 ± 0.0
Trp
0.642TrpAla: 0.642 ± 0.32
0.092TrpCys: 0.092 ± 0.088
0.184TrpAsp: 0.184 ± 0.156
0.918TrpGlu: 0.918 ± 0.303
0.367TrpPhe: 0.367 ± 0.243
1.009TrpGly: 1.009 ± 0.408
0.184TrpHis: 0.184 ± 0.172
0.734TrpIle: 0.734 ± 0.238
0.734TrpLys: 0.734 ± 0.253
0.642TrpLeu: 0.642 ± 0.236
0.092TrpMet: 0.092 ± 0.081
0.642TrpAsn: 0.642 ± 0.213
0.275TrpPro: 0.275 ± 0.164
0.459TrpGln: 0.459 ± 0.182
0.734TrpArg: 0.734 ± 0.265
1.285TrpSer: 1.285 ± 0.352
0.642TrpThr: 0.642 ± 0.324
0.367TrpVal: 0.367 ± 0.167
0.092TrpTrp: 0.092 ± 0.085
0.459TrpTyr: 0.459 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.753TyrAla: 2.753 ± 0.441
0.275TyrCys: 0.275 ± 0.16
2.937TyrAsp: 2.937 ± 0.427
2.57TyrGlu: 2.57 ± 0.415
1.652TyrPhe: 1.652 ± 0.391
1.835TyrGly: 1.835 ± 0.382
0.734TyrHis: 0.734 ± 0.267
2.57TyrIle: 2.57 ± 0.595
4.038TyrLys: 4.038 ± 0.68
3.304TyrLeu: 3.304 ± 0.75
0.551TyrMet: 0.551 ± 0.246
1.927TyrAsn: 1.927 ± 0.477
1.009TyrPro: 1.009 ± 0.242
2.019TyrGln: 2.019 ± 0.369
1.927TyrArg: 1.927 ± 0.505
1.468TyrSer: 1.468 ± 0.307
1.377TyrThr: 1.377 ± 0.337
2.294TyrVal: 2.294 ± 0.425
0.275TyrTrp: 0.275 ± 0.168
1.927TyrTyr: 1.927 ± 0.413
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 63 proteins (10898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski