Amino acid dipepetide frequency for Oceanihabitans sp. IOP_32

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.252AlaAla: 4.252 ± 0.086
0.558AlaCys: 0.558 ± 0.024
3.18AlaAsp: 3.18 ± 0.064
4.044AlaGlu: 4.044 ± 0.093
3.593AlaPhe: 3.593 ± 0.061
3.994AlaGly: 3.994 ± 0.09
1.33AlaHis: 1.33 ± 0.042
5.749AlaIle: 5.749 ± 0.084
4.972AlaLys: 4.972 ± 0.094
7.138AlaLeu: 7.138 ± 0.106
1.51AlaMet: 1.51 ± 0.047
3.689AlaAsn: 3.689 ± 0.074
1.916AlaPro: 1.916 ± 0.066
2.524AlaGln: 2.524 ± 0.054
1.965AlaArg: 1.965 ± 0.051
4.215AlaSer: 4.215 ± 0.08
3.798AlaThr: 3.798 ± 0.088
4.408AlaVal: 4.408 ± 0.07
0.617AlaTrp: 0.617 ± 0.024
2.61AlaTyr: 2.61 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.443CysAla: 0.443 ± 0.023
0.098CysCys: 0.098 ± 0.011
0.419CysAsp: 0.419 ± 0.025
0.479CysGlu: 0.479 ± 0.026
0.422CysPhe: 0.422 ± 0.028
0.573CysGly: 0.573 ± 0.03
0.179CysHis: 0.179 ± 0.016
0.565CysIle: 0.565 ± 0.028
0.546CysLys: 0.546 ± 0.025
0.629CysLeu: 0.629 ± 0.027
0.136CysMet: 0.136 ± 0.012
0.447CysAsn: 0.447 ± 0.023
0.324CysPro: 0.324 ± 0.022
0.209CysGln: 0.209 ± 0.016
0.199CysArg: 0.199 ± 0.015
0.522CysSer: 0.522 ± 0.028
0.412CysThr: 0.412 ± 0.034
0.399CysVal: 0.399 ± 0.021
0.052CysTrp: 0.052 ± 0.008
0.304CysTyr: 0.304 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.899AspAla: 3.899 ± 0.075
0.417AspCys: 0.417 ± 0.022
3.004AspAsp: 3.004 ± 0.062
3.384AspGlu: 3.384 ± 0.072
3.651AspPhe: 3.651 ± 0.063
3.378AspGly: 3.378 ± 0.111
0.888AspHis: 0.888 ± 0.033
4.679AspIle: 4.679 ± 0.079
4.277AspLys: 4.277 ± 0.076
5.382AspLeu: 5.382 ± 0.072
1.149AspMet: 1.149 ± 0.038
3.11AspAsn: 3.11 ± 0.063
1.48AspPro: 1.48 ± 0.051
1.302AspGln: 1.302 ± 0.035
1.751AspArg: 1.751 ± 0.045
3.023AspSer: 3.023 ± 0.067
2.843AspThr: 2.843 ± 0.057
3.707AspVal: 3.707 ± 0.064
0.686AspTrp: 0.686 ± 0.027
2.855AspTyr: 2.855 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
4.869GluAla: 4.869 ± 0.083
0.31GluCys: 0.31 ± 0.018
3.638GluAsp: 3.638 ± 0.069
4.184GluGlu: 4.184 ± 0.093
2.87GluPhe: 2.87 ± 0.052
3.42GluGly: 3.42 ± 0.066
1.29GluHis: 1.29 ± 0.038
5.136GluIle: 5.136 ± 0.084
5.526GluLys: 5.526 ± 0.096
6.096GluLeu: 6.096 ± 0.084
1.38GluMet: 1.38 ± 0.038
4.733GluAsn: 4.733 ± 0.076
1.529GluPro: 1.529 ± 0.043
2.284GluGln: 2.284 ± 0.054
2.414GluArg: 2.414 ± 0.061
3.303GluSer: 3.303 ± 0.065
3.991GluThr: 3.991 ± 0.065
4.066GluVal: 4.066 ± 0.07
0.524GluTrp: 0.524 ± 0.027
2.145GluTyr: 2.145 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
2.893PheAla: 2.893 ± 0.059
0.369PheCys: 0.369 ± 0.021
3.127PheAsp: 3.127 ± 0.062
3.411PheGlu: 3.411 ± 0.061
2.565PhePhe: 2.565 ± 0.072
3.629PheGly: 3.629 ± 0.078
0.798PheHis: 0.798 ± 0.028
3.994PheIle: 3.994 ± 0.078
4.404PheLys: 4.404 ± 0.083
4.638PheLeu: 4.638 ± 0.078
1.066PheMet: 1.066 ± 0.035
3.724PheAsn: 3.724 ± 0.087
1.633PhePro: 1.633 ± 0.044
1.416PheGln: 1.416 ± 0.041
1.575PheArg: 1.575 ± 0.042
4.066PheSer: 4.066 ± 0.072
3.074PheThr: 3.074 ± 0.072
3.066PheVal: 3.066 ± 0.056
0.566PheTrp: 0.566 ± 0.024
2.165PheTyr: 2.165 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.213GlyAla: 4.213 ± 0.08
0.597GlyCys: 0.597 ± 0.046
3.316GlyAsp: 3.316 ± 0.065
3.429GlyGlu: 3.429 ± 0.061
3.731GlyPhe: 3.731 ± 0.069
4.366GlyGly: 4.366 ± 0.098
1.198GlyHis: 1.198 ± 0.034
5.129GlyIle: 5.129 ± 0.086
4.74GlyLys: 4.74 ± 0.088
5.786GlyLeu: 5.786 ± 0.08
1.494GlyMet: 1.494 ± 0.041
3.358GlyAsn: 3.358 ± 0.083
1.222GlyPro: 1.222 ± 0.039
1.729GlyGln: 1.729 ± 0.047
2.088GlyArg: 2.088 ± 0.052
3.68GlySer: 3.68 ± 0.076
3.809GlyThr: 3.809 ± 0.116
4.512GlyVal: 4.512 ± 0.092
0.681GlyTrp: 0.681 ± 0.026
2.605GlyTyr: 2.605 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.033HisAla: 1.033 ± 0.034
0.197HisCys: 0.197 ± 0.012
0.903HisAsp: 0.903 ± 0.032
0.973HisGlu: 0.973 ± 0.031
1.181HisPhe: 1.181 ± 0.035
1.083HisGly: 1.083 ± 0.036
0.548HisHis: 0.548 ± 0.026
1.715HisIle: 1.715 ± 0.048
1.428HisLys: 1.428 ± 0.041
1.947HisLeu: 1.947 ± 0.044
0.308HisMet: 0.308 ± 0.019
1.023HisAsn: 1.023 ± 0.034
0.923HisPro: 0.923 ± 0.036
0.747HisGln: 0.747 ± 0.028
0.667HisArg: 0.667 ± 0.022
1.087HisSer: 1.087 ± 0.032
1.01HisThr: 1.01 ± 0.031
1.116HisVal: 1.116 ± 0.033
0.247HisTrp: 0.247 ± 0.015
0.907HisTyr: 0.907 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.617IleAla: 5.617 ± 0.088
0.589IleCys: 0.589 ± 0.028
5.096IleAsp: 5.096 ± 0.076
5.796IleGlu: 5.796 ± 0.09
3.436IlePhe: 3.436 ± 0.071
4.976IleGly: 4.976 ± 0.081
1.35IleHis: 1.35 ± 0.042
6.242IleIle: 6.242 ± 0.112
6.352IleLys: 6.352 ± 0.096
7.085IleLeu: 7.085 ± 0.101
1.468IleMet: 1.468 ± 0.039
5.261IleAsn: 5.261 ± 0.077
3.344IlePro: 3.344 ± 0.066
2.4IleGln: 2.4 ± 0.049
2.553IleArg: 2.553 ± 0.052
5.57IleSer: 5.57 ± 0.084
5.126IleThr: 5.126 ± 0.105
4.709IleVal: 4.709 ± 0.07
0.633IleTrp: 0.633 ± 0.026
2.739IleTyr: 2.739 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.726LysAla: 5.726 ± 0.096
0.388LysCys: 0.388 ± 0.021
4.667LysAsp: 4.667 ± 0.086
5.738LysGlu: 5.738 ± 0.095
2.944LysPhe: 2.944 ± 0.06
4.511LysGly: 4.511 ± 0.08
1.832LysHis: 1.832 ± 0.051
6.366LysIle: 6.366 ± 0.091
6.718LysLys: 6.718 ± 0.11
6.912LysLeu: 6.912 ± 0.094
1.841LysMet: 1.841 ± 0.043
5.733LysAsn: 5.733 ± 0.095
2.723LysPro: 2.723 ± 0.064
3.194LysGln: 3.194 ± 0.073
3.163LysArg: 3.163 ± 0.069
4.735LysSer: 4.735 ± 0.084
5.611LysThr: 5.611 ± 0.086
4.407LysVal: 4.407 ± 0.086
0.76LysTrp: 0.76 ± 0.031
2.983LysTyr: 2.983 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
5.994LeuAla: 5.994 ± 0.083
0.689LeuCys: 0.689 ± 0.027
5.148LeuAsp: 5.148 ± 0.081
6.444LeuGlu: 6.444 ± 0.085
4.916LeuPhe: 4.916 ± 0.094
5.855LeuGly: 5.855 ± 0.086
1.593LeuHis: 1.593 ± 0.043
7.335LeuIle: 7.335 ± 0.108
8.661LeuLys: 8.661 ± 0.118
8.567LeuLeu: 8.567 ± 0.128
2.083LeuMet: 2.083 ± 0.046
6.323LeuAsn: 6.323 ± 0.095
3.344LeuPro: 3.344 ± 0.063
3.232LeuGln: 3.232 ± 0.059
3.284LeuArg: 3.284 ± 0.062
6.69LeuSer: 6.69 ± 0.079
5.136LeuThr: 5.136 ± 0.082
5.445LeuVal: 5.445 ± 0.087
0.769LeuTrp: 0.769 ± 0.029
3.085LeuTyr: 3.085 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
1.693MetAla: 1.693 ± 0.047
0.133MetCys: 0.133 ± 0.011
1.072MetAsp: 1.072 ± 0.037
1.259MetGlu: 1.259 ± 0.036
0.898MetPhe: 0.898 ± 0.052
1.311MetGly: 1.311 ± 0.042
0.416MetHis: 0.416 ± 0.021
1.456MetIle: 1.456 ± 0.045
1.996MetLys: 1.996 ± 0.047
1.916MetLeu: 1.916 ± 0.048
0.554MetMet: 0.554 ± 0.031
1.123MetAsn: 1.123 ± 0.031
0.839MetPro: 0.839 ± 0.029
0.808MetGln: 0.808 ± 0.028
0.871MetArg: 0.871 ± 0.032
1.382MetSer: 1.382 ± 0.042
1.091MetThr: 1.091 ± 0.037
1.396MetVal: 1.396 ± 0.037
0.146MetTrp: 0.146 ± 0.012
0.672MetTyr: 0.672 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.27AsnAla: 4.27 ± 0.069
0.491AsnCys: 0.491 ± 0.027
3.399AsnAsp: 3.399 ± 0.072
3.592AsnGlu: 3.592 ± 0.066
3.173AsnPhe: 3.173 ± 0.069
3.702AsnGly: 3.702 ± 0.072
1.316AsnHis: 1.316 ± 0.039
5.178AsnIle: 5.178 ± 0.078
4.934AsnLys: 4.934 ± 0.077
5.863AsnLeu: 5.863 ± 0.1
1.329AsnMet: 1.329 ± 0.047
4.371AsnAsn: 4.371 ± 0.088
2.747AsnPro: 2.747 ± 0.069
2.373AsnGln: 2.373 ± 0.055
2.373AsnArg: 2.373 ± 0.047
3.754AsnSer: 3.754 ± 0.071
4.233AsnThr: 4.233 ± 0.065
3.442AsnVal: 3.442 ± 0.074
0.794AsnTrp: 0.794 ± 0.037
2.923AsnTyr: 2.923 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
1.762ProAla: 1.762 ± 0.06
0.234ProCys: 0.234 ± 0.017
1.85ProAsp: 1.85 ± 0.045
2.849ProGlu: 2.849 ± 0.06
1.881ProPhe: 1.881 ± 0.051
1.688ProGly: 1.688 ± 0.047
0.64ProHis: 0.64 ± 0.022
2.776ProIle: 2.776 ± 0.058
2.666ProLys: 2.666 ± 0.052
3.059ProLeu: 3.059 ± 0.057
0.696ProMet: 0.696 ± 0.028
2.363ProAsn: 2.363 ± 0.058
0.768ProPro: 0.768 ± 0.036
1.112ProGln: 1.112 ± 0.037
0.924ProArg: 0.924 ± 0.032
2.034ProSer: 2.034 ± 0.051
1.907ProThr: 1.907 ± 0.052
2.166ProVal: 2.166 ± 0.057
0.319ProTrp: 0.319 ± 0.019
1.378ProTyr: 1.378 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.266GlnAla: 2.266 ± 0.052
0.173GlnCys: 0.173 ± 0.013
1.861GlnAsp: 1.861 ± 0.048
2.193GlnGlu: 2.193 ± 0.051
1.646GlnPhe: 1.646 ± 0.039
1.893GlnGly: 1.893 ± 0.046
0.621GlnHis: 0.621 ± 0.025
2.715GlnIle: 2.715 ± 0.058
2.677GlnLys: 2.677 ± 0.061
3.482GlnLeu: 3.482 ± 0.058
0.746GlnMet: 0.746 ± 0.028
2.256GlnAsn: 2.256 ± 0.051
1.072GlnPro: 1.072 ± 0.036
1.394GlnGln: 1.394 ± 0.043
1.163GlnArg: 1.163 ± 0.04
1.824GlnSer: 1.824 ± 0.044
1.826GlnThr: 1.826 ± 0.05
2.102GlnVal: 2.102 ± 0.048
0.325GlnTrp: 0.325 ± 0.019
1.377GlnTyr: 1.377 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.313ArgAla: 2.313 ± 0.05
0.196ArgCys: 0.196 ± 0.014
1.849ArgAsp: 1.849 ± 0.047
2.061ArgGlu: 2.061 ± 0.052
1.97ArgPhe: 1.97 ± 0.045
1.942ArgGly: 1.942 ± 0.052
0.684ArgHis: 0.684 ± 0.029
2.84ArgIle: 2.84 ± 0.058
2.707ArgLys: 2.707 ± 0.06
3.353ArgLeu: 3.353 ± 0.063
0.827ArgMet: 0.827 ± 0.03
2.018ArgAsn: 2.018 ± 0.049
1.112ArgPro: 1.112 ± 0.033
1.121ArgGln: 1.121 ± 0.036
1.262ArgArg: 1.262 ± 0.045
1.821ArgSer: 1.821 ± 0.05
1.826ArgThr: 1.826 ± 0.043
2.131ArgVal: 2.131 ± 0.043
0.342ArgTrp: 0.342 ± 0.02
1.532ArgTyr: 1.532 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
3.819SerAla: 3.819 ± 0.067
0.615SerCys: 0.615 ± 0.028
3.233SerAsp: 3.233 ± 0.07
3.831SerGlu: 3.831 ± 0.066
3.616SerPhe: 3.616 ± 0.066
4.338SerGly: 4.338 ± 0.08
1.149SerHis: 1.149 ± 0.033
5.146SerIle: 5.146 ± 0.082
5.262SerLys: 5.262 ± 0.082
5.733SerLeu: 5.733 ± 0.095
1.198SerMet: 1.198 ± 0.041
3.927SerAsn: 3.927 ± 0.078
1.936SerPro: 1.936 ± 0.047
2.108SerGln: 2.108 ± 0.047
2.201SerArg: 2.201 ± 0.055
3.903SerSer: 3.903 ± 0.076
3.526SerThr: 3.526 ± 0.08
3.927SerVal: 3.927 ± 0.064
0.657SerTrp: 0.657 ± 0.031
2.628SerTyr: 2.628 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
3.946ThrAla: 3.946 ± 0.104
0.394ThrCys: 0.394 ± 0.024
3.134ThrAsp: 3.134 ± 0.077
3.507ThrGlu: 3.507 ± 0.06
3.028ThrPhe: 3.028 ± 0.052
4.011ThrGly: 4.011 ± 0.105
1.174ThrHis: 1.174 ± 0.041
5.018ThrIle: 5.018 ± 0.099
4.235ThrLys: 4.235 ± 0.076
5.837ThrLeu: 5.837 ± 0.078
0.98ThrMet: 0.98 ± 0.033
3.603ThrAsn: 3.603 ± 0.09
2.455ThrPro: 2.455 ± 0.065
2.03ThrGln: 2.03 ± 0.041
1.65ThrArg: 1.65 ± 0.043
3.724ThrSer: 3.724 ± 0.076
3.648ThrThr: 3.648 ± 0.099
3.88ThrVal: 3.88 ± 0.12
0.528ThrTrp: 0.528 ± 0.026
2.366ThrTyr: 2.366 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
4.023ValAla: 4.023 ± 0.073
0.511ValCys: 0.511 ± 0.024
3.32ValAsp: 3.32 ± 0.064
3.79ValGlu: 3.79 ± 0.071
3.676ValPhe: 3.676 ± 0.062
3.84ValGly: 3.84 ± 0.072
1.01ValHis: 1.01 ± 0.033
4.928ValIle: 4.928 ± 0.078
4.696ValLys: 4.696 ± 0.08
6.455ValLeu: 6.455 ± 0.083
1.274ValMet: 1.274 ± 0.04
3.709ValAsn: 3.709 ± 0.073
2.088ValPro: 2.088 ± 0.055
1.636ValGln: 1.636 ± 0.041
1.886ValArg: 1.886 ± 0.047
4.314ValSer: 4.314 ± 0.076
3.466ValThr: 3.466 ± 0.126
4.264ValVal: 4.264 ± 0.086
0.563ValTrp: 0.563 ± 0.025
2.384ValTyr: 2.384 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.524TrpAla: 0.524 ± 0.024
0.093TrpCys: 0.093 ± 0.009
0.585TrpAsp: 0.585 ± 0.029
0.629TrpGlu: 0.629 ± 0.027
0.555TrpPhe: 0.555 ± 0.024
0.582TrpGly: 0.582 ± 0.029
0.211TrpHis: 0.211 ± 0.014
0.692TrpIle: 0.692 ± 0.026
0.748TrpLys: 0.748 ± 0.033
1.027TrpLeu: 1.027 ± 0.037
0.287TrpMet: 0.287 ± 0.019
0.645TrpAsn: 0.645 ± 0.035
0.2TrpPro: 0.2 ± 0.015
0.418TrpGln: 0.418 ± 0.021
0.391TrpArg: 0.391 ± 0.021
0.597TrpSer: 0.597 ± 0.021
0.506TrpThr: 0.506 ± 0.023
0.605TrpVal: 0.605 ± 0.028
0.131TrpTrp: 0.131 ± 0.012
0.372TrpTyr: 0.372 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.507TyrAla: 2.507 ± 0.056
0.304TyrCys: 0.304 ± 0.019
2.065TyrAsp: 2.065 ± 0.047
2.117TyrGlu: 2.117 ± 0.05
2.424TyrPhe: 2.424 ± 0.056
2.591TyrGly: 2.591 ± 0.048
0.819TyrHis: 0.819 ± 0.027
2.681TyrIle: 2.681 ± 0.06
3.404TyrLys: 3.404 ± 0.066
3.689TyrLeu: 3.689 ± 0.07
0.706TyrMet: 0.706 ± 0.027
2.842TyrAsn: 2.842 ± 0.072
1.416TyrPro: 1.416 ± 0.042
1.578TyrGln: 1.578 ± 0.044
1.525TyrArg: 1.525 ± 0.043
2.51TyrSer: 2.51 ± 0.058
2.308TyrThr: 2.308 ± 0.078
2.085TyrVal: 2.085 ± 0.051
0.458TyrTrp: 0.458 ± 0.023
1.765TyrTyr: 1.765 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2767 proteins (954352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski